EP1443951A4 - Interactions moleculaires dans les cellules - Google Patents

Interactions moleculaires dans les cellules

Info

Publication number
EP1443951A4
EP1443951A4 EP02756934A EP02756934A EP1443951A4 EP 1443951 A4 EP1443951 A4 EP 1443951A4 EP 02756934 A EP02756934 A EP 02756934A EP 02756934 A EP02756934 A EP 02756934A EP 1443951 A4 EP1443951 A4 EP 1443951A4
Authority
EP
European Patent Office
Prior art keywords
cells
molecular interactions
interactions
molecular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02756934A
Other languages
German (de)
English (en)
Other versions
EP1443951A2 (fr
Inventor
Peter S Lu
Joshua D Rabinowitz
Johannes Schweizer
Deanna Marie Carrick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arbor Vita Corp
Original Assignee
Arbor Vita Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arbor Vita Corp filed Critical Arbor Vita Corp
Publication of EP1443951A2 publication Critical patent/EP1443951A2/fr
Publication of EP1443951A4 publication Critical patent/EP1443951A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP02756934A 2001-08-03 2002-08-02 Interactions moleculaires dans les cellules Withdrawn EP1443951A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30984101P 2001-08-03 2001-08-03
US309841P 2001-08-03
US36006102P 2002-02-25 2002-02-25
US360061P 2002-02-25
PCT/US2002/024655 WO2003014303A2 (fr) 2001-08-03 2002-08-02 Interactions moleculaires dans les cellules

Publications (2)

Publication Number Publication Date
EP1443951A2 EP1443951A2 (fr) 2004-08-11
EP1443951A4 true EP1443951A4 (fr) 2006-05-03

Family

ID=26977039

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02756934A Withdrawn EP1443951A4 (fr) 2001-08-03 2002-08-02 Interactions moleculaires dans les cellules

Country Status (4)

Country Link
EP (1) EP1443951A4 (fr)
AU (1) AU2002321903A1 (fr)
CA (1) CA2457424A1 (fr)
WO (1) WO2003014303A2 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6942981B1 (en) 1999-05-14 2005-09-13 Arbor Vita Corporation Method of determining interactions with PDZ-domain polypeptides
EP1531842A4 (fr) 2000-12-22 2007-03-07 Dana Farber Cancer Inst Inc Regulation de la proliferation cellulaire par muc1
AU2003291558B2 (en) * 2001-08-03 2009-08-13 Arbor Vita Corporation Molecular interactions in neurons
EP1578365A4 (fr) * 2002-11-14 2009-09-23 Arbor Vita Corp Interactions moleculaires dans des neurones
DE10254601A1 (de) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
WO2004076646A2 (fr) * 2003-02-27 2004-09-10 Arbor Vita Corporation Methodes et compositions destinees a traiter le cancer du col uterin
WO2004096199A2 (fr) * 2003-05-02 2004-11-11 Scottish Biomedical Limited Regulation du facteur d'echange du nucleotide guanine pour une proteine appartenant a la famille rap des petites gtpases
WO2004108142A2 (fr) * 2003-06-06 2004-12-16 The University Of Manchester Traitement d'etats lies au vieillissement
EP1995256A1 (fr) 2003-07-30 2008-11-26 University of Pittsburgh of the Commonwealth System of Higher Education Agonistes d'épitope de cellule T EPHA2 T et utilisations correspondantes
WO2005042573A1 (fr) 2003-10-24 2005-05-12 Dana-Farber Cancer Institute, Inc. Modulation de l'interaction de muc1 avec des ligands de muc1
EP1709084A4 (fr) 2003-12-23 2008-05-28 Nono Inc Polypeptides pour la modulation de la liaison des proteines du canal de recepteur de potentiel transitoire et proteines associees au recepteur de potentiel transitoire
ATE554106T1 (de) 2003-12-23 2012-05-15 Arbor Vita Corp Antikörper für onkogene stämme von hpv und verfahren zu deren verwendung
DE102004024617A1 (de) 2004-05-18 2005-12-29 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
EP1814575A4 (fr) * 2004-11-24 2010-07-07 Neopro Labs Llc Methodes et compositions pour traiter des troubles
US9408381B2 (en) 2004-12-21 2016-08-09 Musc Foundation For Research Development Alpha Connexin c-Terminal (ACT) peptides for use in transplant
BRPI0519737A2 (pt) 2004-12-21 2009-01-27 Musc Found For Res Dev composiÇÕes e mÉtodos para promover a cura de feridas e a regeneraÇço de tecidos
DE102005022182A1 (de) * 2005-05-09 2006-11-16 Combinature Biopharm Ag Modulatoren der PDZ-Domäne
US20070014803A1 (en) * 2005-07-01 2007-01-18 Arbor Vita Corporation Methods and compositions for diagnosis and treatment of viral and bacterial infections
EP1790664A1 (fr) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Anticorps monoclonaux contre claudin-18 pour le traitement du cancer
US8633160B2 (en) 2005-12-30 2014-01-21 Nono Inc. Small molecule inhibitors of PDZ interactions
WO2008097840A2 (fr) 2007-02-02 2008-08-14 Dana-Farber Cancer Institute, Inc. Méthodes et compositions associées à la régulation de muc1 par hsf1 et stat3
US7871784B2 (en) 2007-02-02 2011-01-18 Dana-Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of apoptosis by MUC1 and BH3-containing proapoptotic proteins
DK2320927T3 (en) 2008-07-09 2015-09-14 Univ Copenhagen Modified peptides as potent inhibitors of the PSD-95 / NMDA receptor interaction
SG11201405359YA (en) 2012-03-01 2014-09-26 Firststring Res Inc Topical gels containing alpha connexin c-terminal (act) peptides
WO2013167153A1 (fr) 2012-05-09 2013-11-14 Ganymed Pharmaceuticals Ag Anticorps utiles dans le diagnostic du cancer
US20160166637A1 (en) * 2013-08-02 2016-06-16 Virginia Tech Intellectual Properties, Inc. Methods of treating a cancer through targeted disruption of alpha connexin 43-zonula occludens-1 (zo-1) interaction
EP3074030A4 (fr) * 2013-11-26 2017-08-16 Trustees of Dartmouth College Procédé permettant d'atténuer ou de soulager des déficits synaptiques et cognitifs
CA2958879A1 (fr) 2014-08-22 2016-02-25 Auckland Uniservices Limited Modulateurs de canaux
BR112020000115A2 (pt) * 2017-07-05 2020-07-07 Biocells (Beijing) Biotech Co., Ltd. sais farmaceuticamente aceitáveis de polipeptídeos e uso dos mesmos

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976819A (en) * 1995-11-21 1999-11-02 National Jewish Medical And Research Center Product and process to regulate actin polymerization in T lymphocytes
US6911526B2 (en) * 1996-07-22 2005-06-28 The Trustees Of Columbia University In The City Of New York Compounds that inhibit the interaction between signal-transducing proteins and the GLGF (PDZ/DHR) domain and uses thereof
EP1131351A2 (fr) * 1998-11-20 2001-09-12 Mount Sinai Hospital Peptides modulant l'interaction des ephrines de classe b avec les domaines pdz
EP1178817A2 (fr) * 1999-05-14 2002-02-13 Arbor Vita Corporation Interactions moleculaires dans les cellules hematopoietiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
WO2003014303A3 (fr) 2003-08-14
CA2457424A1 (fr) 2003-02-20
EP1443951A2 (fr) 2004-08-11
WO2003014303A2 (fr) 2003-02-20
AU2002321903A1 (en) 2003-02-24

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20040223

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

A4 Supplementary search report drawn up and despatched

Effective date: 20060320

17Q First examination report despatched

Effective date: 20090327

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: ARBOR VITA CORPORATION

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20120216