EP1706154A4 - Improved gastrin releasing peptide compounds - Google Patents

Improved gastrin releasing peptide compounds

Info

Publication number
EP1706154A4
EP1706154A4 EP04777906A EP04777906A EP1706154A4 EP 1706154 A4 EP1706154 A4 EP 1706154A4 EP 04777906 A EP04777906 A EP 04777906A EP 04777906 A EP04777906 A EP 04777906A EP 1706154 A4 EP1706154 A4 EP 1706154A4
Authority
EP
European Patent Office
Prior art keywords
peptide compounds
releasing peptide
gastrin releasing
improved
improved gastrin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04777906A
Other languages
German (de)
French (fr)
Other versions
EP1706154A1 (en
Inventor
Enrico Cappelletti
Luciano Lattuada
Karen E Linder
Ed Marinelli
Palaniappa Nanjappan
Natarajan Raju
Rolf E Swenson
Michael Tweedle
Kondareddiar Ramalingam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Imaging SpA
Original Assignee
Bracco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2003/041328 external-priority patent/WO2004065407A2/en
Priority claimed from US10/828,925 external-priority patent/US7611692B2/en
Application filed by Bracco SpA filed Critical Bracco SpA
Publication of EP1706154A1 publication Critical patent/EP1706154A1/en
Publication of EP1706154A4 publication Critical patent/EP1706154A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0493—Steroids, e.g. cholesterol, testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57572—Gastrin releasing peptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/086—Bombesin; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP04777906A 2003-12-24 2004-07-12 Improved gastrin releasing peptide compounds Withdrawn EP1706154A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2003/041328 WO2004065407A2 (en) 2003-01-13 2003-12-24 Improved gastrin releasing peptide compounds
US10/828,925 US7611692B2 (en) 2003-01-13 2004-04-20 Gastrin releasing peptide compounds
PCT/US2004/022115 WO2005067983A1 (en) 2003-12-24 2004-07-12 Improved gastrin releasing peptide compounds

Publications (2)

Publication Number Publication Date
EP1706154A1 EP1706154A1 (en) 2006-10-04
EP1706154A4 true EP1706154A4 (en) 2008-11-26

Family

ID=36928823

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04777906A Withdrawn EP1706154A4 (en) 2003-12-24 2004-07-12 Improved gastrin releasing peptide compounds

Country Status (9)

Country Link
EP (1) EP1706154A4 (en)
JP (1) JP2008501627A (en)
KR (1) KR20060121244A (en)
AU (1) AU2004314112A1 (en)
BR (1) BRPI0418194A (en)
CA (1) CA2549318A1 (en)
IL (1) IL175785A0 (en)
RU (1) RU2006126637A (en)
WO (1) WO2005067983A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102456989B1 (en) 2020-06-12 2022-10-21 (주)케어젠 Deoxycholic acid-Peptide Conjugate Having Anti-Obesity Activity and Uses Thereof

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995032741A1 (en) * 1994-05-26 1995-12-07 Bracco S.P.A. Bile acid conjugates, derivatives thereof with metal complexes and related uses
US5474756A (en) * 1986-01-23 1995-12-12 Bracco International B.V. Method for imaging mammalian tissue using 1-substituted-1,4,7-tricarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US5723578A (en) * 1987-09-24 1998-03-03 The Administrators Of Tulane Educational Fund Peptide analogs of bombesin
WO2000038738A1 (en) * 1998-12-23 2000-07-06 Bracco Imaging S.P.A. Blood pool agents for nuclear magnetic resonance diagnostics
WO2001062777A1 (en) * 2000-02-24 2001-08-30 Dabur Research Foundation Bombesin analogs for treatment of cancer
WO2002087631A1 (en) * 2001-05-02 2002-11-07 University Of Missouri System Gastrin-receptor-avid peptide conjugates
US20030050436A1 (en) * 1987-09-24 2003-03-13 Biomeasure Inc., Massachusetts Corporation Octapeptide bombesin analogs
US20030171561A1 (en) * 1991-08-01 2003-09-11 Pillai Radhakrishna K. Aminocarboxylate ligands having substituted aromatic amide moieties
WO2004062574A2 (en) * 2003-01-13 2004-07-29 Bracco Imaging S.P.A. Improved linkers for radiopharmaceutical compounds
WO2004065407A2 (en) * 2003-01-13 2004-08-05 Bracco Imaging S.P.A. Improved gastrin releasing peptide compounds

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474756A (en) * 1986-01-23 1995-12-12 Bracco International B.V. Method for imaging mammalian tissue using 1-substituted-1,4,7-tricarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US5723578A (en) * 1987-09-24 1998-03-03 The Administrators Of Tulane Educational Fund Peptide analogs of bombesin
US20030050436A1 (en) * 1987-09-24 2003-03-13 Biomeasure Inc., Massachusetts Corporation Octapeptide bombesin analogs
US20030171561A1 (en) * 1991-08-01 2003-09-11 Pillai Radhakrishna K. Aminocarboxylate ligands having substituted aromatic amide moieties
WO1995032741A1 (en) * 1994-05-26 1995-12-07 Bracco S.P.A. Bile acid conjugates, derivatives thereof with metal complexes and related uses
WO2000038738A1 (en) * 1998-12-23 2000-07-06 Bracco Imaging S.P.A. Blood pool agents for nuclear magnetic resonance diagnostics
WO2001062777A1 (en) * 2000-02-24 2001-08-30 Dabur Research Foundation Bombesin analogs for treatment of cancer
WO2002087631A1 (en) * 2001-05-02 2002-11-07 University Of Missouri System Gastrin-receptor-avid peptide conjugates
WO2004062574A2 (en) * 2003-01-13 2004-07-29 Bracco Imaging S.P.A. Improved linkers for radiopharmaceutical compounds
WO2004065407A2 (en) * 2003-01-13 2004-08-05 Bracco Imaging S.P.A. Improved gastrin releasing peptide compounds

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HOFFMAN T J ET AL: "NOVEL SERIES OF 111IN-LABELED BOMBESIN ANALOGS AS POTENTIAL RADIOPHARMACEUTICALS FOR SPECIFIC TARGETING OF GASTRIN-RELEASING PEPTIDE RECEPTORS EXPRESSED ON HUMAN PROSTATE CANCER CELLS", JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, RESTON, VA, US, vol. 44, no. 5, 1 January 2003 (2003-01-01), pages 823 - 831, XP008051690, ISSN: 0161-5505 *
ROGERS B E ET AL: "IN VITRO AND IN VIVO EVALUATION OF A 64C-LABELED POLYETHYLENE GLYCOL-BOMBESIN CONJUGATE", CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, LIEBERT, US, vol. 19, no. 1, 1 January 2004 (2004-01-01), pages 25 - 34, XP008051692 *
See also references of WO2005067983A1 *
SMITH C J ET AL: "Gastrin releasing peptide (GRP) receptor targeted radiopharmaceuticals: A concise update", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER, NY, US, vol. 30, no. 8, 1 November 2003 (2003-11-01), pages 861 - 868, XP004482850, ISSN: 0969-8051 *
SMITH C J ET AL: "Radiochemical investigations of <177>Lu-DOTA-8-Aoc-BBN[7-14]NH2: an in vitro/in vivo assessment of the targeting ability of this new radiopharmaceutical for PC-3 human prostate cancer cells", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER, NY, US, vol. 30, no. 2, 1 February 2003 (2003-02-01), pages 101 - 109, XP004413110, ISSN: 0969-8051 *

Also Published As

Publication number Publication date
IL175785A0 (en) 2006-10-05
EP1706154A1 (en) 2006-10-04
RU2006126637A (en) 2008-01-27
BRPI0418194A (en) 2007-04-27
AU2004314112A1 (en) 2005-07-28
CA2549318A1 (en) 2005-07-28
JP2008501627A (en) 2008-01-24
KR20060121244A (en) 2006-11-28
WO2005067983A1 (en) 2005-07-28

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20060718

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20081028

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: BRACCO IMAGING S.P.A

17Q First examination report despatched

Effective date: 20090603

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20091014