BRPI0418194A - improved gastrin-releasing peptide compounds - Google Patents

improved gastrin-releasing peptide compounds

Info

Publication number
BRPI0418194A
BRPI0418194A BRPI0418194-8A BRPI0418194A BRPI0418194A BR PI0418194 A BRPI0418194 A BR PI0418194A BR PI0418194 A BRPI0418194 A BR PI0418194A BR PI0418194 A BRPI0418194 A BR PI0418194A
Authority
BR
Brazil
Prior art keywords
releasing peptide
compounds
peptide compounds
improved
patient
Prior art date
Application number
BRPI0418194-8A
Other languages
Portuguese (pt)
Inventor
Enrico Cappelleti
Luciano Lattuada
Karen E Linder
Edmund R Marinelli
Palaniappa Nanjappan
Natarajan Raju
Rolf E Swenson
Michael Tweedle
Kondareddiar Ramalingam
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2003/041328 external-priority patent/WO2004065407A2/en
Priority claimed from US10/828,925 external-priority patent/US7611692B2/en
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Publication of BRPI0418194A publication Critical patent/BRPI0418194A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0493—Steroids, e.g. cholesterol, testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57572—Gastrin releasing peptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/086—Bombesin; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"COMPOSTOS PEPTìDEOS LIBERADORES DE GASTRINA APERFEIçOADOS". A presente invenção se refere a novos compostos aperfeiçoados para uso no diagnóstico de imagem ou terapia que tem a fórmula M-N-O-P-G, na qual M é uma etiqueta ótica ou um quelator do metal (na forma complexada com um radionuclídeo metal ou não), N-O-P são ligantes e G é o peptídeo alvo receptor GRP. Os métodos para obter a imagem de um paciente e/ou fornecer radioterapia ou fototerapia a um paciente que usa os compostos da invenção são também fornecidos. Os métodos e kits para preparar um agente radioterapêutico são adicionalmente fornecidos."PERFECT GASTRINE-RELEASING PEPTIDE COMPOUNDS". The present invention relates to novel compounds improved for use in imaging diagnosis or therapy having the formula MNOPG, wherein M is an optical label or a metal chelator (in the form complexed with a metal radionuclide or not), NOP are ligands and G is the GRP receptor target peptide. Methods for imaging a patient and / or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a radiotherapeutic agent are additionally provided.

BRPI0418194-8A 2003-12-24 2004-07-12 improved gastrin-releasing peptide compounds BRPI0418194A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2003/041328 WO2004065407A2 (en) 2003-01-13 2003-12-24 Improved gastrin releasing peptide compounds
US10/828,925 US7611692B2 (en) 2003-01-13 2004-04-20 Gastrin releasing peptide compounds
PCT/US2004/022115 WO2005067983A1 (en) 2003-12-24 2004-07-12 Improved gastrin releasing peptide compounds

Publications (1)

Publication Number Publication Date
BRPI0418194A true BRPI0418194A (en) 2007-04-27

Family

ID=36928823

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0418194-8A BRPI0418194A (en) 2003-12-24 2004-07-12 improved gastrin-releasing peptide compounds

Country Status (9)

Country Link
EP (1) EP1706154A4 (en)
JP (1) JP2008501627A (en)
KR (1) KR20060121244A (en)
AU (1) AU2004314112A1 (en)
BR (1) BRPI0418194A (en)
CA (1) CA2549318A1 (en)
IL (1) IL175785A0 (en)
RU (1) RU2006126637A (en)
WO (1) WO2005067983A1 (en)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX174467B (en) * 1986-01-23 1994-05-17 Squibb & Sons Inc 1,4,7-TRISCARBOXIMETHYL-1,4,7,10-TETRAAZACICLODO DECAN SUBSTITUTE IN 1 AND ANALOG COMPOUNDS
US5877277A (en) * 1987-09-24 1999-03-02 Biomeasure, Inc. Octapeptide bombesin analogs
US5723578A (en) * 1987-09-24 1998-03-03 The Administrators Of Tulane Educational Fund Peptide analogs of bombesin
US6875864B2 (en) * 1991-08-01 2005-04-05 Bracco International B.V. Aminocarboxylate ligands having substituted aromatic amide moieties
IT1269839B (en) * 1994-05-26 1997-04-15 Bracco Spa CONJUGATES OF BILIARY ACIDS, THEIR DERIVATIVES WITH METALLIC COMPLEXES AND RELATED USES
CA2346154A1 (en) * 2001-05-02 2002-11-02 University Of Missouri Gastrin receptor-avid peptide conjugates
IT1304501B1 (en) * 1998-12-23 2001-03-19 Bracco Spa USE OF BILIARY ACID DERIVATIVES CONJUGATED WITH METALLIC COMPLEXES LIKE "BLOOD POOL AGENTS" FOR THE DIAGNOSTIC INVESTIGATION THROUGH RESONANCE
EP1261626A1 (en) * 2000-02-24 2002-12-04 Dabur Research Foundation Bombesin analogs for treatment of cancer
US7226577B2 (en) * 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
AU2003303714B2 (en) * 2003-01-13 2009-02-19 Bracco Imaging S.P.A. Improved linkers for radiopharmaceutical compounds

Also Published As

Publication number Publication date
AU2004314112A1 (en) 2005-07-28
JP2008501627A (en) 2008-01-24
KR20060121244A (en) 2006-11-28
RU2006126637A (en) 2008-01-27
CA2549318A1 (en) 2005-07-28
WO2005067983A1 (en) 2005-07-28
EP1706154A4 (en) 2008-11-26
IL175785A0 (en) 2006-10-05
EP1706154A1 (en) 2006-10-04

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: CONFORME ARTIGO 10O DA RESOLUCAO 124/06, CABE SER ARQUIVADO REFERENTE AO NAO RECOLHIMENTO DA 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2143 DE 31/01/2012.