EP1480693A1 - Surveillance de la temperature cerebrale - Google Patents
Surveillance de la temperature cerebraleInfo
- Publication number
- EP1480693A1 EP1480693A1 EP03703603A EP03703603A EP1480693A1 EP 1480693 A1 EP1480693 A1 EP 1480693A1 EP 03703603 A EP03703603 A EP 03703603A EP 03703603 A EP03703603 A EP 03703603A EP 1480693 A1 EP1480693 A1 EP 1480693A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- blood
- catheter
- brain
- infusion
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
- A61F2007/126—Devices for heating or cooling internal body cavities for invasive application, e.g. for introducing into blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/369—Temperature treatment
Definitions
- a method for brain hypothermia comprising, in a first phase to enable an early and fast onset of the hypothermia, the steps of:
- One embodiment comprises a third hypothermia phase for maintained hypothermia or follows the brain-selective hypothermia phase, the third hypothermia phase comprising the steps of: - inserting into a blood vessel an extraction catheter for extraction of blood;
- An embodiment of an equipment for brain hypothermia in a living being comprises:
- a flexible elongated infusion catheter said catheter having a proximal end being attachable to an outlet of said container, said catheter having a sufficiently small diameter to be percutaneously insertable into a blood vessel and its tip forwarded to or into the vicinity of the blood vessel feeding the brain with blood so that the infusion solution will find its way to the brain.
- An equipment for brain hypothermia comprising, to enable an early and fast onset of the hypothermia:
- said venous infusion catheter having a distal end devised to be percutaneously inserted into a peripheral vein;
- cooling device configured for cooling the infusion solution to a second temperature in the range of 0-37 degrees Celsius
- the infusion solution is a hypotonic saline solution
- said first amount of infusion solution is in the range of 1-2 liters or in the range of 10-60 ml/kg;
- the infusion solution has an altered osmolarity, e.g. a low osmolarity, in order to lessen the circulatory volume load of the infusion solution when infused into the patient; - wherein the infusion solution is provided in a container that is air-sealed at steady state at a temperature in the range of 37 degrees Celsius;
- Embodiments may further comprise a device for applying a pressure from the outside of the extremity with the peripheral artery for decreasing peripheral blood circulation. Further embodiments further comprises:
- a temperature sensor configured to be percutaneously inserted in a blood vessel draining blood from the brain; and being configured to: - sensing the temperature in the blood of said blood vessel thus providing an indication of the temperature in the brain;
- a further developed embodiment is followed by a third hypothermia phase for maintained hypothermia, and comprises:
- an extraction catheter being configured to be inserted into a blood vessel for extraction of blood
- an arterial infusion catheter being configured to be inserted into the vicinity of an artery supplying blood to the brain;
- - coupling means for establishing a first extra-corporeal blood circuit for cooled blood between said extraction catheter and said arterial infusion catheter via a pumping means and a temperature regulating device capable of cooling extracted blood; and being configured to: - extracting blood from said blood vessel via said extraction catheter leading a first amount of said extracted blood into said first extra-corporeal blood circuit;
- a venous infusion catheter being configured to be inserted into a vein of the venous system; and further being configured to:
- a temperature sensor would be configured to adjusting the infusion rate of said cooled blood dependent on said sensed temperature for achieving a desired temperature in the brain; or to adjusting the temperature of said cooled blood dependent on said sensed temperature for achieving a desired temperature in the brain.
- An embodiment of an equipment for brain hypothermia comprises, to enable a brain-selective hypothermia:
- a distal end of said arterial infusion catheter being configured to be percutaneously inserted into an artery in or in the vicinity of a branch artery supplying blood to the brain;
- a cooling device configured to cooling the infusion solution to a second temperature lower than said first temperature, to enable the cold infusion solution to cool the blood flowing to the brain while avoiding air bubbles arising in the infusion solution and an efficient temperature regulation of the brain.
- An embodiment of equipment for brain hypothermia comprises, to enable a maintained hypothermia: - an extraction catheter configured to be inserted into a blood vessel for extraction of blood;
- an arterial infusion catheter configured to be inserted in an artery into the vicinity of an artery supplying blood to the brain
- a venous infusion catheter being configured to be inserted into a vein of the venous system
- a cooling device for cooling a second amount of said extracted blood
- a heating device for heating a first amount of said extracted blood
- a basic embodiment of an equipment for brain hypothermia comprises:
- a distal end of said infusion catheter being configured to be percutaneously inserted into a blood vessel that supplies the brain with blood;
- a specifically developed catheter wherein: the catheter being configured to assume a curvature at its distal part; comprises - a first lumen having a plurality of openings positioned close to a distal end of the catheter and at the outer arc of the curvature;
- FIG. la is a block diagram indicating three phases for regulating the brain temperature according to embodiments of the invention.
- FIG. lb is a block diagram indicating the steps of a method according to one embodiment of the invention.
- FIG. 2 is a schematic illustration of an example of a first embodiment of the system according to the invention, here also called the emergency whole body control phase;
- FIG. 3a is a block diagram indicating the steps of a method according to one embodiment of the invention.
- FIG. 3b illustrates schematically an example of how a catheter is arranged in the arteria subclavia dexter, in a second embodiment of the system according to the invention, here also called the brain selective temperature control phase;
- FIG. 4 is a block diagram indicating the steps of a method according to one embodiment of the invention.
- FIG. 5 shows schematically an example of a double lumen catheter applicable in embodiments of the invention
- FIG. 6a illustrates schematically a first example of a the inventive system configured in an embodiment here called the maintained temperature control phase
- FIG. 6b illustrates schematically a second embodiment of the inventive system configured in an embodiment of the maintained temperature control phase
- FIG. 6c illustrates schematically a third embodiment of the inventive system configured in an embodiment of the maintained temperature control phase
- FIG. 7a, 7b and 7c show schematically embodiments of a temperature regulating device
- the invention will be explained by reference to examples of embodiments thereof, primarily relating to cooling the brain in a case of stroke, trauma or neonatal asphyxia, or before, during or after a circulatory arrest in a human patient.
- the control of the temperature is performed in conjunction with another treatment procedure, such as infusion or inhalation of pharmaceuticals, a gas or a gas mixture, respectively that have brain protective properties.
- gases are different anaesthetic gases such as Isofluran or hydrogen gas.
- substances having brain protective properties it is here understood such substances that: - decreases the effects of the occurrence of free radicals, that is a substance scavenging free radicals;
- a simple and quick initial control of the temperature of the brain and the body is achieved by the emergency temperature control phase comprising in more general terms the step of initiating as soon as possible an intravenous infusion of a solution that has a controlled temperature, into a blood vessel of the living being by for example ambulance personnel or other nursing staff.
- a temperature controlled solution to the body of a human being in the amount of about 10-60 ml/kg, e.g. 1 to 3 liters, or even more.
- the solution is for example a saline solution possibly comprising antioxidant or other pharmaceuticals having anti-ischaemic properties or suppressing inflammatory processes.
- inhalation of selected gases can be provided, which gases may have brain-protective properties. Examples of gases or gas mixtures could be different anaesthetic gases such as Isofluran or hydrogen gas.
- the infusion solution is preferably a cold or ice cold solution, e.g., a saline solution possibly comprising an antioxidant.
- FIG. lb cf. Fig. 2 the steps of:
- an infusion catheter into a selected peripheral blood vessel, preferably a vein 206 such as the median cubital vein 206 or saphenous vein, or a central blood vessel 208, 210, 212, 214 such as the jugular vein 210, 214 or the subclavian vein 208, 212; 1102 positioning the tip of the infusion catheter as close to the venous inlet of the heart as possible without getting adverse cardiac effects of the quick infusion of a temperature controlled solution; 1104 controlUng or regulating the temperature, e.g. cooling, of an infusion solution by means of a temperature regulating means, e.g.
- a temperature regulating means e.g.
- a cooling means 1106 infusing the temperature controlled infusion solution, e.g., a cold or ice cold saline solution, preferably having an altered osmolarity, e.g. a low osmolarity, and comprising for example ischemic protective pharmaceuticals into the blood vessel.
- the temperature controlled infusion solution e.g., a cold or ice cold saline solution, preferably having an altered osmolarity, e.g. a low osmolarity, and comprising for example ischemic protective pharmaceuticals into the blood vessel.
- One embodiment may also possibly comprise the step of
- an infusion catheter is introduced, preferably percutaneously, into a selected blood vessel, preferably a vein, of the living being such as the median cubital vein, saphenous vein, cephalic vein or basilic vein.
- a selected blood vessel preferably a vein
- the chosen venous catheter is designed such and of the type that the involved personnel are well acquainted with.
- the inner diameter of the infusion catheter is typically in the range of 1-4 mm, preferably in the range of 2-3 mm, and the length of the infusion catheter is at least about 3 cm.
- the tip positioning according to step 1102 is preferably performed by means of indication means such as markings arranged on the outer surface of the infusion catheter or small diameter- changes of the catheter, whereby the indication means indicates the length of the catheter that has been introduced into the living being.
- the position of the catheter tip can be determined without the use of any imaging techniques.
- the temperature of the infusion solution is regulated or controlled, i.e. the infusion solution is temperature controlled.
- the infusion solution is preferably a cooled hypotonic saline solution, i.e. a saline solution having an osmotic pressure lower than the blood.
- An infusion solution having a low osmolarity is preferably chosen in order to lessen the circulatory volume load of the infusion solution.
- infusion solution having a temperature in the range of 0- 37 degrees Celsius, preferably 0-10 degrees Celsius, more preferably in the range of 0-4 degrees Celsius, can be infused, whereby a lowered body and brain temperature is achieved.
- it is sufficient to infuse an infusion solution having a temperature in the range of 10-37 degrees Celsius since infusion of a infusion solution having a temperature lower than the body temperature will cause a decreased brain temperature.
- the infusion solution is cooled by means of a peltier element, i.e. an apparatus which by means of electricity, produces cooling of a metal part in an electrical circuit which metal part cools the infusion solution.
- a peltier element i.e. an apparatus which by means of electricity, produces cooling of a metal part in an electrical circuit which metal part cools the infusion solution.
- suitable cooling means can also be used.
- a container comprising the infusion solution can be placed in an icebox or in a container comprising ice or ice cubes.
- a cooled infusion solution in steady state with the atmospheric pressure may give rise to gas bubbles or air bubbles of different sizes when supplied to a patient, due to the lower gas solubility at higher temperatures. Such air bubbles may be very harmful to the patient if they are conveyed to the brain.
- Another way of avoiding or decreasing the amount of air bubbles is to provide the infusion solution in a sealed or air-sealed container, for example in a sealed container manufactured of a gas impermeable plastic or a plastic-like material, and sealing performed at steady state at a temperature in the range of 37 degrees Celsius.
- a gas or a gas mixture having brain protective properties is inhaled through for example a facial mask.
- gases are different anaesthetic gases such as NO, Isofluran and hydrogen gas.
- substances having brain protective properties it is here understood such substances that:
- FIG. 2 shows this embodiment of the invention applied in a human patient for cooling the brain.
- a container 201 for example a plastic bag, having a temperature controlled infusion solution 202, is coupled to an infusion catheter 204.
- the infusion solution is cooled in a cooler 203 before use or is maintained in a cooling box 205.
- the infusion catheter is percutaneously introduced into the right median vein 206 and inserted as close to the venous inlet of the heart as possible without getting adverse cardiac effects due to a quick infusion of a cooled infusion solution.
- the treatment would be analogue but of course with a heated infusion solution.
- the brain-selective temperature control phase may be achieved, either as a complement to the emergency whole body temperature control procedure or as separate temperature control procedure.
- the brain-selective temperature control phase comprises the steps of: 1200 possibly introducing by surgical cut-down or percutaneously with e.g. Seldinger technique a guide wire-catheter system into a selected relatively peripheral artery, for example arteria radialis, arteria ulnaris or arteria brachialis to provide a high amount of cooled infusion to the brain;
- an arterial infusion catheter into the selected artery, for example arteria radialis or arteria brachialis by means of a guide- wire; 1204 positioning the tip of the arterial infusion catheter in a selected relatively central or brain close artery, preferably in the right arteria subclavia, truncus brachiocephalica, the ascending aorta, arteria carotis communis or in another selected artery;
- a supplying means such as a pumping means, e.g., a perfusion pump, to the selected site of infusion
- 1212 checking the temperature of the brain or the affected brain hemisphere by means of the temperature sensor sensing the temperature in the blood flow in the respective brain draining blood vessels, e.g. the respective jugular vein, thus being dependent on the brain temperature
- 1214 adjusting the infusion speed or the infusion rate, i.e. the amount of the temperature controlled infusion solution supplied per unit of time, so that a desired and predetermined temperature is achieved in the brain or the affected brain hemisphere, thus preferably dependent on the sensed temperature.
- a guide wire-catheter system is possibly introduced, percutaneously or by surgical cut-down, into a selected blood vessel supplying blood to the brain.
- the catheter is introduced into the right arteria radialis or- the right arteria brachialis, and advanced to the predetermined position, whereby a high concentration of cooled blood can be supplied to the brain.
- a device for infusion of an infusion fluid preferably consisting of a guide wire and a heparinized and hydrophilic arterial infusion catheter is inserted.
- the tip of the arterial infusion catheter is in step 1204 positioned in for example the right arteria subclavia, arteria brachiocephalica or in the ascending aorta.
- An external pressure is possibly applied in step 1206 on the arm used for the arterial infusion catheter.
- the pressure is preferably achieved by means of a pressure means, for example by applying a circumferential tourniquet around the selected arm, the pressure means can further be arranged for cooling the arm or for preventing peripheral circulation of blood.
- the temperature sensor is preferably coupled to an externally arranged display means displaying the measured temperature of the blood in the jugular vein(s) to an operator. It should be understood that measurement of the temperature is preferably performed in the internal jugular vein since this will more accurately reflect the temperature of the brain or brain hemisphere.
- a temperature controlled infusion solution e.g. a cold or icecold saline solution, is infused into the selected artery by means of the arterial infusion catheter and a supplying means, such as a pumping means, e.g. a perfusion pump.
- step 1212 the temperature of the brain or the affected brain hemisphere is controlled by means of the temperature sensor, and in step 1214, the infusion speed of the infusion solution is adjusted to achieve a desired and predetermined temperature in the brain or the affected brain hemisphere.
- the surface of the arterial infusion catheter is preferably coated with an anticoagulant compound to prevent coagulation of blood on the catheter surface and in the surroundings of the arterial infusion catheter.
- the arterial infusion catheter has an externally arranged indication means, such as markings or diameter-changes, in order to indicate the position of the catheter tip in the selected artery, e.g. the right arteria subclavia, truncus brachiocephalicus or ascending aorta.
- the infusion catheter 304 is inserted via the right arteria subclavia 308 into the truncus brachiocepahlica 316.
- a low infusion rate will cause the infusion solution to flow up into the right common carotid 318. If the infusion rate is increased a part of the infusion solution will flow up into the right common carotid 318 and another part will flow into the ascending aorta 314 and up into the left common carotid 320. However, if the velocity of the infusion solution is increased further, the infusion solution will flow down into the coronary arteries, which should be avoided because of possible detrimental effects on the cardiac performance.
- the heat exchanger should be capable of regulating blood to a temperature between 0 and 37 degrees Celsius. In some cases, a small temperature fall of only a few degrees is desirable, for example a cooUng to 34 degrees Celsius. In other cases a larger temperature fall is desirable, such as down to 0-5 degrees Celsius. Within other areas of application, a heating of the blood may be desirable, such as from 37 degrees Celsius to about 40 degrees Celsius. As the brain or selected brain hemisphere is cooled/heated, the general body temperature also falls/rises, and accordingly the temperature of the extracted blood. The heat exchanger is therefore controlled so as to keep the blood returned to the body after cooling/heating at the desired temperature.
- the blood conduit may be attached to a per se known oxygenator or a deoxygenator, before or after the heat exchanger, in order to oxygenate or to deoxygenate the blood.
- One outlet end of the extra-corporeal blood circuit is attached to the proximal end of the arterial infusion catheter reaching into the right arteria subclavia, truncus brachiocephalicus, ascending aorta or arteria carotis communis, from the heat exchanger or in relevant cases from the oxygenator or deoxygenator, which completes the configuration of the temperature controlling system and makes it ready for use.
- priming solution such as a saline solution or blood
- the blood flow through the shunt 938 is stopped, for example by means of an artery forceps, and the circulation of blood can be started and the temperature of the brain can be monitored by means of a temperature sensor 942 arranged in a jugular vein of the patient 920.
- a temperature sensor 942 arranged in a jugular vein of the patient 920.
- the general body temperature also falls, possibly to undesirable levels.
- a part of the reinfusable blood is in step 310 deviated by way of a Y- formed connector into a heating device and a circulation pump and further introduced into the venous system of the patient.
- the outlet end of this part of the extra-corporeal blood circuit is attached to the proximal end of the venous infusion catheter.
- step 1312 venous or arterial blood is circulated extra-corporeally from the patient through the heat exchanger regulating the temperature of the blood and back to the patient.
- circulation of blood through the extra-corporeal circuit is started, involving the extraction of blood from the vein or artery, cooling or heating it to the desired temperature in the heat exchanger(-s), for example to a temperature between 0 and 37 degrees Celsius, optionally regulating oxygenation by means of an oxygenator, and finally reintroducing it into the patient via the arterial infusion catheter.
- the temperature controlled blood flows from there into the brain or the affected brain hemisphere, which temperature is controlled swiftly and efficiently.
- step 1314 the temperature controlled blood is reintroduced into the patient through the arterial infusion catheter arranged in an artery leading blood to the brain, whereby the reintroduced blood regulates the oxygenation and temperature of the brain or the selected brain hemisphere.
- heated blood having a temperature in the range of 37-40 degrees Celsius, is optionally reintroduced into the patient through the venous infusion catheter, whereby undesired general cooling effects on the rest of the body are diminished.
- step 1318 the temperature regulated extra-corporeal circulation is maintained at the desired temperature levels of the brain or the affected brain hemisphere for a desired period of time thereafter.
- the infusion catheter described above can be positioned in the internal jugular vein on one side of the neck.
- the infusion catheter is preferably positioned with its tip directed cranially. This can be accomplished by means of puncturing the internal jugular vein with a needle. A guide wire can then be introduced through the needle and into the vein in the cranial direction and an introducer, e.g. an introducer of approximately 9 French, is placed into the vein.
- the infusion catheter is a triple lumen balloon catheter 1000, cf. Fig 9, is placed through the introducer and placed with the balloon 1002 at the level of the angle of the mandible.
- the triple lumen balloon catheter 1000 can for example be an 8 French catheter having a length of approximately 25 centimeters.
- the three lumens are intended for introduction of a pressure recording means, for infusion of a brain-protective fluid and for inflation/deflation of the balloon.
- the first lumen 1004 ends approximately 1.5 cm proximally of the catheter tip.
- Cold cristalloid solution is infused through a second lumen 1006 of the catheter 1000 with its balloon 1002 inflated, which balloon 1002 is inflated and deflated by means of a third lumen 1008.
- the infusion rate is regulated in order not to have the vein pressure to exceed about 25 mniHg.
- the infusion of cristalloid solution is subsequently followed by the infusion of blood extracted from the remaining jugular veins or the femoral veins or arteries.
- the blood has passed through a cooler, possibly a pump and possibly an oxygenator/deoxygenator passed to the catheter in the jugular vein.
- a double lumen catheter e.g. an approximately 16 French double lumen catheter
- a first lumen ends approximately 25 mm from the tip of the catheter.
- a thermistor at the opening of the first lumen is recording the temperature of the blood in the distal part of the inferior vena cava.
- Blood is then aspirated from the first lumen with a pump, passed through a heater and infused through the tip of the infusion catheter via a second lumen of the infusion catheter. Temperature is in this way automatically regulated in the inferior vena cava to stay between approximately 37 and 36 degrees Celsius.
- blood can also extracted from a femoral artery and the blood flow from the femoral artery can be controlled by a flow controller (not shown) arranged at the catheter in the internal vena jugularis causing the blood to flow due to the pressure difference in the artery and the vein, respectively.
- a flow controller not shown
- the pump is not necessary.
- a double lumen catheter can be introduced into the superior vena cava via the other internal vena jugularis .
- the temperature regulating device 700 is used for both cooling and heating a fluid.
- the temperature regulating device 700 is designed as a double heat exchanger comprising a peltier element 702 and two conduits 704,704' confining passages 706,706' having inlets 710,710' and outlets 712,712'.
- fluid passing though the passages 706,706' is cooled and heated, respectively.
- the temperature regulating device 700 is provided with a power supply 716 supplying power to the peltier element and a control unit 718 controlling the temperature regulation.
- the conduit 704 or the conduits 704,704' is/are provided with a plastic or plastic-like housing or cover 708 or covers 708, 708', by means of which the conduit 704 or conduits 704,704' is/are arranged to be attachable and detachable at the peltier element 702.
- the conduit 704,704' and the cover 708,708' is preferably manufactured as a disposable or disposables, preferably as a sterile disposable or disposables provided with for example an anticoagulant agent on the inner surface of the conduit 704,704'.
- the temperature regulating device 700 is manufactured as a disposable and preferably as a disposable having sterile inner surfaces of the conduit 704,704' not to contaminate the fluid to be temperature regulated and inner surfaces provided with an anticoagulant agent.
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Thermal Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
Abstract
Cette invention, qui a trait à une technique, ainsi qu'à l'équipement correspondant, de surveillance de la température cérébrale ou de la température d'un hémisphère cérébral, concerne, plus particulièrement, une technique et l'équipement correspondant, permettant de surveiller, rapidement et efficacement, la température cérébrale ainsi que de conserver au cerveau une température basse. Cette technique se subdivise en trois étapes. Il s'agit, dans un premier temps, d'une surveillance d'urgence de la température de l'ensemble du corps, permettant une surveillance, notamment sur les lieux d'un accident. La deuxième étape de surveillance sélective de la température cérébrale permet de contrôler celle-ci plus efficacement, notamment en salle d'urgence, et la troisième étape de surveillance du maintien en l'état de la température, permet un contrôle encore plus efficace de la température durant une période prédéterminée.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72857 | 1998-05-05 | ||
US10/072,857 US20020161349A1 (en) | 2000-06-05 | 2002-02-05 | Cerebral temperature control |
PCT/SE2003/000187 WO2003066137A1 (fr) | 2002-02-05 | 2003-02-05 | Surveillance de la temperature cerebrale |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1480693A1 true EP1480693A1 (fr) | 2004-12-01 |
Family
ID=27732324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03703603A Withdrawn EP1480693A1 (fr) | 2002-02-05 | 2003-02-05 | Surveillance de la temperature cerebrale |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1480693A1 (fr) |
AU (1) | AU2003206313A1 (fr) |
CA (1) | CA2476382A1 (fr) |
WO (1) | WO2003066137A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8721699B2 (en) | 2005-05-13 | 2014-05-13 | Benechill, Inc. | Methods and devices for non-invasive cerebral and systemic cooling |
US9358150B2 (en) | 2005-05-13 | 2016-06-07 | Benechill, Inc. | Methods and devices for non-invasive cerebral and systemic cooling alternating liquid mist/gas for induction and gas for maintenance |
US7824436B2 (en) | 2005-05-13 | 2010-11-02 | Benechill, Inc. | Methods and devices for non-invasive cerebral and systemic cooling |
WO2008118864A2 (fr) * | 2007-03-23 | 2008-10-02 | Thermal Therapeutic Systems, Inc. | Dispositif d'hyperthermie portable |
US8608696B1 (en) | 2009-02-24 | 2013-12-17 | North Carolina State University | Rapid fluid cooling devices and methods for cooling fluids |
CN102802717A (zh) | 2009-06-19 | 2012-11-28 | 贝尼奇尔股份有限公司 | 用于使鼻腔降温的设备 |
CN111419528A (zh) * | 2020-04-20 | 2020-07-17 | 首都医科大学宣武医院 | 低温治疗导管和低温治疗系统 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5308320A (en) * | 1990-12-28 | 1994-05-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Portable and modular cardiopulmonary bypass apparatus and associated aortic balloon catheter and associated method |
US6110139A (en) * | 1997-10-21 | 2000-08-29 | Loubser; Paul Gerhard | Retrograde perfusion monitoring and control system |
US6042559A (en) * | 1998-02-24 | 2000-03-28 | Innercool Therapies, Inc. | Insulated catheter for selective organ perfusion |
US6383172B1 (en) * | 1999-04-02 | 2002-05-07 | Coaxia, Inc. | Retrograde venous perfusion with isolation of cerebral circulation |
SE0002100D0 (sv) * | 2000-06-05 | 2000-06-05 | Jostra Ab | Cerebral temperering |
-
2003
- 2003-02-05 CA CA002476382A patent/CA2476382A1/fr not_active Abandoned
- 2003-02-05 AU AU2003206313A patent/AU2003206313A1/en not_active Abandoned
- 2003-02-05 WO PCT/SE2003/000187 patent/WO2003066137A1/fr not_active Application Discontinuation
- 2003-02-05 EP EP03703603A patent/EP1480693A1/fr not_active Withdrawn
Non-Patent Citations (1)
Title |
---|
See references of WO03066137A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2003066137A1 (fr) | 2003-08-14 |
CA2476382A1 (fr) | 2003-08-14 |
AU2003206313A1 (en) | 2003-09-02 |
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