EP1778266A4 - COMPOSITIONS AND METHODS FOR PREVENTING AND REGULATING INSULIN-INDUCED HYPOGLYCEMIA - Google Patents
COMPOSITIONS AND METHODS FOR PREVENTING AND REGULATING INSULIN-INDUCED HYPOGLYCEMIAInfo
- Publication number
- EP1778266A4 EP1778266A4 EP05787795A EP05787795A EP1778266A4 EP 1778266 A4 EP1778266 A4 EP 1778266A4 EP 05787795 A EP05787795 A EP 05787795A EP 05787795 A EP05787795 A EP 05787795A EP 1778266 A4 EP1778266 A4 EP 1778266A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- insulin
- prevention
- compositions
- methods
- control
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 208000013016 Hypoglycemia Diseases 0.000 title 1
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 230000002218 hypoglycaemic effect Effects 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Obesity (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58444904P | 2004-06-29 | 2004-06-29 | |
| PCT/US2005/022812 WO2006004696A2 (en) | 2004-06-29 | 2005-06-27 | Compositions and methods for the prevention and control of insulin-induced hypoglycemia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1778266A2 EP1778266A2 (en) | 2007-05-02 |
| EP1778266A4 true EP1778266A4 (en) | 2009-09-09 |
Family
ID=35783298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP05787795A Withdrawn EP1778266A4 (en) | 2004-06-29 | 2005-06-27 | COMPOSITIONS AND METHODS FOR PREVENTING AND REGULATING INSULIN-INDUCED HYPOGLYCEMIA |
Country Status (11)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2816114C (en) | 2010-11-03 | 2019-02-12 | Jan Jezek | Novel composition comprising glucagon |
| EP3344231B1 (en) * | 2015-09-04 | 2022-04-13 | Latitude Pharmaceuticals, Inc. | Stabilized glucagon solutions |
| GB201611077D0 (en) | 2016-06-24 | 2016-08-10 | Arecor Ltd | Novel composition |
| EP3576748B1 (en) * | 2017-02-03 | 2023-04-05 | Vanderbilt University | Systems, compositions and methods for treating diabetes |
| CN110913888A (zh) * | 2017-07-14 | 2020-03-24 | Xeris药物公司 | 治疗先天性高胰岛素血症的方法 |
| WO2019108640A1 (en) * | 2017-11-28 | 2019-06-06 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Methods and kits for evaluating metabolism |
| MX2022016265A (es) * | 2020-06-26 | 2023-02-09 | Xeris Pharmaceuticals Inc | Composiciones terapeuticas de liberacion sostenida estable en solventes polares aproticos y metodos de preparacion de los mismos. |
| GB202109087D0 (en) * | 2021-06-24 | 2021-08-11 | Norwegian Univ Sci & Tech Ntnu | Therapeutic methods and devices |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004060387A1 (en) * | 2002-12-27 | 2004-07-22 | Diobex, Inc. | Compositions and methods for the prevention and control of insulin-induced hypoglycemia |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3897551A (en) * | 1971-04-05 | 1975-07-29 | Lilly Co Eli | Iodoglucagons and process for prolonging the biological activity of glucagon |
| US5321008A (en) * | 1991-01-10 | 1994-06-14 | Amylin Pharmaceuticals, Inc. | Methods and compositions for treatment of diabetes mellitus, hypoglycemia, and other conditions |
| WO2004046106A1 (en) * | 2002-11-18 | 2004-06-03 | Pfizer Products Inc. | Dipeptidyl peptidase iv inhibiting fluorinated cyclic amides |
-
2005
- 2005-06-27 ZA ZA200700708A patent/ZA200700708B/xx unknown
- 2005-06-27 WO PCT/US2005/022812 patent/WO2006004696A2/en active Application Filing
- 2005-06-27 CN CNA2005800270476A patent/CN101001638A/zh active Pending
- 2005-06-27 KR KR1020077002164A patent/KR20070029276A/ko not_active Withdrawn
- 2005-06-27 EP EP05787795A patent/EP1778266A4/en not_active Withdrawn
- 2005-06-27 AU AU2005260025A patent/AU2005260025A1/en not_active Abandoned
- 2005-06-27 CA CA002571030A patent/CA2571030A1/en not_active Abandoned
- 2005-06-27 JP JP2007519344A patent/JP2008505087A/ja active Pending
- 2005-06-27 MX MXPA06014970A patent/MXPA06014970A/es not_active Application Discontinuation
-
2006
- 2006-12-26 IL IL180361A patent/IL180361A0/en unknown
-
2007
- 2007-01-10 NO NO20070174A patent/NO20070174L/no not_active Application Discontinuation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004060387A1 (en) * | 2002-12-27 | 2004-07-22 | Diobex, Inc. | Compositions and methods for the prevention and control of insulin-induced hypoglycemia |
Non-Patent Citations (7)
| Title |
|---|
| CRYER PHILIP E ET AL: "Hypoglycemia in diabetes.", DIABETES CARE JUN 2003, vol. 26, no. 6, June 2003 (2003-06-01), pages 1902 - 1912, XP002538099, ISSN: 0149-5992 * |
| DE GALAN B E ET AL: "Pathophysiology and management of recurrent hypoglycaemia and hypoglycaemia unawareness in diabetes", NETHERLANDS JOURNAL OF MEDICINE, vol. 64, no. 8, September 2006 (2006-09-01), pages 269 - 279, XP002538100, ISSN: 0300-2977 * |
| EDELMAN S V ET AL: "Subcutaneous infusion of very low dose-glucagon averts insulin induced hypoglycaemia in patients with type 1 diabetes mellitus", DIABETOLOGIA, vol. 49, no. Suppl. 1, September 2006 (2006-09-01), & 42ND ANNUAL MEETING OF THE EUROPEAN-ASSOCIATION-FOR-THE-STUDY-OF-DIA BETES (EASD); COPENHAGEN, DENMARK; SEPTEMBER 14 -17, 2006, pages 506, XP009120428, ISSN: 0012-186X * |
| EDELMAN STEVEN ET AL: "Nocturnal administration of very low dose glucagon in patients with type 1 diabetes reduces episodes of nocturnal hypoglycemia", DIABETES, vol. 56, no. Suppl. 1, June 2007 (2007-06-01), & 67TH ANNUAL MEETING OF THE AMERICAN-DIABETES-ASSOCIATION; CHICAGO, IL, USA; JUNE 22 -26, 2007, pages A8 - A9, XP009120378, ISSN: 0012-1797 * |
| FANELLI C G ET AL: "Glucagon: the effects of its excess and deficiency on insulin action.", NUTRITION, METABOLISM, AND CARDIOVASCULAR DISEASES : NMCD MAR 2006, vol. 16 Suppl 1, March 2006 (2006-03-01), pages S28 - S34, XP002538101, ISSN: 0939-4753 * |
| HAYMOND M W ET AL: "Mini-dose glucagon rescue for hypoglycemia in children with type 1 diabetes.", DIABETES CARE APR 2001, vol. 24, no. 4, April 2001 (2001-04-01), pages 643 - 645, XP002538098, ISSN: 0149-5992 * |
| ISLEY WILLIAM ET AL: "Very low dose glucagon averts insulin induced Hypoglycemia in patients with type 1 diabetes", DIABETES, vol. 55, no. Suppl. 1, June 2006 (2006-06-01), & 66TH ANNUAL MEETING OF THE AMERICAN-DIABETES-ASSOCIATION; WASHINGTON, DC, USA; JUNE 09 -13, 2006, pages A117, XP009120392, ISSN: 0012-1797 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06014970A (es) | 2007-03-07 |
| WO2006004696A2 (en) | 2006-01-12 |
| JP2008505087A (ja) | 2008-02-21 |
| KR20070029276A (ko) | 2007-03-13 |
| IL180361A0 (en) | 2007-06-03 |
| CN101001638A (zh) | 2007-07-18 |
| NO20070174L (no) | 2007-03-13 |
| ZA200700708B (en) | 2009-03-25 |
| EP1778266A2 (en) | 2007-05-02 |
| CA2571030A1 (en) | 2006-01-12 |
| AU2005260025A1 (en) | 2006-01-12 |
| WO2006004696A3 (en) | 2006-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20070117 |
|
| AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR |
|
| AX | Request for extension of the european patent |
Extension state: AL BA HR LV MK YU |
|
| DAX | Request for extension of the european patent (deleted) | ||
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20090806 |
|
| 17Q | First examination report despatched |
Effective date: 20120522 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20121002 |