EP1640703A3 - Absorption spectrometric analysis microchip - Google Patents

Absorption spectrometric analysis microchip Download PDF

Info

Publication number
EP1640703A3
EP1640703A3 EP05019660A EP05019660A EP1640703A3 EP 1640703 A3 EP1640703 A3 EP 1640703A3 EP 05019660 A EP05019660 A EP 05019660A EP 05019660 A EP05019660 A EP 05019660A EP 1640703 A3 EP1640703 A3 EP 1640703A3
Authority
EP
European Patent Office
Prior art keywords
chamber
light
spectrometric analysis
sensing
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP05019660A
Other languages
German (de)
French (fr)
Other versions
EP1640703B1 (en
EP1640703A2 (en
Inventor
Shigeki Matsumoto
Shigenori Nozawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ushio Denki KK
Original Assignee
Ushio Denki KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ushio Denki KK filed Critical Ushio Denki KK
Publication of EP1640703A2 publication Critical patent/EP1640703A2/en
Publication of EP1640703A3 publication Critical patent/EP1640703A3/en
Application granted granted Critical
Publication of EP1640703B1 publication Critical patent/EP1640703B1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0325—Cells for testing reactions, e.g. containing reagents
    • G01N2021/0328—Arrangement of two or more cells having different functions for the measurement of reactions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

An absorption spectrometric analysis microchip with a chamber for holding a sample, a chamber for holding a reagent which reacts with this sample, a mixing chamber for mixing the reagent with the sample with the formation of a mixture and a sensing part with a sensing chamber for holding the mixture with a light incidence surface for the entry of light into the sensing chamber and a light exit surface for emergence of light from the sensing chamber. At least one of the light incidence surface and light exit surface is located in a recess area of the sensing part.
EP05019660A 2004-09-22 2005-09-09 Absorption spectrometric analysis microchip Expired - Fee Related EP1640703B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2004274673A JP4375183B2 (en) 2004-09-22 2004-09-22 Microchip

Publications (3)

Publication Number Publication Date
EP1640703A2 EP1640703A2 (en) 2006-03-29
EP1640703A3 true EP1640703A3 (en) 2006-06-07
EP1640703B1 EP1640703B1 (en) 2009-09-09

Family

ID=35462319

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05019660A Expired - Fee Related EP1640703B1 (en) 2004-09-22 2005-09-09 Absorption spectrometric analysis microchip

Country Status (6)

Country Link
US (1) US7981689B2 (en)
EP (1) EP1640703B1 (en)
JP (1) JP4375183B2 (en)
CN (1) CN100570332C (en)
DE (1) DE602005016506D1 (en)
TW (1) TW200610952A (en)

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JP4506375B2 (en) * 2004-09-22 2010-07-21 ウシオ電機株式会社 Absorbance measurement unit
JP4912096B2 (en) * 2006-09-07 2012-04-04 ローム株式会社 Microchip inspection device
US20090141282A1 (en) * 2007-12-04 2009-06-04 Yung-Lieh Chien Concentration measuring structure capable of reducing the effect of environmental temperature
WO2010120786A1 (en) 2009-04-13 2010-10-21 Micronics, Inc. Microfluidic clinical analyzer
CA2786569C (en) 2010-01-29 2019-04-09 Micronics, Inc. Sample-to-answer microfluidic cartridge
US9182353B2 (en) 2010-07-22 2015-11-10 Hach Company Lab-on-a-chip for alkalinity analysis
FR2981283B1 (en) * 2011-10-13 2014-08-29 Chambre De Commerce Et De L Ind De Paris Au Titre De Son Etablissement D Enseignement Superieur Esie MICROFLUIDIC DEVICE FOR ANALYZING A FLUID UNDER PRESSURE.
US8741234B2 (en) * 2011-12-27 2014-06-03 Honeywell International Inc. Disposable cartridge for fluid analysis
US9180449B2 (en) 2012-06-12 2015-11-10 Hach Company Mobile water analysis
USD768872S1 (en) 2012-12-12 2016-10-11 Hach Company Cuvette for a water analysis instrument
WO2014100732A1 (en) 2012-12-21 2014-06-26 Micronics, Inc. Fluidic circuits and related manufacturing methods
US10518262B2 (en) 2012-12-21 2019-12-31 Perkinelmer Health Sciences, Inc. Low elasticity films for microfluidic use
EP2935559B1 (en) 2012-12-21 2020-09-16 PerkinElmer Health Sciences, Inc. Fluorescence detection system
US10386377B2 (en) 2013-05-07 2019-08-20 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
JP6484222B2 (en) 2013-05-07 2019-03-13 マイクロニクス， インコーポレイテッド Devices for nucleic acid preparation and analysis
CN105189750B (en) 2013-05-07 2020-07-28 珀金埃尔默健康科学有限公司 Method for preparing nucleic acid-containing sample using clay mineral and alkaline solution
EP3163306A4 (en) 2014-06-30 2018-01-24 Panasonic Healthcare Holdings Co., Ltd. Substrate for sample analysis, and sample analysis apparatus
WO2016002727A1 (en) 2014-06-30 2016-01-07 パナソニックヘルスケアホールディングス株式会社 Substrate for sample analysis, sample analysis device, sample analysis system, and program for sample analysis system
EP3163307B1 (en) 2014-06-30 2021-03-03 PHC Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and method for removing liquid from liquid that contains magnetic particles
JP6588910B2 (en) 2014-06-30 2019-10-09 Ｐｈｃホールディングス株式会社 Sample analysis substrate, sample analysis apparatus, sample analysis system, and program for sample analysis system
EP3232203B1 (en) 2014-12-12 2022-02-02 PHC Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and program for sample analysis system
KR20180080396A (en) * 2017-01-02 2018-07-12 한국전자통신연구원 Bio-sensor
WO2022155142A1 (en) * 2021-01-12 2022-07-21 Repligen Corporation Offline and inline determination of concentration of metabolites in cell culture fluid

Citations (5)

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US4088448A (en) * 1975-09-29 1978-05-09 Lilja Jan Evert Apparatus for sampling, mixing the sample with a reagent and making particularly optical analyses
US4226531A (en) * 1977-08-29 1980-10-07 Instrumentation Laboratory Inc. Disposable multi-cuvette rotor
US5798215A (en) * 1993-02-18 1998-08-25 Biocircuits Corporation Device for use in analyte detection assays
US20030152927A1 (en) * 2000-10-25 2003-08-14 Jakobsen Mogens Havsteen Closed substrate platforms suitable for analysis of biomolecules
JP2004109099A (en) * 2002-09-16 2004-04-08 Jun Kikuchi Method of analyzing blood, apparatus for analyzing blood, and method of manufacturing apparatus for analyzing blood

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US6046840A (en) * 1995-06-19 2000-04-04 Reflectivity, Inc. Double substrate reflective spatial light modulator with self-limiting micro-mechanical elements
US6088102A (en) * 1997-10-31 2000-07-11 Silicon Light Machines Display apparatus including grating light-valve array and interferometric optical system
EP1046032A4 (en) * 1998-05-18 2002-05-29 Univ Washington Liquid analysis cartridge
US6188519B1 (en) * 1999-01-05 2001-02-13 Kenneth Carlisle Johnson Bigrating light valve
AU2099401A (en) * 1999-12-14 2001-06-25 Combustion Specialists, Inc. Sensing system for detection and control of deposition on pendant tubes in recovery and power boilers
JP3760810B2 (en) * 2001-07-06 2006-03-29 ソニー株式会社 Light modulation element, GLV device, and laser display
JP2003279471A (en) 2002-03-20 2003-10-02 Nippon Sheet Glass Co Ltd Chip for microchemical system and microchemical system
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JP2004077305A (en) * 2002-08-19 2004-03-11 Nec Corp Detector
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US6822780B1 (en) * 2003-06-23 2004-11-23 Northrop Grumman Corporation Vertically stacked spatial light modulator with multi-bit phase resolution
US7691328B2 (en) * 2003-10-03 2010-04-06 National Institute For Materials Science Chip using method and test chip
US7710632B2 (en) * 2004-09-27 2010-05-04 Qualcomm Mems Technologies, Inc. Display device having an array of spatial light modulators with integrated color filters

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4088448A (en) * 1975-09-29 1978-05-09 Lilja Jan Evert Apparatus for sampling, mixing the sample with a reagent and making particularly optical analyses
US4226531A (en) * 1977-08-29 1980-10-07 Instrumentation Laboratory Inc. Disposable multi-cuvette rotor
US5798215A (en) * 1993-02-18 1998-08-25 Biocircuits Corporation Device for use in analyte detection assays
US20030152927A1 (en) * 2000-10-25 2003-08-14 Jakobsen Mogens Havsteen Closed substrate platforms suitable for analysis of biomolecules
JP2004109099A (en) * 2002-09-16 2004-04-08 Jun Kikuchi Method of analyzing blood, apparatus for analyzing blood, and method of manufacturing apparatus for analyzing blood

Also Published As

Publication number Publication date
CN100570332C (en) 2009-12-16
JP4375183B2 (en) 2009-12-02
TWI343994B (en) 2011-06-21
CN1752741A (en) 2006-03-29
US7981689B2 (en) 2011-07-19
TW200610952A (en) 2006-04-01
EP1640703B1 (en) 2009-09-09
US20060061760A1 (en) 2006-03-23
DE602005016506D1 (en) 2009-10-22
EP1640703A2 (en) 2006-03-29
JP2006090774A (en) 2006-04-06

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