EP1549598A4 - Napththalene derivatives which inhibit the cytokine or biological activity of macrophage migration inhibitory factor (mif) - Google Patents

Napththalene derivatives which inhibit the cytokine or biological activity of macrophage migration inhibitory factor (mif)

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Publication number
EP1549598A4
EP1549598A4 EP03724672A EP03724672A EP1549598A4 EP 1549598 A4 EP1549598 A4 EP 1549598A4 EP 03724672 A EP03724672 A EP 03724672A EP 03724672 A EP03724672 A EP 03724672A EP 1549598 A4 EP1549598 A4 EP 1549598A4
Authority
EP
European Patent Office
Prior art keywords
napththalene
mif
cytokine
inhibit
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03724672A
Other languages
German (de)
French (fr)
Other versions
EP1549598A1 (en
Inventor
Eric Francis Morand
Magdy Naguib Iskander
Basil Danylec
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cortical Pty Ltd
Original Assignee
Cortical Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPS2834A external-priority patent/AUPS283402A0/en
Priority claimed from AUPS2833A external-priority patent/AUPS283302A0/en
Application filed by Cortical Pty Ltd filed Critical Cortical Pty Ltd
Publication of EP1549598A1 publication Critical patent/EP1549598A1/en
Publication of EP1549598A4 publication Critical patent/EP1549598A4/en
Withdrawn legal-status Critical Current

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    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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AUPS2834A AUPS283402A0 (en) 2002-06-07 2002-06-07 Combination therapy
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Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY140679A (en) 2001-05-24 2010-01-15 Avanir Pharmaceuticals Inhibitors of macrohage migration inhibitory factor and methods for identifying the same
TW200418829A (en) 2003-02-14 2004-10-01 Avanir Pharmaceutics Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
JP2007503388A (en) 2003-08-22 2007-02-22 アバニール・ファーマシューティカルズ Substituted naphthyridine derivatives as inhibitors of macrophage migration inhibitory factor and their use in the treatment of human diseases
WO2005058304A1 (en) * 2003-12-17 2005-06-30 Cortical Pty Ltd Implantable device containing inhibitor of macrophage migration inhibitory factor
WO2005087210A2 (en) 2004-03-17 2005-09-22 Lars Michael Larsen Prevention of retinopathy by inhibition of the visual cycle
WO2006102191A1 (en) 2005-03-24 2006-09-28 Avanir Pharmaceuticals Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors
US7915285B2 (en) 2005-09-26 2011-03-29 The Regents Of The University Of Colorado Method for treating drug and behavioral addictions
ES2279730B1 (en) * 2006-02-14 2008-08-01 Italfarmaco, S.A. USE OF SULFONIC ACID DERIVATIVES IN THE TREATMENT OF OCULAR VASOPROLIFERATIVE DISEASES.
WO2007142924A1 (en) * 2006-05-31 2007-12-13 Avigen, Inc. Ibudilast for inhibiting macrophage migration inhibitory factor (mif) activity
WO2007142923A1 (en) * 2006-05-31 2007-12-13 Avigen, Inc. Mif inhibitors for treating neuropathic pain and associated syndromes
ATE509925T1 (en) 2006-11-17 2011-06-15 Pfizer SUBSTITUTED BICYCLOCARBONIC ACID AMIDE COMPOUNDS
US9540322B2 (en) 2008-08-18 2017-01-10 Yale University MIF modulators
US9643922B2 (en) 2008-08-18 2017-05-09 Yale University MIF modulators
SG181702A1 (en) 2009-12-16 2012-07-30 Pola Chem Ind Inc Preventing or ameliorating agent for pigmentation
JP6509112B2 (en) * 2012-07-03 2019-05-08 プラブダ,ジェイ Methods for the treatment, diagnosis and / or monitoring of the progression of oxo related conditions
JP6615753B2 (en) * 2013-10-04 2019-12-04 レジニアス リミテッド Biomarkers for cell therapy
CN104958285A (en) * 2015-06-10 2015-10-07 江琴 Non-small cell lung cancer resistant medicinal composition and an application thereof
WO2018138050A1 (en) 2017-01-26 2018-08-02 Bayer Aktiengesellschaft Condensed bicyclic heterocyclene derivatives as pest control agents
JP7158420B2 (en) * 2017-02-24 2022-10-21 アルツェオン・インコーポレーテッド Methods for treating neurodegenerative disorders
CN108863775B (en) * 2018-05-07 2022-05-03 常州佳德医药科技有限公司 Preparation method of 6-hydroxy-1-naphthoic acid
CN111533718B (en) * 2020-05-12 2022-05-17 浙江海洲制药有限公司 Method for preparing benzbromarone

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4297372A (en) * 1978-12-20 1981-10-27 American Cyanamid Company Ureide inhibitors of connective tissue destruction
WO1985004099A1 (en) * 1984-03-21 1985-09-26 Key Pharmaceuticals, Inc. Sustained release oral dosage form for naproxyn
US4681894A (en) * 1986-09-26 1987-07-21 Ortho Pharmaceutical Corporation Hydroxamic acids and esters
US5194446A (en) * 1989-06-12 1993-03-16 A. H. Robins Company, Incorporated Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals
WO1996020187A2 (en) * 1994-12-23 1996-07-04 Alcon Laboratories, Inc. Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory products
US5756125A (en) * 1992-08-31 1998-05-26 G. D. Searle & Co. Controlled release naproxen sodium plus naproxen combination tablet
US5962531A (en) * 1997-01-28 1999-10-05 Syntex (U.S.A.) Inc. 5-aroylnaphthalene derivatives as anti-inflammatory agents

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4009197A (en) * 1967-01-13 1977-02-22 Syntex Corporation 2-(6-Substituted-2'-naphthyl) acetic acid derivatives and the salts and esters thereof
US3904682A (en) * 1967-01-13 1975-09-09 Syntex Corp 2-(6{40 -Methoxy-2{40 -naphthyl)acetic acid
CA960689A (en) * 1967-01-13 1975-01-07 Syntex Corporation 2-naphthyl acetic acid derivatives and compositions
NL6809942A (en) * 1968-07-12 1970-01-14 2-Naphthyl-acetic acid derivs. - useful as antiinflammatory, analgesic, antipyretic and anti:pruritc agents
US3562336A (en) * 1968-07-24 1971-02-09 Syntex Corp Synthesis of naphthalene derivatives
DE2051012A1 (en) * 1970-10-17 1972-04-20 Syntex Corp., Panama 1,6-methano-(10)-annulenes - with anti-inflammatory analgesic antipyr hypocholesterolaemic and fibrinolytic activity
US3978124A (en) * 1971-11-04 1976-08-31 Syntex Corporation 6-Substituted 2-naphthyl α-substituted acetamides
US3998966A (en) * 1971-11-04 1976-12-21 Syntex Corporation Anti-inflammatory, analgesic, anti-pyretic and anti-pruritic 6-substituted 2-naphthyl acetic acid derivative-containing compositions and methods of use thereof
US3969415A (en) * 1971-12-01 1976-07-13 Sandoz, Inc. 1-(2-Naphthyl)-2,3-butadien-1-ols
BE792079A (en) * 1971-12-01 1973-05-29 Sandoz Sa NEW INSATURE COMPOUNDS, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
US3935273A (en) * 1972-01-31 1976-01-27 Syntex Corporation Naphthyl acetaldehyde derivatives
FR2187319B1 (en) * 1972-06-09 1975-06-20 Bottu Exploit Labo
US3958012A (en) * 1972-10-27 1976-05-18 Syntex Corporation D 2-(6-Substituted-2-naphthyl)-propanals
GB1474377A (en) * 1973-09-11 1977-05-25 Beecham Group Ltd Naphthalene derivatives
US3959395A (en) * 1974-12-26 1976-05-25 Monsanto Company Recovery of polymerization inhibitor
US3994968A (en) * 1975-01-10 1976-11-30 Syntex Corporation 2-(5'-Halo-6'-methoxynaphth-2'-yl)-acrylic acid
JPS52133962A (en) * 1976-04-30 1977-11-09 Grelan Pharmaceut Co Ltd Synthesis of 2-(6-methoxy-2-naphthyl)-propionic acid
DE3469169D1 (en) * 1983-04-21 1988-03-10 Merck Frosst Canada Inc Leukotriene antagonists, their production and use and compositions containing them
CA1285951C (en) * 1985-10-28 1991-07-09 Raj N. Misra Naphthalenyl- and quinolinyl-amino substituted phenols
JPS62103074A (en) * 1985-10-29 1987-05-13 Hamari Yakuhin Kogyo Kk Production of 2-(6-methoxy-2-naphthyl)-1,2-epoxypropane
JPS63203631A (en) * 1987-02-19 1988-08-23 Nippon Kayaku Co Ltd Production of alpha-arylpropionic acid
US4767776A (en) * 1987-02-20 1988-08-30 Warner-Lambert Company N-1H-tetrazol-5-yl-2-naphthalene carboxamides and their use as antiallergy and antiinflammatory agents
IL85700A0 (en) * 1987-03-24 1988-08-31 Takeda Chemical Industries Ltd 1,4-disubstituted piperazine compounds,their production and use
IT1216929B (en) * 1987-04-16 1990-03-14 Enichem Sintesi PROCEDURE FOR THE SYNTHESIS OF 2-ARYL-PROPIONIC ACIDS.
AU611699B2 (en) * 1987-07-31 1991-06-20 American Home Products Corporation Naphthalene propionic acid derivatives
US5208344A (en) * 1987-07-31 1993-05-04 American Home Products Corporation Naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents
US5084575A (en) * 1987-07-31 1992-01-28 American Home Products Corporation Quinoline substituted naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents
JPS6476063A (en) * 1987-09-18 1989-03-22 Dainichiseika Color Chem Electrophotographic sensitive body
US4937373A (en) * 1988-12-08 1990-06-26 Hoffmann-La Roche Inc. Substituted naphthalene carboxylic acids
US5032588A (en) * 1989-12-08 1991-07-16 Abbott Laboratories Thiazole lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids
DE3943286A1 (en) * 1989-12-29 1991-07-04 Hoechst Ag AZO COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A DYE
US5837689A (en) * 1993-06-16 1998-11-17 Glycomed Incorporated Sialyl lewis-x mimetics containing naphthyl backbones
ES2103181B1 (en) * 1994-08-01 1998-04-01 Menarini Lab NAFTALENIC AMIDES WITH ANTAGONIST ACTION OF THE LEUKOTRENEES.
US6011029A (en) * 1996-02-26 2000-01-04 Bristol-Myers Squibb Company Inhibitors of farnesyl protein transferase
CA2206997A1 (en) * 1996-07-10 1998-01-10 Eli Lilly And Company Benzothiophene compounds and methods of use
CN1251577A (en) * 1997-02-21 2000-04-26 武田药品工业株式会社 Fused ring compounds, process for producing same and use thereof
AU8224998A (en) * 1997-07-04 1999-01-25 Nycomed Amersham Plc Peroxidase-catalysed fluorescence
ES2150848B1 (en) * 1998-04-15 2001-07-01 Menarini Lab HETEROCICLES METILOXINAFTIL SUBSTITUTED WITH ANTAGONIST ACTION OF LEUCOTRIENOS.
AU2108601A (en) * 1999-12-15 2001-06-25 Axys Pharmaceuticals, Inc. Salicylamides as serine protease inhibitors
WO2004014377A1 (en) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc 4-hydroxyquinoline derivatives as matrix metalloproteinase inhibitors

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4297372A (en) * 1978-12-20 1981-10-27 American Cyanamid Company Ureide inhibitors of connective tissue destruction
WO1985004099A1 (en) * 1984-03-21 1985-09-26 Key Pharmaceuticals, Inc. Sustained release oral dosage form for naproxyn
US4681894A (en) * 1986-09-26 1987-07-21 Ortho Pharmaceutical Corporation Hydroxamic acids and esters
US5194446A (en) * 1989-06-12 1993-03-16 A. H. Robins Company, Incorporated Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals
US5756125A (en) * 1992-08-31 1998-05-26 G. D. Searle & Co. Controlled release naproxen sodium plus naproxen combination tablet
WO1996020187A2 (en) * 1994-12-23 1996-07-04 Alcon Laboratories, Inc. Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory products
US5962531A (en) * 1997-01-28 1999-10-05 Syntex (U.S.A.) Inc. 5-aroylnaphthalene derivatives as anti-inflammatory agents

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
A. KOJ: "Termination of acute-phase response: role of some cytokines and anti-inflammatory drugs", GENERAL PHARMACOLOGY, vol. 31, no. 1, 1998, pages 9 - 18, XP002461928 *
KRUG ET AL: "Tolerability and efficacy of nabumetone and naproxen in the treatment of rheumatoid arthritis", CLINICAL THERAPEUTICS, EXCERPTA MEDICA, PRINCETON, NJ, US, vol. 22, no. 1, January 2000 (2000-01-01), pages 40 - 52, XP005508903, ISSN: 0149-2918 *
M. LEECH ET AL.: "Macrophage migration inhibitory factor in rheumatoid arthritis", ARTHRITIS & RHEUMATISM, vol. 42, no. 8, August 1999 (1999-08-01), pages 1601 - 1608, XP002461927 *
See also references of WO03104178A1 *
WIEBALCK ET AL: "2a NSAIDs and other non-opioids in chronic pain", BAILLIERE'S CLINICAL ANAESTHESIOLOGY, BAILLIERE TINDALL, PHILADELPHIA, US, vol. 12, no. 1, March 1998 (1998-03-01), pages 19 - 38, XP005119211, ISSN: 0950-3501 *

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