EP1778206A4 - Small molecule inhibitors of anti-apoptotic bcl-2 family members and the uses thereof - Google Patents

Small molecule inhibitors of anti-apoptotic bcl-2 family members and the uses thereof

Info

Publication number
EP1778206A4
EP1778206A4 EP05806407A EP05806407A EP1778206A4 EP 1778206 A4 EP1778206 A4 EP 1778206A4 EP 05806407 A EP05806407 A EP 05806407A EP 05806407 A EP05806407 A EP 05806407A EP 1778206 A4 EP1778206 A4 EP 1778206A4
Authority
EP
European Patent Office
Prior art keywords
small molecule
family members
molecule inhibitors
apoptotic bcl
bcl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05806407A
Other languages
German (de)
French (fr)
Other versions
EP1778206A2 (en
Inventor
Shaomeng Wang
Guoping Wang
Guozhi Tang
Renxiao Wang
Zaneta Nikolovska-Coleska
Dajon Wang
Liang Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan
Original Assignee
University of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan filed Critical University of Michigan
Priority claimed from PCT/US2005/029634 external-priority patent/WO2006023778A2/en
Publication of EP1778206A2 publication Critical patent/EP1778206A2/en
Publication of EP1778206A4 publication Critical patent/EP1778206A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP05806407A 2004-08-20 2005-08-22 Small molecule inhibitors of anti-apoptotic bcl-2 family members and the uses thereof Withdrawn EP1778206A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60341104P 2004-08-20 2004-08-20
PCT/US2005/029634 WO2006023778A2 (en) 2004-08-20 2005-08-22 Small molecule inhibitors of anti-apoptotic bcl-2 family members and the uses thereof

Publications (2)

Publication Number Publication Date
EP1778206A2 EP1778206A2 (en) 2007-05-02
EP1778206A4 true EP1778206A4 (en) 2009-08-05

Family

ID=37897167

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05806407A Withdrawn EP1778206A4 (en) 2004-08-20 2005-08-22 Small molecule inhibitors of anti-apoptotic bcl-2 family members and the uses thereof

Country Status (4)

Country Link
EP (1) EP1778206A4 (en)
CN (1) CN101039662A (en)
MX (1) MX2007002104A (en)
ZA (1) ZA200702257B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME02642B (en) * 2008-12-05 2017-06-20 Abbvie Inc Sulfonamide derivatives as bcl- 2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
WO2011029842A1 (en) * 2009-09-10 2011-03-17 Novartis Ag Sulfonamides as inhibitors of bcl-2 family proteins for the treatment of cancer
ES2693107T3 (en) * 2011-01-25 2018-12-07 The Regents Of The University Of Michigan Inhibitors of Bcl-2 / Bcl-xL for use in the treatment of cancer
JP2015503516A (en) * 2011-12-23 2015-02-02 ノバルティス アーゲー Compound for inhibiting interaction between BCL2 and binding partner
BR112014015322A2 (en) * 2011-12-23 2017-06-13 Novartis Ag compounds and compositions for inhibiting bcl2 interaction with binding partners
JP2015503517A (en) * 2011-12-23 2015-02-02 ノバルティス アーゲー Compound for inhibiting interaction between BCL2 and binding partner
FR3008977A1 (en) * 2013-07-23 2015-01-30 Servier Lab NOVEL ISOINDOLINE OR ISOQUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR3008976A1 (en) * 2013-07-23 2015-01-30 Servier Lab "NOVEL INDOLIZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM"
WO2018187894A1 (en) * 2017-04-10 2018-10-18 师健友 Drug for treating tumor diseases, and having antibacterial, antivirus and anti-inflammatory effects
CN109776414B (en) * 2019-01-02 2022-04-22 山东大学 Bcl-2 protein inhibitor and preparation method and application thereof
CN111393366B (en) * 2020-06-05 2020-09-01 北京华氏开元医药科技有限公司 Tetrahydroisoquinoline derivatives, preparation method, pharmaceutical composition and application

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2686123A (en) * 1951-07-19 1954-08-10 Us Agriculture Stabilization of dehydrated vegetable material
US6114397A (en) * 1990-07-12 2000-09-05 The United States Of America As Represented By The Department Of Health And Human Services Gossypol for the treatment of cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2686123A (en) * 1951-07-19 1954-08-10 Us Agriculture Stabilization of dehydrated vegetable material
US6114397A (en) * 1990-07-12 2000-09-05 The United States Of America As Represented By The Department Of Health And Human Services Gossypol for the treatment of cancer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AMOLAK CHAND JAIN ET AL: "SYNTHESIS OF SOME NATURALLY OCCURRING ACETYLCHROMENES", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, CHEMICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 52, no. 4, 1 January 1979 (1979-01-01), pages 1203/1204, XP001068520, ISSN: 0009-2673 *
G. SCHILL, E. LOGEMANN: "4,6-Di-n-alkylpyrogallol-trimethyläther. Modellreaktionen zu gezielten Catenan-Synthesen", CHEMISCHE BERICHTE, vol. 106, 1973, pages 2910 - 2917, XP002533464 *
M. C. SUTTER: "The pharmacology of isolated veins", BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, vol. 24, no. 3, 1965, pages 742 - 751, XP009118730 *

Also Published As

Publication number Publication date
MX2007002104A (en) 2007-10-10
EP1778206A2 (en) 2007-05-02
ZA200702257B (en) 2009-06-24
CN101039662A (en) 2007-09-19

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: XU, LIANG

Inventor name: WANG, DAJON

Inventor name: NIKOLOVSKA-COLESKA, ZANETA

Inventor name: WANG, RENXIAO

Inventor name: TANG, GUOZHI

Inventor name: WANG, GUOPING

Inventor name: WANG, SHAOMENG

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