EP1633797A4 - Biodegradable branched polylactide derivativescapable of forming polymeric micelles, and their preparation method and use - Google Patents

Biodegradable branched polylactide derivativescapable of forming polymeric micelles, and their preparation method and use

Info

Publication number
EP1633797A4
EP1633797A4 EP04808305A EP04808305A EP1633797A4 EP 1633797 A4 EP1633797 A4 EP 1633797A4 EP 04808305 A EP04808305 A EP 04808305A EP 04808305 A EP04808305 A EP 04808305A EP 1633797 A4 EP1633797 A4 EP 1633797A4
Authority
EP
European Patent Office
Prior art keywords
preparation
derivativescapable
forming polymeric
polymeric micelles
biodegradable branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP04808305A
Other languages
German (de)
French (fr)
Other versions
EP1633797A1 (en
EP1633797B1 (en
Inventor
Min-Hyo Seo
Bong-Oh Kim
In-Ja Choi
Myung-Seob Shim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Samyang Corp
Original Assignee
Samyang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Corp filed Critical Samyang Corp
Publication of EP1633797A1 publication Critical patent/EP1633797A1/en
Publication of EP1633797A4 publication Critical patent/EP1633797A4/en
Application granted granted Critical
Publication of EP1633797B1 publication Critical patent/EP1633797B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/78—Preparation processes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C08G63/912—Polymers modified by chemical after-treatment derived from hydroxycarboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to a biodegradable branched polylactic acid derivative of formula 1, and preparation method and use thereof: <formula 1> 1-(R—X)n wherein each of X, R, I and n is defined as in the detailed description.
EP04808305A 2003-12-04 2004-12-03 Biodegradable branched polylactide derivativescapable of forming polymeric micelles, and their preparation method and use Active EP1633797B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020030087459A KR20050054129A (en) 2003-12-04 2003-12-04 Biodegradable branched polylactide derivatives capable of forming polymeric micelles, and their preparation method and use
PCT/KR2004/003174 WO2005054333A1 (en) 2003-12-04 2004-12-03 Biodegradable branched polylactide derivativescapable of forming polymeric micelles, and their preparation method and use

Publications (3)

Publication Number Publication Date
EP1633797A1 EP1633797A1 (en) 2006-03-15
EP1633797A4 true EP1633797A4 (en) 2009-05-13
EP1633797B1 EP1633797B1 (en) 2010-01-27

Family

ID=36642449

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04808305A Active EP1633797B1 (en) 2003-12-04 2004-12-03 Biodegradable branched polylactide derivativescapable of forming polymeric micelles, and their preparation method and use

Country Status (13)

Country Link
US (1) US8021652B2 (en)
EP (1) EP1633797B1 (en)
JP (2) JP2006526053A (en)
KR (2) KR20050054129A (en)
CN (1) CN100386358C (en)
AT (1) ATE456600T1 (en)
AU (1) AU2004295264B2 (en)
CA (1) CA2523989C (en)
DE (1) DE602004025344D1 (en)
HK (1) HK1089459A1 (en)
MX (1) MXPA05011584A (en)
NZ (1) NZ543001A (en)
WO (1) WO2005054333A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8778322B2 (en) * 2001-10-18 2014-07-15 Samyang Biopharmaceuticals Corporation pH responsive biodegradable polylactic acid derivatives forming polymeric micelles and uses thereof for poorly water soluble drug delivery
EP1367080A1 (en) 2002-05-29 2003-12-03 Hycail B.V. Hyperbranched poly(hydroxycarboxylic acid) polymers
JP2012233208A (en) * 2005-10-03 2012-11-29 Dai Ichi Kogyo Seiyaku Co Ltd Functional filler and resin composition containing same
US7794495B2 (en) * 2006-07-17 2010-09-14 Advanced Cardiovascular Systems, Inc. Controlled degradation of stents
US8802126B2 (en) * 2008-06-30 2014-08-12 Abbott Cardiovascular Systems Inc. Polyester implantable medical device with controlled in vivo biodegradability
US8137818B2 (en) * 2008-07-28 2012-03-20 Tate & Lyle Ingredients Americas Llc Poly(lactic acid)-containing compositions for use in imparting oil, grease, or water resistance to paper
JP5567581B2 (en) * 2008-11-07 2014-08-06 サムヤン バイオファーマシューティカルズ コーポレイション High-purity polylactic acid, salt or derivative thereof, and purification method thereof
EP2201935B1 (en) * 2008-12-26 2020-07-08 Samyang Biopharmaceuticals Corporation Polymeric micelle composition containing a poorly soluble drug and preparation method of the same
ES2379676T3 (en) * 2009-04-23 2012-04-30 Vivoxid Oy Biocompatible composite material and its use
FR2967416B1 (en) * 2010-11-15 2012-12-21 Ipsen Pharma Sas PROCESS FOR THE PREPARATION OF VARIOUS ARCHITECTURE POLYMERS AND AMIDE AMORCING
KR101467275B1 (en) * 2011-12-19 2014-12-02 주식회사 삼양바이오팜 Composition of biodegradable polymer microparticles with high dispersibility and method for preparing the same
WO2013124867A1 (en) 2012-02-21 2013-08-29 Amrita Vishwa Vidyapeetham University Polymer - polymer or polymer - protein core - shell nano medicine loaded with multiple drug molecules
FR2995901B1 (en) * 2012-09-21 2015-08-14 Inst Corps Gras Etudes Et Rech S Tech Iterg NOVEL BIOSOURCES PRE-POLYMERS AND THEIR USES FOR THE PREPARATION OF USEFUL POLYMERS AS ADDITIVES IN A POLY (LACTIC ACID) MATRIX
JP6164860B2 (en) * 2013-02-15 2017-07-19 三井化学株式会社 Polymandelic acid
WO2014141289A1 (en) 2013-03-12 2014-09-18 Amrita Vishwa Vidyapeetham University Photo - chemo composition on the basis of microcapsules with a core -shell structure
CN104292444B (en) * 2014-10-15 2016-06-29 四川大学 There is the synthetic method of the class meteor plektron polylactic acid of controllable precise molecular structure
US20230087601A1 (en) * 2020-02-21 2023-03-23 Natureworks Llc Cosmetic compositions containing low molecular weight amorphous grade polylactic acid resin
KR102460624B1 (en) 2020-09-22 2022-10-28 가톨릭대학교 산학협력단 A drug delivery system capable of controlled drug release and x-ray imaging and use thereof
CN114437319B (en) * 2022-01-12 2023-08-15 青岛科技大学 Method for rapidly and controllably preparing glycolide-lactide copolymer by using plug flow reactor
CN114773581B (en) * 2022-04-25 2024-06-25 万华化学集团股份有限公司 Polylactic acid composition and preparation method thereof
CN115260478B (en) * 2022-07-19 2024-02-02 绍兴文理学院 Preparation method and application of high-strength high-toughness polylactic acid copolymer

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JP3065384B2 (en) * 1991-06-05 2000-07-17 旭硝子株式会社 Method for producing lactide polymer
JPH06322805A (en) * 1993-05-13 1994-11-22 Matsushita Electric Ind Co Ltd Toilet with image recognizing device
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
SI9620107A (en) 1995-08-10 1998-10-31 Kazunori Kataoka Block polymer having functional groups at both ends
KR0180334B1 (en) 1995-09-21 1999-03-20 김윤 Drug messenger using el-2l-2 micelle and method for sealing drug to it
EP0895517B1 (en) * 1996-04-23 2004-11-17 Ipsen Manufacturing Ireland Limited Acidic polylactic polymers
JPH10110019A (en) * 1996-10-08 1998-04-28 Kazunori Kataoka Stabilized polymeric micelle and its use as carrier for biologically active substance
US6461631B1 (en) * 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
JP4565290B2 (en) * 1999-12-01 2010-10-20 東洋紡績株式会社 Oxyacid aliphatic polyester having high hydroxyl group concentration and oxyacid aliphatic polyester composition
EP1306013A1 (en) * 2001-03-28 2003-05-02 Hycail B.V. Biodegradable gum base
US8778322B2 (en) 2001-10-18 2014-07-15 Samyang Biopharmaceuticals Corporation pH responsive biodegradable polylactic acid derivatives forming polymeric micelles and uses thereof for poorly water soluble drug delivery
KR100492805B1 (en) 2001-10-18 2005-06-07 주식회사 삼양사 Polymeric micelle composition with improved stability
KR100531269B1 (en) 2001-12-04 2005-11-28 주식회사 삼양사 Polymeric compositions for forming micelles or nanoparticles which are stable in aqueous solution
CA2523987C (en) * 2003-10-10 2009-08-04 Samyang Corporation Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery

Non-Patent Citations (1)

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Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
JP2009263680A (en) 2009-11-12
WO2005054333A1 (en) 2005-06-16
EP1633797A1 (en) 2006-03-15
DE602004025344D1 (en) 2010-03-18
JP2006526053A (en) 2006-11-16
AU2004295264A1 (en) 2005-06-16
KR20050054129A (en) 2005-06-10
US20070003625A1 (en) 2007-01-04
KR100724719B1 (en) 2007-06-04
CA2523989A1 (en) 2005-06-16
CA2523989C (en) 2009-01-27
MXPA05011584A (en) 2005-12-14
US8021652B2 (en) 2011-09-20
CN1780868A (en) 2006-05-31
NZ543001A (en) 2009-09-25
KR20060009831A (en) 2006-02-01
AU2004295264B2 (en) 2009-10-29
CN100386358C (en) 2008-05-07
HK1089459A1 (en) 2006-12-01
ATE456600T1 (en) 2010-02-15
EP1633797B1 (en) 2010-01-27
JP5579406B2 (en) 2014-08-27

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