EP1487399A1 - Use of olive tree extracts as a deodorant - Google Patents

Abstract

The invention relates to the use of olive trees extracts as a deodorant. Extracts from olive trees, especially leaves from olive trees and/or from waste water produced during the production of olive oil, have an anti-microbial effect against micro-organisms which are responsible for the decomposition of sweat.

Description

Use of extracts from the olive tree as a deodorant

The invention is in the field of cosmetics and relates to the use of extracts from the olive tree as a deodorant.

State of the art

Deodorants are used in cosmetics to remove unpleasant body odors, which mainly result from the fact that originally odorless substances in the body's sweat are decomposed into malodorous compounds by microorganisms. Accordingly, deodorants are active ingredients, such as antimicrobial agents, enzyme inhibitors, odor absorbers or odor maskers, and antiperspirants.

Sweat secretion is mostly minimized by so-called antiperspirants such as aluminum salts and zinc salts, which have an astringent effect. On the other hand, antimicrobial substances are also used which reduce the bacterial flora and thus reduce the decomposition of the components in sweat. The flow of sweat is not influenced by the latter principle. German patent application DE 42 37 551 discloses a composition which contains constituents of the herb of the genus Equisetum and constituents of the herb and / or the flower of the genus Lavandula and has a good antiperspirant effect which occurs very quickly after application and which also persists, when the antiperspirant effect of this composition has waned. This indicates that this composition also effectively prevents the unpleasant odor from secretion products of the body that have already been excreted and for a long time.

However, there is still a need for well-tolerated substances with a low negative effect on the bacterial flora of the skin, little influence on the secretion of sweat and a long-lasting effectiveness. Furthermore, it was an object of the invention to develop cosmetic deodorants which are distinguished by good skin tolerance. Description of the invention

The invention relates to the use of extracts from the olive tree as a deodorant. Surprisingly, it has been found that extracts from the olive tree, in particular from the leaves of the olive tree and / or from the wastewater from olive oil production, have a microbicidal action against bacteria which have the main effect on sweat-decomposing processes. The inhibition of these bacteria leads to a long-lasting effectiveness against unpleasant body odors. In particular, the microflora typical of the armpit skin is effectively inhibited by the use of the olive leaf extract over a long period of time. The plant extracts of the olive tree are also characterized by good dermatological tolerance.

Extracts of the olive tree

The extracts to be used according to the invention are prepared by customary extraction methods. Regarding the suitable conventional extraction methods such as maceration, remaceration, digestion, movement maceration, vortex extraction, ultrasound extraction, countercurrent extraction, percolation, repercolation, evacolation (extraction under reduced pressure), diacolation and solid-liquid extraction under continuous reflux , which is carried out in a Soxhlet extractor, which is familiar to a person skilled in the art and in principle all can be used, is exemplary of Hager's Handbook of Pharmaceutical Practice, (5th edition, vol. 2, pp. 1026-1030, Springer Verlag, Berlin- Heidelberg-New-York 1991). Fresh or dried parts of the olive tree can be used as the starting material, but usually leaves are used which are mechanically shredded before extraction. All grinding methods known to the person skilled in the art are suitable here, for example crushing with a mortar.

Water, organic solvents or mixtures of organic solvents and water, in particular low molecular weight alcohols, hydrocarbons, ketones, esters or halogen-containing hydrocarbons with more or less high water contents (distilled or not distilled), preferably aqueous, alcoholic solutions, can preferably be used as solvents for carrying out the extractions a temperature of greater than or equal to 20 ° C can be used. Extraction with water, methanol, ethanol, hexane, cyclohexane, pentane, acetone, propylene glycols, polyethylene glycols, ethyl acetate, dichloromethane, trichloromethane and mixtures thereof is particularly preferred. The extraction is usually carried out at 20 to 100 ° C, preferably at 20 to 85 ° C, in particular either at the boiling point of the solvent used or at room temperature. In one possible embodiment, the extraction takes place under an inert gas atmosphere to avoid oxidation of the ingredients of the extract. The extraction times are set by the person skilled in the art, depending on the starting material, the extraction process, the extraction temperature, the ratio of solvent to raw material, and others. After the extraction, the crude extracts obtained can optionally be subjected to further customary steps, such as purification, concentration and / or decolorization. If desired, the extracts produced in this way can, for example, be subjected to a selective separation of individual undesirable ingredients. The extraction can be carried out to any desired degree of extraction, but is usually carried out until exhaustion. The present invention includes the knowledge that the extraction conditions and the yields of the final extracts can be selected depending on the desired field of use. If desired, the extracts can then be subjected to spray drying or freeze drying, for example.

The amount of the extracts used in the preparations mentioned depends on the type of application of the extracts and on the concentration of the individual ingredients. The total amount of the olive tree leaf extract which is contained in the preparations according to the invention is generally 0.01 to 15% by weight, preferably 0.05 to 5% by weight, in particular 0.1 to 3% by weight, based on the final preparation, with the proviso that the quantities with water and possibly other auxiliary substances and additives add up to 100% by weight.

Olive tree leaf extracts are preferably used, which are standardized with regard to their main ingredient oleuropein. They contain 1 to 40% by weight, preferably 5 to 30% by weight, particularly preferably 10 to 25% by weight and especially 18 to 22% by weight oleuropein, based on the dry extract.

Extracts from the wastewater of olive tree production are produced by drying the water, preferably by spray drying ^, after the addition of auxiliaries such as mannitol or sodium casinate. They are adjusted to a content of polyphenols, preferably hydroxytyrosol and tyrosol, which is at least 0.5% by weight, preferably at least 1% by weight and particularly preferably at least 2% by weight, based on the dry extract.

Active substance in the sense of the invention relates to the proportion of substances and auxiliaries and additives which are contained in the preparations, with the exception of the additionally added water. Deodorant preparations

Another object of the invention are deodorant preparations containing the extracts of the olive tree, preferably from the leaves of the olive tree and / or from the wastewater of olive oil production, and at least one substance selected from the group formed by germ-inhibiting agents, enzyme inhibitors, odor absorbers or odor maskers as well Antiperspirants, preferably a substance selected from the group consisting of cationic chitosan, salts of aluminum, zirconium or zinc and their complex compounds.

In principle, all substances effective against gram-positive bacteria are suitable as germ-inhibiting agents, such as. B. 4-hydroxybenzoic acid and its salts and esters, N- (4-chlorophenyl) -N ^' - (3,4 dichlorophenyl) urea, 2,4,4 ^' trichloro-2 ^' hydroxydiphenyl ether (triclosan), 4-chloro -3,5-dimethylphenol, 2,2 ^{'-methylene-bis} (6-bromo-4-chlorophenol), 3-methyl-4- (1-methylethyl) phenol, 2-benzyl-4-chlorophenol, 3- (4 -Chlorphenoxy) -1, 2-propanediol, 3-iodo-2-propynyl butyl carbamate, chlorhexidine, 3,4,4 ^' trichlorocarbanilide (TTC), antibacterial fragrances, thymoi, thyme oil, eugenol, clove oil, menthol, mint oil, famesol , Phenoxyethanol, Glycerinmonocaprinat, Glycerinmonocapry- lat, Glycerinmonolaurat (GML), Diglycerinmonocaprinat (DMC), Salicylic acid N-alkylamides such as. B. salicylic acid-n-octylamide or salicylic acid-n-decylamide.

Esterase inhibitors, for example, are suitable as enzyme inhibitors. These are preferably trialkyl citrates such as trimethyl citrate, tripropyl citrate, triisopropyl citrate, tributyl citrate and in particular triethyl citrate (Hydagen® CAT, Cognis GmbH, Düsseldorf / FRG). This is used in amounts of 0.05 to 5% by weight, preferably 0.1 to 3% by weight and particularly preferably 0.5 to 2% by weight, based on the deodorant preparations in combination with the olive tree leaf extracts.

The substances inhibit enzyme activity and thereby reduce odor. Other substances which can be considered as esterase inhibitors are sterol sulfates or phosphates, such as, for example, lanosterol, cholesterol, campesterol, stigmasterol and sitosterol sulfate or phosphate, dicarboxylic acids and their esters, such as, for example, glutaric acid, glutaric acid monoethyl ester, glutaric acid diethyl ester, Adipic acid, adipic acid monoethyl ester, adipic acid diethyl ester, malonic acid and malonic acid diethyl ester, hydroxycarboxylic acids and their esters such as citric acid, malic acid, tartaric acid or tartaric acid diethyl ester and zinc glycinate.

Suitable odor absorbers are substances that absorb odor-forming compounds and can retain them to a large extent. They reduce the partial pressure of the individual components and reduce like their spreading speed. It is important that perfumes must remain unaffected. Odor absorbers are not effective against bacteria. They contain, for example, a complex zinc salt of ricinoleic acid or special, largely odorless fragrances, which are known to the person skilled in the art as "fixators", such as, for example, the main component. B. extracts of Labdanum or Styrax or certain abietic acid derivatives. Fragrance substances or perfume oils act as odor maskers which, in addition to their function as odor maskers, give the deodorants their respective fragrance. Perfume oils are, for example, mixtures of natural and synthetic fragrances. Natural fragrances are extracts of flowers, stems and leaves, fruits, fruit peels, roots, woods, herbs and grasses, needles and branches as well as resins and balms. Animal raw materials, such as civet and castoreum, are also suitable. Typical synthetic fragrance compounds are products of the ester, ether, aldehyde, ketone, alcohol and hydrocarbon type. Fragrance compounds of the ester type are, for example, benzyl acetate, p-tert-butylcyclohexyl acetate, linalyl acetate, phenylethyl acetate, linalyl benzoate, benzyl formate, allyl cyclohexyl propionate, styrallyl propionate and benzyl salicylate. The ethers include, for example, benzyl ethyl ether, the aldehydes, for example, the linear alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetal dehyde, cyclamenaldehyde, hydroxycitronellal, lilial and bourgeonal, the ketones, for example, the ionone and methyl cedryl ketone, and the alcohols Anethole, citronellol, eugenol, isoeugenol, geraniol ,. Linalool, phenylethyl alcohol and terpineol, the hydrocarbons mainly include the terpenes and balsams. However, preference is given to using mixtures of different fragrances which together produce an appealing fragrance. Essential oils of lower volatility, which are mostly used as aroma components, are also suitable as perfume oils, e.g. sage oil, chamomile oil, clove oil, lemon balm oil, mint oil, cinnamon leaf oil, linden blossom oil, juniper berry oil, vetiver oil, oliban oil, galbanum oil, labdanum oil and lavandin oil. Bergamot oil, dihydromyrcenol, lilial, lyral, citronellol, phenylethyl alcohol, α-hexylcinnamaldehyde, geraniol, benzylacetone, cyclamenaldehyde, linalool, boisambrene forte, ambroxan, indole, hedione, sandelice, lemon oil, mandarine oil, cyclo-allyl oil, orange-oil alaline oil, orange-oil oil, orange-oil oil, orange-oil oil , Muscatel sage oil, ß-damascone, geranium oil bourbon, cyclohexyl salicylate, Vertofix Coeur, Iso-E-Super, Fixolide NP, evernyl, iraldein gamma, phenylacetic acid, geranyl acetate, benzyl acetate, rose oxide, romilate, irotyl and floramate used alone or in mixtures.

Antiperspirants (antiperspirants) reduce sweat formation by influencing the activity of the eccrine sweat glands and thus counteract armpit wetness and body odor. Salts of aluminum, zirconium or zinc are particularly suitable as astringent antiperspirant active ingredients. Such suitable antiperspirant active ingredients are, for example, aluminum chloride, aluminum chlorohydrate, aluminum dichlorohydrate, aluminum sesquichlorohydrate and their complex compounds, for. B. with propylene glycol-1, 2nd Aluminum hydroxyallantoinate, aluminum chloro Ride tartrate, aluminum-zirconium trichlorohydrate, aluminum-zirconium tetrachlorohydrate, aluminum-zirconium pentachlorohydrate and their complex compounds z. B. with amino acids such as Glycine.

Aqueous or anhydrous formulations of deodorants typically contain the following ingredients:

> Deodorants (see above),

> Oil components,

> nonionic emulsifiers,

> Co-emulsifiers,

> Consistency adjusters, auxiliaries such as B. thickeners or complexing agents and / or

> non-aqueous solvents such as As ethanol, propylene glycol and / or glycerin.

In addition, customary oil-soluble and water-soluble auxiliaries can be present in smaller amounts in deodorants. Such oil soluble aids can e.g. his:

> anti-inflammatory, skin-protecting or fragrant essential oils,

> synthetic skin-protecting agents and / or

> Oil-soluble perfume oils.

Customary water-soluble additives are, for example, preservatives, water-soluble fragrances, pH adjusting agents, for example Puffergernische, ^{'water-soluble} thickeners, such as water-soluble natural or synthetic polymers such as xanthan gum, hydroxyethylcellulose, polyvinylpyrrolidone or high molecular weight polyethylene oxides.

Industrial applicability

The present invention also relates to the use of the olive tree extracts for the production of deodorant preparations. The amount of extracts from the leaves of the olive tree and / or from the wastewater from olive oil production is usually in the order of 0.01 to 15% by weight, preferably 0.05 to 5% by weight, in particular 0.1 to 3 wt .-% - based on the preparations. The deodorant preparations can be in the form of creams, gels, lotions, alcoholic and aqueous / alcoholic solutions, emulsions, wax / fat masses, stick preparations, powders or ointments. These agents can also be used as further auxiliaries and additives, mild surfactants, oil bodies, emulsifiers, superfatting agents, consistency enhancers, thickeners, polymers, silicone compounds, fats, waxes, biogenic agents, film formers, swelling agents, antioxidants, hydrotropes, preservatives, solubilizers, perfume oils, dyes and the like included.

surfactants

Typical examples of particularly suitable mild, i.e. particularly skin-compatible surfactants are fatty alcohol polyglycol ether sulfates, monoglyceride sulfates, mono- and / or dialkyl sulfosuccinates, fatty acid taurides, fatty acid glutamates, α- olefin sulfonates, Ethercarbo.nsäuren, alkyl oligoglucosides, fatty acid glucamides, alkylamidobetaines, amphoacetals and / or protein fatty acid condensates, the latter preferably based on wheat proteins.

oil body

Guerbet alcohols based on fatty alcohols having 6 to 18, preferably 8 to 10 carbon atoms, esters of linear C6-C22 fatty acids with linear or branched C6-C22 fatty alcohols or esters of branched C6-Ci3-carboxylic acids come as oil bodies, for example. linear or branched C6-C22 fatty alcohols. such as myristyl myristate, myristyl palmitate, myristyl stearate, Myristylisostearat, myristyl, Myristylbehenat, Myristylerucat, cetyl myristate, cetyl palmitate, Ce tylstearat, Cetylisostearat, cetyl oleate, cetyl behenate, Cetylerucat, Stearylmyristat, stearyl palmitate, stearyl stearate, Stearylisostearat, stearyl oleate, stearyl behenate, Stearylerucat, isostearyl, isostearyl palmitate, Isostearylstearat, isostearyl isostearate, Isostearyloleat, isostearyl behenate, Isostearyloleat, oleyl myristate, oleyl palmitate, oleyl stearate, oleyl isostearate, oleyl oleate, Oleylbehenat, oleyl erucate, behenyl myristate, behenyl palmitate, behenyl, Behenylisostearat, behenyl oleate, behenyl behenate, behenyl erucate, erucyl myristate, erucyl, erucyl, erucyl, erucyl oleate, Erucyl behenate and erucylerucate. In addition, esters of linear C6-C22 fatty acids with branched alcohols, in particular 2-ethylhexanol, esters of Ci8-C3 - alkylhydroxycarboxylic acids with linear or branched C6-C22 fatty alcohols, in particular dioctyl matte, esters of linear and / or branched fatty acids with polyhydric alcohols (such as propylene glycol, dimer diol or trimer triol) and / or Guerbet alcohols, triglycerides based on C.- cio fatty acids, liquid mono- / di- / triglyceride mixtures based on Cδ-cis fatty acids, esters of C6-C ₂ fatty alcohols and / or Guerbet alcohols with aromatic carboxylic acids, in particular benzoic acid, esters of C2-Ci2-dicarboxylic acids with linear or branched alcohols with 1 to 22 carbon atoms or polyols with 2 to 10 carbon atoms and 2 to 6 hydroxyl groups, vegetable Oils, branched primary alcohols, substituted cyclohexanes, linear and branched C6-C22 fatty alcohol carbonates, such as dicaprylyl carbonates (Cetiol® CC), Guerbet carbonates based on fatty alcohols with 6 to 18, preferably 8 to 10 C atoms, esters of benzoic acid with linear and / or branched C6-C22 alcohols (e.g. Finsolv® TN), linear or branched, symmetrical or unsymmetrical dialkyl ethers with 6 to 22 carbon atoms per alkyl group, such as dicaprylyl ether (Cetiol® OE), ring opening products of epoxidized fatty acid esters with polyols , Silicone oils (cyclomethicones, silicon methicone types, etc.) and / or aliphatic or naphthenic hydrocarbons, such as w he squalane, squalene or dialkyl cyclohexane into consideration.

Emulqatoren

Examples of suitable emulsifiers are nonionic surfactants from at least one of the following groups:

> Addition products of 2 to 30 moles of ethylene oxide and / or 0 to 5 moles of propylene oxide with linear fatty alcohols with 8 to 22 C atoms, with fatty acids with 12 to 22 C atoms, with alkylphenols with 8 to 15 C atoms in the Alkyl group and alkylamines with 8 to 22 carbon atoms in the alkyl radical;

> Alkyl and / or alkenyl oligoglycosides with 8 to 22 carbon atoms in the alk (en) yl radical and their ethoxylated analogs;

> Addition products of 1 to 15 mol ethylene oxide onto castor oil and / or hardened castor oil;

> Adducts of 15 to 60 moles of ethylene oxide with castor oil and / or hardened castor oil;

> Partial esters of glycerol and / or sorbitan with unsaturated, linear or saturated, branched fatty acids with 12 to 22 carbon atoms and / or hydroxycarboxylic acids with 3 to 18 carbon atoms and their adducts with 1 to 30 moles of ethylene oxide;

> _. Partial esters of polyglycerol (average degree of self-condensation 2 to 8), polyethylene glycol (molecular weight 400 to 5000), trimethylolpropane, pentaerythritol, sugar alcohols (eg sorbitol), alkyl glucosides (eg methyl glucoside, butyl glucoside, lauryl glucoside) and poly (cellulose glucose) with (eg cellulose glucose) and / or unsaturated, linear or branched ten fatty acids with 12 to 22 carbon atoms and / or hydroxycarboxylic acids with 3 to 18 carbon atoms and their adducts with 1 to 30 moles of ethylene oxide;

> Mixed esters of pentaerythritol, fatty acids, citric acid and fatty alcohol and / or mixed esters of fatty acids with 6 to 22 carbon atoms, methyl glucose and polyols, preferably glycerol or polyglycerol.

> Mono-, di- and trialkyl phosphates and mono-, di- and / or tri-PEG-alkyl phosphates and their salts;

> Wool wax alcohols;

> Polysiloxane-polyalkyl-polyether copolymers or corresponding derivatives;

> Block copolymers e.g. Polyethylene glycol 30 dipolyhydroxystearate;

> Polymer emulsifiers, e.g. Pemulen types (TR-1, TR-2) from Goodrich;

> Polyalkylene glycols as well

> Glycerine carbonate.

> Ethylene oxide investment products

The adducts of ethylene oxide and / or of propylene oxide with fatty alcohols, fatty acids, alkylphenols or with castor oil are known, commercially available products. These are mixtures of homologs whose average degree of alkoxylation is the ratio of the amounts of ethylene oxide and / or propylene oxide and substrate, with which the addition reaction is carried out. Ci2 / i8 fatty acid monoesters and diesters of adducts of ethylene oxide with glycerol are known as refatting agents for cosmetic preparations.

Alkyl and / or alkenyl oligoglycosides

Alkyl and / or alkenyl oligoglycosides, their preparation and their use are known from the prior art. They are produced in particular by reacting glucose or oligosaccharides with primary alcohols with 8 to 18 carbon atoms. With regard to the glycoside residue, both monoglycosides in which a cyclic sugar residue is glycosidically bonded to the fatty alcohol and oligomeric glycosides with a degree of oligomerization of up to preferably about 8 are suitable. The degree of oligomerization is a statistical mean value which is based on a homolog distribution customary for such technical products. ,. > Partial glycerides

Typical examples of suitable partial glycerides are hydroxystearic acid monoglyceride, hydroxystearic acid diglyceride, isostearic acid, Isostearinsäurediglycerid, oleic acid monoglyceride, oleic acid diglyceride, Ricinolsäuremoglycerid, Ricinolsäurediglycerid, linoleic acid monoglyceride, Linolsäurediglycerid, Linolensäuremonoglycerid, Linolensäurediglycerid, Erucasäuremonoglycerid, Erucasäurediglycerid, Weinsäuremonoglycerid, Weinsäurediglyce- chloride, Citronensäuremonoglycerid, Citronendiglycerid, Äpfelsäuremonoglycerid, Malic acid diglyceride and their technical mixtures, which may still contain small amounts of triglyceride from the manufacturing process. Addition products of 1 to 30, preferably 5 to 10, mol of ethylene oxide onto the partial glycerides mentioned are also suitable.

sorbitan

As sorbitan sorbitan, sorbitan sesquiisostearate, sorbitan come diisostearate, sorbitan triisostearate, sorbitan monooleate, sorbitan dioleate, trioleate, Sorbitanmonoerucat, Sorbitansesquierucat, Sorbitandierucat, Sorbitantrieru- cat, Sorbitanmonoricinoleat, Sorbitansesquiricinoleat, Sorbitandiricinoleat, Sorbitantriricinoleat, Sorbitanmonohydroxystearat, Sorbitansesquihydroxystearat, Sorbitandihydroxystearat, sorting bitantrihydroxystearat , Sorbitan monotartrate, sorbitan sesqui-tartrate, sorbitan ditartrate, sorbitan tritartrate, sorbitan monocitrate, sorbitan sesquicitrate, sorbitan dicitrate, sorbitan tricitrate, sorbitan monomaleate, sorbitan sesquimaleate, sorbitan-dicarbeat, and sorbitan dittreatate, as well as sorbitan dehydrate products, are also suitable up to 10 moles of ethylene oxide to the sorbitan esters mentioned.

> Polyglycerol esters

Typical examples of suitable polyglycerol esters are polyglyceryl-2 dipolyhydroxystearates (Dehymuls® PGPH), polyglycerol-3 diisostearates (Lameform® TGI), polyglyceryl-4 isostates (Isolan® Gl 34), polyglyceryl-3 oleates, diisostearoyl polyglyearyl-3 diisostearates (Isolan® PDI), Polyglyceryl-3 Methylglucose Distearate (Tego Care® 450), Poiyglyceryl-3 Beeswax (Cera Bellina®), Polyglyceryl-4 Caprate (Polyglycerol Caprate T2010 / 90), Polyglyceryl-3 Cetyl Ether ( Chimexane® NL), Polyglyceryl-3 Distearate (Cremophor® GS 32) and Polyglyceryl Polyricinoleate (Admul® WOL 1403) Polyglyceryl Dimerate Isostearate and their mixtures. Examples of other suitable polyol esters are those with 1 to 30, if appropriate Moles of ethylene oxide reacted mono-, di- and triesters of trimethylolpropane or pentaerythritol with lauric acid, coconut fatty acid, tallow fatty acid, palmitic acid, stearic acid, oleic acid, behenic acid and the like.

Anionic emulsifiers

Typical anionic emulsifiers are aliphatic fatty acids with 12 to 22 carbon atoms, such as, for example, palmitic acid, stearic acid or behenic acid, and dicarboxylic acids with 12 to 22 carbon atoms, such as, for example, azelaic acid or sebacic acid.

Amphoteric and cationic emulsifiers

Zwitterionic surfactants can also be used as emulsifiers. Zwitterionic surfactants are those surface-active compounds which carry at least one quaternary ammonium group and at least one carboxylate and one sulfonate group in the molecule. Particularly suitable zwitterionic surfactants are the so-called betaines such as the N-alkyl-N, N-dimethylammonium glycinate, for example coconut alkyldimethylammonium glycinate, N-acylaminopropyl-N, N-dimethylammonium glycinate, for example coconut acylaminopropyldimethylammonium glycinate, and 2-alkyl-3 -car- boxylmethyl-3-hydroxyethylimidazolines each having 8 to 18 carbon atoms in the alkyl or acyl group and the cocoacylaminoethylhydroxyethylcarboxymethylglycinate. Particularly loading ^"vorzugt st known under the CTFA name Cocamidopropyl Betaine Fettsäurea- mid derivative. Likewise suitable emulsifiers are ampholytic surfactants. Under rule ampholytic surfactants are surface-active compounds which, in addition to a C / iβ alkyl or acyl group contain at least one free amino group and at least one -COOH or -S0 ₃ H group in the molecule and are capable of forming internal salts Examples of suitable ampholytic surfactants are N-alkylglycines, N-alkylpropionic acids, N-alkylaminobutyric acids, N- Alkyliminodipropionic acids, N-hydroxyethyl-N-alkylamidopropylglycine, N-alkyltaurine, N-alkylsarcosine, 2-alkylaminopropionic acid and alkylaminoacetic acid, each with about 8 to 18 carbon atoms in the alkyl group. Particularly preferred ampholytic surfactants are N-coconut alkylaminopropionate , the cocoacylaminoethylamino propionate and the Ci2 / i8 acyl sarcosine. Finally, cationic surfactants also come as E emulsifiers into consideration, those of the esterquat type, preferably methylquaternized di- ^' fatty acid triethanolamine ester salts, being particularly preferred. Fats and waxes

Typical examples of fats are glycerides, i.e. Solid or liquid vegetable or animal products, which consist essentially of mixed glycerol esters of higher fatty acids, come as waxes, among others. natural waxes, e.g. Candelilla wax, camauba wax, japan wax, esparto grass wax, cork wax, guaruma wax, rice germ oil wax, sugar cane wax, ouricury wax, montan wax, beeswax, shellac wax, walnut, lanolin (wool wax), pretzel fat, ceresin, ozokerite (earth wax), petrolatum, paraffin waxes chemically modified waxes (hard waxes), e.g. Montanester waxes, Sasol waxes, hydrogenated jojoba waxes and synthetic waxes, such as Polyalkylene waxes and polyethylene glycol waxes in question. In addition to fats, fat-like substances such as lecithins and phospholipids can also be used as additives. The skilled worker understands the term lecithins to mean those glycerophospholipids which are formed from fatty acids, glycerol, phosphoric acid and choline by esterification. Lecithins are therefore often used in the professional world as phosphatidylcholines (PC). Examples of natural lecithins are the cephalins, which are also referred to as phosphatidic acids and are derivatives of 1,2-diacyl-sn-glycerol-3-phosphoric acids. In contrast, phospholipids are usually understood to be mono- and preferably diesters of phosphoric acid with glycerol (glycerol phosphates), which are generally classed as fats. In addition, sphingosines or sphingolipids are also suitable.

Consistency agents and thickeners

As consistency agents are primarily fatty alcohols or hydroxy fatty alcohols with 12 to 22 and preferably 16 to 18 carbon atoms and in addition partial glycerides, fatty acids or hydroxy fatty acids. A combination of these substances with alkyl oligoglucosides and / or fatty acid N-methyl glucamides of the same chain length and / or polyglycerol poly-12-hydroxystearates is preferred. Suitable thickeners are, for example, Aerosil types (hydrophilic silicas), polysaccharides, in particular xanthan gum, guar guar, agar agar, alginates and tyloses, carboxymethyl cellulose and hydroxyethyl and hydroxypropyl cellulose, and also higher molecular weight polyethylene glycol mono- and diesters of fatty acids, polyacrylates, (eg Carbopole® and Pemulen types from Goodrich; Synthalene® from Sigma; Keltrol types from Kelco; Sepigel types from Seppic; Salcare types from Allied Colloids), polyacrylamides, polymers, polyvinyl alcohol and polyvinylpyrrolidone, as special Bentonites such as Bentone® Gel VS-5PC (Rheox), which is a mixture of cyclopentasiloxane, disteardimonium hectorite and propylene carbonate, have also proven effective. Surfactants such as ethoxylated fatty acid glycerides, esters of fatty acids with polyols such as for example pentaerythritol or trimethylolpropane, fatty alcohol ethoxylates with a narrow homolog distribution or alkylodogog lucoside as well as electrolytes such as table salt and ammonium chloride.

Überfettunqsmittel

Substances such as lanolin and lecithin and polyethoxylated or acylated lanolin and lecithin derivatives, polyol fatty acid esters, monoglycerides and fatty acid alkanolamides can be used as superfatting agents, the latter simultaneously serving as foam stabilizers.

stabilizers

Metal salts of fatty acids, such as e.g. Magnesium, aluminum and / or zinc stearate or ricinoleate are used.

polymers

Suitable cationic polymers are, for example, cationic cellulose derivatives, e.g. a quaternized hydroxyethyl cellulose available under the name Polymer JR 400® from Amerchol, cationic starch, copolymers of diallylammonium salts and acrylamides, quaternized vinylpyrrolidone / vinylimidazole polymers such as e.g. Luviquat® (BASF), condensation products of polyglycols and amines, quaternized collagen polypeptides, such as, for example, lauryl-dimonium hydroxypropyl hydrolyzed collagen (Lamequat®L / Grünau), quaternized wheat polypeptides, polyethyleneimine, cationic silicone polymers, e.g. Amodimethicones, copolymers of adipic acid and dimethylaminohydroxypropyldiethylenetriamine (Cartaretine® / Sandoz), copolymers of acrylic acid with dimethyldiallylammonium chloride (Merquat® 550 / Chemviron), polyaminopolyamides, and their cross-linked water-soluble polymers, optionally microcrystalline, e.g., condensation products from dihalogen, such as dihalogen products Dibromobutane with bisdialkylamines, e.g. Bis-dimethylamino-1,3-propane, cationic guar gum, e.g. Jaguar® CBS, Jaguar® C-17, Jaguar® C-16 from Celanese, quaternized ammonium salt polymers, e.g. Mirapol® A-15, Mirapol® AD-1, Mirapol® AZ-1 from Miranol.

Anionic, zwitterionic, amphoteric and nonionic polymers include, for example, vinyl acetate / crotonic acid copolymers, vinylpyrrolidone / vinyl acrylate copolymers, vinyllace- tat / butyl maleate / isobornyl acrylate copolymers, methyl vinyl ether / maleic anhydride copolymers and their esters, uncrosslinked and polyol crosslinked polyacrylic acids, acrylamidopropyltrimethylammonium chloride / acrylate copolymers, octylacrylamide / methylmethacrylate lat , Vinyl pyrrolidone / vinyl acetate copolymers, vinyl pyrrolidone / dimethylaminoethyl methacrylate / vinyl caprolactam terpolymers and optionally derivatized cellulose ethers and silicones in question.

silicone compounds

Suitable silicone compounds are, for example, dimethylpolysiloxanes, methylphenylpolysuoxanes, cyclic silicones and amino, fatty acid, alcohol, polyether, epoxy, fluorine, glycoside and / or alkyl-modified silicone compounds, which can be both liquid and resinous at room temperature. Simethicones, which are mixtures of dimethicones with an average chain length of 200 to 300 dimethyisiloxane units and hydrogenated silicates, are also suitable.

Biogenic agents

Examples of biogenic active ingredients include tocopherol, tocopherol acetate, tocopherol palmitate, ascorbic acid, (deoxy) ribonucic acid and its fragmentation products, β-glucans, retinoin, bisabolol, allantoin, phytantriol, panthenol, AHA acids, amino acids, ceramides, pseudoce-ram to understand essential oils, plant extracts and vitamin complexes. film formers

Common film formers are, for example, chitosan, microcrystalline chitosan, quaternized chitosan, polyvinylpyrrolidone, vinylpyrrolidone-vinyl acetate copolymers, polymers of the acrylic acid series, quaternary cellulose derivatives, collagen, hyaluronic acid or its salts and similar compounds.

swelling agent

Montmorillonites, clay minerals, pemulene and alkyl-modified carbopol types (Goodrich) can serve as swelling agents for aqueous phases. Hvdrotrope

Hydrotropes, such as ethanol, isopropyl alcohol, or polyols can also be used to improve the flow behavior. Polyols that come into consideration here preferably have 2 to 15 carbon atoms and at least two hydroxyl groups. The polyols can also contain further functional groups, in particular amino groups, or be modified with nitrogen. Typical examples are

> Glycerin;

> Alkylene glycols, such as, for example, ethylene glycol, diethylene glycol, propylene glycol, butylene glycol, hexylene glycol and polyethylene glycols with an average molecular weight of 100 to 1,000 daltons;

> technical oligoglycerol mixtures with a degree of self-condensation of 1.5 to 10 such as technical diglycerol mixtures with a diglycerol content of 40 to 50% by weight;

> Methyl compounds, such as in particular trimethylolethane, trimethylolpropane, trimethylolbutane, pentaerythritol and dipentaerythritol;

> Lower alkyl glucosides, especially those with 1 to 8 carbons in the alkyl radical, such as methyl and butyl glucoside;

> Sugar alcohols with 5 to 12 carbon atoms, such as sorbitol or mannitol,

> Sugar with 5 to 12 carbon atoms, such as glucose or sucrose;

> Aminosugars such as glucamine;

> Dialcohol amines, such as diethanolamine or 2-amino-1, 3-propanediol.

preservative

Suitable preservatives are, for example, phenoxyethanol, formaldehyde solution, parabens, pentanediol or sorbic acid, as well as the silver complexes known under the name Surfacine® and the other classes of substances listed in Appendix 6, Parts A and B of the Cosmetics Regulation.

Perfume oils and flavors

Perfume oils include mixtures of natural and synthetic fragrances. Natural fragrances are extracts of flowers (lily, lavender, roses, jasmine, neroli, ylang-ylang), stems and leaves (geranium, patchouli, petitgrain), fruits (anise, coriander, caraway, juniper der), fruit peels (bergamot, lemon, oranges), roots (macis, angelica, celery, cardamom, costus, iris, calmus), woods (pine, sandal, guaiac, cedar, rosewood), herbs and grasses ( Tarragon, lemongrass, sage, thyme), needles and twigs (spruce, fir, pine, mountain pine), resins and balsams (galbanum, elemi, benzoin, myrrh, olibanum, opoponax). Animal raw materials, such as civet and castoreum, are also suitable. Typical synthetic fragrance compounds are products of the ester, ether, aldehyde, ketone, alcohol and hydrocarbon type. Fragrance compounds of the ester type are, for example, benzyl acetate, phenoxyethyl isobutyrate, p-tert-butylcyclohexyl acetate, linalyl acetate, dimethylbenzylcarbinylacetate, phenylethyl acetate, unalylbenzoate, benzyl formate, ethyl methylphenylglycinate, allylcyclohexylatexylpropylionylpionylpylpropionate. The ethers include, for example, benzylethyl ether, the aldehydes, for example, the linear alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamenaldehyde, hydroxycitronellal, lilial and bourgeonal, the ketones include, for example, the jonones, α-isomethylionone and methylcedryl ketone the alcohols ethanol, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol and terpineol, the hydrocarbons mainly include the terpenes and balsams. However, preference is given to using mixtures of different fragrances which together produce an appealing fragrance. Essential oils of lower volatility, which are mostly used as aroma components, are also suitable as perfume oils, for example sage oil, chamomile oil, clove oil, lemon balm oil, mint oil, cinnamon leaf oil, linden blossom oil, juniper berry oil, vetiver oil, oliban oil, galbanum oil, labola oil and lavandin oil. Bergamot oil, dihydromyrcenol, lilial, lyral, citronellol, phenylethyl alcohol, α-hexylcinnamaldehyde, geraniol, benzylacetone, cyclamenaldehyde, linalool, boisambrene forte, ambroxan, indole, hedione, sandelice, lemon oil, mandarin oil, lavalyl oil, orangol glycol, orangol glycol, oranganol oil, are preferred , Muscatel sageiol, ß-damascone, geranium oil bourbon, cyclohexyl salicylate, Vertofix Coeur, Iso-E-Super, Fixolide NP, evernyl, iraldein gamma, phenylacetic acid, geranyl acetate, benzyl acetate, rose oxide, romilllate, irotyl and floramate, used alone or in mixtures.

Suitable flavors are, for example, peppermint oil, spearmint oil, anise oil, stemanis oil, caraway oil, eucalyptus oil, fennel oil, lemon oil, wintergreen oil, clove oil, menthol and the like.

dyes

The dyes which can be used are those which are suitable and approved for cosmetic purposes. Examples are Kochillerill A (Cl 16255), Patent Blue V (C.1.42051), Indigotin (C.1.73015), Chlorophyllin (01.75810), Quinoline Yellow (CI47005), Titanium Dioxide (C.1.77891), Indanthrene Blue RS (Cl 69800) and Madder Lacquer ( CI58000). Luminol can also be used as the luminescent dye be included. These dyes are usually used in concentrations of 0.001 to 0.1% by weight. %, based on the mixture as a whole.

Examples

Leaves of the olive tree (Olea europaea) were collected, dried, ground and passed through a 55-60 vol. % Ethanol / water mixture extracted at 60 ° C for 4 hours. The eluate was dried, ground and sieved and adjusted to a content of approximately 20% by weight oleuropein.

An agar diffusion test was carried out to determine the antimicrobial activity on microorganisms of the bacterial flora of the skin and scalp.

agar diffusion test

Test germs:

1. Corynebacterium (C.) minutissimum ATCC 23348 1, 5 x 10 ⁸ CFU / ml

2. Staphylococcus (S.) epidermidis ATCC 12228 2.5 x 10 ⁸ CFU / ml

3. Propionibacterium (P.) acnes ATCC 11829 3.1 x 10 ⁸ CFU / ml

Production of test germ suspensions (aerobic bacteria):

The test germs were subcultured on Columbia blood agar (bioMerieux Art. 43049). Sufficient colonies were homogenized in NaCl peptone buffer using a swab so that the turbidity corresponded to the McFarland Standard 1.0.

Production of test germ suspensions (anaerobic bacteria):

The test germs were subcultured on Schaedler agar (bioMerieux Art. 43273). So many colonies were homogenized in NaCl peptone buffer using swabs that the turbidity corresponded to the McFarland Standard 1.0.

Sample preparation:

A test concentration of 5% by weight of olive tree leaf extract (Herbalia®Olive - Cognis Iberia SL, Poligono San Vicente, 08755 Castellbisbal, Barcelona (Spain)) was obtained by weighing out 0.5 g of dry extract and dissolving to 10 ml with 15% by volume of ethanol ( Merck, Art. 100971).

controls:

K1 test leaves unvaccinated

K2 test papers + 10 resp. 20 ul 15 vol% ethanol incubation Conditions:

3 test plates were created for each batch. The agar plates were

18 h at 36 ° C germ 1, 2

Incubated 72 h at 36 ° C anaerobic germ 3.

Test procedure

The test germs were homogenized 2% with the appropriate test medium (see below). 15 ml of this was poured into petri dishes.

Müller Hinton-Agar Merck, Art. 5437 Germ 1, 2

Wilkens Chalgren Oxoid, Art. CM 643 Germ 3

After solidification and drying of the plates, 5 sterile test plates (6mm diameter, BioMerieux, Art. 54991) were laid out (3 x sample, 2 x control). Two batches were carried out for each sample: batch 1 with 10 μl, batch 2 with 20 μl. After incubation, the inhibition zone diameters [mm] were measured.

Especially with a batch size of 20 μl, the microorganisms from the olive tree leaf extract are significantly inhibited. Staphylococcus epidermidis is subject to inhibition even at very low sample concentrations. The results show that in particular microorganisms that are characteristic of the armpit microflora are effectively inhibited by olive tree leaf extract. Tables 2a and 2b below contain a number of formulation examples with olive tree leaf extract. The dermatological tolerance and the feeling on the skin after use had been found to be particularly good for all formulations.

Table 2a:

Deodorant preparations PIT Deo Spray (water, preservative ad 100 wt .-%)

Products unless otherwise stated by Cognis Deutschland GmbH & Co.KG.

Table 2b:

Deodorant preparations Deodorant cream (water, preservative ad 100 wt .-%)

Products unless otherwise stated by Cognis Deutschland GmbH & Co.KG.

Claims

claims

1. Use of extracts from the olive tree as a deodorant.

2. Use according to claim 1, characterized in that extracts from the leaves of the olive tree and / or from the wastewater of olive oil production are used.

3. Use according to claims 1 and / or 2, characterized in that the extracts are used in concentrations of 0.01 to 15% by weight.

4. Use according to at least one of claims 1 to 3, characterized in that the extracts contain at least 1% by weight of oleuropein.

5. Use according to at least one of claims 1 to 4, characterized in that the extracts contain at least 1% by weight of polyphenols.

6. Use of extracts from the olive tree to inhibit aerobic and / or anaerobic germs and / or to inhibit yeasts and fungi of the microflora on the skin and scalp.

7. Deodorant preparations containing extracts from the leaves of the olive tree and / or from the wastewater from olive oil production and at least one substance selected from the group formed by germ-inhibiting agents, enzyme inhibitors, odor absorbers or odor maskers and antiperspirants.

8. Deodorant preparations containing extracts from the leaves of the olive tree and / or from the wastewater from olive oil production and at least one substance selected from the group consisting of cationic chitosan, salts of aluminum, zirconium or zinc and their complex compounds.