EP1701612A2 - Chimeric murine model comprising human hepatocytes user for screening compounds - Google Patents
Chimeric murine model comprising human hepatocytes user for screening compoundsInfo
- Publication number
- EP1701612A2 EP1701612A2 EP05701083A EP05701083A EP1701612A2 EP 1701612 A2 EP1701612 A2 EP 1701612A2 EP 05701083 A EP05701083 A EP 05701083A EP 05701083 A EP05701083 A EP 05701083A EP 1701612 A2 EP1701612 A2 EP 1701612A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- mouse
- murine model
- anyone
- hepatocytes
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
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- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
- C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0271—Chimeric animals, e.g. comprising exogenous cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05701083A EP1701612A2 (en) | 2004-01-09 | 2005-01-07 | Chimeric murine model comprising human hepatocytes user for screening compounds |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04290065A EP1552740A1 (en) | 2004-01-09 | 2004-01-09 | Chimeric murine model comprising human hepatocytes - use for screening compounds |
EP05701083A EP1701612A2 (en) | 2004-01-09 | 2005-01-07 | Chimeric murine model comprising human hepatocytes user for screening compounds |
PCT/EP2005/000546 WO2005067709A2 (en) | 2004-01-09 | 2005-01-07 | Chimeric murine model comprising human hepatocytes user for screening compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1701612A2 true EP1701612A2 (en) | 2006-09-20 |
Family
ID=34586020
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04290065A Withdrawn EP1552740A1 (en) | 2004-01-09 | 2004-01-09 | Chimeric murine model comprising human hepatocytes - use for screening compounds |
EP05701083A Withdrawn EP1701612A2 (en) | 2004-01-09 | 2005-01-07 | Chimeric murine model comprising human hepatocytes user for screening compounds |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04290065A Withdrawn EP1552740A1 (en) | 2004-01-09 | 2004-01-09 | Chimeric murine model comprising human hepatocytes - use for screening compounds |
Country Status (2)
Country | Link |
---|---|
EP (2) | EP1552740A1 (en) |
WO (1) | WO2005067709A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080199847A1 (en) | 2004-08-20 | 2008-08-21 | Daiichi Pure Chemicals Co., Ltd. | Method for Predicting the Metabolism of Drug in Human Liver and Liver Function |
CN101550425B (en) * | 2008-03-31 | 2011-03-30 | 北京大学 | Method for manufacturing adjustable liver injury animal model and special carriers thereof |
JP5841322B2 (en) | 2010-04-22 | 2016-01-13 | オレゴン ヘルス アンド サイエンス ユニバーシティ | Fumaryl acetoacetate hydrolase (FAH) deficient pig and use thereof |
JP6484444B2 (en) | 2011-08-26 | 2019-03-13 | イエキュリス コーポレーションYecuris Corporation | Fumaryl acetoacetate hydrolase (FAH) deficient and immunodeficient rats and their use |
EP2644027A1 (en) | 2012-03-26 | 2013-10-02 | Institut Pasteur | Transgenic immunodefficient mouse expressing human SIRPalpha. |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6509514B1 (en) * | 2000-03-17 | 2003-01-21 | Kmt Hepatech, Inc. | Chimeric animal model susceptible to human hepatitis C virus infection |
-
2004
- 2004-01-09 EP EP04290065A patent/EP1552740A1/en not_active Withdrawn
-
2005
- 2005-01-07 EP EP05701083A patent/EP1701612A2/en not_active Withdrawn
- 2005-01-07 WO PCT/EP2005/000546 patent/WO2005067709A2/en not_active Application Discontinuation
Non-Patent Citations (1)
Title |
---|
See references of WO2005067709A3 * |
Also Published As
Publication number | Publication date |
---|---|
EP1552740A1 (en) | 2005-07-13 |
WO2005067709A3 (en) | 2005-11-24 |
WO2005067709A2 (en) | 2005-07-28 |
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