EP1809298A4 - Neuroprotective spirostenol pharmaceutical compositions - Google Patents
Neuroprotective spirostenol pharmaceutical compositionsInfo
- Publication number
- EP1809298A4 EP1809298A4 EP05812949A EP05812949A EP1809298A4 EP 1809298 A4 EP1809298 A4 EP 1809298A4 EP 05812949 A EP05812949 A EP 05812949A EP 05812949 A EP05812949 A EP 05812949A EP 1809298 A4 EP1809298 A4 EP 1809298A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- spirostenol
- neuroprotective
- pharmaceutical compositions
- pharmaceutical
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61869604P | 2004-10-14 | 2004-10-14 | |
US11/031,538 US20060009433A1 (en) | 2003-03-14 | 2005-01-07 | Neuroprotective spirostenol pharmaceutical compositions |
PCT/US2005/037023 WO2006044665A2 (en) | 2004-10-14 | 2005-10-14 | Neuroprotective spirostenol pharmaceutical compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1809298A2 EP1809298A2 (en) | 2007-07-25 |
EP1809298A4 true EP1809298A4 (en) | 2008-06-18 |
Family
ID=36203560
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP05812949A Withdrawn EP1809298A4 (en) | 2004-10-14 | 2005-10-14 | Neuroprotective spirostenol pharmaceutical compositions |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1809298A4 (en) |
JP (1) | JP2008516972A (en) |
AU (1) | AU2005295617A1 (en) |
CA (1) | CA2584333A1 (en) |
WO (1) | WO2006044665A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2006231451A1 (en) * | 2005-04-01 | 2006-10-12 | Georgetown University | Use of spirostenols to treat mitochondrial disorders |
GB0619860D0 (en) * | 2006-10-06 | 2006-11-15 | Birkeland Innovasjon As | Treatment of insulin resistance and disorders associated therewith |
WO2015163318A1 (en) * | 2014-04-25 | 2015-10-29 | レジリオ株式会社 | Therapeutic agent for diseases associated with nerve axon dysfunction, including therapeutic agent for alzheimer's disease |
WO2024024395A1 (en) * | 2022-07-29 | 2024-02-01 | 国立大学法人富山大学 | Pharmaceutical or food and beverage composition for prevention or treatment of optic nerve disorder |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002011708A2 (en) * | 2000-08-04 | 2002-02-14 | Symphar S.A. | Methods for inducing apolipoprotein e secretion |
WO2003077869A2 (en) * | 2002-03-15 | 2003-09-25 | Samaritan Pharmaceuticals, Inc | Neuroprotective spirostenol pharmaceutical compositions |
WO2003086411A1 (en) * | 2002-04-15 | 2003-10-23 | Chengdu Di'ao Pharmaceutical Group Co., Ltd. | Compounds and preparation methods of carboxylate and monoester succinate derivative of diosgenin |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4303214A1 (en) * | 1993-02-04 | 1994-08-11 | Wolfgang Marks | Treatment of diseases of viral, viroidal or oncogenic origin by steroid saponins or their aglycones |
CN1131237C (en) * | 1997-09-26 | 2003-12-17 | 中国人民解放军军事医学科学院放射医学研究所 | Usage of steroi saponin for preventing and curing senile dementia and new steroid saponin |
IL138664A0 (en) * | 1998-03-26 | 2001-10-31 | Phytopharm Plc | Smilagenin and anzurogenin-d for the treatment of alheimer's disease |
-
2005
- 2005-10-14 WO PCT/US2005/037023 patent/WO2006044665A2/en active Application Filing
- 2005-10-14 JP JP2007536942A patent/JP2008516972A/en not_active Withdrawn
- 2005-10-14 CA CA002584333A patent/CA2584333A1/en not_active Abandoned
- 2005-10-14 AU AU2005295617A patent/AU2005295617A1/en not_active Abandoned
- 2005-10-14 EP EP05812949A patent/EP1809298A4/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002011708A2 (en) * | 2000-08-04 | 2002-02-14 | Symphar S.A. | Methods for inducing apolipoprotein e secretion |
WO2003077869A2 (en) * | 2002-03-15 | 2003-09-25 | Samaritan Pharmaceuticals, Inc | Neuroprotective spirostenol pharmaceutical compositions |
WO2003086411A1 (en) * | 2002-04-15 | 2003-10-23 | Chengdu Di'ao Pharmaceutical Group Co., Ltd. | Compounds and preparation methods of carboxylate and monoester succinate derivative of diosgenin |
Non-Patent Citations (4)
Title |
---|
KOLDAMOVA R P, LEFTEROV I M, IKONOMOVIC M D, SKOKO J, LEFTEROV P I, ISANSKI B A, DEKOSKY S T, LAZO J S: "22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 15, 11 April 2003 (2003-04-11), pages 13244 - 13256, XP002476236 * |
LECANU L ET AL: "Identification of naturally occurring spirostenols preventing beta-amyloid-induced neurotoxicity", STEROIDS, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 69, no. 1, January 2004 (2004-01-01), pages 1 - 16, XP004484607, ISSN: 0039-128X * |
LIU ZHONGRONG ET AL: "Preparation of carboxylate and monoester succinate derivatives of diosgenin and their bioactivities for treating and preventing cerebrovascular and cardiovascular diseases", HCAPLUS, 23 October 2003 (2003-10-23), XP002391897 * |
YAO Z-X ET AL: "22R-Hydroxycholesterol Protects Neuronal Cells from Beta-Amyloid-Induced Cytotoxicity by Binding to Beta-Amyloid Peptide", JOURNAL OF NEUROCHEMISTRY, NEW YORK, NY, US, vol. 83, 2002, pages 1110 - 1119, XP003015166, ISSN: 0022-3042 * |
Also Published As
Publication number | Publication date |
---|---|
WO2006044665A2 (en) | 2006-04-27 |
AU2005295617A1 (en) | 2006-04-27 |
EP1809298A2 (en) | 2007-07-25 |
WO2006044665A3 (en) | 2007-07-05 |
JP2008516972A (en) | 2008-05-22 |
CA2584333A1 (en) | 2006-04-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20070504 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL BA HR MK YU |
|
R17D | Deferred search report published (corrected) |
Effective date: 20070705 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 31/585 20060101ALI20070801BHEP Ipc: A61K 31/58 20060101ALI20070801BHEP Ipc: A61K 31/56 20060101ALI20070801BHEP Ipc: A61K 31/59 20060101ALI20070801BHEP Ipc: A01N 45/00 20060101AFI20070801BHEP |
|
DAX | Request for extension of the european patent (deleted) | ||
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 25/28 20060101ALI20080429BHEP Ipc: A61K 31/585 20060101ALI20080429BHEP Ipc: A61K 31/58 20060101ALI20080429BHEP Ipc: A61K 31/56 20060101ALI20080429BHEP Ipc: A61K 31/59 20060101ALI20080429BHEP Ipc: A01N 45/00 20060101AFI20070801BHEP |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20080519 |
|
17Q | First examination report despatched |
Effective date: 20080819 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20090303 |