SU193524A1 - - Google Patents
Info
- Publication number
- SU193524A1 SU193524A1 SU1067705A SU1067705A SU193524A1 SU 193524 A1 SU193524 A1 SU 193524A1 SU 1067705 A SU1067705 A SU 1067705A SU 1067705 A SU1067705 A SU 1067705A SU 193524 A1 SU193524 A1 SU 193524A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- phthalimidoalkylpiperazines
- methoxyphenyl
- boiling
- methanol
- treated
- Prior art date
Links
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 238000009835 boiling Methods 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 2
- -1 o-methoxyphenyl Chemical group 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000005712 crystallization Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229910000042 hydrogen bromide Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
Description
СПОСОБ ПОЛУЧЕНИЯ ФТАЛИМИДОАЛКИЛПИПЕРАЗИНОВMETHOD OF OBTAINING PHTHALIMIDOALKYLPIPERAZINES
Изобретение относитс к области получени соединений, которые могут найти применение в пренаративиай органической химии.This invention relates to the field of the preparation of compounds that can be used in organic chemistry.
Предложенный способ получени фталимидоалкилпиперазинов заключаетс в том, что N-арилпиперазин обрабатывают N-галоидалкилфталимидом при кип чении в 1метаиоле.The proposed method for the preparation of phthalimidoalkylpiperazines is that the N-arylpiperazine is treated with N-haloalkylphthalimide by boiling in 1M of the metal.
Пример. 1,96 г N-хлорметилфталнмида и 1,92 г 1М-(о-метоксифенил)-иинеразина кин т т в 30 мл метанола 6 час. Реакционную смесь упаривают под вакуумом до начала кристаллизации, добавл ют сухой эфнр до полного осаждени нродукта и отфильтровывают осадок. После перекристаллизации из этанола эфира получают 2,76 г (72%) бесцветных кристаллов N- (о-метоксифенил)-N (рталимидометилпинеразина сол нокнслого с т и;г 190°С. Найдено, %: С 61,34; П 5,47; N 10,78.Example. 1.96 g of N-chloromethylphthalmide and 1.92 g of 1M- (o-methoxyphenyl) -inerazine are thrown in 30 ml of methanol for 6 hours. The reaction mixture is evaporated in vacuo until crystallization begins, dry ether is added until complete precipitation of the product and the precipitate is filtered off. After recrystallization from ethanol of the ester, 2.76 g (72%) of colorless crystals of N- (o-methoxyphenyl) -N (ptalimidomethylpinerazine hydrochloride layer with t and; g 190 ° C are obtained. Found: C 61.34; P 5, 47; N 10.78.
С,аН17М;зОз-НС1.C, aH17M; ZOZ-HC1.
Вычислено, %: С 61,58; Н 5,72; N 10,84.Calculated,%: C, 61.58; H 5.72; N 10.84.
Аналогичным образом получают:Similarly, receive:
Х-(о-мегоксифеннл) - М-(р-фталнмндоэтил)ииперазин бромнстоводород)1ый, т. пл. 232°С;X- (o-megoxifenl) - M- (p-phthalnmndoethyl) iiperazine hydrogen bromide) 1st, so pl. 232 ° C;
КТ-(о-.1етокспфеиил) - К - (у - фталимндопропи .т)-нинеразин сол нокислый, т. нл. 220°С.KT- (o-.1etoxpfeiil) - K - (y-phthalimndopropi. T) -nenerasin hydrochloric acid, t. Nl. 220 ° C.
Предмет изобретени Subject invention
Способ полученн фталнмидоалкилпнперазинов , отличающийс тем, что N-арнлпипера3iiH обрабатывают М-галондалкилфталимидом нрн кип чении о метаноле.The method obtained by phthalnimido alkyl inneprazines, characterized in that the N-arnylpiper 3iiH is treated with m-halonalkylphthalimide, nrn boiling with methanol.
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU193524A1 true SU193524A1 (en) |
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