EP1689463A1 - Nanotube treatments for internal medical devices - Google Patents

Nanotube treatments for internal medical devices

Info

Publication number
EP1689463A1
EP1689463A1 EP04795499A EP04795499A EP1689463A1 EP 1689463 A1 EP1689463 A1 EP 1689463A1 EP 04795499 A EP04795499 A EP 04795499A EP 04795499 A EP04795499 A EP 04795499A EP 1689463 A1 EP1689463 A1 EP 1689463A1
Authority
EP
European Patent Office
Prior art keywords
nanotubes
new
medical device
nanotube
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP04795499A
Other languages
German (de)
English (en)
French (fr)
Inventor
Greg Olsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Ltd Barbados
Boston Scientific Corp
Original Assignee
Boston Scientific Ltd Barbados
Boston Scientific Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Ltd Barbados, Boston Scientific Corp filed Critical Boston Scientific Ltd Barbados
Publication of EP1689463A1 publication Critical patent/EP1689463A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/10—Inorganic materials
    • A61L29/103—Carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/082—Inorganic materials
    • A61L31/084—Carbon; Graphite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/624—Nanocapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces

Definitions

  • the treated insertable medical device 20 in this embodiment includes an outside surface 25, an inside surface 24, an internal channel 26, and a wall or strut 23.
  • the outside surface 25 of the wall 23 of the device 20 has been coated with a single layer of nanotubes and therapeutic while the inside surface 24 of the wall 23 has been treated with more than a single layer of nanotubes and therapeutic.
  • the nanotubes and therapeutic in this embodiment have been interfaced with one another without the benefit of a carrier.
  • the nanotubes are not within a polymer or other carrier as in other embodiments.
  • therapeutic agents used in conjunction with the present invention include, for example, pharmaceutically active compounds, proteins, cells, oligonucleotides, ribozymes, anti-sense oligonucleotides, DNA compacting agents, gene/vector systems (i.e., any vehicle that allows for the uptake and expression of nucleic acids), nucleic acids (including, for example, recombinant nucleic acids; naked DNA, cDNA, RNA; genomic DNA, cDNA or RNA in a non-infectious vector or in a viral vector and which f rther may have attached peptide targeting sequences; antisense nucleic acid (RNA or DNA); and DNA chimeras which include gene sequences and encoding for ferry proteins such as membrane translocating sequences ("MTS") and herpes simplex virus-1 (“VP22”)), and viral, liposomes and cationic and anionic polymers and neutral polymers that are selected from a number of types depending on the desired application.
  • gene/vector systems i.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
EP04795499A 2003-11-04 2004-10-18 Nanotube treatments for internal medical devices Ceased EP1689463A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/699,694 US20050096509A1 (en) 2003-11-04 2003-11-04 Nanotube treatments for internal medical devices
PCT/US2004/034351 WO2005046749A1 (en) 2003-11-04 2004-10-18 Nanotube treatments for internal medical devices

Publications (1)

Publication Number Publication Date
EP1689463A1 true EP1689463A1 (en) 2006-08-16

Family

ID=34551031

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04795499A Ceased EP1689463A1 (en) 2003-11-04 2004-10-18 Nanotube treatments for internal medical devices

Country Status (4)

Country Link
US (1) US20050096509A1 (https=)
EP (1) EP1689463A1 (https=)
JP (1) JP2007525254A (https=)
WO (1) WO2005046749A1 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7419601B2 (en) * 2003-03-07 2008-09-02 Seldon Technologies, Llc Nanomesh article and method of using the same for purifying fluids
US20100098877A1 (en) * 2003-03-07 2010-04-22 Cooper Christopher H Large scale manufacturing of nanostructured material
JP4520983B2 (ja) * 2003-03-07 2010-08-11 セルドン テクノロジーズ，インコーポレイテッド ナノ物質による流体の浄化
US7972616B2 (en) 2003-04-17 2011-07-05 Nanosys, Inc. Medical device applications of nanostructured surfaces
US20050038498A1 (en) * 2003-04-17 2005-02-17 Nanosys, Inc. Medical device applications of nanostructured surfaces
US7056409B2 (en) 2003-04-17 2006-06-06 Nanosys, Inc. Structures, systems and methods for joining articles and materials and uses therefor
US20060122596A1 (en) * 2003-04-17 2006-06-08 Nanosys, Inc. Structures, systems and methods for joining articles and materials and uses therefor
US7579077B2 (en) * 2003-05-05 2009-08-25 Nanosys, Inc. Nanofiber surfaces for use in enhanced surface area applications
US20050221072A1 (en) * 2003-04-17 2005-10-06 Nanosys, Inc. Medical device applications of nanostructured surfaces
JP4871726B2 (ja) * 2003-04-28 2012-02-08 ナノシス・インク． 超疎液性表面、その作製法及び用途
TWI427709B (zh) * 2003-05-05 2014-02-21 Nanosys Inc 用於增加表面面積之應用的奈米纖維表面
US7803574B2 (en) 2003-05-05 2010-09-28 Nanosys, Inc. Medical device applications of nanostructured surfaces
US20110039690A1 (en) 2004-02-02 2011-02-17 Nanosys, Inc. Porous substrates, articles, systems and compositions comprising nanofibers and methods of their use and production
US8025960B2 (en) 2004-02-02 2011-09-27 Nanosys, Inc. Porous substrates, articles, systems and compositions comprising nanofibers and methods of their use and production
US20050260355A1 (en) * 2004-05-20 2005-11-24 Jan Weber Medical devices and methods of making the same
US20060136042A1 (en) * 2004-12-22 2006-06-22 Scimed Life Systems, Inc. Vulnerable plaque stent
EP1879600B1 (en) * 2005-05-06 2012-11-21 The University of Kentucky Research Foundation Nanotubes as mitochondrial uncouplers
WO2008045021A2 (en) * 2005-08-01 2008-04-17 Rensselaer Polytechnic Institute Blood compatible nanomaterials and methods of making and using the same
US20070067882A1 (en) * 2005-09-21 2007-03-22 Liliana Atanasoska Internal medical devices having polyelectrolyte-containing extruded regions
US20070100279A1 (en) * 2005-11-03 2007-05-03 Paragon Intellectual Properties, Llc Radiopaque-balloon microcatheter and methods of manufacture
US9440003B2 (en) * 2005-11-04 2016-09-13 Boston Scientific Scimed, Inc. Medical devices having particle-containing regions with diamond-like coatings
US20070191766A1 (en) * 2006-02-10 2007-08-16 Boston Scientific Scimed, Inc. Balloon catheter having nanotubes
US20080255425A1 (en) * 2007-04-13 2008-10-16 Ethicon Endo-Surgery, Inc. Nanoparticle treated medical devices
US20090068244A1 (en) * 2007-09-12 2009-03-12 Boston Scientific Scimed, Inc. Polymeric/carbon composite materials for use in medical devices
WO2009073854A1 (en) 2007-12-06 2009-06-11 Nanosys, Inc. Resorbable nanoenhanced hemostatic structures and bandage materials
US8319002B2 (en) 2007-12-06 2012-11-27 Nanosys, Inc. Nanostructure-enhanced platelet binding and hemostatic structures
US8187221B2 (en) * 2008-07-11 2012-05-29 Nexeon Medsystems, Inc. Nanotube-reinforced balloons for delivering therapeutic agents within or beyond the wall of blood vessels, and methods of making and using same
US8540889B1 (en) 2008-11-19 2013-09-24 Nanosys, Inc. Methods of generating liquidphobic surfaces
US20100158193A1 (en) * 2008-12-22 2010-06-24 Bates Mark C Interventional Devices Formed Using Compositions Including Metal-Coated Nanotubes Dispersed In Polymers, And Methods Of Making And Using Same
KR20120083360A (ko) * 2009-08-28 2012-07-25 이노베이티브 헬스 테크놀로지스, 엘엘씨 방향성 세포 성장을 위한 폴리머 접착 필름
US8361140B2 (en) 2009-12-29 2013-01-29 Boston Scientific Scimed, Inc. High strength low opening pressure stent design

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9418937D0 (en) * 1994-09-20 1994-11-09 Isis Innovation Opening and filling carbon nanotubes
WO1999064085A1 (de) * 1998-06-09 1999-12-16 Franz Herbst Verfahren zur herstellung von biokompatiblen oberflächen
ATE362382T1 (de) * 2000-03-15 2007-06-15 Orbusneich Medical Inc Beschichtung welche ein anhaften von endothelzellen stimuliert
WO2002080996A1 (de) * 2001-04-03 2002-10-17 Franz Herbst Medizinisches implantat und verfahren zu seiner herstellung
US7168605B2 (en) * 2001-09-18 2007-01-30 Boston Scientific Scimed, Inc. Microtubes for therapeutic delivery
CA2457189C (en) * 2001-09-28 2011-08-09 Boston Scientific Limited Medical devices comprising nanomaterials and therapeutic methods utilizing the same
US20030104028A1 (en) * 2001-11-29 2003-06-05 Hossainy Syed F.A. Rate limiting barriers for implantable devices and methods for fabrication thereof
AU2003219718A1 (en) * 2002-02-06 2003-09-02 Orbus Medical Technologies Inc. Medical device with coating that promotes endothelial cell adherence and differentiation
TW200307563A (en) * 2002-02-14 2003-12-16 Sixty Inc C Use of BUCKYSOME or carbon nanotube for drug delivery
AU2003237128A1 (en) * 2002-05-03 2003-11-17 Duke University Carbon nanotubules for storage of nitric oxide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2005046749A1 *

Also Published As

Publication number Publication date
WO2005046749A1 (en) 2005-05-26
JP2007525254A (ja) 2007-09-06
US20050096509A1 (en) 2005-05-05

Similar Documents

Publication Publication Date Title
US20050096509A1 (en) Nanotube treatments for internal medical devices
US8354120B2 (en) Using bucky paper as a therapeutic aid in medical applications
US8114466B2 (en) Methods of applying coating to the inside surface of a stent
EP2173400B1 (en) Implantable medical devices having adjustable pore volume and methods for making the same
US7482034B2 (en) Expandable mask stent coating method
US8173200B2 (en) Selective application of therapeutic agent to a medical device
JP4663236B2 (ja) コートされた医療用インプラント・デリバリー・システム及びその組立方法
US7435256B2 (en) Method and apparatus for controlled delivery of active substance
US20050147734A1 (en) Method and system for coating tubular medical devices
US20080107794A1 (en) System and method for coating a medical device
US20080077218A1 (en) Injection of therapeutic into porous regions of a medical device
WO2007145755A1 (en) Coating a workpiece using a metering device and workpieces coated with this metering device
US7168605B2 (en) Microtubes for therapeutic delivery
US20050120951A1 (en) Medical implant processing chamber
WO2007133348A1 (en) Partially coated workpiece and method of making same
US20080097569A1 (en) Reduction of burst release from therapeutically treated medical devices
US8147899B2 (en) Methods and systems for depositing coating on a medical device
US20050181116A1 (en) Method for coating a medical device using a matrix assisted pulsed-laser evaporation technique and associated system and medical device

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20060504

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

17Q First examination report despatched

Effective date: 20061110

DAX Request for extension of the european patent (deleted)
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 20090327