EP1503801A4 - Administration non invasive de polypeptides a travers la barriere hemato-encephalique et selection in vivo de ligands endocytotiques - Google Patents
Administration non invasive de polypeptides a travers la barriere hemato-encephalique et selection in vivo de ligands endocytotiquesInfo
- Publication number
- EP1503801A4 EP1503801A4 EP03727872A EP03727872A EP1503801A4 EP 1503801 A4 EP1503801 A4 EP 1503801A4 EP 03727872 A EP03727872 A EP 03727872A EP 03727872 A EP03727872 A EP 03727872A EP 1503801 A4 EP1503801 A4 EP 1503801A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- polypeptides
- blood
- brain barrier
- invasive delivery
- vivo selection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000008499 blood brain barrier function Effects 0.000 title 1
- 210000001218 blood-brain barrier Anatomy 0.000 title 1
- 230000001159 endocytotic effect Effects 0.000 title 1
- 238000001727 in vivo Methods 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16641—Use of virus, viral particle or viral elements as a vector
- C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Physics & Mathematics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US188184 | 1980-09-18 | ||
AUPS1935A AUPS193502A0 (en) | 2002-04-26 | 2002-04-26 | Molecules that mediate internalisation in cells |
AUPS193502 | 2002-04-26 | ||
US10/188,184 US20030083299A1 (en) | 2000-11-04 | 2002-07-02 | Non-invasive delivery of polypeptides through the blood-brain barrier |
PCT/IB2003/002371 WO2003091387A2 (fr) | 2002-04-26 | 2003-04-28 | Administration non invasive de polypeptides a travers la barriere hemato-encephalique et selection in vivo de ligands endocytotiques |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1503801A2 EP1503801A2 (fr) | 2005-02-09 |
EP1503801A4 true EP1503801A4 (fr) | 2006-02-08 |
Family
ID=29271266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03727872A Withdrawn EP1503801A4 (fr) | 2002-04-26 | 2003-04-28 | Administration non invasive de polypeptides a travers la barriere hemato-encephalique et selection in vivo de ligands endocytotiques |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1503801A4 (fr) |
JP (2) | JP2005535580A (fr) |
CA (1) | CA2483980C (fr) |
WO (1) | WO2003091387A2 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006070290A2 (fr) * | 2004-06-23 | 2006-07-06 | Ferguson Ian A | Agents et procedes pour le diagnostic et le suivi precoces de la maladie d'alzheimer et d'autres troubles neurologiques |
US20110077204A1 (en) * | 2006-01-24 | 2011-03-31 | Kagoshima University | Agent for Targeted Drug Delivery To Cerebral Neurons |
JP2011024499A (ja) * | 2009-07-27 | 2011-02-10 | Nec Soft Ltd | 核酸の製造方法、デリバリー対象物質を臓器特異的にデリバリー可能なデリバリー用タグ核酸およびその用途 |
US20130123647A1 (en) | 2011-05-03 | 2013-05-16 | The Research Foundation Of State University Of New York | Methods Useful in Optimizing the Treatment of Neuropathies and Targeting Tissues with Cosmetic Botulinum Injections |
CN113838541B (zh) * | 2021-09-29 | 2023-10-10 | 脸萌有限公司 | 设计配体分子的方法和装置 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994004695A1 (fr) * | 1992-08-14 | 1994-03-03 | The Rockefeller University | Vecteur defectif de l'herpesvirus avec promoteur du gene de preproenkephaline du rat |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6770797B2 (en) * | 2001-06-01 | 2004-08-03 | Rhode Island Hospital | Non-Transgenic nonhuman model for Alzheimer's Disease using a AD7c-NTP nucleic acid |
-
2003
- 2003-04-28 JP JP2003587923A patent/JP2005535580A/ja active Pending
- 2003-04-28 EP EP03727872A patent/EP1503801A4/fr not_active Withdrawn
- 2003-04-28 CA CA2483980A patent/CA2483980C/fr not_active Expired - Fee Related
- 2003-04-28 WO PCT/IB2003/002371 patent/WO2003091387A2/fr active Application Filing
-
2013
- 2013-01-23 JP JP2013010399A patent/JP2013136586A/ja active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994004695A1 (fr) * | 1992-08-14 | 1994-03-03 | The Rockefeller University | Vecteur defectif de l'herpesvirus avec promoteur du gene de preproenkephaline du rat |
Non-Patent Citations (12)
Title |
---|
BERRY M ET AL: "GENE THERAPY FOR CENTRAL NERVOUS SYSTEM REPAIR", CURRENT OPINION IN MOLECULAR THERAPEUTICS, CURRENT DRUGS, LONDON,, GB, vol. 3, no. 4, August 2001 (2001-08-01), pages 338 - 349, XP009055046, ISSN: 1464-8431 * |
GLORIOSO J C ET AL: "Use of HSV vectors to modify the nervous system", CURRENT OPINION IN DRUG DISCOVERY AND DEVELOPMENT, CURRENT DRUGS, LONDON, GB, vol. 5, no. 2, 2002, pages 289 - 295, XP002278729, ISSN: 1367-6733 * |
KASSNER P D ET AL: "Genetic selction of phage engineered for receptor-mediated gene transfer to mammalian cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 264, 1999, pages 921 - 928, XP002189963, ISSN: 0006-291X * |
KAY M A ET AL: "VIRAL VECTORS FOR GENE THERAPY: THE ART OF TURNING INFECTIOUS AGENTS INTO VEHICLES OF THERAPEUTICS", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 7, no. 1, January 2001 (2001-01-01), pages 33 - 40, XP008042487, ISSN: 1078-8956 * |
MAZARAKIS N D ET AL: "RABIES VIRUS GLYCOPROTEIN PSEUDOTYPING OF LENTIVIRAL VECTORS ENABLES RETROGRADE AXONAL TRANSPORT AND ACCESS TO THE NERVOUS SYSTEM AFTER PERIPHERAL DELIVERY", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 10, no. 19, 15 September 2001 (2001-09-15), pages 2109 - 2121, XP001058914, ISSN: 0964-6906 * |
PALMER J A ET AL: "Development and optimization of herpes simplex virus vectors for multiple long-term delivery to the peripheral nervous system", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 74, no. 12, June 2000 (2000-06-01), pages 5604 - 5618, XP002164866, ISSN: 0022-538X * |
PICKARD GARY E ET AL: "Intravitreal injection of the attenuated pseudorabies virus PRV Bartha results in infection of the hamster suprachiasmatic nucleus only by retrograde transsynaptic transport via autonomic circuits", JOURNAL OF NEUROSCIENCE, vol. 22, no. 7, 1 April 2002 (2002-04-01), pages 2701 - 2710, XP002358460, ISSN: 0270-6474 * |
See also references of WO03091387A2 * |
SOUDAIS CLAIRE ET AL: "Preferential transduction of neurons by canine adenovirus vectors and their efficient retrograde transport in vivo", FASEB JOURNAL (FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY), BETHESDA, US, vol. 15, no. 12, October 2001 (2001-10-01), pages 2283 - 2285, XP002347771, ISSN: 0892-6638 * |
WANG S ET AL: "Transgene expression in the brain stem effected by intramuscular injection of polyethylenimine/DNA complexes.", MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY. MAY 2001, vol. 3, no. 5 Pt 1, May 2001 (2001-05-01), pages 658 - 664, XP002358454, ISSN: 1525-0016 * |
YAMAMURA J ET AL: "Long-term gene expression in the anterior horn motor neurons after intramuscular inoculation of a live herpes simplex virus vector", GENE THERAPY, vol. 7, no. 11, June 2000 (2000-06-01), pages 934 - 941, XP002358455, ISSN: 0969-7128 * |
YAN Q ET AL: "Retrograde transport of nerve growth factor (NGF) in motoneurons of developing rats: assessment of potential neurotrophic effects.", NEURON. JUN 1988, vol. 1, no. 4, June 1988 (1988-06-01), pages 335 - 343, XP002358456, ISSN: 0896-6273 * |
Also Published As
Publication number | Publication date |
---|---|
CA2483980C (fr) | 2013-07-16 |
EP1503801A2 (fr) | 2005-02-09 |
WO2003091387A2 (fr) | 2003-11-06 |
WO2003091387A9 (fr) | 2004-02-26 |
WO2003091387A3 (fr) | 2004-01-08 |
JP2013136586A (ja) | 2013-07-11 |
JP2005535580A (ja) | 2005-11-24 |
CA2483980A1 (fr) | 2003-11-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20041126 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20051223 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: DELGENE INVERSTOR SERVICES PTY LTD. |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20150421 |