EP1560595A4 - Humanes gamma-interferon neutralisierende fab-fragmente aus vollhumanem antikörper - Google Patents

Humanes gamma-interferon neutralisierende fab-fragmente aus vollhumanem antikörper

Info

Publication number
EP1560595A4
EP1560595A4 EP02784189A EP02784189A EP1560595A4 EP 1560595 A4 EP1560595 A4 EP 1560595A4 EP 02784189 A EP02784189 A EP 02784189A EP 02784189 A EP02784189 A EP 02784189A EP 1560595 A4 EP1560595 A4 EP 1560595A4
Authority
EP
European Patent Office
Prior art keywords
fab fragments
neutralizing activity
antibody fab
human antibody
fully human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02784189A
Other languages
English (en)
French (fr)
Other versions
EP1560595A2 (de
Inventor
Rajendra V Deshpande
Mei-Mei Tsai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Priority claimed from PCT/US2002/033556 external-priority patent/WO2004046306A2/en
Publication of EP1560595A2 publication Critical patent/EP1560595A2/de
Publication of EP1560595A4 publication Critical patent/EP1560595A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/249—Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP02784189A 2002-10-17 2002-10-17 Humanes gamma-interferon neutralisierende fab-fragmente aus vollhumanem antikörper Withdrawn EP1560595A4 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2002/033556 WO2004046306A2 (en) 2001-10-05 2002-10-17 Fully human antibody fab fragments with human interferon-gamma neutralizing activity

Publications (2)

Publication Number Publication Date
EP1560595A2 EP1560595A2 (de) 2005-08-10
EP1560595A4 true EP1560595A4 (de) 2005-12-28

Family

ID=34374685

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02784189A Withdrawn EP1560595A4 (de) 2002-10-17 2002-10-17 Humanes gamma-interferon neutralisierende fab-fragmente aus vollhumanem antikörper

Country Status (5)

Country Link
EP (1) EP1560595A4 (de)
JP (1) JP2006502739A (de)
AU (1) AU2002347978B2 (de)
CA (1) CA2502668C (de)
MX (1) MXPA05003949A (de)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002005A1 (en) * 1989-08-11 1991-02-21 Adolfo Turano Natural human anti-gamma interferon antibodies detected and purified by synthetic peptides
WO2000032634A1 (en) * 1998-12-01 2000-06-08 Protein Design Labs, Inc. Humanized antibodies to gamma-interferon

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1015480A2 (de) * 1997-08-18 2000-07-05 Innogenetics N.V. Interferon gamma bindende moleküle zur behandlung von septischem schock, cachexia, immunkrankheiten und hautkrankheiten

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002005A1 (en) * 1989-08-11 1991-02-21 Adolfo Turano Natural human anti-gamma interferon antibodies detected and purified by synthetic peptides
WO2000032634A1 (en) * 1998-12-01 2000-06-08 Protein Design Labs, Inc. Humanized antibodies to gamma-interferon

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FIORENTINI S ET AL: "A partially humanized monoclonal antibody to human IFN-gamma inhibits cytokine effects both in vitro and in vivo", SCANDINAVIAN JOURNAL OF IMMUNOLOGY, vol. 55, no. 3, March 2002 (2002-03-01), pages 284 - 292, XP002347393, ISSN: 0300-9475 *
GREEN L L: "Antibody engineering via genetic engineering of the mouse: XenoMouse strains are a vehicle for the facile generation of therapeutic human monoclonal antibodies", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 231, no. 1-2, 10 December 1999 (1999-12-10), pages 11 - 23, XP004187631, ISSN: 0022-1759 *
GRIFFITHS A D ET AL: "ISOLATION OF HIGH AFFINITY HUMAN ANTIBODIES DIRECTLY FROM LARGE SYNTHETIC REPERTOIRES", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 13, no. 14, 15 July 1994 (1994-07-15), pages 3245 - 3260, XP000455240, ISSN: 0261-4189 *
MAYNARD J ET AL: "ANTIBODY ENGINEERING", ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, ANNUAL REVIEW INCO., PALO ALTO, CA, US, vol. 2, 2000, pages 339 - 376, XP009039750 *
See also references of WO2004046306A2 *

Also Published As

Publication number Publication date
CA2502668A1 (en) 2004-06-03
MXPA05003949A (es) 2005-06-17
AU2002347978A1 (en) 2004-06-15
JP2006502739A (ja) 2006-01-26
EP1560595A2 (de) 2005-08-10
CA2502668C (en) 2013-07-30
AU2002347978B2 (en) 2009-10-08

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