EP1517695A4 - Osteopontine, oligodendrocytes et myelinisation - Google Patents

Osteopontine, oligodendrocytes et myelinisation

Info

Publication number
EP1517695A4
EP1517695A4 EP03742164A EP03742164A EP1517695A4 EP 1517695 A4 EP1517695 A4 EP 1517695A4 EP 03742164 A EP03742164 A EP 03742164A EP 03742164 A EP03742164 A EP 03742164A EP 1517695 A4 EP1517695 A4 EP 1517695A4
Authority
EP
European Patent Office
Prior art keywords
myelination
osteopontin
oligodendrocytes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03742164A
Other languages
German (de)
English (en)
Other versions
EP1517695A2 (fr
Inventor
Jean Merrill
Su-Fen Pu
Olga Khorkova
Zhongqi Ji
Fernando Camacho
Steve Busch
Min Wang
Ting Chen
Robert J Dinerstein
Zhengbin Yao
Yangde Chen
Xin Zhang
Karen Chandross
Lan Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0224017.4A external-priority patent/GB0224017D0/en
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Publication of EP1517695A2 publication Critical patent/EP1517695A2/fr
Publication of EP1517695A4 publication Critical patent/EP1517695A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5029—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell motility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/585—Integrins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/285—Demyelinating diseases; Multipel sclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Developmental Biology & Embryology (AREA)
EP03742164A 2002-06-25 2003-06-24 Osteopontine, oligodendrocytes et myelinisation Withdrawn EP1517695A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US39103502P 2002-06-25 2002-06-25
US391035P 2002-06-25
GB0224017 2002-10-16
GBGB0224017.4A GB0224017D0 (en) 2002-06-25 2002-10-16 Osteopontin oligodendrocytes and myelination
PCT/US2003/019864 WO2004001014A2 (fr) 2002-06-25 2003-06-24 Osteopontine, oligodendrocytes et myelinisation

Publications (2)

Publication Number Publication Date
EP1517695A2 EP1517695A2 (fr) 2005-03-30
EP1517695A4 true EP1517695A4 (fr) 2010-09-01

Family

ID=30001991

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03742164A Withdrawn EP1517695A4 (fr) 2002-06-25 2003-06-24 Osteopontine, oligodendrocytes et myelinisation

Country Status (11)

Country Link
EP (1) EP1517695A4 (fr)
JP (1) JP2005535313A (fr)
CN (1) CN1662249A (fr)
AU (1) AU2003278205B2 (fr)
BR (1) BR0312042A (fr)
CA (1) CA2489905A1 (fr)
IL (1) IL165932A0 (fr)
MX (1) MXPA04012803A (fr)
NO (1) NO20045560L (fr)
RU (1) RU2005101633A (fr)
WO (1) WO2004001014A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005238092B2 (en) * 2004-05-03 2010-06-17 Peter Maccallum Cancer Institute Methods for stem cell expansion and differentiation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063241A2 (fr) * 1999-04-15 2000-10-26 Children's Medical Center Corporation Procedes et compositions de modulation d'une reponse immunitaire
WO2002092122A2 (fr) * 2001-05-17 2002-11-21 Applied Research Systems Ars Holding N.V. Utilisation d'osteopontine dans le traitement et/ou la prevention de maladies neurologiques
WO2003046135A2 (fr) * 2001-11-21 2003-06-05 The Board Of Trustees Of The Leland Stanford Junior University Compositions et methodes associees a l'osteopontine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063241A2 (fr) * 1999-04-15 2000-10-26 Children's Medical Center Corporation Procedes et compositions de modulation d'une reponse immunitaire
WO2002092122A2 (fr) * 2001-05-17 2002-11-21 Applied Research Systems Ars Holding N.V. Utilisation d'osteopontine dans le traitement et/ou la prevention de maladies neurologiques
WO2003046135A2 (fr) * 2001-11-21 2003-06-05 The Board Of Trustees Of The Leland Stanford Junior University Compositions et methodes associees a l'osteopontine

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHABAS DOROTHEE ET AL: "The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US LNKD- DOI:10.1126/SCIENCE.1062960, vol. 294, no. 5547, 23 November 2001 (2001-11-23), pages 1731 - 1735, XP002299870, ISSN: 0036-8075 *
ELLISON J A ET AL: "MATRIX REMODELING AFTER STROKE DE NOVO EXPRESSION OF MATRIX PROTEINS AND INTEGRIN RECEPTORS", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY, US LNKD- DOI:10.1111/J.1749-6632.1999.TB07996.X, vol. 890, 1 January 1999 (1999-01-01), pages 204 - 222, XP001029484, ISSN: 0077-8923 *
JANSSON MARIANNE ET AL: "Cutting edge: Attenuated experimental autoimmune encephalomyelitis is Eta-1/osteopontin-deficient mice", JOURNAL OF IMMUNOLOGY, vol. 168, no. 5, 1 March 2002 (2002-03-01), pages 2096 - 2099, XP002591250, ISSN: 0022-1767 *
WANG X ET AL: "DELAYED EXPRESSION OF OSTEOPONTIN AFTER FOCAL STROKE IN THE RAT", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 18, no. 6, 15 March 1998 (1998-03-15), pages 2075 - 2083, XP001029483, ISSN: 0270-6474 *

Also Published As

Publication number Publication date
JP2005535313A (ja) 2005-11-24
EP1517695A2 (fr) 2005-03-30
AU2003278205B2 (en) 2008-01-24
CN1662249A (zh) 2005-08-31
CA2489905A1 (fr) 2003-12-31
IL165932A0 (en) 2006-01-15
MXPA04012803A (es) 2005-06-08
AU2003278205A1 (en) 2004-01-06
NO20045560L (no) 2004-12-20
BR0312042A (pt) 2005-05-24
WO2004001014A2 (fr) 2003-12-31
RU2005101633A (ru) 2005-06-10
WO2004001014A3 (fr) 2004-12-29

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

RIN1 Information on inventor provided before grant (corrected)

Inventor name: LEE, LAN

Inventor name: CHANDROSS, KAREN

Inventor name: ZHANG, XIN

Inventor name: CHEN, YANGDE

Inventor name: YAO, ZHENGBIN

Inventor name: DINERSTEIN, ROBERT, J.

Inventor name: CHEN, TING

Inventor name: WANG, MIN

Inventor name: BUSCH, STEVE

Inventor name: CAMACHO, FERNANDO

Inventor name: JI, ZHONGQI

Inventor name: KHORKOVA, OLGA

Inventor name: PU, SU-FEN

Inventor name: MERRILL, JEAN

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: AVENTIS PHARMACEUTICALS, INC.

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 25/00 20060101ALI20100720BHEP

Ipc: G01N 33/567 20060101ALI20100720BHEP

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Ipc: C12Q 1/70 20060101ALI20100720BHEP

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