EP1824814A2 - Preparation of a quaternary ammonium hydroxide and use thereof for the preparation of q quaternary ammonium salt - Google Patents
Preparation of a quaternary ammonium hydroxide and use thereof for the preparation of q quaternary ammonium saltInfo
- Publication number
- EP1824814A2 EP1824814A2 EP05809075A EP05809075A EP1824814A2 EP 1824814 A2 EP1824814 A2 EP 1824814A2 EP 05809075 A EP05809075 A EP 05809075A EP 05809075 A EP05809075 A EP 05809075A EP 1824814 A2 EP1824814 A2 EP 1824814A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- quaternary ammonium
- hydroxide
- denatonium
- preparation
- halide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
Definitions
- the invention relates to a process for the preparation of a quaternary ammonium hydroxide, in particular N- ⁇ 2-[(2,6-dimethylphenyl)-amino]-2-oxoethyl ⁇ -N,N-diethyl- benzenemethanaminium hydroxide (i.e. denatonium hydroxide), and the use thereof for the preparation of a quaternary ammonium salt, in particular of denatonium benzoate or a denatonium fatty acid derivative.
- a quaternary ammonium hydroxide in particular N- ⁇ 2-[(2,6-dimethylphenyl)-amino]-2-oxoethyl ⁇ -N,N-diethyl- benzenemethanaminium hydroxide (i.e. denatonium hydroxide)
- denatonium hydroxide i.e. denatonium hydroxide
- Quaternary ammonium compounds in particular denatonium benzoate or denatonium capsaicinate, provide an enhanced bitter and/or spicy, pungent flavor, and for that reason may be applied as an aversive agent, biocide, antifoulant or flavorant.
- These compounds are often incorporated into compositions or coatings in order to deter either ingestion by humans or to repel mammals, reptiles, fish and birds from an article coated therewith, but also the use as a denaturant for alcohol and tallow or as a bitter flavoring agent in food.
- denatonium benzoate or related quaternary salts, starting from a denatonium halide.
- GB 955,309 teaches a synthesis route for a quaternary ammonium benzoate involving denatonium chloride, wherein the denatonium chloride is first prepared by reacting lignocaine with benzyl chloride in an organic solvent, and then contacted with alcoholic caustic alkali or an ion-exchange resin in the hydroxide form to give denatonium hydroxide.
- This intermediate product is converted to denatonium benzoate, or related salts, using benzoic acid and methanol.
- GB 955,309 it is generally understood that the quality of a quaternary denatonium salt such as denatonium benzoate or denatonium capsaicinate is largely determined by the purity of the starting material, i.e. the denatonium halide.
- denatonium halide is first subjected to isolation and purification steps involving vacuum distillation in an organic environment and centrifu ⁇ ation or crystallization, before it is converted to a hygroscopic and unstable denatonium hydroxide intermediate. It is mentioned in GB 955,309 that the quaternary hydroxide is best used in the organic solvent in which it is prepared to produce the final quaternary ammonium compound of interest.
- denatonium halides are known to be extremely bitter and highly contaminating compounds, every working step involving these compounds requires costly precautions to avoid contact while handling. This is especially the case where such a compound is isolated from its solvent environment.
- the present invention relates to a process for the preparation of a quaternary ammonium hydroxide R + OH " , in which R + has the formula:
- R 1 and R 2 each independently represent an alkyl group containing from 1 to 4 carbon atoms, for example methyl, ethyl, n-propyl or n-butyl groups
- R 3 represents a benzyl group or a substituted benzyl group, such as o- or p-chlorobenzyl
- said process comprising forming an aqueous solution containing a quaternary ammonium halide having said cation R + , and said halide preferably being a Cl " ion, contacting said aqueous solution with hydroxide ions, to obtain a quaternary ammonium hydroxide, and isolating said quaternary ammonium hydroxide.
- the quaternary ammonium hydroxide rather than the corresponding ammonium halide starting material is isolated. It is found that the purity of the hydroxide form has a direct effect on the quality of the final product to be prepared from this compound, but that the quaternary ammonium hydroxide is isolated much more straightforwardly than the halide form, despite the warnings for instability of the hydroxide given in GB 955,309.
- the invention takes advantage of the water- insolubility of the quaternary ammonium hydroxide by exchanging the halide ions with hydroxide ions in an aqueous environment rather than in the organic, mostly alcoholic environment applied in the prior art.
- the quaternary ammonium halide is provided in an aqueous environment which is preferably washed at least once with an organic solvent, preferably toluene.
- the aqueous solution provided to the reaction comprises quaternary ammonium halide in an amount between 30 wt% and 90 wt%, more preferably between 50 wt% and 75 wt%, based on the weight of the aqueous solution.
- the source of hydroxide ions in the above-mentioned reaction can be caustic alkali or an ion-exchange resin in the hydroxide form. It is preferred that the hydroxide ions are provided by an aqueous caustic alkali solution, preferably a sodium hydroxide solution having a concentration of at least 40 wt% and up to 60 wt%, more preferably 45 - 55 wt%, most preferably 48 - 52 wt%, based on the weight of the solution.
- the reaction is preferably performed at atmospheric conditions and at temperatures between 10 - 50 0 C, more preferably between 20 and 40 0 C, most preferably between 25 and 30 0 C.
- the quaternary ammonium halide and the hydroxide ions are provided in such relative amounts that there is an excess hydroxide ions over ⁇ uaternarv ammonium halide, "excess” meaning a molar ratio of hydroxide ions to quaternary ammonium halide higher than 1:1, preferably between 1.1:1 and 2:1, more preferably between 1:1:1 and 1.3:1.
- the solvent comprises at least 80 wt% of water, preferably at least 90 wt%, more preferably at least 95 wt% of water, based on the total weight of the solvent, and most preferably the solvent does not contain a detectable amount of organic solvent at all.
- solvent it is meant both the water provided by the aqueous solution containing the quaternary ammonium halide and the solvent containing the hydroxide ions.
- quaternary ammonium hydroxide Purification of the quaternary ammonium hydroxide involves washing with excess water to remove salts such as sodium or potassium hydroxide present in solution. Due to its aforementioned water-insolubility, the quaternary ammonium hydroxide precipitates as it forms, and the solid can be isolated in crystalline form by centrifugation and/or filtering techniques known to those skilled in the art.
- the invention also relates to a denatonium hydroxide in its crystalline form, having a melting point between 150 and 160 0 C, more preferably 150 - 157 0 C, preferably having an off-white appearance, which can be obtained by the above- described process.
- the quaternary ammonium halide is preferably formed from the reaction of a tertiary amine of the formula:
- a halide having the general formula R 3 halide wherein R 1 , R 2 and R 3 each have the aforementioned meaning, and the halide being a F, Cl, Br, I group, preferably a Cl group, wherein the reaction is performed in aqueous conditions.
- the tertiary amine according to formula (II) is a lignocaine ( ⁇ -diethylamino-2,6- dimethylacetanilide or lidocaine) compound, or a derivative thereof.
- the lignocaine is understood to comprise both its acidic and its free base form.
- Lignocaine, having the formula (II) in which R 1 and R 2 are ethyl groups can for instance be prepared by reacting N-chloroacetyl-2,6-dimethylaniline with diethylamine in the presence of aqueous sodium carbonate.
- the preferred quaternary ammonium hydroxide of the present invention is a N- ⁇ 2-[(2,6- dimethylphenyl)-amino]-2-oxoethyl ⁇ -N,N-diethyl-benzenemethanaminium hydroxide or denatonium hydroxide, meaning that R 1 and R 2 are ethyl groups and R 3 is a benzyl group in formula (I).
- the process of the present invention allows for the production of an extremely bitter quaternary ammonium salt from a lignocaine compound in a one-pot synthesis involving mostly water, without the necessity to intervene in between through isolation of an intermediate compound, up to the point where quaternary ammonium hydroxide is obtained as a stable solid. Extensive contact with contaminating intermediate states and distillations at reduced pressure and high temperatures can thus be avoided.
- the invention also relates to a process for the preparation of a quaternary ammonium salt having a benzoate, a hydrogen phthalate, a hydrogen tartrate, a hydrogen oxalate or a capsaicinate anion, or their substituted analogues, or a iatty acid derivative, by reacting the corresponding isolated quaternary ammonium hydroxide of the invention with the conjugated acid of the anion, i.e. benzoic acid, phtalic acid, tartaric acid, oxalic acid, capsaicin, or with the fatty acid, respectively, in the presence of an organic solvent such as methanol or acetone, preferably acetone.
- an organic solvent such as methanol or acetone, preferably acetone.
- a fatty acid derivative it is meant the conjugated base of a fattv acid, such as palmitate. linolate. linolenate or eruciate.
- Fatty acids in the context of the invention are aliphatic monocarboxylic acids containing a long hydrocarbon chain, either saturated or unsaturated, preferably having a carbon chain length from Cl 2 to C22.
- the quaternary ammonium salt is preferably a denatonium benzoate, prepared from the reaction of a denatonium hydroxide according to the invention with benzoic acid, preferably using acetone as the solvent.
- the quaternary ammonium salt is preferably a denatonium fatty acid derivative, prepared from the reaction of a denatonium hydroxide with a fatty acid.
- the denatonium fatty acid derivative is preferably denatonium palmitate, linolate, linoleate or ericuiate.
- EXAMPLE 1 Preparation of N- ⁇ 2-rr2.6-dimethvbhenylVaminol-2-oxoethyli-N.N- diethyl-benzenemethanaminium hydroxide (denatonium hydroxide) 250 gram (1.07 mol) of 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide (Lignocaine) was added to 600 ml of water at 30-35 °C. It was then slowly heated to 70-90 °C, followed by the addition of 175.4 gram (1.39 mol) benzyl chloride at 70-90 °C.
- the temperature was maintained at 70-90 °C for 20-24 hours while monitoring the reaction by thin layer chromatography for every 4 hours, until the remaining unreacted Lignocaine was less than 10 %.
- the reaction mass was then cooled to 35-40 °C.
- the aqueous reaction solution was extracted with 100 ml of toluene (twice) at 35-40 °C. Approximately 920 gram of aqueous denatonium chloride solution was obtained.
- the assay was 50.7 % as measured by titrimetry.
- 50% sodium hydroxide solution (129.3 gram sodium hydroxide in 129.3 ml water) was added hereto, i.e. 1.25 mol sodium hydroxide against 1 mol denatonium chloride, at 25-30 °C over a period of 3.0 hrs.
- the solid denatonium hydroxide was filtered and washed with 400 ml demineralised water and finally with 50 ml acetone.
- the temperature was maintained for 20-24 hrs at 70-90 °C while monitoring the reaction by thin layer chromatography for every 4 hrs, until the unreacted lignocaine was less than 10%.
- the reaction mass was cooled to 35 - 40 °C.
- the aqueous reaction solution was extracted with 250 ml of toluene [twice] at 35 - 40 °C and the two layers separated.
- the upper layer was the toluene layer and the lower layer was the aqueous layer containing the denatonium chloride.
- About 3000 gram of an aqueous denatonium chloride solution was obtained, with a yield of 73.4 % denatonium chloride, as measured by titrimetry.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05809075A EP1824814A2 (en) | 2004-12-06 | 2005-11-30 | Preparation of a quaternary ammonium hydroxide and use thereof for the preparation of q quaternary ammonium salt |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63297604P | 2004-12-06 | 2004-12-06 | |
EP04078299 | 2004-12-06 | ||
PCT/NL2005/050055 WO2006062406A2 (en) | 2004-12-06 | 2005-11-30 | Preparation of a quaternary ammonium hydroxide and use thereof for the preparation of q quaternary ammonium salt |
EP05809075A EP1824814A2 (en) | 2004-12-06 | 2005-11-30 | Preparation of a quaternary ammonium hydroxide and use thereof for the preparation of q quaternary ammonium salt |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1824814A2 true EP1824814A2 (en) | 2007-08-29 |
Family
ID=34928707
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP05809075A Withdrawn EP1824814A2 (en) | 2004-12-06 | 2005-11-30 | Preparation of a quaternary ammonium hydroxide and use thereof for the preparation of q quaternary ammonium salt |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1824814A2 (en) |
CN (1) | CN101111473A (en) |
BR (1) | BRPI0518466A2 (en) |
CA (1) | CA2591272A1 (en) |
WO (1) | WO2006062406A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102016009766A1 (en) | 2016-08-11 | 2018-02-15 | Julius-Maximilians-Universität Würzburg | Production of bitter substance derivatives |
CN110354754A (en) * | 2019-07-10 | 2019-10-22 | 齐齐哈尔大学 | Amide bond quaternary cationics with different the morphology of the aggregate |
CN112593078B (en) * | 2020-12-03 | 2022-08-05 | 江西理工大学 | Synthetic method of organic quaternary ammonium salt |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB955309A (en) * | 1959-11-20 | 1964-04-15 | Edinburgh Pharmaceutical Ind L | New quaternary salts and compositions containing them |
GB8727504D0 (en) * | 1987-11-24 | 1987-12-23 | Glaxo Group Ltd | Chemical compositions |
US5891919A (en) * | 1997-09-19 | 1999-04-06 | Burlington Bio-Medical & Scientific Corp. | Denatonium capsaicinate and methods of producing the same |
-
2005
- 2005-11-30 CA CA002591272A patent/CA2591272A1/en not_active Abandoned
- 2005-11-30 WO PCT/NL2005/050055 patent/WO2006062406A2/en active Application Filing
- 2005-11-30 BR BRPI0518466-5A patent/BRPI0518466A2/en not_active Application Discontinuation
- 2005-11-30 CN CNA2005800475419A patent/CN101111473A/en active Pending
- 2005-11-30 EP EP05809075A patent/EP1824814A2/en not_active Withdrawn
Non-Patent Citations (1)
Title |
---|
See references of WO2006062406A2 * |
Also Published As
Publication number | Publication date |
---|---|
CN101111473A (en) | 2008-01-23 |
WO2006062406A2 (en) | 2006-06-15 |
WO2006062406A3 (en) | 2006-09-28 |
CA2591272A1 (en) | 2006-06-15 |
BRPI0518466A2 (en) | 2008-11-18 |
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