EP1592811A2 - Procedes pour controler in vivo des activites de medicaments - Google Patents

Procedes pour controler in vivo des activites de medicaments

Info

Publication number
EP1592811A2
EP1592811A2 EP04710266A EP04710266A EP1592811A2 EP 1592811 A2 EP1592811 A2 EP 1592811A2 EP 04710266 A EP04710266 A EP 04710266A EP 04710266 A EP04710266 A EP 04710266A EP 1592811 A2 EP1592811 A2 EP 1592811A2
Authority
EP
European Patent Office
Prior art keywords
gene
encodes
cps
locusid
chromosome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04710266A
Other languages
German (de)
English (en)
Inventor
Michael Burczynski
Natalie Twine
Andrew J. Dorner
William L. Trepicchio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of EP1592811A2 publication Critical patent/EP1592811A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne des procédés, des systèmes et un équipement utilisés pour contrôler in vivo des activités de CCI-779 ou d'autres médicaments. Cette invention permet d'identifier de nombreux gènes d'activité de médicament. Les profils d'expression de ces gènes dans des cellules mononucléaires du sang périphérique peuvent être modulés par CCI-779 ou par d'autres médicaments. Ces gènes peuvent ainsi être utilisés en tant que marqueurs de substitution pour contrôler in vivo des activités de médicaments.
EP04710266A 2003-02-11 2004-02-11 Procedes pour controler in vivo des activites de medicaments Withdrawn EP1592811A2 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US44613303P 2003-02-11 2003-02-11
US446133P 2003-02-11
US45978203P 2003-04-03 2003-04-03
US459782P 2003-04-03
US53824604P 2004-01-23 2004-01-23
US538246P 2004-01-23
PCT/US2004/004118 WO2004072265A2 (fr) 2003-02-11 2004-02-11 Procedes pour controler in vivo des activites de medicaments

Publications (1)

Publication Number Publication Date
EP1592811A2 true EP1592811A2 (fr) 2005-11-09

Family

ID=32872756

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04710266A Withdrawn EP1592811A2 (fr) 2003-02-11 2004-02-11 Procedes pour controler in vivo des activites de medicaments

Country Status (4)

Country Link
EP (1) EP1592811A2 (fr)
AU (1) AU2004210986A1 (fr)
CA (1) CA2515677A1 (fr)
WO (1) WO2004072265A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006006948A2 (fr) * 2002-11-14 2006-01-19 Dharmacon, Inc. Methodes et compositions permettant de selectionner des arnsi presentant une fonctionnalite amelioree
MXPA05005283A (es) 2002-11-21 2005-07-25 Wyeth Corp Metodos para diagnostico de rcc y otros tumores solidos.
US20050287532A9 (en) * 2003-02-11 2005-12-29 Burczynski Michael E Methods for monitoring drug activities in vivo
US7643943B2 (en) 2003-02-11 2010-01-05 Wyeth Llc Methods for monitoring drug activities in vivo
CA2523798A1 (fr) * 2003-04-29 2004-11-11 Wyeth Procedes de pronostic et de traitement de tumeurs solides
WO2006097388A2 (fr) * 2005-02-08 2006-09-21 Innogenetics N.V. Variants d'acides nucleiques dans le gene c1qr1 associe a une immunite innee modifiee
ZA200800901B (en) 2005-07-14 2010-05-26 Takeda San Diego Inc Histone deacetylase inhibitors
AU2013206613B2 (en) * 2005-09-12 2017-03-02 Biontech Ag Identification of tumor-associated antigens for diagnosis and therapy
EP1762575A1 (fr) * 2005-09-12 2007-03-14 Ganymed Pharmaceuticals AG Identification d' antigènes associés aux tumeurs pour diagnose et thérapie
JP2010509909A (ja) * 2006-11-16 2010-04-02 ジェントロン リミテッド ライアビリティー カンパニー 癌診断のための方法、システム、および組成物
EP2464731B1 (fr) 2009-08-11 2016-10-05 CuRNA, Inc. Traitement de maladies associées à l'adiponectine (adipoq) par inhibition du produit de transcription anti-sens naturel d'une adiponectine (adipoq)
EP2563764B1 (fr) 2010-04-26 2015-02-25 Merck Sharp & Dohme Corp. Nouveaux inhibiteurs de spiropipéridine prolylcarboxypeptidase
US8921394B2 (en) 2010-04-27 2014-12-30 Merck Sharp & Dohme Corp. Prolylcarboxypeptidase inhibitors
WO2011143057A1 (fr) 2010-05-11 2011-11-17 Merck Sharp & Dohme Corp. Inhibiteurs inédits de la prolylcarboxypeptidase
WO2011146300A1 (fr) 2010-05-17 2011-11-24 Merck Sharp & Dohme Corp. Nouveaux inhibiteurs de prolylcarboxypeptidase
WO2011156220A1 (fr) 2010-06-08 2011-12-15 Merck Sharp & Dohme Corp. Nouveaux inhibiteurs de prolylcarboxypeptidase
WO2011156246A1 (fr) 2010-06-11 2011-12-15 Merck Sharp & Dohme Corp. Nouveaux inhibiteurs de prolylcarboxypeptidase
WO2019099753A1 (fr) * 2017-11-15 2019-05-23 The Translational Genomics Research Institute Tests de biomarqueurs de substitution et procédés de tests de chimie sanguine standard
CN112852964B (zh) * 2021-03-08 2022-02-11 镇江市第一人民医院 一种环状RNA hsa_circ_0059707及其特异性扩增引物和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002061144A2 (fr) * 2001-01-31 2002-08-08 Whitehead Institute For Biomedical Research Diagnostic de tumeur cerebrale et prediction de resultat de traitement

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030104371A1 (en) * 1997-09-24 2003-06-05 Strom Terry B. Methods of evaluating transplant rejection
CA2359816C (fr) * 1999-01-06 2010-08-03 Genenews Inc. Technique de detection de transcrits geniques dans le sang et leur utilisation
TWI286074B (en) * 2000-11-15 2007-09-01 Wyeth Corp Pharmaceutical composition containing CCI-779 as an antineoplastic agent
MXPA05005283A (es) * 2002-11-21 2005-07-25 Wyeth Corp Metodos para diagnostico de rcc y otros tumores solidos.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002061144A2 (fr) * 2001-01-31 2002-08-08 Whitehead Institute For Biomedical Research Diagnostic de tumeur cerebrale et prediction de resultat de traitement

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
IDEGUCHI H. ET AL.: "Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM", THE BIOCHEMICAL JOURNAL, vol. 367, 2002, pages 87 - 95 *

Also Published As

Publication number Publication date
WO2004072265A2 (fr) 2004-08-26
WO2004072265A3 (fr) 2005-03-03
AU2004210986A1 (en) 2004-08-26
CA2515677A1 (fr) 2004-08-26

Similar Documents

Publication Publication Date Title
WO2004072265A2 (fr) Procedes pour controler in vivo des activites de medicaments
Agnelli et al. Molecular classification of multiple myeloma: a distinct transcriptional profile characterizes patients expressing CCND1 and negative for 14q32 translocations
EP1824997B1 (fr) Alterations genetiques utiles pour predire la response de neoplasies malignes a des traitements medicaux bases sur le taxane
US11591655B2 (en) Diagnostic transcriptomic biomarkers in inflammatory cardiomyopathies
JP4938672B2 (ja) ｐ５３の状態と遺伝子発現プロファイルとの関連性に基づき、癌を分類し、予後を予測し、そして診断する方法、システム、およびアレイ
US8017321B2 (en) Gefitinib sensitivity-related gene expression and products and methods related thereto
US20040018513A1 (en) Classification and prognosis prediction of acute lymphoblastic leukemia by gene expression profiling
US20120245235A1 (en) Classification of cancers
US20080226645A1 (en) Methods and compositions for assessment and treatment of asthma
CA2524173A1 (fr) Techniques et appareils de diagnostic de lam et de mds
AU2003298689A1 (en) Methods for diagnosing rcc and other solid tumors
US20110166028A1 (en) Methods for predicting treatment response based on the expression profiles of biomarker genes in notch mediated cancers
KR20130137054A (ko) 방광암 검출용 소변 표지
US20040029151A1 (en) Molecular genetic profiling of gleason grades 3 and 4/5 prostate cancer
US20060240441A1 (en) Gene expression profiles and methods of use
AU2004298604A1 (en) Molecular signature of the PTEN tumor suppressor
US20090004173A1 (en) Diagnosis and Treatment of Drug Resistant Leukemia
US20080274906A1 (en) Novel Predictors of Transplant Rejection Determined by Peripheral Blood Gene-Expression Profiling
WO2012022634A1 (fr) Classification, diagnostic et pronostic du myélome multiple
US8568974B2 (en) Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia, outcome correlations and diagnostic and therapeutic methods related to same
AU2005316291A1 (en) Methods for assessing patients with acute myeloid leukemia
US20050272052A1 (en) Molecular genetic profiling of gleason grades 3 and 4/5 prostate cancer
US20070134690A1 (en) Diagnosis of systemic onset juvenile idiopathic arthritis through blood leukocyte microarray analysis
AU2004256182A1 (en) Genes regulated in ovarian cancer as prognostic and therapeutic targets
US20110294686A1 (en) Egfr inhibitor therapy responsiveness

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20050804

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK

RIN1 Information on inventor provided before grant (corrected)

Inventor name: TREPICCHIO, WILLIAM, L.

Inventor name: DORNER, ANDREW, J.

Inventor name: TWINE, NATALIE

Inventor name: BURCZYNSKI, MICHAEL

DAX Request for extension of the european patent (deleted)
17Q First examination report despatched

Effective date: 20070824

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: WYETH LLC

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20110901