EP1435958A1 - Use of phosphorodiesterase iv inhibitors - Google Patents
Use of phosphorodiesterase iv inhibitorsInfo
- Publication number
- EP1435958A1 EP1435958A1 EP02777150A EP02777150A EP1435958A1 EP 1435958 A1 EP1435958 A1 EP 1435958A1 EP 02777150 A EP02777150 A EP 02777150A EP 02777150 A EP02777150 A EP 02777150A EP 1435958 A1 EP1435958 A1 EP 1435958A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- ethyl
- dihydro
- benzyl
- methoxyphenyl
- dimethoxyphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Definitions
- the invention relates to the use of compounds of the formula I, disclosed in EP 0 738 715 A2,
- R 1 and R 2 each independently of one another H or A
- R 3 and R 4 each independently of one another -OH, -OR 10 , -SR 10 ,
- R 5 is an unsubstituted or mono- or disubstituted by R 6 and / or R 7 substituted phenyl radical
- Q is absent or alkylene with 1-6 C atoms
- R 6 and R 7 each independently of one another -NH 2 , -NR 8 R 9 , -NHR 10 ,
- R 8 and R 9 each independently of one another H, acyl with 1-8 C atoms, which is replaced by 1-5 F and / or Cl atoms can be substituted, -COOA, -SO-A, -S0 2 A, -CONH 2l -CONHA, -CONA 2 , -CO-COOH, -CO-COOA, -CO-CONH 2 , - CO-CONHA or -CO-CONA 2 , A alkyl with 1 to 6 carbon atoms, which by 1-5 F and / or
- Cl atoms can be substituted, R 10 and R 11 each independently of one another A, cycloalkyl with 3-7 C atoms, methylene cycloalkyl with 4-8 C atoms or alkenyl with 2-8 C atoms and Hal F, Cl, Br or I mean
- R 1 and R 2 are each independently H or A
- R 3 and R 4 each independently of one another -OH, -OR 10 , -SR 10 ,
- R 5 is an unsubstituted or mono- or disubstituted phenyl radical R 6 and / or R 7 , Q is absent or alkylene with 1 -6 C atoms,
- R 6 and R 7 each independently of one another -NH 2) -NR 8 R 9 , -NHR 10 , -NR 10 R 11 , -N0 2 , shark, -CN, -OA, -COOH or -COOA, R 8 and R 9 each independently of one another H, acyl with 1 -8 C-
- Atoms which can be substituted by 1-5 F and / or Cl atoms, -COOA, -SO-A, -S0 2 A, -CONH 2) -CONHA, -CONA 2 , -CO-COOH, -CO -COOA, -CO-CONH 2l -CO-CONHA or -CO-CONA 2 ,
- a alkyl with 1 to 6 carbon atoms which is represented by 1 -5 F and / or
- Cl atoms can be substituted, R 10 and R 1 each independently of one another A, cycloalkyl with 3-7 C atoms, methylene cycloalkyl with 4-8 C atoms or alkenyl with 2-8 C atoms and
- B is an aromatic heterocycle with 1 to 4 N, O and / or S atoms, bonded via N or C, which may be unsubstituted or substituted once, twice or three times by shark, A and / or OA, and can also be fused to a benzene or pyridine ring,
- Q is absent or alkylene with 1 -6 C atoms
- R 1 and R 2 are each independently H or A
- R 3 and R 4 each independently of one another -OH, OR 5 , -SR 5 , -SO-R 5 , -S0 2 -R 5 , shark, methylenedioxy, -N0 2l -NH 2 , -NHR 5 or -NR 5 R 6 ,
- R 5 and R 6 each independently of one another A, cycloalkyl with 3-7 C atoms, methylene cycloalkyl with 4-8 C atoms or alkenyl with 2-8 C atoms,
- a alkyl having 1 to 10 carbon atoms, which can be substituted by 1 to 5 F and / or Cl atoms and Hal F, Cl, Broder I mean
- R 1 and R 2 each independently of one another H or A, R 3 H, OA or O-C m H 2m + 1-n X n ,
- A is alkyl with 1-6 C atoms, m is 1, 2, 3, 4, 5 or 6 and n is 1,2,3,4,5,6,7,8,9, 10, 11, 12 or 13 .
- R 1 and R 2 are each independently H or A, R 3 and R 4 each independently of one another OH, OA, SA, SOA, S0 2 A, shark, methylenedioxy, cycloalkyloxy with 3-7 C atoms or 0-C m H 2m + 1-k F k ,
- R 6 and R 7 each independently of one another H or A, Q alkylene with 1 -6 C atoms,
- R 1 and R 2 are each independently H or A
- R 3 and R 4 each independently of one another -OH, OA, -SA,
- Atoms that are substituted by 1 to 5 F and / or Cl atoms can be tuiert, cycloalkyl with 3-7 C-atoms or methylene cycloalkyl with 4-8 C-atoms,
- Q is absent or alkylene with 1 -4 C atoms
- Y is absent or alkylene with 1 -10 C atoms
- NHA NHA
- NAA an unsubstituted or simply substituted by A or OH saturated 3-8-membered heterocycle with at least one N atom, in which further CH 2 groups have been replaced by NH, NA, S or O.
- the object of the invention was to find new uses of the compounds of the formulas I, in particular those which can lead to the production of medicaments.
- the compounds according to the invention can be used for the treatment of asthmatic diseases.
- the anti-asthmatic effect of the PDE IV inhibitors is e.g. by T.J. Torphy et al. in Thorax, 46, 512-523 (1991) and can e.g. B. by the method of T. Olson, Acta allergologica 26, 438-447 (1971) can be determined.
- the compounds also show an inhibitory effect on the formation of TNF (tumor necrosis factor) and are therefore suitable for the treatment of allergic and inflammatory diseases, autoimmune diseases and graft rejection reactions.
- TNF tumor necrosis factor
- PDE IV inhibitors in the treatment of asthma, inflammatory diseases, diabetes mellitus, atopic dermatitis, psoriasis, AIDS, tumor growth or tumor metastases is e.g. described in EP 779 291.
- the anti-inflammatory effect of the substances according to the invention and their effectiveness for the treatment of, for example, autoimmune diseases, Multiple sclerosis or rheumatoid arthritis can be analogous to the methods of N. Sommer et al., Nature Medicine, 1, 244-248 (1995) or L. Sekut et al., Clin. Exp. Immunol., 100, 126-132 (1995).
- the invention furthermore relates to the use of the compounds of the formulas I and their physiologically acceptable salts and / or solvates for the production of a medicament for inhibiting the growth of neoplastic cells.
- Neoplastic cells are understood to mean cancer cells.
- the invention relates in particular to the use of the compounds of the formulas I and their physiologically acceptable salts and / or solvates for the production of a medicament for the treatment and / or prophylaxis of cancer.
- the invention furthermore relates to the use of the compounds of the formulas I and their physiologically acceptable salts and / or solvates for the production of a medicament for the treatment of neoplastic damage.
- the invention furthermore relates to the use of the compounds of the formulas I and their physiologically acceptable salts and / or solvates for the production of a medicament for the treatment of precancerogenic damage.
- Precancerogenic damage means, for example, benign growths in the intestine that can lead to colon cancer.
- Precancerogenic damage includes in particular those in US
- Irregularities in apoptosis play a role in the formation of precancerogenic damage. Regulation of apoptosis is also known to play an important role in diseases associated with abnormal cell growth, such as e.g. benign prostatic hyperplasia, neurodegenerative diseases, e.g. Parkinson's, autoimmune diseases including multiple sclerosis and rheumatoid arthritis or infectious diseases such as AIDS.
- diseases associated with abnormal cell growth such as e.g. benign prostatic hyperplasia, neurodegenerative diseases, e.g. Parkinson's, autoimmune diseases including multiple sclerosis and rheumatoid arthritis or infectious diseases such as AIDS.
- the compounds of the formula I modulate apoptosis and are used in the treatment or prophylaxis of cancer.
- the invention thus relates to the use of the compounds of the formulas I and their physiologically acceptable salts and / or solvates for the production of a medicament for regulating apoptosis in human cells.
- the compounds of the formulas I can be used as active pharmaceutical ingredients in human and veterinary medicine. They can also be used as intermediates for the production of further active pharmaceutical ingredients.
- the compounds of the formulas I can have a chiral center and can therefore occur in several stereoisomeric forms. All of these forms (e.g. R and S forms) and their mixtures (e.g. the R, S-
- parenteral or topical application and do not react with the new compounds, e.g. water, vegetable oils, benzyl alcohols, alkylene glycols, polyethylene glycols, glycerol triacetate, gelatin, carbohydrates such as lactose or starch, magnesium stearate, talc, petroleum jelly.
- Tablets, pills, dragees, capsules, powders, granules, syrups, juices or drops are used in particular for oral use, suppositories for rectal use, solutions, preferably oily or aqueous solutions, furthermore suspensions, emulsions or implants for which topical application ointments, creams or powder.
- the new compounds can also be lyophilized and the resulting lyophilisates e.g. can be used for the production of injectables.
- the specified preparations can be sterilized and / or contain auxiliaries such as lubricants, preservatives, stabilizers and / or wetting agents, emulsifiers, salts for influencing the osmotic pressure, buffer substances, coloring, flavoring and / or one or more further active ingredients, eg one or more vitamins.
- the compounds of the formulas I and their physiologically acceptable salts can be used in combating diseases in which an increase in the cAMP (cyclo-adenosine monophosphate) level leads to inhibition or prevention of inflammation and muscle relaxation.
- cAMP cyclo-adenosine monophosphate
- Particular use can be made of the invention
- the substances according to the invention are generally preferably used in doses between about 1 and 500 mg, in particular between see 5 and 100 mg administered per dosage unit.
- the daily dosage is preferably between about 0.02 and 10 mg / kg body weight.
- the specific dose for each patient depends on a wide variety of factors, for example on the effectiveness of the particular compound used, on the age, body weight, general health, sex, on the diet, on the time and route of administration, on the rate of excretion and on the combination of drugs and severity of the respective disease to which the therapy applies. Oral application is preferred.
- Compounds of the formula I can contain one or more centers of asymmetry. In this case, they are usually in racemic form. Racemates obtained can be separated into their enantiomers mechanically or chemically by methods known per se. Diastereomers are preferably formed from the racemic mixture by reaction with an optically active release agent.
- the invention relates in particular to the use of a) compounds, disclosed in EP 0 738 715 A2, selected from the
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- Diabetes (AREA)
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Abstract
The invention relates to the use of Phosphodiesterase IV inhibitors and/or the physiologically acceptable salts thereof in the production of a medicament for the treatment of osteoporosis, tumors, tumor metastases, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, ulzerative colitis and AIDS.
Description
Verwendung von Phosphodiesterase IV - Inhibitoren Use of phosphodiesterase IV inhibitors
rfindung betrifft die Verwendung von Verbindungen der Formel I, offenbart in EP 0 738 715 A2,The invention relates to the use of compounds of the formula I, disclosed in EP 0 738 715 A2,
worin wherein
R1 und R2 jeweils unabhängig voneinander H oder A, R3 und R4 jeweils unabhängig voneinander -OH, -OR10, -S-R10,R 1 and R 2 each independently of one another H or A, R 3 and R 4 each independently of one another -OH, -OR 10 , -SR 10 ,
-SO-R 0, -S02-R1°, Hai, Methylendioxy, -N02l -NH2,-SO-R 0 , -S0 2 -R 1 °, shark, methylenedioxy, -N0 2l -NH 2 ,
-NHR10 oder -NR10R11, R5 einen unsubstituierten oder ein- oder zweifach durch R6 und/oder R7 substituierten Phenylrest, Q fehlt oder Alkylen mit 1-6 C-Atomen,-NHR 10 or -NR 10 R 11 , R 5 is an unsubstituted or mono- or disubstituted by R 6 and / or R 7 substituted phenyl radical, Q is absent or alkylene with 1-6 C atoms,
R6 und R7 jeweils unabhängig voneinander -NH2, -NR8R9, -NHR10,R 6 and R 7 each independently of one another -NH 2 , -NR 8 R 9 , -NHR 10 ,
-NR10R11, -N02, Hai, -CN, -OA, -COOH oder -COOA, R8 und R9 jeweils unabhängig voneinander H, Acyl mit 1-8 C- Atomen, das durch 1-5 F- und/oder Cl-Atome substituiert sein kann, -COOA, -SO-A, -S02A, -CONH2l -CONHA, -CONA2, -CO-COOH, -CO-COOA, -CO-CONH2, -CO-CONHA oder -CO-CONA2, A Alkyl mit 1 bis 6 C-Atomen, das durch 1-5 F- und/oder-NR 10 R 11 , -N0 2 , shark, -CN, -OA, -COOH or -COOA, R 8 and R 9 each independently of one another H, acyl with 1-8 C atoms, which is replaced by 1-5 F and / or Cl atoms can be substituted, -COOA, -SO-A, -S0 2 A, -CONH 2l -CONHA, -CONA 2 , -CO-COOH, -CO-COOA, -CO-CONH 2 , - CO-CONHA or -CO-CONA 2 , A alkyl with 1 to 6 carbon atoms, which by 1-5 F and / or
Cl-Atome substituiert sein kann, R10 und R11 jeweils unabhängig voneinander A, Cycloalkyl mit 3-7 C- Atomen, Methylencycloalkyl mit 4-8 C-Atomen oder Alkenyl mit 2-8 C-Atomen und
Hal F, Cl, Br oder I bedeuten,Cl atoms can be substituted, R 10 and R 11 each independently of one another A, cycloalkyl with 3-7 C atoms, methylene cycloalkyl with 4-8 C atoms or alkenyl with 2-8 C atoms and Hal F, Cl, Br or I mean
Verbindungen der Formel I, offenbart in EP 0 723 962 B1 ,Compounds of the formula I, disclosed in EP 0 723 962 B1,
worin R1 und R2 jeweils unabhängig voneinander H oder A,wherein R 1 and R 2 are each independently H or A,
R3 und R4 jeweils unabhängig voneinander -OH, -OR10, -S-R10,R 3 and R 4 each independently of one another -OH, -OR 10 , -SR 10 ,
-SO-R10, -S02-R10, Hai, Methylendioxy, -N02, -NH2,-SO-R 10 , -S0 2 -R 10 , shark, methylenedioxy, -N0 2 , -NH 2 ,
-NHR10 oder -NR10R11,-NHR 10 or -NR 10 R 11 ,
R5 einen unsubstituierten oder ein- oder zweifach durch R6 und/oder R7 substituierten Phenylrest, Q fehlt oder Alkylen mit 1 -6 C-Atomen,R 5 is an unsubstituted or mono- or disubstituted phenyl radical R 6 and / or R 7 , Q is absent or alkylene with 1 -6 C atoms,
R6 und R7 jeweils unabhängig voneinander -NH2) -NR8R9, -NHR10, -NR10R11, -N02, Hai, -CN, -OA, -COOH oder -COOA, R8 und R9 jeweils unabhängig voneinander H, Acyl mit 1 -8 C-R 6 and R 7 each independently of one another -NH 2) -NR 8 R 9 , -NHR 10 , -NR 10 R 11 , -N0 2 , shark, -CN, -OA, -COOH or -COOA, R 8 and R 9 each independently of one another H, acyl with 1 -8 C-
Atomen, das durch 1-5 F- und/oder Cl-Atome substituiert sein kann, -COOA, -SO-A, -S02A, -CONH2) -CONHA, -CONA2, -CO-COOH, -CO-COOA, -CO-CONH2l -CO-CONHA oder -CO-CONA2,Atoms, which can be substituted by 1-5 F and / or Cl atoms, -COOA, -SO-A, -S0 2 A, -CONH 2) -CONHA, -CONA 2 , -CO-COOH, -CO -COOA, -CO-CONH 2l -CO-CONHA or -CO-CONA 2 ,
A Alkyl mit 1 bis 6 C-Atomen, das durch 1 -5 F- und/oderA alkyl with 1 to 6 carbon atoms, which is represented by 1 -5 F and / or
Cl-Atome substituiert sein kann, R10 und R1 jeweils unabhängig voneinander A, Cycloalkyl mit 3-7 C- Atomen, Methylencycloalkyl mit 4-8 C-Atomen oder Alkenyl mit 2-8 C-Atomen
undCl atoms can be substituted, R 10 and R 1 each independently of one another A, cycloalkyl with 3-7 C atoms, methylene cycloalkyl with 4-8 C atoms or alkenyl with 2-8 C atoms and
Hai F, Cl, Br oder I bedeuten,Shark F, Cl, Br or I mean
Verbindungen der Formel I, offenbart in EP 0 763 534 A1 ,Compounds of formula I, disclosed in EP 0 763 534 A1,
worin wherein
B einen aromatischen Heterocyclus mit 1 bis 4 N-, O- und/oder S-Atomen, über N oder C gebunden, der un- substituiert oder ein-, zwei- oder dreifach durch Hai, A und/oder OA substituiert sein kann, und auch an einen Benzol- oder Pyridinring kondensiert sein kann,B is an aromatic heterocycle with 1 to 4 N, O and / or S atoms, bonded via N or C, which may be unsubstituted or substituted once, twice or three times by shark, A and / or OA, and can also be fused to a benzene or pyridine ring,
Q fehlt oder Alkylen mit 1 -6 C-Atomen,Q is absent or alkylene with 1 -6 C atoms,
X CH2, S oder O,X CH 2 , S or O,
R1 und R2 jeweils unabhängig voneinander H oder A,R 1 and R 2 are each independently H or A,
R3 und R4 jeweils unabhängig voneinander -OH, OR5, -S-R5, -SO-R5, -S02-R5, Hai, Methylendioxy, -N02l -NH2, -NHR5 oder -NR5R6,R 3 and R 4 each independently of one another -OH, OR 5 , -SR 5 , -SO-R 5 , -S0 2 -R 5 , shark, methylenedioxy, -N0 2l -NH 2 , -NHR 5 or -NR 5 R 6 ,
R5 und R6 jeweils unabhängig voneinander A, Cycloalkyl mit 3-7 C-Atomen, Methylencycloalkyl mit 4-8 C-Atomen oder Alkenyl mit 2-8 C-Atomen,R 5 and R 6 each independently of one another A, cycloalkyl with 3-7 C atoms, methylene cycloalkyl with 4-8 C atoms or alkenyl with 2-8 C atoms,
A Alkyl mit 1 bis 10 C-Atomen, das durch 1 bis 5 F- und/oder Cl-Atome substituiert sein kann und
Hal F, Cl, Broder I bedeuten,A alkyl having 1 to 10 carbon atoms, which can be substituted by 1 to 5 F and / or Cl atoms and Hal F, Cl, Broder I mean
d) Verbindungen der Formel I, offenbart in EP 0539806 B1 ,d) compounds of the formula I, disclosed in EP 0539806 B1,
worinwherein
R1 und R2 jeweils unabhängig voneinander H oder A, R3 H,OAoderO-CmH2m+1-nXn,R 1 and R 2 each independently of one another H or A, R 3 H, OA or O-C m H 2m + 1-n X n ,
R -0-CmH2m+i-nXn,R -0-CmH 2m + i-nXn,
X F oder Cl,X F or Cl,
A Alkyl mit 1-6 C-Atomen, m 1, 2, 3, 4, 5 oder 6 und n 1,2,3,4,5,6,7,8,9, 10, 11, 12 oder 13 bedeuten,A is alkyl with 1-6 C atoms, m is 1, 2, 3, 4, 5 or 6 and n is 1,2,3,4,5,6,7,8,9, 10, 11, 12 or 13 .
e) Verbindungen der Formel I, offenbart in EP 0618201 A1 ,e) compounds of the formula I, disclosed in EP 0618201 A1,
1 R2 1 R 2
N-NN-N
Q-R5 QR 5
worinwherein
R1 und R2 jeweils unabhängig voneinander H oder A,
R3 und R4 jeweils unabhängig voneinander OH, OA, SA, SOA, S02A, Hai, Methylendioxy, Cycloalkyloxy mit 3-7 C- Atomen oder 0-CmH2m+1-kFk,R 1 and R 2 are each independently H or A, R 3 and R 4 each independently of one another OH, OA, SA, SOA, S0 2 A, shark, methylenedioxy, cycloalkyloxy with 3-7 C atoms or 0-C m H 2m + 1-k F k ,
R5 -NR6R7 oder -N (CH2)n,R 5 -NR 6 R 7 or -N (CH 2 ) n ,
wobei eine CH2-Gruppe auch durch Sauerstoff ersetzt sein kann, R6 und R7 jeweils unabhängig voneinander H oder A, Q Alkylen mit 1 -6 C-Atomen,where a CH 2 group can also be replaced by oxygen, R 6 and R 7 each independently of one another H or A, Q alkylene with 1 -6 C atoms,
A Alkyl mit 1 -6 C-Atomen,A alkyl with 1 -6 carbon atoms,
Hai F, Cl, Br oder I, m 1 , 2, 3, 4, 5 oder 6, n 3, 4, 5 oder 6, k 1 , 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 , 12 oder 13 bedeuten,Shark F, Cl, Br or I, m 1, 2, 3, 4, 5 or 6, n 3, 4, 5 or 6, k 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13 mean
Verbindungen der Formel I, offenbart in DE 196 04 388 A1 ,Compounds of the formula I, disclosed in DE 196 04 388 A1,
worin wherein
R1 und R2 jeweils unabhängig voneinander H oder A,R 1 and R 2 are each independently H or A,
R3 und R4 jeweils unabhängig voneinander -OH, OA, -S-A,R 3 and R 4 each independently of one another -OH, OA, -SA,
-SO-A, -S02-A, Hai, Methylendioxy, -NO2) -NH2, -NHA oder -NAA', A und A' jeweils unabhängig voneinander Alkyl mit 1 bis 10 C--SO-A, -S0 2 -A, shark, methylenedioxy, -NO 2) -NH 2 , -NHA or -NAA ', A and A' each independently of one another alkyl with 1 to 10 C-
Atomen, das durch 1 bis 5 F- und/oder Cl-Atome substi-
tuiert sein kann, Cycloalkyl mit 3-7 C-Atomen oder Me- thylencycloalkyl mit 4-8 C-Atomen,Atoms that are substituted by 1 to 5 F and / or Cl atoms can be tuiert, cycloalkyl with 3-7 C-atoms or methylene cycloalkyl with 4-8 C-atoms,
B -Y-R5 oder -O-Y-R5,B -YR 5 or -OYR 5 ,
Q fehlt oder Alkylen mit 1 -4 C-Atomen,Q is absent or alkylene with 1 -4 C atoms,
Y fehlt oder Alkylen mit 1 -10 C-Atomen,Y is absent or alkylene with 1 -10 C atoms,
X CH2 oder S,X CH 2 or S,
R5 NH2) NHA, NAA' oder einen unsubstituierten oder einfach durch A oder OH substituierten gesättigten 3-8- gliedrigen Heterocyclus mit mindestens einem N-Atom, worin zusätzlich weitere CH2-Gruppen durch NH, NA, S oder O ersetzt sein können, Hai F, Cl, Br oder I bedeuten,R 5 NH 2) NHA, NAA 'or an unsubstituted or simply substituted by A or OH saturated 3-8-membered heterocycle with at least one N atom, in which further CH 2 groups have been replaced by NH, NA, S or O. can mean shark F, Cl, Br or I,
und/oder ihrer physiologisch unbedenklichen Salze zur Herstellung eines Arzneimittels zur Behandlung von Osteoporose, Tumoren, Tumormetastasen, Atherosklerose, rheumatoide Arthritis, multiple Sklerose, Diabetes mellitus, ulzerative Kolitis und AIDS.and / or their physiologically acceptable salts for the manufacture of a medicament for the treatment of osteoporosis, tumors, tumor metastases, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, ulcerative colitis and AIDS.
Der Erfindung lag die Aufgabe zugrunde, neue Verwendungen der Verbindungen der Formeln I aufzufinden, insbesondere solche, die zur Herstel- lung von Arzneimitteln führen können.The object of the invention was to find new uses of the compounds of the formulas I, in particular those which can lead to the production of medicaments.
Es wurde gefunden, daß die Verbindungen der Formeln I und ihre Salze bei guter Verträglichkeit sehr wertvolle pharmakologische Eigenschaften besitzen.It has been found that the compounds of the formula I and their salts have very valuable pharmacological properties with good tolerability.
Insbesondere zeigen sie eine selektive Phosphodiesterase IV-Hemmung, die mit einer intrazellulären Erhöhung von cAMP verbunden ist (N. Sommer et al., Nature Medicine, 1 , 244-248 (1995)).
Die PDE IV-Hemmung kann z.B. analog C.W. Davis in Biochim. biophys. Acta 797, 354-362 (1984) nachgewiesen werden.In particular, they show selective phosphodiesterase IV inhibition, which is associated with an intracellular increase in cAMP (N. Sommer et al., Nature Medicine, 1, 244-248 (1995)). The PDE IV inhibition can, for example, analogously to CW Davis in Biochim. biophys. Acta 797, 354-362 (1984).
Die erfindungsgemäßen Verbindungen können zur Behandlung von asthmatischen Erkrankungen eingesetzt werden. Die antiasthmatische Wirkung der PDE IV-Hemmer ist z.B. von T.J. Torphy et al. in Thorax, 46, 512-523 (1991) beschrieben und kann z. B. nach der Methode von T. Ols- son, Acta allergologica 26, 438-447 (1971 ), bestimmt werden.The compounds according to the invention can be used for the treatment of asthmatic diseases. The anti-asthmatic effect of the PDE IV inhibitors is e.g. by T.J. Torphy et al. in Thorax, 46, 512-523 (1991) and can e.g. B. by the method of T. Olson, Acta allergologica 26, 438-447 (1971) can be determined.
Da cAMP knochenabbauende Zellen hemmt und knochenaufbauende Zellen stimuliert (S. Kasugai et al., M681 und K. Miyamoto, M 682, in Abstract der American Society for Bone and Mineral Research 18th annual meeting, 1996), können die erfindungsgemäßen Verbindungen zur Behandlung von Osteoporose eingesetzt werden.Since cAMP bone-degrading cells and inhibits bone building cells stimulated (S. Kasugai et al., M681 and K. Miyamoto, M 682, in the abstract of the American Society for Bone and Mineral Research 18 th annual meeting, 1996), the novel compounds for the treatment can of osteoporosis.
Die Verbindungen zeigen außerdem eine hemmende Wirkung auf die Bildung von TNF (Tumor Nekrose Faktor) und eignen sich daher zur Behandlung von allergischen und entzündlichen Krankheiten, Autoimmunkrankheiten und Transplantatabstoßungsreaktionen.The compounds also show an inhibitory effect on the formation of TNF (tumor necrosis factor) and are therefore suitable for the treatment of allergic and inflammatory diseases, autoimmune diseases and graft rejection reactions.
Sie können zur Behandlung von Gedächtnisstörungen, Tumoren, Tumormetastasen, Atherosklerose, rheumatoide Arthritis, multiple Sklerose, Morbus Crohn, atopische Dermatitis, Diabetes mellitus, Ulzerative Kolitis und AIDS eingesetzt werden.They can be used to treat memory disorders, tumors, tumor metastases, atherosclerosis, rheumatoid arthritis, multiple sclerosis, Crohn's disease, atopic dermatitis, diabetes mellitus, ulcerative colitis and AIDS.
Die Wirkung von PDE IV-Hemmem bei der Behandlung von Asthma, ent- zündlichen Erkrankungen, Diabetes mellitus, atopischer Dermatitis, Pso- riasis, AIDS, Tumorwachstum oder Tumormetastasen ist z.B. in der EP 779 291 beschrieben.The effect of PDE IV inhibitors in the treatment of asthma, inflammatory diseases, diabetes mellitus, atopic dermatitis, psoriasis, AIDS, tumor growth or tumor metastases is e.g. described in EP 779 291.
Die antiinflammatorische Wirkung der erfindungsgemäßen Substanzen und ihre Wirksamkeit zur Behandlung von z.B. Autoimmunerkrankungen,
Multiplesklerose oder rheumatoider Arthritis kann analog den Methoden von N. Sommer et al., Nature Medicine, 1 , 244-248 (1995) oder L. Sekut et al., Clin. Exp. Immunol., 100, 126-132 (1995) bestimmt werden.The anti-inflammatory effect of the substances according to the invention and their effectiveness for the treatment of, for example, autoimmune diseases, Multiple sclerosis or rheumatoid arthritis can be analogous to the methods of N. Sommer et al., Nature Medicine, 1, 244-248 (1995) or L. Sekut et al., Clin. Exp. Immunol., 100, 126-132 (1995).
Die Wirkung von PDE IV-Hemmern bei der Tumorbehandlung ist z.B. in der WO 95 35 281 , WO 95 17 399 oder WO 96 00 215 beschrieben.The effect of PDE IV inhibitors in tumor treatment is e.g. described in WO 95 35 281, WO 95 17 399 or WO 96 00 215.
Überraschenderweise wurde gefunden, daß die Verbindungen der For- mein I zur Behandlung von Krebs geeignet sind.Surprisingly, it has been found that the compounds of the formula I are suitable for the treatment of cancer.
Gegenstand der Erfindung ist weiterhin die Verwendung der Verbindungen der Formeln I sowie deren physiologisch unbedenklichen Salze und/oder Solvate zur Herstellung eines Arzneimittels zur Inhibierung des Wachstums neoplastischer Zellen.The invention furthermore relates to the use of the compounds of the formulas I and their physiologically acceptable salts and / or solvates for the production of a medicament for inhibiting the growth of neoplastic cells.
Unter neoplastischen Zellen werden Krebszellen verstanden.Neoplastic cells are understood to mean cancer cells.
Gegenstand der Erfindung ist insbesondere die Verwendung der Verbindungen der Formeln I sowie deren physiologisch unbedenklichen Salze und/oder Solvate zur Herstellung eines Arzneimittels zur Behandlung und/oder Prophylaxe von Krebserkrankungen.The invention relates in particular to the use of the compounds of the formulas I and their physiologically acceptable salts and / or solvates for the production of a medicament for the treatment and / or prophylaxis of cancer.
Gegenstand der Erfindung ist weiterhin die Verwendung der Verbindungen der Formeln I sowie deren physiologisch unbedenklichen Salze und/oder Solvate zur Herstellung eines Arzneimittels zur Behandlung neoplastischer Schädigungen.The invention furthermore relates to the use of the compounds of the formulas I and their physiologically acceptable salts and / or solvates for the production of a medicament for the treatment of neoplastic damage.
Gegenstand der Erfindung ist weiterhin die Verwendung der Verbindungen der Formeln I sowie deren physiologisch unbedenklichen Salze und/oder Solvate zur Herstellung eines Arzneimittels zur Behandlung präcanceroge- ner Schädigungen.
Unter präcancerogenen Schädigungen versteht man z.B. gutartige Wucherungen im Darm, die zu Darmkrebs führen können.The invention furthermore relates to the use of the compounds of the formulas I and their physiologically acceptable salts and / or solvates for the production of a medicament for the treatment of precancerogenic damage. Precancerogenic damage means, for example, benign growths in the intestine that can lead to colon cancer.
Unter präcancerogenen Schädigungen werden insbesondere die in USPrecancerogenic damage includes in particular those in US
5,948,911 in Spalte 4, Zeilen 49-60 genannten Läsionen verstanden.5,948,911 in column 4, lines 49-60.
Unregelmäßigkeiten der Apoptose (Zelltod) spielen eine Rolle bei der Bildung präcancerogener Schädigungen. Auch ist bekannt, daß die Regulierung von Apoptose bei Krankheiten eine wichtige Rolle spielt, die im Zusammenhang mit einem abnormalen Zellwachstum stehen, wie z.B. gutartige Prostatahyperplasie, neurodegenera- tive Erkrankungen, wie z.B. Parkinson, Autoimmunkrankheiten einschließ- lieh Multiple Sklerose und rheumatoide Arthrithis oder Infektionskrankheiten wie AIDS.Irregularities in apoptosis (cell death) play a role in the formation of precancerogenic damage. Regulation of apoptosis is also known to play an important role in diseases associated with abnormal cell growth, such as e.g. benign prostatic hyperplasia, neurodegenerative diseases, e.g. Parkinson's, autoimmune diseases including multiple sclerosis and rheumatoid arthritis or infectious diseases such as AIDS.
Die Verbindungen der Formeln I, modulieren Apoptose und finden Verwendung bei der Behandlung oder Prophylaxe von Krebserkrankungen.The compounds of the formula I modulate apoptosis and are used in the treatment or prophylaxis of cancer.
Gegenstand der Erfindung ist somit die Verwendung der Verbindungen der Formeln I sowie deren physiologisch unbedenklichen Salze und/oder Solvate zur Herstellung eines Arzneimittels zur Regulierung von Apoptose in menschlichen Zellen.The invention thus relates to the use of the compounds of the formulas I and their physiologically acceptable salts and / or solvates for the production of a medicament for regulating apoptosis in human cells.
Die Verbindungen der Formeln I können als Arzneimittelwirkstoffe in der Human- und Veterinärmedizin eingesetzt werden. Ferner können sie als Zwischenprodukte zur Herstellung weiterer Arzneimittelwirkstoffe eingesetzt werden.The compounds of the formulas I can be used as active pharmaceutical ingredients in human and veterinary medicine. They can also be used as intermediates for the production of further active pharmaceutical ingredients.
Die Verbindungen der Formeln I können ein chirales Zentrum aufweisen und können daher in mehreren stereoisomeren Formen auftreten. Alle die- se Formen (z. B. R- und S-Formen) und deren Gemische (z. B. die R,S-The compounds of the formulas I can have a chiral center and can therefore occur in several stereoisomeric forms. All of these forms (e.g. R and S forms) and their mixtures (e.g. the R, S-
Formen) sind in den Formeln I eingeschlossen.
Diese Verbindungen der Formeln I können als Arzneimittel in der Humanoder Veterinärmedizin verwendet werden. Als Trägerstoffe kommen organische oder anorganische Substanzen in Frage, die sich für die enteraleForms) are included in the formulas I. These compounds of the formula I can be used as medicaments in human or veterinary medicine. Suitable carriers are organic or inorganic substances that are suitable for enteral
(z.B. orale), parenterale oder topische Applikation eignen und mit den neuen Verbindungen nicht reagieren, beispielsweise Wasser, pflanzliche Öle, Benzylalkohole, Alkylenglykole, Polyethylenglykole, Glycerintriacetat, Gelatine, Kohlehydrate wie Lactose oder Stärke, Magnesiumstearat, Talk, Vaseline. Zur oralen Anwendung dienen insbesondere Tabletten, Pillen, Dragees, Kapseln, Pulver, Granulate, Sirupe, Säfte oder Tropfen, zur rektalen Anwendung Suppositorien, zur parenteralen Anwendung Lösungen, vorzugsweise ölige oder wässrige Lösungen, ferner Suspensionen, Emul- sionen oder Implantate, für die topische Anwendung Salben, Cremes oder Puder. Die neuen Verbindungen können auch lyophilisiert und die erhaltenen Lyophilisate z.B. zur Herstellung von Injektionspräparaten verwendet werden. Die angegebenen Zubereitungen können sterilisiert sein und/oder Hilfsstoffe wie Gleit-, Konservierungs-, Stabilisierungs- und/oder Netzmittel, Emulgatoren, Salze zur Beeinflussung des osmotischen Druckes, Puffersubstanzen, Färb-, Geschmacks- und /oder ein oder mehrere weitere Wirkstoffe enthalten, z.B. ein oder mehrere Vitamine.(e.g. oral), parenteral or topical application and do not react with the new compounds, e.g. water, vegetable oils, benzyl alcohols, alkylene glycols, polyethylene glycols, glycerol triacetate, gelatin, carbohydrates such as lactose or starch, magnesium stearate, talc, petroleum jelly. Tablets, pills, dragees, capsules, powders, granules, syrups, juices or drops are used in particular for oral use, suppositories for rectal use, solutions, preferably oily or aqueous solutions, furthermore suspensions, emulsions or implants for which topical application ointments, creams or powder. The new compounds can also be lyophilized and the resulting lyophilisates e.g. can be used for the production of injectables. The specified preparations can be sterilized and / or contain auxiliaries such as lubricants, preservatives, stabilizers and / or wetting agents, emulsifiers, salts for influencing the osmotic pressure, buffer substances, coloring, flavoring and / or one or more further active ingredients, eg one or more vitamins.
Die Verbindungen der Formeln I und ihre physiologisch unbedenklichen Salze können bei der Bekämpfung von Krankheiten, bei denen eine Erhöhung des cAMP(cyclo-Adenosin-monophosphat)-Spiegels zu Entzündungshemmung oder -Verhinderung und Muskelentspannung führt, einge- setzt werden. Besondere Verwendung können die erfindungsgemäßenThe compounds of the formulas I and their physiologically acceptable salts can be used in combating diseases in which an increase in the cAMP (cyclo-adenosine monophosphate) level leads to inhibition or prevention of inflammation and muscle relaxation. Particular use can be made of the invention
Verbindungen bei der Behandlung von Osteoporose, Tumoren, Tumormetastasen, Asthma, chronischer Bronchitis, atopischer Dermatitis, Psoriasis und anderer Hautkrankheiten und Autoimmunerkrankungen finden.Find compounds in the treatment of osteoporosis, tumors, tumor metastases, asthma, chronic bronchitis, atopic dermatitis, psoriasis and other skin diseases and autoimmune diseases.
Dabei werden die erfindungsgemäßen Substanzen in der Regel vorzugsweise in Dosierungen zwischen etwa 1 und 500 mg, insbesondere zwi-
sehen 5 und 100 mg pro Dosierungseinheit verabreicht. Die tägliche Dosierung liegt vorzugsweise zwischen etwa 0,02 und 10 mg/kg Körpergewicht. Die spezielle Dosis für jeden Patienten hängt jedoch von den verschiedensten Faktoren ab, beispielsweise von der Wirksamkeit der einge- setzten speziellen Verbindung, vom Alter, Körpergewicht, allgemeinen Gesundheitszustand, Geschlecht, von der Kost, vom Verabreichungszeitpunkt und -weg, von der Ausscheidungsgeschwindigkeit, Arzneistoffkombination und Schwere der jeweiligen Erkrankung, welcher die Therapie gilt. Die orale Applikation ist bevorzugt.The substances according to the invention are generally preferably used in doses between about 1 and 500 mg, in particular between see 5 and 100 mg administered per dosage unit. The daily dosage is preferably between about 0.02 and 10 mg / kg body weight. However, the specific dose for each patient depends on a wide variety of factors, for example on the effectiveness of the particular compound used, on the age, body weight, general health, sex, on the diet, on the time and route of administration, on the rate of excretion and on the combination of drugs and severity of the respective disease to which the therapy applies. Oral application is preferred.
Verbindungen der Formeln I können ein oder mehrere Asymmetriezentren enthalten. In diesem Fall liegen sie gewöhnlich in racemischer Form vor. Erhaltene Racemate können nach an sich bekannten Methoden mechanisch oder chemisch in ihre Enantiomeren getrennt werden. Vorzugsweise werden aus dem racemischen Gemisch durch Umsetzung mit einem optisch-aktiven Trennmittel Diastereomere gebildet.Compounds of the formula I can contain one or more centers of asymmetry. In this case, they are usually in racemic form. Racemates obtained can be separated into their enantiomers mechanically or chemically by methods known per se. Diastereomers are preferably formed from the racemic mixture by reaction with an optically active release agent.
Gegenstand der Erfindung ist insbesondere die Verwendung von a) Verbindungen, offenbart in EP 0 738 715 A2, ausgewählt aus derThe invention relates in particular to the use of a) compounds, disclosed in EP 0 738 715 A2, selected from the
Gruppegroup
2-(4-Nitrobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on, F. 126°;2- (4-nitrobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one, mp 126 °;
2-(3-Nitrobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on, F. 122°;2- (3-nitrobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one, mp 122 °;
2-(2-Nitrobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on;2- (2-nitrobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(2,3-Dinitrobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on;2- (2,3-dinitrobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(2,4-Dinitrobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on;2- (2,4-dinitrobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(2-Methoxybenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on;
2-(4-Methoxybenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- py dazin-3-on;2- (2-methoxybenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one; 2- (4-methoxybenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropy dazin-3-one;
2-(2-Chlorbenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on;2- (2-chlorobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(2,6-Dichlorbenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on;2- (2,6-dichlorobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Cyanbenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on; 2-(4-Carboxybenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on;2- (4-cyanobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one; 2- (4-carboxybenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Nitrobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro- pyridazin-3-on; 2-(3-Nitrobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro- pyridazin-3-on;2- (4-nitrobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (3-nitrobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(2-Nitrobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro- pyridazin-3-on;2- (2-nitrobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(2,3-Dinitrobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetra- hydro-pyridazin-3-on;2- (2,3-dinitrobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetra-hydro-pyridazin-3-one;
2-(2,4-Dinitrobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetra- hydro-pyridazin-3-on;2- (2,4-dinitrobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetra-hydro-pyridazin-3-one;
2-(2-Methoxybenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetra- hydro-pyridazin-3-on;2- (2-methoxybenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetra-hydro-pyridazin-3-one;
2-(4-Methoxybenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetra- hydro-pyridazin-3-on;2- (4-methoxybenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetra-hydro-pyridazin-3-one;
2-(2-Chlorbenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro- pyhdazin-3-on;2- (2-chlorobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyhdazin-3-one;
2-(2,6-Dichlorbenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetra- hydro-pyridazin-3-on;2- (2,6-dichlorobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetra-hydro-pyridazin-3-one;
2-(4-Cyanbenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro- pyridazin-3-on;2- (4-cyanobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Carboxybenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetra- hydro-pyridazin-3-on;
2-(4-Nitrobenzyl)-6-(3-methoxy-4-trifluormethoxyphenyl)-5-ethyl-2- (4-carboxybenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetra-hydro-pyridazin-3-one; 2- (4-nitrobenzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydro-ρyridazin-3-on;2,3,4,5-tetrahydro-ρyridazin-3-one;
2-(4-Nitrobenzyl)-6-(3-methoxy-4-difluormethoxyphenyl)-5-ethyl-2- (4-nitrobenzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -5-ethyl-
2,3,4,5- tetrahydro-pyridazin-3-on;2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Nitrobenzyl)-6-(3-methoxy-4-fluormethoxyphenyl)-5-ethyl-2- (4-nitrobenzyl) -6- (3-methoxy-4-fluormethoxyphenyl) -5-ethyl-
2,3,4,5- tetrahydro-pyridazin-3-on;2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Nitrobenzyl)-6-(3-difluormethoxy-4-methoxyphenyl)-5-ethyl- 2,3,4,5- tetrahydro-pyridazin-3-on; 2-(4-Nitrobenzyl)-6-(3-trifluormethoxy-4-methoxyphenyl)-5-ethyl-2- (4-nitrobenzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4-nitrobenzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-
2,3,4,5- tetrahydro-pyridazin-3-on;2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Nitrobenzyl)-6-(3-Fluormethoxy-4-methoxyphenyl)-5-ethyl- 2,3,4,5- tetrahydro-pyridazin-3-on; 2-(4-Nitrobenzyl)-6-(3-Methoxy-4-ethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydro-pyridazin-3-on;2- (4-nitrobenzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4-nitrobenzyl) -6- (3-methoxy-4-ethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Nitrobenzyl)-6-(3-Ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5- tetrahydro-pyridazin-3-on;2- (4-nitrobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Nitrobenzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl-2, 3,4,5- tetrahydro-pyridazin-3-on;2- (4-nitrobenzyl) -6- (3-hydroxy-4-methoxyphenyl) -5-ethyl-2, 3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Nitrobenzyl)-6-(4-methylsulfonylyphenyl)-5-ethyl-2,3,4,5-tetra- hydro-pyridazin-3-on;2- (4-nitrobenzyl) -6- (4-methylsulfonylyphenyl) -5-ethyl-2,3,4,5-tetra-hydro-pyridazin-3-one;
2-(4-Nitrobenzyl)-6-(4-methylenoxyphenyl)-5-ethyl-2,3,4,5-tetra- hydro-pyridazin-3-on;2- (4-nitrobenzyl) -6- (4-methyleneoxyphenyl) -5-ethyl-2,3,4,5-tetra-hydro-pyridazin-3-one;
2-(4-Nitrobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl- 2,3,4,5- tetrahydro-pyridazin-3-on;2- (4-nitrobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Aminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on, F. 184°;2- (4-aminobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one, mp 184 °;
2-(3-Aminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on, F. 140°;2- (3-aminobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one, mp 140 °;
2-(2-Aminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on;2- (2-aminobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(2,3-Diaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on;
2-(2,4-Diaminobenzyl)-6-(3,4-dimethoxyphenyi)-2,3,4,5-tetrahydro- pyridazin-3-on;2- (2,3-diaminobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one; 2- (2,4-diaminobenzyl) -6- (3,4-dimethoxyphenyi) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Aminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydro-pyridazin-3-on;2- (4-aminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-Aminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydro-pyridazin-3-on, F. 49°;2- (3-aminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one, mp 49 °;
2-(2-Aminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydro-pyridazin-3-on; 2-(2,3-Diaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetra- hydro-pyridazin-3-on;2- (2-aminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (2,3-diaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetra-hydro-pyridazin-3-one;
2-(2,4-Diaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetra- hydro-pyridazin-3-on; 2-(4-Aminobenzyl)-6-(3-methoxy-4-trifluormethoxyphenyl)-5-ethyl-2- (2,4-diaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetra-hydro-pyridazin-3-one; 2- (4-aminobenzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydro-pyridazin-3-on;2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Aminobenzyl)-6-(3-methoxy-4-difluormethoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-aminobenzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Aminobenzyl)-6-(3-methoxy-4-fluormethoxyphenyl)-5-ethyl- 2,3,4,5- tetrahydro-pyridazin-3-on;2- (4-aminobenzyl) -6- (3-methoxy-4-fluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Aminobenzyl)-6-(3-difluormethoxy-4-methoxyphenyl)-5-ethyl- 2,3,4, 5-tetrahydro-pyridazin-3-on;2- (4-aminobenzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Aminobenzyl)-6-(3-trifluormethoxy-4-methoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-aminobenzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Aminobenzyl)-6-(3-Fluormethoxy-4-methoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-aminobenzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Aminobenzyl)-6-(3-Methoxy-4-ethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydro-pyridazin-3-on;2- (4-aminobenzyl) -6- (3-methoxy-4-ethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Aminobenzyl)-6-(3-Ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5- tetrahydro-pyridazin-3-on;2- (4-aminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Aminobenzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl-2, 3,4,5- tetrahydro-pyτidazin-3-on;2- (4-aminobenzyl) -6- (3-hydroxy-4-methoxyphenyl) -5-ethyl-2, 3,4,5-tetrahydro-pyτidazin-3-one;
2-(4-Aminobenzyl)-6-(4-methylsulfonylphenyl)-5-ethyl-2,3,4,5-tetra- hydro-pyridazin-3-on;
2-(4-Aminobenzyl)-6-(4-methylenoxyphenyl)-5-ethyl-2,3,4,5-tetra- hydro-pyridazin-3-on;2- (4-aminobenzyl) -6- (4-methylsulfonylphenyl) -5-ethyl-2,3,4,5-tetra-hydro-pyridazin-3-one; 2- (4-aminobenzyl) -6- (4-methyleneoxyphenyl) -5-ethyl-2,3,4,5-tetra-hydro-pyridazin-3-one;
2-(4-Aminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2- (4-aminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydro-pyridazin-3-on;2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-Aminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2- (3-aminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydro-pyridazin-3-on, F. 109°;2,3,4,5-tetrahydro-pyridazin-3-one, mp 109 °;
2-(4-Aminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on; 2-(4-Aminophenethyl)-6-(3,4-dimethoxypheπyl)-5-ethyl-2,3,4,5-tetra- hydro-pyridazin-3-on;2- (4-aminophenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one; 2- (4-aminophenethyl) -6- (3,4-dimethoxypheπyl) -5-ethyl-2,3,4,5-tetra-hydro-pyridazin-3-one;
2-(3-Aminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on, F. 112°; 2-(4-Carboxybenzyl)-6-(3,4-dihydroxyphenyl)-5-ethyl-2,3,4,5- tetrahydro-pyridazin-3-on;2- (3-aminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one, mp 112 °; 2- (4-carboxybenzyl) -6- (3,4-dihydroxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Butyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on, F. 148°;2- (4-butyrylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one, mp 148 °;
2-(4-Acetamidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on, F. 183°;2- (4-acetamidobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one, mp 183 °;
2-(4-Trifluoracetamidobenzyl)-6-(3,4-dimethoxyphenyl)-2, 3,4,5- tetrahydropyridazin-3-on, F. 210°;2- (4-trifluoroacetamidobenzyl) -6- (3,4-dimethoxyphenyl) -2, 3,4,5-tetrahydropyridazin-3-one, mp 210 °;
2-(4-Methylsulfonamidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on, F. 138°;2- (4-methylsulfonamidobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one, mp 138 °;
2-(4-Propionylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2, 3,4,5- tetrahydropyridazin-3-on, F. 176°;2- (4-propionylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2, 3,4,5-tetrahydropyridazin-3-one, mp 176 °;
2-(4-tert.-Butylcarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5- tetrahydropyridazin-3-on, F. 155°;2- (4-tert-butylcarbonylaminobenzyl) -6- (3,4-dimethoxyphenyl) - 2,3,4,5-tetrahydropyridazin-3-one, mp 155 °;
2-(4-lsobutyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;2- (4-isobutyrylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;2- (4-methoxycarbonylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pivalylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;
2-(4-Cyclopentylcarbamoylbenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;2- (4-pivalylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one; 2- (4-cyclopentylcarbamoylbenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ethoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2, 3,4,5- tetrahydropyridazin-3-on, F. 147°;2- (4-ethoxycarbonylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2, 3,4,5-tetrahydropyridazin-3-one, mp 147 °;
2-(4-Methoxalylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2, 3,4,5- tetrahydropyridazin-3-on;2- (4-methoxalylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2, 3,4,5-tetrahydropyridazin-3-one;
2-(4-Ureidobenzyl)-6-(3,4-dimethoxyphenyl)-2, 3,4,5- tetrahydropyridazin-3-on; 2-(4-Pentanoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;2- (4-ureidobenzyl) -6- (3,4-dimethoxyphenyl) -2, 3,4,5-tetrahydropyridazin-3-one; 2- (4-pentanoylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Hexanoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2, 3,4,5- tetrahydropyridazin-3-on; 2-(4-Pentafluorpropionylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2- (4-hexanoylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2, 3,4,5-tetrahydropyridazin-3-one; 2- (4-Pentafluorpropionylaminobenzyl) -6- (3,4-dimethoxyphenyl) -
2,3,4,5- tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Acetamidobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydropyridazin-3-on;2- (4-acetamidobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Trifluoracetamidobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2- (4-Trifluoracetamidobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-
2,3,4,5- tetrahydropyridazin-3-on, F. 133°;2,3,4,5-tetrahydropyridazin-3-one, mp 133 °;
2-(4-Methylsulfonamidobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl- 2,3,4,5- tetrahydropyridazin-3-on;2- (4-methylsulfonamidobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Propionylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2, 3,4,5- tetrahydropyridazin-3-on, F. 81 °;2- (4-propionylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2, 3,4,5-tetrahydropyridazin-3-one, mp 81 °;
2-(4-tert.-Butylcarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydropyridazin-3-on;2- (4-tert-butylcarbonylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Butyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydropyridazin-3-on, F. 117°;2- (4-butyrylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, mp 117 °;
2-(4-lsobutyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydropyridazin-3-on;2- (4-isobutyrylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2- (4-Methoxycarbonylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydropyridazin-3-on, F. 144°;2,3,4,5-tetrahydropyridazin-3-one, mp 144 °;
2-(4-Pivalylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydropyridazin-3-on;
2-(4-Cyclopentylcarbamoylbenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2- (4-pivalylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-Cyclopentylcarbamoylbenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ethoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2- (4-Ethoxycarbonylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydropyridazin-3-on, F.154°;2,3,4,5-tetrahydropyridazin-3-one, mp 154 °;
2-(4-Methoxalylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2- (4-Methoxalylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-
2,3,4,5- tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ureidobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydropyridazin-3-on; 2-(4-Pentanoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydropyridazin-3-on;2- (4-ureidobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-pentanoylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Hexanoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2, 3,4,5- tetrahydropyridazin-3-on; 2-(4-Pentafluorpropionylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-hexanoylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2, 3,4,5-tetrahydropyridazin-3-one; 2- (4-pentafluoropropionylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Acetamidobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5- tetrahydropyridazin-3-on;2- (4-acetamidobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Trifluoracetamidobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2- (4-Trifluoracetamidobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methylsulfonamidobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-methylsulfonamidobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Propionylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydropyridazin-3-on;2- (4-propionylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Butyrylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2- (4-Butyrylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-
2,3,4,5- tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-lsobutyrylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydropyridazin-3-on;2- (4-isobutyrylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxycarbonylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-methoxycarbonylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pivalylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2- (4-Pivalylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-
2,3,4,5- tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Cyclopentylcarbamoylbenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;
2-(4-Ethoxycarbonylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-cyclopentylcarbamoylbenzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-ethoxycarbonylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxalylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2- (4-Methoxalylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ureidobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2, 3,4,5- tetrahydropyridazin-3-on;2- (4-ureidobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2, 3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentanoylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyI)-5-ethyl- 2,3,4,5-tetrahydropyridazin-3-on; 2-(4-Hexanoylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2- (4-pentanoylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-Hexanoylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentafluorpropionylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)- 5- ethyl-2,3,4,5-tetrahydropyridazin-3-on; 2-(4-Acetamidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2- (4-pentafluoropropionylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-Acetamidobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Trifluoracetamidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)- 5- ethyl-2,3,4,5-tetrahydropyridazin-3-on, F. 162°;2- (4-trifluoroacetamidobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, mp 162 °;
2-(4-Methylsulfonamidobenzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-methylsulfonamidobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Propionylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on, F. 69°;2- (4-propionylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, mp 69 °;
2-(4-tert.-Butylcarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-tert-butylcarbonylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Butyrylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-butyrylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-lsobutyrylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-isobutyrylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxycarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-methoxycarbonylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pivalylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-pivalylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-CycIopentylcarbamoylbenzyl)-6-(3-cycIopentyloxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;
2-(4-Ethoxycarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on, F. 73°;2- (4-Cyclopentylcarbamoylbenzyl) -6- (3-Cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-ethoxycarbonylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, mp 73 °;
2-(4-Methoxalylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2- (4-Methoxalylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -
5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ureidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2- (4-Ureidobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentanoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on; 2-(4-Hexanoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-pentanoylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-hexanoylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentafluorpropionylaminobenzyl)-6-(3-cyclopentyloxy-4- methoxy-phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on; 2-(4-Acetamidophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydropyridazin-3-on;2- (4-pentafluoropropionylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-acetamidophenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Trifluoracetamidophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydropyridazin-3-on;2- (4-trifluoroacetamidophenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methylsulfonamidophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2- (4-Methylsulfonamidophenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Propionylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl- 2,3,4,5- tetrahydropyridazin-3-on;2- (4-propionylaminophenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Butyrylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2, 3,4,5- tetrahydropyridazin-3-on;2- (4-butyrylaminophenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2, 3,4,5-tetrahydropyridazin-3-one;
2-(4-lsobutyrylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl- 2,3,4, 5-tetrahydropyridazin-3-on;2- (4-isobutyrylaminophenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxycarbonylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-methoxycarbonylaminophenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pivalylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydropyridazin-3-on;2- (4-pivalylaminophenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Cyclopentylcarbamoylphenethyl)-6-(3,4-dimethoxyphenyl)-5- ethyl- 2,3,4,5-tetrahydropyridazin-3-on;2- (4-cyclopentylcarbamoylphenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ethoxycarbonylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;
2-(4-Methoxalylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydropyridazin-3-on;2- (4-ethoxycarbonylaminophenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-methoxalylaminophenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ureidophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2, 3,4,5- tetrahydropyridazin-3-on;2- (4-ureidophenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2, 3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentanoylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2- (4-Pentanoylaminophenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-
2,3,4, 5-tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Hexanoylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl- 2,3,4,5- tetrahydropyridazin-3-on; 2-(4-Pentafluorpropionylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-hexanoylaminophenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-pentafluoropropionylaminophenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Acetamidobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydropyridazin-3-on; 2-(3-Trifluoracetamidobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2- (3-acetamidobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (3-Trifluoracetamidobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-
2,3,4,5- tetrahydropyridazin-3-on, F. 142°;2,3,4,5-tetrahydropyridazin-3-one, mp 142 °;
2-(3-Methylsulfonamidobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl- 2,3,4,5- tetrahydropyridazin-3-on;2- (3-methylsulfonamidobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Propionylaminobenzyf)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydropyridazιn-3-on, F. 126°;2- (3-propionylaminobenzyf) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazιn-3-one, mp 126 °;
2-(3-Butyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydropyridazin-3-on;2- (3-butyrylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(3-lsobutyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydropyridazin-3-on;2- (3-isobutyrylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Methoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydropyridazin-3-on;2- (3-methoxycarbonylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Pivalylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydropyridazin-3-on;2- (3-pivalylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Cyclopentylcarbamoylbenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydropyridazin-3-on;2- (3-cyclopentylcarbamoylbenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Ethoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2- (3-Ethoxycarbonylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydropyridazin-3-on, F. 54°;2,3,4,5-tetrahydropyridazin-3-one, mp 54 °;
2-(3-Methoxalylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2- (3-Methoxalylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-
2,3,4,5- tetrahydropyridazin-3-on;
2-(3-Ureidobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one; 2- (3-ureidobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Pentanoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2, 3,4,5- tetrahydropyridazin-3-on;2- (3-pentanoylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2, 3,4,5-tetrahydropyridazin-3-one;
2-(3-Hexanoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydropyridazin-3-on;2- (3-hexanoylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Pentafluorpropionylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on; 2-(4-Acetamidobenzyl)-6-(3-fluormethoxy-4-methoxyphenyl)-5-ethyl-2- (3-pentafluoropropionylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-Acetamidobenzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Trifluoracetamidobenzyl)-6-(3-fluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on; 2-(4-Methylsulfonamidobenzyl)-6-(3-fluormethoxy-4-methoxyphenyl)-2- (4-trifluoroacetamidobenzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-Methylsulfonamidobenzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -
5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Propionylaminobenzyl)-6-(3-fluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-propionylaminobenzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Butyrylaminobenzyl)-6-(3-fluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-butyrylaminobenzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-lsobutyrylaminobenzyl)-6-(3-fluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-isobutyrylaminobenzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxycarbonylaminobenzyl)-6-(3-fluormethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyhdazin-3-on;2- (4-methoxycarbonylaminobenzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyhdazin-3-one;
2-(4-Pivalylaminobenzyl)-6-(3-fluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-pivalylaminobenzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Cyclopentylcarbamoylbenzyl)-6-(3-fluormethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-cyclopentylcarbamoylbenzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ethoxycarbonylaminobenzyl)-6-(3-fluormethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-ethoxycarbonylaminobenzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxalylaminobenzyl)-6-(3-fluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-methoxalylaminobenzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ureidobenzyl)-6-(3-fluormethoxy-4-methoxyphenyl)-5-ethyl- 2,3,4,5- tetrahydropyridazin-3-on;
2-(4-Pentanoylaminobenzyl)-6-(3-fluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-ureidobenzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-pentanoylaminobenzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Hexanoylaminobenzyl)-6-(3-fluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-hexanoylaminobenzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentafluorpropionylaminobenzyl)-6-(3-fluormethoxy-4-methoxy- pheny.)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-Pentafluoropropionylaminobenzyl) -6- (3-fluoromethoxy-4-methoxypheny.) - 5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-AcetamidobenzyI)-6-(3-difluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on; 2-(4-Trifluoracetamidobenzyl)-6-(3-difluormethoxy-4-methoxyphenyl)-2- (4-AcetamidobenzyI) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-Trifluoracetamidobenzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -
5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methylsulfonamidobenzyl)-6-(3-difluormethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on; 2-(4-Propionylaminobenzyl)-6-(3-difluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-methylsulfonamidobenzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-propionylaminobenzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Butyrylaminobenzyl)-6-(3-difluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-butyrylaminobenzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-lsobutyrylaminobenzyl)-6-(3-difluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-isobutyrylaminobenzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxycarbonylaminobenzyl)-6-(3-difluormethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-methoxycarbonylaminobenzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pivalylaminobenzyl)-6-(3-difluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-pivalylaminobenzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Cyclopentylcarbamoylbenzyl)-6-(3-difluormethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-cyclopentylcarbamoylbenzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ethoxycarbonylaminobenzyl)-6-(3-difluormethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-ethoxycarbonylaminobenzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxalylaminobenzyl)-6-(3-difluormethoxy-4-methoxyphenyl)- 5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-methoxalylaminobenzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ureidobenzyl)-6-(3-difluormethoxy-4-methoxyphenyl)-5-ethyl- 2,3,4,5- tetrahydropyridazin-3-on;2- (4-ureidobenzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentanoylaminobenzyl)-6-(3-difluormethoxy-4-methoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydroρyridazin-3-on;
2-(4-Hexanoylaminobenzyl)-6-(3-difluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-pentanoylaminobenzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-hexanoylaminobenzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentafluorpropionylaminobenzyl)-6-(3-difluormethoxy-4- methoxy-phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-pentafluoropropionylaminobenzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Acetamidobenzyl)-6-(3-trifluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-acetamidobenzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-T fluoracetamidobenzyl)-6-(3-trifluormethoxy-4-methoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydropyridazin-3-on; 2-(4-Methylsulfonamidobenzyl)-6-(3-trifluormethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-T fluoroacetamidobenzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-methylsulfonamidobenzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Propionylaminobenzyl)-6-(3-trifluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on; 2-(4-Butyrylaminobenzyl)-6-(3-trifluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-propionylaminobenzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-butyrylaminobenzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-lsobutyrylaminobenzyl)-6-(3-trifluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-isobutyrylaminobenzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxycarbonylaminobenzyl)-6-(3-trifluormethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-methoxycarbonylaminobenzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pivalylaminobenzyl)-6-(3-t fluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-pivalylaminobenzyl) -6- (3-t fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Cyclopentylcarbamoylbenzyl)-6-(3-trifluormethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-cyclopentylcarbamoylbenzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ethoxycarbonylaminobenzyl)-6-(3-trifluormethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-ethoxycarbonylaminobenzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxalylaminobenzyl)-6-(3-trifluormethoxy-4-methoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-methoxalylaminobenzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ureidobenzyl)-6-(3-trifluormethoxy-4-methoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydropyridazin-3-on;2- (4-ureidobenzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentanoylaminobenzyl)-6-(3-trifluormethoxy-4-methoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-pentanoylaminobenzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-HexanoyIaminobenzyl)-6-(3-trifluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;
2-(4-Pentafluorpropionylaminobenzyl)-6-(3-trifluormethoxy-4- methoxy-phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on.2- (4-hexanoyaminobenzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-Pentafluoropropionylaminobenzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one.
2-(4-Acetamidobenzyl)-6-(3-methoxy-4-fluormethoxyphenyl)-5-ethyl-2- (4-Acetamidobenzyl) -6- (3-methoxy-4-fluormethoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Trifluoracetamidobenzyl)-6-(3-methoxy-4-fluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-trifluoroacetamidobenzyl) -6- (3-methoxy-4-fluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methylsulfonamidobenzyl)-6-(3-methoxy-4-fluormethoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydropyridazin-3-on; 2-(4-Propionylaminobenzyl)-6-(3-methoxy-4-fluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-methylsulfonamidobenzyl) -6- (3-methoxy-4-fluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-propionylaminobenzyl) -6- (3-methoxy-4-fluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Butyrylaminobenzyl)-6-(3-methoxy-4-fluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on; 2-(4-lsobutyrylaminobenzyl)-6-(3-methoxy-4-fluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-butyrylaminobenzyl) -6- (3-methoxy-4-fluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-isobutyrylaminobenzyl) -6- (3-methoxy-4-fluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxycarbonylaminobenzyl)-6-(3-methoxy-4-fluormethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-methoxycarbonylaminobenzyl) -6- (3-methoxy-4-fluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pivalylaminobenzyl)-6-(3-methoxy-4-fluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-pivalylaminobenzyl) -6- (3-methoxy-4-fluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Cyclopentylcarbamoylbenzyl)-6-(3-methoxy-4-fluormethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-cyclopentylcarbamoylbenzyl) -6- (3-methoxy-4-fluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ethoxycarbonylaminobenzyl)-6-(3-methoxy-4-fluormethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-ethoxycarbonylaminobenzyl) -6- (3-methoxy-4-fluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxalylaminobenzyl)-6-(3-methoxy-4-fluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-methoxalylaminobenzyl) -6- (3-methoxy-4-fluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ureidobenzyl)-6-(3-methoxy-4-fluormethoxyphenyl)-5-ethyl- 2,3,4,5- tetrahydropyridazin-3-on;2- (4-ureidobenzyl) -6- (3-methoxy-4-fluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentanoylaminobenzyl)-6-(3-methoxy-4-fluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-pentanoylaminobenzyl) -6- (3-methoxy-4-fluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Hexanoylaminobenzyl)-6-(3-methoxy-4-fluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-hexanoylaminobenzyl) -6- (3-methoxy-4-fluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentafluorpropionylaminobenzyl)-6-(3-methoxy-4-fluormethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;
2-(4-Acetamidobenzyl)-6-(3-methoxy-4-difluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-pentafluoropropionylaminobenzyl) -6- (3-methoxy-4-fluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-acetamidobenzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Trifluoracetamidobenzyl)-6-(3-methoxy-4-difluormethoxyphenyl)-2- (4-Trifluoracetamidobenzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -
5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methylsulfonamidobenzyl)-6-(3-methoxy-4-difluormethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-methylsulfonamidobenzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Propionylaminobenzyl)-6-(3-methoxy-4-difluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on; 2-(4-Butyrylaminobenzyl)-6-(3-methoxy-4-difluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-propionylaminobenzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-butyrylaminobenzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-lsobutyrylaminobenzyl)-6-(3-methoxy-4-difluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on; 2-(4-Methoxycarbonylaminobenzyl)-6-(3-methoxy-4-difluormethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-isobutyrylaminobenzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-methoxycarbonylaminobenzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pivalylaminobenzyl)-6-(3-methoxy-4-difluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-pivalylaminobenzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Cyclopentylcarbamoylbenzyl)-6-(3-methoxy-4-difluormethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-cyclopentylcarbamoylbenzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ethoxycarbonylaminobenzyl)-6-(3-methoxy-4-difluormethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-ethoxycarbonylaminobenzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxalylaminobenzyl)-6-(3-methoxy-4-difluormethoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-methoxalylaminobenzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ureidobenzyl)-6-(3-methoxy-4-difluormethoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydropyridazin-3-on;2- (4-ureidobenzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentanoylaminobenzyl)-6-(3-methoxy-4-difluormethoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-pentanoylaminobenzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Hexanoylaminobenzyl)-6-(3-methoxy-4-difluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-hexanoylaminobenzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentafluorpropionylaminobenzyl)-6-(3-methoxy-4- difluormethoxy-phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-pentafluoropropionylaminobenzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Acetamidobenzyl)-6-(3-methoxy-4-trifluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;
2-(4-Trifluoracetamidobenzyl)-6-(3-methoxy-4-trifluormethoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-acetamidobenzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-trifluoroacetamidobenzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methylsulfonamidobenzyl)-6-(3-methoxy-4-trifluormethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-methylsulfonamidobenzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Propionylaminobenzyl)-6-(3-methoxy-4-trifluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-propionylaminobenzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Butyrylaminobenzyl)-6-(3-methoxy-4-trifluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on; 2-(4-lsobutyrylaminobenzyl)-6-(3-methoxy-4-trifluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-butyrylaminobenzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-isobutyrylaminobenzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxycarbonylaminobenzyl)-6-(3-methoxy-4-trifluormethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on; 2-(4-Pivalylaminobenzyl)-6-(3-methoxy-4-trifluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-methoxycarbonylaminobenzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4-pivalylaminobenzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Cyclopentylcarbamoylbenzyl)-6-(3-methoxy-4-trifluormethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-cyclopentylcarbamoylbenzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ethoxycarbonylaminobenzyl)-6-(3-methoxy-4-trifluormethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-ethoxycarbonylaminobenzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxalylaminobenzyl)-6-(3-methoxy-4-trifluormethoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-methoxalylaminobenzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ureidobenzyl)-6-(3-methoxy-4-trifluormethoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydropyridazin-3-on;2- (4-ureidobenzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentanoylaminobenzyl)-6-(3-methoxy-4-trifluormethoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-pentanoylaminobenzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Hexanoylaminobenzyl)-6-(3-methoxy-4-trifluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-hexanoylaminobenzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentafluorpropionylaminobenzyl)-6-(3-methoxy-4- trifluormethoxy-phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (4-pentafluoropropionylaminobenzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Acetamidobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2, 3,4,5- tetrahydropyridazin-3-on, F. 170°;2- (4-acetamidobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -2, 3,4,5-tetrahydropyridazin-3-one, mp 170 °;
2-(4-Trifluoracetamidobenzyl)-6-(3-ethoxy-4-methoxyρhenyl)-2,3,4,5- tetrahyd ropyridazin-3-on ;
2-(4-Methylsulfonamidobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2- (4-trifluoroacetamidobenzyl) -6- (3-ethoxy-4-methoxyρhenyl) -2,3,4,5-tetrahydropyridazin-3-one; 2- (4-Methylsulfonamidobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -
2,3,4,5- tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Propionylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;2- (4-propionylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Buty rylaminobenzyl)-6-(3-ethoxy-4-methoxyρhenyl)-2, 3,4,5- tetrahydropyridazin-3-on;2- (4-butylaminobenzyl) -6- (3-ethoxy-4-methoxyρhenyl) -2, 3,4,5-tetrahydropyridazin-3-one;
2-(4-lsobutyrylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2, 3,4,5- tetrahydropyridazin-3-on; 2-(4-Methoxycarbonylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2- (4-isobutyrylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -2, 3,4,5-tetrahydropyridazin-3-one; 2- (4-Methoxycarbonylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -
2,3,4,5-tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pivalylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on; 2-(4-Cyclopentylcarbamoylbenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2- (4-pivalylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one; 2- (4-Cyclopentylcarbamoylbenzyl) -6- (3-ethoxy-4-methoxyphenyl) -
2,3,4,5-tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ethoxycarbonylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)- 2,3,4,5-tetrahydropyridazin-3-on, F. 128°;2- (4-ethoxycarbonylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) - 2,3,4,5-tetrahydropyridazin-3-one, mp 128 °;
2-(4-Methoxalylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;2- (4-methoxalylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ureidobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;2- (4-ureidobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentanoylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2, 3,4,5- tetrahydropyridazin-3-on;2- (4-pentanoylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -2, 3,4,5-tetrahydropyridazin-3-one;
2-(4-Hexanoylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2, 3,4,5- tetrahydropyridazin-3-on;2- (4-hexanoylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -2, 3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentafluorpropionylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)- 2,3,4,5-tetrahydropyridazin-3-on;2- (4-pentafluoropropionylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Acetamidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)- 2,3,4,5- tetrahydropyridazin-3-on;2- (4-acetamidobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) - 2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Trifluoracetamidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2- (4-Trifluoracetamidobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -
2,3,4,5-tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methylsulfonamidobenzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-2,3,4,5-tetrahydropyridazin-3-on;
2-(4-Propionylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)- 2,3,4,5-tetrahydropyridazin-3-on;2- (4-methylsulfonamidobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one; 2- (4-propionylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) - 2,3,4,5-tetrahydropyridazin-3-one;
2-(4-tert.-Butylcarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-2,3,4,5-tetrahydropyridazin-3-on;2- (4-tert-butylcarbonylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Butyrylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2- (4-Butyrylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -
2,3,4,5-tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-lsobutyrylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)- 2,3,4,5-tetrahydropyridazin-3-on; 2-(4-Methoxycarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-2,3,4,5-tetrahydropyridazin-3-on;2- (4-isobutyrylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) - 2,3,4,5-tetrahydropyridazin-3-one; 2- (4-methoxycarbonylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-P.valylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxypheny.)- 2,3,4,5-tetrahydropyridazin-3-on; 2-(4-Cyclopentylcarbamoylbenzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-2,3,4,5-tetrahydropyridazin-3-on;2- (4-P.valylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxypheny.) - 2,3,4,5-tetrahydropyridazin-3-one; 2- (4-cyclopentylcarbamoylbenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ethoxycarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-2,3,4,5-tetrahydropyridazin-3-on;2- (4-ethoxycarbonylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxalylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2- (4-Methoxalylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -
2,3,4,5-tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Ureidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2, 3,4,5- tetrahydropyridazin-3-on;2- (4-ureidobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -2, 3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentanoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)- 2,3,4,5-tetrahydropyridazin-3-on;2- (4-pentanoylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) - 2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Hexanoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2- (4-Hexanoylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -
2,3,4,5-tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentafluorpropionylaminobenzyl)-6-(3-cyclopentyloxy-4- methoxy-phenyl)-2,3,4,5-tetrahydropyridazin-3-on;2- (4-pentafluoropropionylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Acetamidophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;2- (4-acetamidophenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Trifluoracetamidophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;2- (4-trifluoroacetamidophenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methylsulfonamidophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;
2-(4-Propionylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;2- (4-methylsulfonamidophenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one; 2- (4-propionylaminophenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Butyrylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;2- (4-butyrylaminophenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-lsobutyrylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2, 3,4,5- tetrahydropyridazin-3-on;2- (4-isobutyrylaminophenethyl) -6- (3,4-dimethoxyphenyl) -2, 3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxycarbonylaminophenethyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydropyridazin-3-on; 2-(4-Pivalylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2, 3,4,5- tetrahydropyridazin-3-on;2- (4-methoxycarbonylaminophenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one; 2- (4-pivalylaminophenethyl) -6- (3,4-dimethoxyphenyl) -2, 3,4,5-tetrahydropyridazin-3-one;
2-(4-Cyclopentylcarbamoylphenethyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5- tetrahydropyridazin-3-on; 2-(4-Ethoxycarbonylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2- (4-cyclopentylcarbamoylphenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one; 2- (4-Ethoxycarbonylaminophenethyl) -6- (3,4-dimethoxyphenyl) -
2,3,4,5- tetrahydropyridazin-3-on;2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Methoxalylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2, 3,4,5- tetrahydropyridazin-3-on;2- (4-methoxalylaminophenethyl) -6- (3,4-dimethoxyphenyl) -2, 3,4,5-tetrahydropyridazin-3-one;
2-(4-Ureidophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;2- (4-ureidophenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentanoylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;2- (4-pentanoylaminophenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Hexanoylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;2- (4-hexanoylaminophenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Pentafluorpropionylaminophenethyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydropyridazin-3-on;2- (4-pentafluoropropionylaminophenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Acetamidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on, F. 105°;2- (3-acetamidobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one, mp 105 °;
2-(3-Trifluoracetamidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on, F. 136°;2- (3-trifluoroacetamidobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one, mp 136 °;
2-(3-Methylsulfonamidobenzyl)-6-(3,4-dimethoxyphenyl)-2, 3,4,5- tetrahydropyhdazin-3-on, F. 177°;2- (3-methylsulfonamidobenzyl) -6- (3,4-dimethoxyphenyl) -2, 3,4,5-tetrahydropyhdazin-3-one, mp 177 °;
2-(3-Propionylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on, F. 152°;
2-(3-tert.-Butylcarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5- tetrahydropyridazin-3-on;2- (3-propionylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one, mp 152 °; 2- (3-tert-butylcarbonylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Butyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2, 3,4,5- tetrahydropyridazin-3-on;2- (3-butyrylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2, 3,4,5-tetrahydropyridazin-3-one;
2-(3-lsobutyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2, 3,4,5- tetrahydropyridazin-3-on;2- (3-isobutyrylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2, 3,4,5-tetrahydropyridazin-3-one;
2-(3-Methoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2, 3,4,5- tetrahydropyridazin-3-on; 2-(3-Pivalylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;2- (3-methoxycarbonylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2, 3,4,5-tetrahydropyridazin-3-one; 2- (3-pivalylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Cyclopentylcarbamoylbenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on; 2-(3-Ethoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on, F. 179°;2- (3-cyclopentylcarbamoylbenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one; 2- (3-ethoxycarbonylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one, mp 179 °;
2-(3-Methoxalylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;2- (3-methoxalylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Ureidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;2- (3-ureidobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Pentanoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on;2- (3-pentanoylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Hexanoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2, 3,4,5- tetrahydropyridazin-3-on;2- (3-hexanoylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2, 3,4,5-tetrahydropyridazin-3-one;
2-(3-Pentafluorpropionylaminobenzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5- tetrahydropyridazin-3-on;2- (3-pentafluoropropionylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Acetamidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydropyridazin-3-on;2- (3-acetamidobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Thfluoracetamidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydropyridazin-3-on, F. 70°;2- (3-thfluoroacetamidobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) - 5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, mp 70 °;
2-(3-Methylsulfonamidobenzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (3-methylsulfonamidobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Propionylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on, F. 113°;
2-(3-tert.-Butylcarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (3-propionylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, mp 113 °; 2- (3-tert-butylcarbonylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Butyrylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (3-butyrylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(3-lsobutyrylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (3-isobutyrylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Methoxycarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on; 2-(3-Pivalylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (3-methoxycarbonylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (3-pivalylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Cyclopentylcarbamoylbenzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on; 2-(3-Ethoxycarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on, F. 153°;2- (3-cyclopentylcarbamoylbenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (3-ethoxycarbonylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, mp 153 °;
2-(3-Methoxalylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (3-methoxalylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Ureidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydropyridazin-3-on;2- (3-ureidobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Pentanoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (3-pentanoylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Hexanoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (3-hexanoylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(3-Pentafluorpropionylaminobenzyl)-6-(3-cyclopentyloxy-4- methoxy-phenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-on;2- (3-pentafluoropropionylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Nitrobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on, F. 126°;2- (4-nitrobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one, mp 126 °;
2-(4-Nitrophenyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on;2- (4-nitrophenyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
b) Verbindungen, offenbart in EP 0 763 534, ausgewählt aus derb) compounds disclosed in EP 0 763 534 selected from the
Gruppe
2-(4-Nicotinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydro-pyridazin-3-on;group 2- (4-nicotinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-Nicotinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydro-pyridazin-3-on;2- (3-nicotinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-Nicotinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydro-pyridazin-3-on;2- (2-nicotinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Nicotinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2, 3,4,5- tetrahydro-pyridazin-3-on; 2-(3-Nicotinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydro-pyridazin-3-on;2- (4-nicotinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2, 3,4,5-tetrahydro-pyridazin-3-one; 2- (3-nicotinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-Nicotinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2, 3,4,5- tetrahyd ro-pyridazin-3-on ; 2-(4-Nicotinoylamino-benzyl)-6-(3-methoxy-4-trifluormethoxyphenyl)-2- (2-nicotinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2, 3,4,5-tetrahydro-pyridazin-3-one; 2- (4-nicotinoylamino-benzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -
5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Nicotinoylamino-benzyl)-6-(3-methoxy-4-difluormethoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-nicotinoylamino-benzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Nicotinoylaino-benzyl)-6-(3-methoxy-4-fluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-nicotinoylaino-benzyl) -6- (3-methoxy-4-fluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Nicotinoylamino-benzyl)-6-(3-difluormethoxy-4-methoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-nicotinoylamino-benzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Nicotinoylamino-benzyl)-6-(3-trifluormethoxy-4-methoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-nicotinoylamino-benzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Nicotinoylamino-benzyl)-6-(3-fluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-nicotinoylamino-benzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Nicotinoylamino-benzyl)-6-(3-methoxy-4-ethoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-nicotinoylamino-benzyl) -6- (3-methoxy-4-ethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Nicotinoylamino-benzyl)-6-(3-Ethoxy-4-methoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-nicotinoylamino-benzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Nicotinoylamino-benzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-nicotinoylamino-benzyl) -6- (3-hydroxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Nicotinoylamino-benzyl)-6-(4-methylsulfonylphenyl)-5-ethyl- 2,3,4,5-tetrahydro-pyridazin-3-on;
2-(4-Nicotinoylamino-benzyl)-6-(4-methylenoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-nicotinoylamino-benzyl) -6- (4-methylsulfonylphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4-nicotinoylamino-benzyl) -6- (4-methyleneoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Nicotinoylamino-benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2- (4-nicotinoylamino-benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -
5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-Nicotinoylamino-benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2- (3-nicotinoylamino-benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -
5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Nicotinoylamino-phenethyl)-6-(3,4-dimethoxyphenyl)-2, 3,4,5- tetra-hydro-pyridazin-3-on; 2-(4-Nicotinoylamino-phenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2- (4-nicotinoylamino-phenethyl) -6- (3,4-dimethoxyphenyl) -2, 3,4,5-tetra-hydro-pyridazin-3-one; 2- (4-nicotinoylamino-phenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydro-pyridazin-3-on;2,3,4,5-tetrahydro-pyridazin-3-one;
3-(4-Nicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro- 1 ,3,4-thiadiazin-2-on; 3-(3-Nicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-3- (4-nicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (3-nicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-
1 ,3,4-thiadiazin-2-on;1, 3,4-thiadiazin-2-one;
3-(2-Nicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro- 1 ,3,4-thiadiazin-2-on;3- (2-nicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (4-nicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(3-Nicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (3-nicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(2-Nicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (2-nicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3-methoxy-4-trifluormethoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on3- (4-Nicotinoylamino-benzyl) -5- (3-methoxy-4-trifluoromethoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one
3-(4-Nicotinoylamino-benzyl)-5-(3-methoxy-4-difluormethoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on3- (4-Nicotinoylamino-benzyl) -5- (3-methoxy-4-difluoromethoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one
3-(4-Nicotinoylamino-benzyl)-5-(3-methoxy-4-fluormethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-nicotinoylamino-benzyl) -5- (3-methoxy-4-fluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3-difluormethoxy-4-methoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-nicotinoylamino-benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3-trifluormethoxy-4-methoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;
3-(4-Nicotinoylamino-benzyl)-5-(3-fluormethoxy-4-methoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-nicotinoylamino-benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4-nicotinoylamino-benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3- (4-nicotinoylamino-benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-
3,6-dihydro-1 ,3,4-thiadiazin-2-on;3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3- (4-nicotinoylamino-benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-
3,6-dihydro-1 ,3,4-thiadiazin-2-on;3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-Nicotinoylamino-benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (4-nicotinoylamino-benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4-nicotinoylamino-benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(4-methylenoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-Nicotinoylamino-benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-3- (4-nicotinoylamino-benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4-nicotinoylamino-benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(3-Nicotinoylamino-benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (3-nicotinoylamino-benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Nicotinoylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (4-nicotinoylamino-phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Nicotinoylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (4-nicotinoylamino-phenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro- 1 ,3,4-oxadiazin-2-on;3- (4-nicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-Nicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro- 1 ,3,4-oxadiazin-2-on;3- (3-nicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-Nicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro- 1 ,3,4-oxadiazin-2-on;3- (2-nicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4-nicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-Nicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (3-nicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-Nicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-oxadiazin-2-on;
3-(4-Nicotinoylamino-benzyl)-5-(3-methoxy-4-trifluormethoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (2-nicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4-nicotinoylamino-benzyl) -5- (3-methoxy-4-trifluoromethoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3-methoxy-4-difluormethoxyphenyl)-3- (4-nicotinoylamino-benzyl) -5- (3-methoxy-4-difluoromethoxyphenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3-methoxy-4-fluormethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-nicotinoylamino-benzyl) -5- (3-methoxy-4-fluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3-difluormethoxy-4-methoxyphenyl)- 6ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-Nicotinoylamino-benzyl)-5-(3-trifluormethoxy-4-methoxyphenyl)-3- (4-nicotinoylamino-benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) - 6ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4-nicotinoylamino-benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3-fluormethoxy-4-methoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-Nicotinoylamino-benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3- (4-nicotinoylamino-benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4-nicotinoylamino-benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-
3,6-dihydro-1 ,3,4-oxadiazin-2-on;3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-nicotinoylamino-benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-nicotinoylamino-benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4-nicotinoylamino-benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(4-methylenoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4-nicotinoylamino-benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-nicotinoylamino-benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-Nicotinoylamino-benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (3-nicotinoylamino-benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Nicotinoylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4-nicotinoylamino-phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Nicotinoylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4-nicotinoylamino-phenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
2-(4-lsonicotinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydro-pyridazin-3-on;
2-(3-lsonicotinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydro-pyridazin-3-on;2- (4-isonicotinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one; 2- (3-isonicotinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-lsonicotinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydro-pyridazin-3-on;2- (2-isonicotinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-lsonicotinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2- (4-lsonicotinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydro-pyridazin-3-on;2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-lsonicotinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl- 2,3,4, 5-tetrahydro-pyridazin-3-on; 2-(2-lsonicotinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2- (3-isonicotinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (2-lsonicotinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydro-pyridazin-3-on;2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-lsonicotinoylamino-benzyl)-6-(3-methoxy-4-t fluor- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-lsonicotinoylamino-benzyl)-6-(3-methoxy-4-difluor- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-isonicotinoylamino-benzyl) -6- (3-methoxy-4-t fluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4-isonicotinoylamino-benzyl) -6- (3-methoxy-4-difluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-lsonicotinoylamino-benzyl)-6-(3-methoxy-4-fluormethoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-isonicotinoylamino-benzyl) -6- (3-methoxy-4-fluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-lsonicotinoylamino-benzyl)-6-(3-difluormethoxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-isonicotinoylamino-benzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-lsonicotinoylamino-benzyl)-6-(3-t fluormethoxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-isonicotinoylamino-benzyl) -6- (3-t fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-lsonicotinoylamino-benzyl)-6-(3-fluormethoxy-4-methoxyphenyl)- 5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-isonicotinoylamino-benzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-lsonicotinoylamino-benzyl)-6-(3-Methoxy-4-ethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-isonicotinoylamino-benzyl) -6- (3-methoxy-4-ethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-lsonicotinoylamino-benzyl)-6-(3-ethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-isonicotinoylamino-benzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-lsonicotinoylamino-benzyl)-6-(3-hydroxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-isonicotinoylamino-benzyl) -6- (3-hydroxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-lsonicotinoylamino-benzyl)-6-(4-methylsulfonylphenyl)-5-ethyl- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-isonicotinoylamino-benzyl) -6- (4-methylsulfonylphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-lsonicotinoylamino-benzyl)-6-(4-methylenoxyphenyl)-5-ethyl- 2,3,4, 5-tetrahydro-pyhdazin-3-on;
2-(4-lsonicotinoylamino-benzyl)-6-(3-cyclopentyloxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-isonicotinoylamino-benzyl) -6- (4-methyleneoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyhdazin-3-one; 2- (4-isonicotinoylamino-benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-lsonicotinoylamino-benzyl)-6-(3-cyclopentyloxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (3-isonicotinoylamino-benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-lsonicotinoylamino-phenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydro-pyridazin-3-on;2- (4-isonicotinoylamino-phenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-lsonicotinoylamino-phenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydro-pyridazin-3-on; 3-(4-lsonicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-2- (4-isonicotinoylamino-phenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 3- (4-lsonicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-
1 ,3,4-thiadiazin-2-on;1, 3,4-thiadiazin-2-one;
3-(3-lsonicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro- 1 ,3,4-thiadiazin-2-on; 3-(2-lsonicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-3- (3-isonicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (2-lsonicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-
1 ,3,4-thiadiazin-2-on;1, 3,4-thiadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (4-isonicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(3-lsonicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (3-isonicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(2-lsonicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (2-isonicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(3-methoxy-4-trifluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-isonicotinoylamino-benzyl) -5- (3-methoxy-4-trifluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(3-methoxy-4-difluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-isonicotinoylamino-benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(3-methoxy-4-fluormethoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-isonicotinoylamino-benzyl) -5- (3-methoxy-4-fluoromethoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(3-difluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-isonicotinoylamino-benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(3-trifluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-isonicotinoylamino-benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3-fluormethoxy-4-methoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;
3-(4-lsonicotinoylamino-benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-nicotinoylamino-benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4-isonicotinoylamino-benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-isonicotinoylamino-benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-isonicotinoylamino-benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-lsonicotinoylamino-benzyl)-5-(4-methylenoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (4-isonicotinoylamino-benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4-isonicotinoylamino-benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(3-cyclopentyloxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(3-lsonicotinoylamino-benzyl)-5-(3-cyclopentyioxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-isonicotinoylamino-benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (3-isonicotinoylamino-benzyl) -5- (3-cyclopentyioxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-lsonicotinoylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (4-isonicotinoylamino-phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-lsonicotinoylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-isonicotinoylamino-phenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro- 1 ,3,4-oxadiazin-2-on;3- (4-isonicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1,3,4-oxadiazin-2-one;
3-(3-lsonicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro- 1 ,3,4-oxadiazin-2-on;3- (3-isonicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-lsonicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro- 1 ,3,4-oxadiazin-2-on;3- (2-isonicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1,3,4-oxadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4-isonicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-lsonicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (3-isonicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-lsonicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (2-isonicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(3-methoxy-4-trifluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;
3-(4-lsonicotinoylamino-benzyl)-5-(3-methoxy-4-difluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-isonicotinoylamino-benzyl) -5- (3-methoxy-4-trifluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4-isonicotinoylamino-benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(3-methoxy-4-fluormethoxyphenyl)-3- (4-lsonicotinoylamino-benzyl) -5- (3-methoxy-4-fluormethoxyphenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(3-difluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-isonicotinoylamino-benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(3-trifluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-lsonicotinoylamino-benzyl)-5-(3-fluormethoxy-4-methoxyphenyl)-3- (4-isonicotinoylamino-benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4-lsonicotinoylamino-benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-lsonicotinoylamino-benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-isonicotinoylamino-benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4-isonicotinoylamino-benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-isonicotinoylamino-benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-isonicotinoylamino-benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(4-methylenoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4-isonicotinoylamino-benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(3-cyclopentyloxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-isonicotinoylamino-benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-lsonicotinoylamino-benzyl)-5-(3-cyclopentyloxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (3-isonicotinoylamino-benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-lsonicotinoylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4-isonicotinoylamino-phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-lsonicotinoylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-isonicotinoylamino-phenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
2-(4-Picolinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydro-pyridazin-3-on;2- (4-picolinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-Picolinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydro-pyridazin-3-on;
2-(2-Picolinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydro-pyridazin-3-on;2- (3-picolinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one; 2- (2-picolinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Picolinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydro-pyridazin-3-on;2- (4-picolinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-Picolinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2, 3,4,5- tetrahydro-pyridazin-3-on;2- (3-picolinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2, 3,4,5-tetrahydro-pyridazin-3-one;
2-(2-Picolinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydro-pyridazin-3-on; 2-(4-Picolinoylamino-benzyl)-6-(3-methoxy-4-trifluormethoxyphenyl)-2- (2-picolinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4-Picolinoylamino-benzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -
5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Picolinoylamino-benzyl)-6-(3-methoxy-4-difluormethoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-Picolinoylamino-benzyl)-6-(3-methoxy-4-fluormethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-picolinoylamino-benzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4-picolinoylamino-benzyl) -6- (3-methoxy-4-fluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Picolinoylamino-benzyl)-6-(3-difluormethoxy-4-methoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-picolinoylamino-benzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Picolinoylamino-benzyl)-6-(3-thfluormethoxy-4-methoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-picolinoylamino-benzyl) -6- (3-thfluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Picolinoylamino-benzyl)-6-(3-fluormethoxy-4-methoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-picolinoylamino-benzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Picolinoylamino-benzyl)-6-(3-methoxy-4-ethoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-picolinoylamino-benzyl) -6- (3-methoxy-4-ethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Picolinoylamino-benzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-picolinoylamino-benzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Picolinoylamino-benzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-picolinoylamino-benzyl) -6- (3-hydroxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Picolinoylamino-benzyl)-6-(4-methylsulfonylphenyl)-5-ethyl- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-picolinoylamino-benzyl) -6- (4-methylsulfonylphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Picolinoylamino-benzyl)-6-(4-methylenoxyphenyl)-5-ethyl- 2,3,4,5- tetrahydro-pyridazin-3-on;2- (4-picolinoylamino-benzyl) -6- (4-methyleneoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Picolinoylamino-benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;
2-(3-Picolinoylamino-benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-picolinoylamino-benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (3-picolinoylamino-benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Picolinoylamino-phenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydro-pyridazin-3-on;2- (4-picolinoylamino-phenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Picolinoylamino-phenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2- (4-Picolinoylamino-phenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydro-pyridazin-3-on;2,3,4,5-tetrahydro-pyridazin-3-one;
3-(4-Picolinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro- 1 ,3,4-thiadiazin-2-on; 3-(3-Picolinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-3- (4-Picolinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (3-Picolinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-
1 ,3,4-thiadiazin-2-on;1, 3,4-thiadiazin-2-one;
3-(2-Picolinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro- 1 ,3,4-thiadiazin-2-on; 3-(4-Picolinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (2-Picolinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4-picolinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(3-Picolinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (3-picolinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(2-Picolinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (2-picolinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(3-methoxy-4-thfluormethoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-picolinoylamino-benzyl) -5- (3-methoxy-4-thfluoromethoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(3-methoxy-4-difluormethoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-picolinoylamino-benzyl) -5- (3-methoxy-4-difluoromethoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(3-methoxy-4-fluormethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-picolinoylamino-benzyl) -5- (3-methoxy-4-fluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(3-difluormethoxy-4-methoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-picolinoylamino-benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(3-trifluormethoxy-4-methoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-picolinoylamino-benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(3-fluormethoxy-4-methoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-picolinoylamino-benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-thiadiazin-2-on;
3-(4-Picolinoylamino-benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3- (4-picolinoylamino-benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4-Picolinoylamino-benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-
3,6-dihydro-1 ,3,4-thiadiazin-2-on;3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3- (4-Picolinoylamino-benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-
3,6-dihydro-1 ,3,4-thiadiazin-2-on;3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (4-picolinoylamino-benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(4-methylenoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-Picolinoylamino-benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-3- (4-Picolinoylamino-benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4-Picolinoylamino-benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(3-Picolinoylamino-benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-Picolinoylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-3- (3-picolinoylamino-benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4-Picolinoylamino-phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-
1 ,3,4-thiadiazin-2-on;1, 3,4-thiadiazin-2-one;
3-(4-Picolinoylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (4-picolinoylamino-phenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro- 1 ,3,4-oxadiazin-2-on;3- (4-picolinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-Picolinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro- 1 ,3,4-oxadiazin-2-on;3- (3-picolinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-Picolinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro- 1 ,3,4-oxadiazin-2-on;3- (2-picolinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4-picolinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-Picolinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (3-picolinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-Picolinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (2-picolinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(3-methoxy-4-trifluormethoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-picolinoylamino-benzyl) -5- (3-methoxy-4-trifluoromethoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(3-methoxy-4-difluormethoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;
3-(4-Picolinoylamino-benzyl)-5-(3-methoxy-4-fluormethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-picolinoylamino-benzyl) -5- (3-methoxy-4-difluoromethoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4-picolinoylamino-benzyl) -5- (3-methoxy-4-fluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(3-difluormethoxy-4-methoxyphenyl)-3- (4-Picolinoylamino-benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(3-trifluormethoxy-4-methoxyphenyl)-3- (4-Picolinoylamino-benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(3-fluormethoxy-4-methoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-Picolinoylamino-benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3- (4-picolinoylamino-benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4-Picolinoylamino-benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-
3,6-dihydro-1 ,3,4-oxadiazin-2-on;3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-Picolinoylamino-benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3- (4-picolinoylamino-benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4-Picolinoylamino-benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-
3,6-dihydro-1 ,3,4-oxadiazin-2-on;3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4-picolinoylamino-benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(4-methylenoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4-Picolinoylamino-benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-picolinoylamino-benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-Picolinoylamino-benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (3-Picolinoylamino-benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Picolinoylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro- 1 ,3,4-oxadiazin-2-on;3- (4-picolinoylamino-phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Picolinoylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4-picolinoylamino-phenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
2-(4-(Furan-2-carbonylamino)-benzyl)-6-(3,4-dimethoxypheny_)- 2,3,4,5- tetrahydro-pyridazin-3-on;2- (4- (furan-2-carbonylamino) benzyl) -6- (3,4-dimethoxypheny _) - 2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(Furan-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5- tetrahydro-pyridazin-3-on;2- (3- (furan-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-(Furan-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5- tetrahydro-pyridazin-3-on;
2-(4-(Furan-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (2- (furan-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (furan-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(Furan-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (furan-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-(Furan-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (2- (furan-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Furan-2-carbonylamino)-benzyl)-6-(3-methoxy-4-trifluor- methoxy-phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-(Furan-2-carbonylamino)-benzyl)-6-(3-methoxy-4-difluor-- methoxy-phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (furan-2-carbonylamino) benzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3- one; 2- (4- (Furan-2-carbonylamino) benzyl) -6- (3-methoxy-4-difluoro - methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3 -one;
2-(4-(Furan-2-carbonylamino)-benzyl)-6-(3-methoxy-4-fluor-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-(Furan-2-carbonylamino)-benzyl)-6-(3-difluormethoxy-4- methoxy-phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (furan-2-carbonylamino) benzyl) -6- (3-methoxy-4-fluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3- one; 2- (4- (furan-2-carbonylamino) benzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Furan-2-carbonylamino)-benzyl)-6-(3-trifluormethoxy-4- methoxy-phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (furan-2-carbonylamino) benzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Furan-2-carbonylamino)-benzyl)-6-(3-Fluormethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (furan-2-carbonylamino) benzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Furan-2-carbonylamino)-benzyl)-6-(3-methoxy-4-ethoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (furan-2-carbonylamino) benzyl) -6- (3-methoxy-4-ethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Furan-2-carbonylamino)-benzyl)-6-(3-ethoxy-4-methoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (furan-2-carbonylamino) benzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Furan-2-carbonylamino)-benzyl)-6-(3-hydroxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (furan-2-carbonylamino) benzyl) -6- (3-hydroxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Furan-2-carbonylamino)-benzyl)-6-(4-methylsulfonylphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (furan-2-carbonylamino) benzyl) -6- (4-methylsulfonylphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Furan-2-carbonylamino)-benzyl)-6-(4-methylenoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (furan-2-carbonylamino) benzyl) -6- (4-methyleneoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Furan-2-carbonylamino)-benzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (furan-2-carbonylamino) benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(Furan-2-carbonylamino)-benzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;
2-(4-(Furan-2-carbonylamino)-phenethyl)-6-(3,4-dimethoxyphenyl)-2- (3- (furan-2-carbonylamino) benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (furan-2-carbonylamino) phenethyl) -6- (3,4-dimethoxyphenyl) -
2,3,4,5-tetrahydro-pyridazin-3-on;2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Furan-2-carbonylamino)-phenethyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (furan-2-carbonylamino) phenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(3-(Furan-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on; 3-(2-(Furan-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (3- (furan-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (2- (furan-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(3-(Furan-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (3- (furan-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(2-(Furan-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (2- (furan-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-methoxy-4-trifluor- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (3-methoxy-4-trifluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine 2-one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-methoxy-4-difluor- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (3-methoxy-4-difluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine 2-one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-methoxy-4-fluor-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine 2-one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-difluormethoxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (furan-2-carbonylamino) -benzyl) -5- (3-difluoromethoxy-4-methoxy-phenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-trifluormethoxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Furan-2-carbonylamino) -benzyl) -5- (3-trifluoromethoxy-4-methoxy-phenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-fluormethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-methoxy-4-ethoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (3-methoxy-4-ethoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-ethoxy-4-methoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-hydroxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (3-ethoxy-4-methoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4- (furan-2-carbonylamino) benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(4-methylsulfonylphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(4-methylenoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(3-(Furan-2-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one; 3- (3- (furan-2-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Furan-2-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)- 3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(Furan-2-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (furan-2-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1,3,4-thiadiazin-2-one; 3- (4- (furan-2-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-(Furan-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (3- (furan-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-(Furan-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (2- (furan-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-(Furan-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (3- (furan-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-(Furan-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (2- (furan-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-methoxy-4-trifluor- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (3-methoxy-4-trifluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine 2-one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-methoxy-4-difluor- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine 2-one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-methoxy-4-fluor-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-difluormethoxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine 2-one; 3- (4- (furan-2-carbonylamino) benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-trifluormethoxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-fluormethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-methoxy-4-ethoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-ethoxy-4-methoxyphenyl)-3- (4- (furan-2-carbonylamino) benzyl) -5- (3-methoxy-4-ethoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4- (furan-2-carbonylamino) benzyl) -5- (3-ethoxy-4-methoxyphenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-hydroxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-(Furan-2-carbonylamino)-benzyl)-5-(4-methylsulfonylphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4- (furan-2-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(4-methylenoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Furan-2-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (furan-2-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-(Furan-2-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (3- (furan-2-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Furan-2-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)- 3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (furan-2-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1,3,4-oxadiazin-2-one;
3-(4-(Furan-2-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (furan-2-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
2-(4-(Pyrrol-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrrole-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(Pyrrol-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5- tetrahydro-pyridazin-3-on;2- (3- (pyrrole-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-(Pyrrol-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5- tetrahydro-pyridazin-3-on;2- (2- (pyrrole-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrrol-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;
2-(3-(Pyrrol-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrrole-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (3- (pyrrole-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-(Pyrrol-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (2- (pyrrole-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrrol-2-carbonylamino)-benzyl)-6-(3-methoxy-4-trifluor- methoxy-phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrrole-2-carbonylamino) benzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3- one;
2-(4-(Pyrrol-2-carbonylamino)-benzyl)-6-(3-methoxy-4-difluor- methoxy-phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-(Pyrrol-2-carbonylamino)-benzyl)-6-(3-methoxy-4-fluor-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrrole-2-carbonylamino) benzyl) -6- (3-methoxy-4-difluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3- one; 2- (4- (pyrrole-2-carbonylamino) benzyl) -6- (3-methoxy-4-fluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3- one;
2-(4-(Pyrrol-2-carbonylamino)-benzyl)-6-(3-difluormethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-(Pyrrol-2-carbonylamino)-benzyl)-6-(3-trifluormethoxy-4- methoxy-phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrrole-2-carbonylamino) benzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (pyrrole-2-carbonylamino) benzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrrol-2-carbonylamino)-benzyl)-6-(3-Fluormethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrrole-2-carbonylamino) benzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrrol-2-carbonylamino)-benzyl)-6-(3-methoxy-4-ethoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrrole-2-carbonylamino) benzyl) -6- (3-methoxy-4-ethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrrol-2-carbonylamino)-benzyl)-6-(3-ethoxy-4-methoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrrole-2-carbonylamino) benzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrrol-2-carbonylamino)-benzyl)-6-(3-hydroxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrrole-2-carbonylamino) benzyl) -6- (3-hydroxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrrol-2-carbonylamino)-benzyl)-6-(4-methylsulfonylphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrrole-2-carbonylamino) benzyl) -6- (4-methylsulfonylphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrrol-2-carbonylamino)-benzyl)-6-(4-methylenoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrrole-2-carbonylamino) benzyl) -6- (4-methyleneoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrrol-2-carbonylamino)-benzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrrole-2-carbonylamino) benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(Pyrrol-2-carbonylamino)-benzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyhdazin-3-on;2- (3- (pyrrole-2-carbonylamino) benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyhdazin-3-one;
2-(4-(Pyrrol-2-carbonylamino)-phenethyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on;
2-(4-(Pyrrol-2-carbonylamino)-phenethyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrrole-2-carbonylamino) phenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (pyrrole-2-carbonylamino) phenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(3-(Pyrrol-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (3- (pyrrole-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(2-(Pyrrol-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (2- (pyrrole-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(3-(Pyrrol-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(2-(Pyrrol-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (3- (pyrrole-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (2- (pyrrole-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-methoxy-4-trifluor- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3-methoxy-4-trifluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine 2-one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-methoxy-4-difluor- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Pyrrole-2-carbonylamino) benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine 2-one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-methoxy-4-fluor-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine 2-one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-difluormethoxy-4-methoxy- phenyl)-6-ethyi-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine-2- one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-trifluormethoxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine-2- one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-fluormethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-Methoxy-4-ethoxyphenyl)-3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3-methoxy-4-ethoxyphenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-ethoxy-4-methoxyphenyl)-3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3-ethoxy-4-methoxyphenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-hydroxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(4-methylsuIfonylphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(4-methylenoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(3-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(Pyrrol-2-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)-3- (3- (pyrrole-2-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one; 3- (4- (pyrrole-2-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -
3,6-dihydro-1 ,3,4-thiadiazin-2-on;3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Pyrrol-2-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-(Pyrrol-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (3- (pyrrole-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-(Pyrrol-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (2- (pyrrole-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-(Pyrrol-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (3- (pyrrole-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-(Pyrrol-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (2- (pyrrole-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-methoxy-4-trifluor- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3-methoxy-4-trifluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine 2-one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-methoxy-4-difluor- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine 2-one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-methoxy-4-fluor-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine 2-one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-difluormethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-trifluormethoxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one; 3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-fluormethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-methoxy-4-ethoxyphenyl)-3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3-methoxy-4-ethoxyphenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-ethoxy-4-methoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-hydroxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3-ethoxy-4-methoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(4-methylsulfonylphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(4-methylenoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4- (pyrrole-2-carbonylamino) benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Pyrrole-2-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(3-(Pyrrol-2-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (3- (Pyrrole-2-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(Pyrrol-2-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)- 3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1,3,4-oxadiazin-2-one;
3-(4-(Pyrrol-2-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrrole-2-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
2-(4-(Thiophen-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4, 5-tetrahydro-pyridazin-3-on;2- (4- (thiophene-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(Thiophen-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (thiophene-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-(Thiophen-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (2- (thiophene-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Thiophen-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (thiophene-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(Thiophen-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;
2-(2-(Thiophen-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (thiophene-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (2- (thiophene-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Thiophen-2-carbonylamino)-benzyl)-6-(3-methoxy-4-trifluor- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (thiophene-2-carbonylamino) benzyl) -6- (3-methoxy-4-trifluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Thiophen-2-carbonylamino)-benzyl)-6-(3-methoxy-4-difluor- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (thiophene-2-carbonylamino) benzyl) -6- (3-methoxy-4-difluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Thiophen-2-carbonylamino)-benzyl)-6-(3-methoxy-4-fluor- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-(Thiophen-2-carbonylamino)-benzyl)-6-(3-difluormethoxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (thiophene-2-carbonylamino) benzyl) -6- (3-methoxy-4-fluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (thiophene-2-carbonylamino) benzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Thiophen-2-carbonylamino)-benzyl)-6-(3-trifluormethoxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-(Thiophen-2-carbonylamino)-benzyl)-6-(3-fluormethoxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (thiophene-2-carbonylamino) benzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (thiophene-2-carbonylamino) benzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Thiophen-2-carbonylamino)-benzyl)-6-(3-Methoxy-4-ethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (thiophene-2-carbonylamino) benzyl) -6- (3-methoxy-4-ethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Thiophen-2-carbonylamino)-benzyl)-6-(3-ethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (thiophene-2-carbonylamino) benzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Thiophen-2-carbonylamino)-benzyl)-6-(3-hydroxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (thiophene-2-carbonylamino) benzyl) -6- (3-hydroxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-(Thiophen-2-carbonylamino)-benzyl)-6-(4-methylsulfonylphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (thiophene-2-carbonylamino) benzyl) -6- (4-methylsulfonylphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Thiophen-2-carbonylamino)-benzyl)-6-(4-methylenoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (thiophene-2-carbonylamino) benzyl) -6- (4-methyleneoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Thiophen-2-carbonylamino)-benzyl)-6-(3-cyclopentyloxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (thiophene-2-carbonylamino) benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(Thiophen-2-carbonylamino)-benzyl)-6-(3-cyclopentyloxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyhdazin-3-on;2- (3- (thiophene-2-carbonylamino) benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyhdazin-3-one;
2-(4-(Thiophen-2-carbonylamino)-phenethyl)-6-(3,4- dimethoxyphenyl)-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (thiophene-2-carbonylamino) phenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Thiophen-2-carbonylamino)-phenethyl)-6-(3,4- dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-2- (4- (thiophene-2-carbonylamino) phenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 3- (4- (thiophene-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -
3,6-dihydro-1 ,3,4-thiadiazin-2-on, F. 186°;3,6-dihydro-1, 3,4-thiadiazin-2-one, mp 186 °;
3-(3-(Thiophen-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3- (3- (thiophene-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -
3,6-dihydro-1 ,3,4-thiadiazin-2-on;3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(2-(Thiophen-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3- (2- (thiophene-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -
3,6-dihydro-1 ,3,4-thiadiazin-2-on;3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(3-(Thiophen-2-carbonylamino)-benzyl)-5-(3,4-dimethoxypheny.)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (thiophene-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (3- (Thiophene-2-carbonylamino) benzyl) -5- (3,4-dimethoxypheny.) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(2-(Thiophen-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-methoxy-4-trifluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (2- (thiophene-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4- (Thiophene-2-carbonylamino) benzyl) -5- (3-methoxy-4-trifluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine-2- one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-methoxy-4-difluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Thiophene-2-carbonylamino) benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-methoxy-4-fluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (thiophene-2-carbonylamino) benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-difluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Thiophene-2-carbonylamino) benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-trifluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Thiophene-2-carbonylamino) benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-fluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Thiophene-2-carbonylamino) benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-methoxy-4-ethoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Thiophene-2-carbonylamino) benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-ethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Thiophene-2-carbonylamino) benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-hydroxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Thiophene-2-carbonylamino) benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(4-methylsulfonylphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(4-methylenoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (thiophene-2-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4- (thiophene-2-carbonylamino) benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Thiophene-2-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(3-(Thiophen-2-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (3- (Thiophene-2-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Thiophen-2-carbonylamino)-phenethyl)-5-(3,4- dimethoxyphenyl)-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(Thiophen-2-carbonylamino)-phenethyl)-5-(3,4- dimethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Thiophene-2-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4- (Thiophene-2-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)- 3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(3-(Thiophen-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3- (4- (thiophene-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1,3,4-oxadiazin-2-one; 3- (3- (thiophene-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -
3,6-dihydro-1 ,3,4-oxadiazin-2-on;3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-(Thiophen-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)- 3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (2- (thiophene-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1,3,4-oxadiazin-2-one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (thiophene-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-(Thiophen-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (3- (Thiophene-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-(Thiophen-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (2- (thiophene-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-methoxy-4-trifluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Thiophene-2-carbonylamino) benzyl) -5- (3-methoxy-4-trifluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-methoxy-4-difluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Thiophene-2-carbonylamino) benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-methoxy-4-fluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Thiophene-2-carbonylamino) benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-difluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Thiophene-2-carbonylamino) benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-trifluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-fluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (thiophene-2-carbonylamino) benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4- (Thiophene-2-carbonylamino) benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-Methoxy-4-ethoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Thiophene-2-carbonylamino) benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-ethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Thiophene-2-carbonylamino) benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-hydroxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(4-methylsulfonylphenyl)-3- (4- (Thiophene-2-carbonylamino) benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one; 3- (4- (thiophene-2-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(4-methylenoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-(Thiophen-2-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (thiophene-2-carbonylamino) benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4- (Thiophene-2-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(3-(Thiophen-2-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (3- (Thiophene-2-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(Thiophen-2-carbonylamino)-phenethyl)-5-(3,4- dimethoxyphenyl)-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (thiophene-2-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Thiophen-2-carbonylamino)-phenethyl)-5-(3,4- dimethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Thiophene-2-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
2-(4-Pyrazincarbonylamino-benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydro-pyridazin-3-on, F. 197°;2- (4-pyrazinecarbonylamino-benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one, mp 197 °;
2-(3-Pyrazincarbonylamino-benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydro-pyridazin-3-on;2- (3-pyrazinecarbonylamino-benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-Pyrazincarbonylamino-benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydro-pyridazin-3-on;2- (2-pyrazinecarbonylamino-benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Pyrazincarbonylamino-benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-pyrazinecarbonylamino-benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-Pyrazincarbonylamino-benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (3-pyrazinecarbonylamino-benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-Pyrazincarbonylamino-benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydro-pyridazin-3-on;
2-(4-Pyrazincarbonylamino-benzyl)-6-(3-methoxy-4-trifluor-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (2-pyrazinecarbonylamino-benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4-pyrazinecarbonylamino-benzyl) -6- (3-methoxy-4-trifluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Pyrazincarbonylamino-benzyl)-6-(3-methoxy-4-difluor-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-pyrazinecarbonylamino-benzyl) -6- (3-methoxy-4-difluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Pyrazincarbonylamino-benzyl)-6-(3-methoxy-4-fluor-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-pyrazinecarbonylamino-benzyl) -6- (3-methoxy-4-fluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Pyrazincarbonylamino-benzyl)-6-(3-difluormethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-Pyrazincarbonylamino-benzyl)-6-(3-trifluormethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-pyrazinecarbonylamino-benzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4-pyrazinecarbonylamino-benzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Pyrazincarbonylamino-benzyl)-6-(3-fluormethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-Pyrazincarbonylamino-benzyl)-6-(3-methoxy-4-ethoxy-phenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-pyrazinecarbonylamino-benzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4-pyrazinecarbonylamino-benzyl) -6- (3-methoxy-4-ethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Pyrazincarbonylamino-benzyl)-6-(3-ethoxy-4-methoxy-phenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-pyrazinecarbonylamino-benzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Pyrazincarbonylamino-benzyl)-6-(3-hydroxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-pyrazinecarbonylamino-benzyl) -6- (3-hydroxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Pyrazincarbonylamino-benzyl)-6-(4-methylsulfonylphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-pyrazinecarbonylamino-benzyl) -6- (4-methylsulfonylphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Pyrazincarbonylamino-benzyl)-6-(4-methylenoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-pyrazinecarbonylamino-benzyl) -6- (4-methyleneoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Pyrazincarbonylamino-benzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-pyrazinecarbonylamino-benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-Pyrazincarbonylamino-benzyl)-6-(3-cyclopentyloxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (3-pyrazinecarbonylamino-benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Pyrazincarbonylamino-phenethyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-pyrazinecarbonylaminophenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Pyrazincarbonylamino-phenethyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-pyrazinecarbonylamino-phenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on, F. 202°;
3-(3-Pyrazincarbonylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one, mp 202 °; 3- (3-pyrazinecarbonylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(2-Pyrazincarbonylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (2-pyrazinecarbonylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3- (4-Pyrazincarbonylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-
3,6-dihydro-1 ,3,4-thiadiazin-2-on;3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(3-Pyrazincarbonylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(2-Pyrazincarbonylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3- (3-pyrazinecarbonylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (2-Pyrazincarbonylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-
3,6-dihydro-1 ,3,4-thiadiazin-2-on;3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3-methoxy-4-trifluor-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-Pyrazincarbonylamino-benzyl)-5-(3-methoxy-4-difluor-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (3-methoxy-4-trifluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4-pyrazinecarbonylamino-benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3-methoxy-4-fluor-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3-difluormethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3-trifluormethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3-fluormethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3-methoxy-4-ethoxy-phenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3-ethoxy-4-methoxy-phenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3-hydroxy-4-methoxy-phenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (3-hydroxy-4-methoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(4-methylsulfonylphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(4-methylenoxyphenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-thiadiazin-2-on;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3-cyclopentyloxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4-pyrazinecarbonylamino-benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(3-Pyrazincarbonylamino-benzyl)-5-(3-cyclopentyloxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (3-pyrazinecarbonylamino-benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Pyrazincarbonylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (4-pyrazinecarbonylaminophenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Pyrazincarbonylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-Pyrazincarbonylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4-pyrazinecarbonylamino-phenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4-pyrazinecarbonylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-Pyrazincarbonylamino-benzy.)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on; 3-(2-Pyrazincarbonylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (3-pyrazinecarbonylamino-benzy.) - 5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (2-pyrazinecarbonylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-Pyrazincarbonylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (3-pyrazinecarbonylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-Pyrazincarbonylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (2-pyrazinecarbonylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3-methoxy-4-trifluor-methoxy- pheηyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (3-methoxy-4-trifluoro-methoxy-pheηyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3-methoxy-4-difluor-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3-methoxy-4-fluor-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3-difluormethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3-trifluormethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3-fluormethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3-Methoxy-4-ethoxy-phenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4-pyrazinecarbonylamino-benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3-ethoxy-4-methoxy-phenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3-hydroxy-4-methoxy-phenyl)-3- (4-Pyrazincarbonylamino-benzyl) -5- (3-hydroxy-4-methoxy-phenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(4-methylsulfonylphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-Pyrazincarbonylamino-benzyl)-5-(4-methylenoxyphenyl)-6-ethyl-3- (4-pyrazinecarbonylamino-benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4-Pyrazincarbonylamino-benzyl) -5- (4-methylenoxyphenyl) -6-ethyl-
3,6-dihydro-1 ,3,4-oxadiazin-2-on;3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Pyrazincarbonylamino-benzyl)-5-(3-cyclopentyloxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(3-Pyrazincarbonylamino-benzyl)-5-(3-cyclopentyloxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-pyrazinecarbonylamino-benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (3-pyrazinecarbonylamino-benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Pyrazincarbonylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4-pyrazinecarbonylaminophenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-Pyrazincarbonylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4-pyrazinecarbonylaminophenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
2-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-6-(3,4-dimethoxy- phenyl)-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (6-chloropyridazin-3-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-6-(3,4-dimethoxy- phenyl)-2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (6-chloropyridazin-3-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-6-(3,4-dimethoxy- phenyl)-2,3,4,5-tetrahydro-pyridazin-3-on;2- (2- (6-chloropyridazin-3-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-6-(3,4-dimethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3- one;
2-(3-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-6-(3,4-dimethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (6-chloropyridazin-3-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3- one;
2-(2-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-6-(3,4-dimethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (2- (6-chloropyridazin-3-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3- one;
2-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-6-(3-methoxy-4- trifluor-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;
2-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-6-(3-methoxy-4- difluor-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (6-chloro-pyridazin-3-carbonylamino) -benzyl) -6- (3-methoxy-4-trifluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin- 3-one; 2- (4- (6-chloro-pyridazin-3-carbonylamino) -benzyl) -6- (3-methoxy-4-difluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin- 3-one;
2-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-6-(3-methoxy-4- fluor-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (6-chloro-pyridazin-3-carbonylamino) -benzyl) -6- (3-methoxy-4-fluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin- 3-one;
2-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-6-(3-difluormethoxy-2- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -6- (3-difluoromethoxy-
4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-6-(3- trifluormethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3- on;2- (4- (6-chloro-pyridazin-3-carbonylamino) -benzyl) -6- (3- trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3- one;
2-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-6-(3-fluormethoxy- 4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (6-chloro-pyridazin-3-carbonylamino) -benzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3- one;
2-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-6-(3-methoxy-4- ethoxy-phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (6-chloro-pyridazin-3-carbonylamino) -benzyl) -6- (3-methoxy-4-ethoxy-phenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin- 3-one;
2-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-6-(3-ethoxy-4- methoxy-phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (6-chloro-pyridazin-3-carbonylamino) -benzyl) -6- (3-ethoxy-4-methoxy-phenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin- 3-one;
2-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-6-(3-hydroxy-4- methoxy-phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (6-chloro-pyridazin-3-carbonylamino) -benzyl) -6- (3-hydroxy-4-methoxy-phenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin- 3-one;
2-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-6-(4- methylsulfonylphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -6- (4-methylsulfonylphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-6-(4-methylenoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-6-(3-cyclopentyloxy-2- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -6- (4-methyleneoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -6- (3-cyclopentyloxy-
4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-6-(3-cyclopentyloxy- 4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-(6-Chlor-pyridazin-3-carbonylamino)-phenethyl)-6-(3,4- dimethoxyphenyl)-2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (6-chloro-pyridazin-3-carbonylamino) -benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3- one; 2- (4- (6-chloropyridazin-3-carbonylamino) phenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(6-Chlor-pyridazin-3-carbonylamino)-phenethyl)-6-(3,4- dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (6-chloropyridazin-3-carbonylamino) phenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3,4-dimethoxy- phenyl)-3,6-dihydro-1 ,3,4-thiadiazin-2-on;
3-(3-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3,4-dimethoxy- phenyl)-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (3- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(2-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3,4-dimethoxy- phenyl)-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (2- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3,4-dimethoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine 2-one;
3-(3-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3,4-dimethoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(2-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3,4-dimethoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (3- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine 2-one; 3- (2- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine 2-one;
3-(4-(6-ChIor-pyridazin-3-carbonylamino)-benzyl)-5-(3-methoxy-4- trifluor-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3-methoxy-4- difluor-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3-methoxy-4-trifluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4- thiadiazin-2-one; 3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4- thiadiazin-2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3-methoxy-4- fluor-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4- thiadiazin-2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3-difluormethoxy- 4-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine 2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3- trifluormethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine 2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3-fluormethoxy- 4-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine 2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3-methoxy-4- ethoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) -benzyl) -5- (3-methoxy-4-ethoxy-phenyl) -6-ethyl-3,6-dihydro-1, 3,4- thiadiazin-2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3-ethoxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3-ethoxy-4-methoxy-phenyl) -6-ethyl-3,6-dihydro-1, 3,4- thiadiazin-2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3-hydroxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3-hydroxy-4-methoxy-phenyl) -6-ethyl-3,6-dihydro-1, 3,4- thiadiazin-2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(4- methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(4-methylenoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-3- (4- (6-chloro-pyridazin-3-carbonylamino) -benzyl) -5- (4-methyleneoxy-phenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one; 3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3-cyclopentyloxy-
4-methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;4-methoxy-phenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(3-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-3- (3- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3-cyclopentyloxy-
4-methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;4-methoxy-phenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-phenethyl)-5-(3,4- dimethoxyphenyl)-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-phenethyl)-5-(3,4- dimethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3,4-dimethoxy- phenyl)-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (6-chloropyridazin-3-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one; 3- (4- (6-chloropyridazin-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3,4-dimethoxy- phenyl)-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(2-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3,4-dimethoxy- phenyl)-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (3- (6-chloropyridazin-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (2- (6-chloropyridazin-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3,4- dimethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(3-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3,4- dimethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (3- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(2-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3,4- dimethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (2- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3-methoxy-4- trifluor-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3-methoxy-4-trifluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4- oxadiazine-2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3-methoxy-4- difluor-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4- oxadiazine-2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3-methoxy-4- fluor-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4- oxadiazine-2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3-difluormethoxy- 4-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine 2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3- trifluormethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine 2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3-fluormethoxy- 4-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3-methoxy-4- ethoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine 2-one; 3- (4- (6-chloro-pyridazin-3-carbonylamino) -benzyl) -5- (3-methoxy-4-ethoxy-phenyl) -6-ethyl-3,6-dihydro-1, 3,4- oxadiazine-2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3-ethoxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3-ethoxy-4-methoxy-phenyl) -6-ethyl-3,6-dihydro-1, 3,4- oxadiazine-2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3-hydroxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3-hydroxy-4-methoxy-phenyl) -6-ethyl-3,6-dihydro-1, 3,4- oxadiazine-2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(4- methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(4- methylenoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3-cyclopentyloxy- 4-methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(3-(6-Chlor-pyridazin-3-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-3- (4- (6-chloropyridazin-3-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4- oxadiazine-2-one; 3- (3- (6-chloro-pyridazin-3-carbonylamino) benzyl) -5- (3-cyclopentyloxy-
4-methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;4-methoxy-phenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-phenethyl)-5-(3,4- dimethoxyphenyl)-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(6-Chlor-pyridazin-3-carbonylamino)-phenethyl)-5-(3,4- dimethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (6-chloro-pyridazin-3-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
2-(4-(lmidazol-4-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (imidazole-4-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(lmidazol-4-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (imidazole-4-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-(lmidazol-4-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (2- (imidazole-4-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lmidazol-4-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (imidazole-4-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(lmidazol-4-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (imidazole-4-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-(lmidazol-4-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (2- (imidazole-4-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lmidazol-4-carbonylamino)-benzyl)-6-(3-methoxy-4-thfluor- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;
2-(4-(lmidazol-4-carbonylamino)-benzyl)-6-(3-methoxy-4-difluor- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (Imidazole-4-carbonylamino) benzyl) -6- (3-methoxy-4-thfluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (imidazole-4-carbonylamino) benzyl) -6- (3-methoxy-4-difluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lmidazol-4-carbonylamino)-benzyl)-6-(3-methoxy-4-fluor- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (imidazole-4-carbonylamino) benzyl) -6- (3-methoxy-4-fluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lmidazol-4-carbonylamino)-benzyl)-6-(3-difluormethoxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (imidazole-4-carbonylamino) benzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lmidazol-4-carbonylamino)-benzyl)-6-(3-trifluormethoxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-(lmidazol-4-carbonylamino)-benzyl)-6-(3-fluormethoxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (Imidazole-4-carbonylamino) benzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (Imidazole-4-carbonylamino) benzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lmidazol-4-carbonylamino)-benzyl)-6-(3-methoxy-4-ethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-(lmidazol-4-carbonylamino)-benzyl)-6-(3-ethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (imidazole-4-carbonylamino) benzyl) -6- (3-methoxy-4-ethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (Imidazole-4-carbonylamino) benzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lmidazol-4-carbonylamino)-benzyl)-6-(3-hydroxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (imidazole-4-carbonylamino) benzyl) -6- (3-hydroxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lmidazol-4-carbonylamino)-benzyl)-6-(4-methylsulfonylphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (imidazole-4-carbonylamino) benzyl) -6- (4-methylsulfonylphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;
2-(4-(lmidazol-4-carbonylamino)-benzyl)-6-(4-methylenoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (imidazole-4-carbonylamino) benzyl) -6- (4-methyleneoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lmidazol-4-carbonylamino)-benzyl)-6-(3-cyclopentyloxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyhdazin-3-on;2- (4- (imidazole-4-carbonylamino) benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyhdazin-3-one;
2-(3-(lmidazol-4-carbonylamino)-benzyl)-6-(3-cyclopentyloxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (imidazole-4-carbonylamino) benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lmidazol-4-carbonylamino)-phenethyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (imidazole-4-carbonylamino) phenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lmidazol-4-carbonylamino)-phenethyl)-6-(3,4-dimethoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (Imidazole-4-carbonylamino) phenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)- 3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Imidazol-4-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1,3,4-thiadiazin-2-one;
3-(3-(lmidazol-4-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)- 3,6-dihydro-1 ,3,4-thiadiazin-2-on;
3-(2-(lmidazol-4-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3- (3- (Imidazol-4-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1,3,4-thiadiazin-2-one; 3- (2- (imidazole-4-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -
3,6-dihydro-1 ,3,4-thiadiazin-2-on;3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Imidazole-4-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(3-(lmidazol-4-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (3- (Imidazole-4-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(2-(lmidazol-4-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-methoxy-4-trifluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (2- (imidazole-4-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4- (Imidazole-4-carbonylamino) benzyl) -5- (3-methoxy-4-trifluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine-2- one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-methoxy-4-difluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-methoxy-4-fluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Imidazole-4-carbonylamino) benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one; 3- (4- (Imidazole-4-carbonylamino) benzyl) -5- (3-methoxy-4-fluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine-2- one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-difluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Imidazol-4-carbonylamino) benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-trifluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Imidazol-4-carbonylamino) benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-fluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Imidazol-4-carbonylamino) benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-methoxy-4-ethoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Imidazole-4-carbonylamino) benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-ethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Imidazole-4-carbonylamino) benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-hydroxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Imidazole-4-carbonylamino) benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(4-methylsulfonylphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Imidazole-4-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(4-methylenoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Imidazole-4-carbonylamino) benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;
3-(3-(lmidazol-4-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Imidazole-4-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine-2- one; 3- (3- (Imidazole-4-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine-2- one;
3-(4-(lmidazol-4-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)-3- (4- (imidazole-4-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -
3,6-dihydro-1 ,3,4-thiadiazin-2-on;3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(lmidazol-4-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)-3- (4- (imidazole-4-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3,4-dimethoxypheny.)- 3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(3-(lmidazol-4-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3- (4- (Imidazol-4-carbonylamino) benzyl) -5- (3,4-dimethoxypheny.) - 3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (3- (imidazole-4-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -
3,6-dihydro-1 ,3,4-oxadiazin-2-on;3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-(lmidazol-4-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)- 3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (2- (Imidazol-4-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1,3,4-oxadiazin-2-one; 3- (4- (Imidazole-4-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-(lmidazol-4-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (3- (Imidazole-4-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-(lmidazol-4-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (2- (imidazole-4-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-methoxy-4-trifluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Imidazole-4-carbonylamino) benzyl) -5- (3-methoxy-4-trifluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-methoxy-4-difluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Imidazole-4-carbonylamino) benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-methoxy-4-fluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Imidazole-4-carbonylamino) benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-difluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Imidazol-4-carbonylamino) benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-trifluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Imidazol-4-carbonylamino) benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-fluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Imidazol-4-carbonylamino) benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-methoxy-4-ethoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-ethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Imidazole-4-carbonylamino) benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one; 3- (4- (Imidazole-4-carbonylamino) benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-hydroxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Imidazole-4-carbonylamino) benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(4-methylsulfonylphenyl)-3- (4- (imidazole-4-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(4-methylenoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-(lmidazol-4-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (imidazole-4-carbonylamino) benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4- (Imidazole-4-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(3-(lmidazol-4-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-(lmidazol-4-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)-3- (3- (Imidazole-4-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one; 3- (4- (imidazole-4-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -
3,6-dihydro-1 ,3,4-oxadiazin-2-on;3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(lmidazol-4-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Imidazole-4-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
2-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-6-(3,4- dimethoxyphenyl)-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (2,4-dimethylthiazol-5-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-6-(3,4- dimethoxyphenyl)-2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (2,4-dimethylthiazol-5-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-6-(3,4- dimethoxyphenyl)-2,3,4,5-tetrahydro-pyridazin-3-on;2- (2- (2,4-dimethylthiazol-5-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-6-(3,4- dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (2,4-dimethylthiazole-5-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3- one;
2-(3-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-6-(3,4- dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (2,4-dimethylthiazole-5-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3- one;
2-(2-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-6-(3,4- dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (2- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3- one;
2-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-6-(3-methoxy-4- trifluor-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) benzyl) -6- (3-methoxy-4-trifluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro- pyridazin-3-one;
2-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-6-(3-methoxy-4- difluor-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;
2-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-6-(3-methoxy-4- fluor-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -6- (3-methoxy-4-difluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro- pyridazin-3-one; 2- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -6- (3-methoxy-4-fluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro- pyridazin-3-one;
2-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-6-(3-difluor- methoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -6- (3-difluoro-methoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro- pyridazin-3-one;
2-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-6-(3- trifluormethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3- on;2- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazine- 3- on;
2-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-6-(3- fluormethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazine- 3-one;
2-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-6-(3-methoxy-4- ethoxy-phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (2,4-Dimethylthiazole-5-carbonylamino) benzyl) -6- (3-methoxy-4-ethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro- pyridazin-3-one;
2-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-6-(3-ethoxy-4- methoxy-phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -6- (3-ethoxy-4-methoxy-phenyl) -5-ethyl-2,3,4,5-tetrahydro- pyridazin-3-one;
2-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-6-(3-hydroxy-4- methoxy-phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (2,4-Dimethylthiazole-5-carbonylamino) benzyl) -6- (3-hydroxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro- pyridazin-3-one;
2-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-6-(4- methylsulfonylphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (2,4-dimethylthiazole-5-carbonylamino) benzyl) -6- (4-methylsulfonylphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-6-(4- methylenoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (2,4-dimethylthiazol-5-carbonylamino) benzyl) -6- (4-methyleneoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-6-(3-cyclopentyl- oxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyhdazin-3-on; 2-(3-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-6-(3-cyclopentyl- oxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (2,4-dimethylthiazole-5-carbonylamino) benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro- pyhdazin-3-one; 2- (3- (2,4-dimethylthiazole-5-carbonylamino) benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro- pyridazin-3-one;
2-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-phenethyl)-6-(3,4- dimethoxyphenyl)-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-phenethyl)-6-(3,4- dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (2,4-dimethylthiazol-5-carbonylamino) phenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -phenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3- one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3,4- dimethoxyphenyl)-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (2,4-Dimethylthiazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(3-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3,4- dimethoxyphenyl)-3,6-dihydro-1 ,3,4-thiadiazin-2-on;
3-(2-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3,4- dimethoxyphenyl)-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (3- (2,4-Dimethylthiazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (2- (2,4-Dimethylthiazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3,4- dimethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (2,4-dimethylthiazole-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine 2-one;
3-(3-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3,4- dimethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (3- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine 2-one;
3-(2-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3,4- dimethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4- trifluor-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (2- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine 2-one; 3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3-methoxy-4-trifluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3. 4-thiadiazin-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4- difluor-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(2,4-Dimethyl-thiazol-5-carbonyIamino)-benzyl)-5-(3-methoxy-4- fluor-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3. 4-thiadiazin-2-one; 3- (4- (2,4-Dimethyl-thiazole-5-carbonyamino) benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3. 4-thiadiazin-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3-difluor- methoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3-difluoro-methoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3. 4-thiadiazin-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3-trifluor- methoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3-trifluoro-methoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3. 4-thiadiazin-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3- fluormethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4- thiadiazin-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4- ethoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3-methoxy-4-ethoxy-phenyl) -6-ethyl-3,6-dihydro-1,3. 4-thiadiazin-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3-ethoxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3-ethoxy-4-methoxy-phenyl) -6-ethyl-3,6-dihydro-1,3. 4-thiadiazin-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3-hydroxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (2,4-dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3-hydroxy-4-methoxy-phenyl) -6-ethyl-3,6-dihydro-1,3. 4-thiadiazin-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(4- methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (2,4-Dimethylthiazole-5-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(4- methylenoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3-cyclopentyl- oxy-4-methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;
3-(3-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3-cyclopentyl- oxy-4-methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3-cyclopentyl-oxy-4-methoxy-phenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (3- (2,4-dimethyl-thiazole-5-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-phenethyl)-5-(3,4- dimethoxyphenyl)-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (2,4-Dimethylthiazol-5-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-phenethyl)-5-(3,4- dimethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -phenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine 2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3,4- dimethoxyphenyl)-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(3-(lmidazol-4-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3- (4- (2,4-Dimethylthiazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (3- (imidazole-4-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -
3,6-dihydro-1 ,3,4-oxadiazin-2-on;3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3,4- dimethoxyphenyl)-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3,4- dimethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (2- (2,4-Dimethylthiazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4- (2,4-dimethylthiazole-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine 2-one;
3-(3-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3,4- dimethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (3- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine 2-one;
3-(2-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3,4- dimethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (2- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine 2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4- trifluor-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3-methoxy-4-trifluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3. 4-oxadiazin-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4- difluor-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3. 4-oxadiazin-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4- fluor-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3. 4-oxadiazin-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3-difluor- methoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3-difluoro-methoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3. 4-oxadiazin-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3-trifluor- methoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3-trifluoro-methoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3. 4-oxadiazin-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3- fluormethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4- oxadiazine-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4- ethoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3-ethoxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3-methoxy-4-ethoxy-phenyl) -6-ethyl-3,6-dihydro-1,3. 4-oxadiazin-2-one; 3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3-ethoxy-4-methoxy-phenyl) -6-ethyl-3,6-dihydro-1,3. 4-oxadiazin-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3-hydroxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (2,4-dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3-hydroxy-4-methoxy-phenyl) -6-ethyl-3,6-dihydro-1,3. 4-oxadiazin-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(4- methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (2,4-dimethylthiazole-5-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(4- methylenoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3-cyclopentyl- oxy-4-methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (2,4-dimethylthiazole-5-carbonylamino) benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one; 3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -benzyl) -5- (3-cyclopentyl-oxy-4-methoxy-phenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2-one;
3-(3-(2,4-Dimethyl-thiazol-5-carbonylamino)-benzyl)-5-(3-cyclopentyl- oxy-4-methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-(2,4-Dimethyl-thiazoI-5-carbonylamino)-phenethyl)-5-(3,4- dimethoxyphenyl)-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (3- (2,4-dimethyl-thiazole-5-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2-one; 3- (4- (2,4-DimethylthiazoI-5-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(2,4-Dimethyl-thiazol-5-carbonylamino)-phenethyl)-5-(3,4- dimethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (2,4-Dimethyl-thiazole-5-carbonylamino) -phenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine 2-one;
2-(4-(lsoxazol-5-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on, F. 217°;2- (4- (isoxazole-5-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) - 2,3,4,5-tetrahydro-pyridazin-3-one, mp 217 °;
2-(3-(lsoxazol-5-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (isoxazol-5-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-(lsoxazol-5-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (2- (isoxazol-5-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lsoxazol-5-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (isoxazole-5-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(lsoxazol-5-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (isoxazole-5-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-(lsoxazol-5-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (2- (isoxazole-5-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lsoxazol-5-carbonylamino)-benzyl)-6-(3-methoxy-4-trifluor- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (isoxazol-5-carbonylamino) benzyl) -6- (3-methoxy-4-trifluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lsoxazol-5-carbonylamino)-benzyl)-6-(3-methoxy-4-difluor- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;
2-(4-(lsoxazol-5-carbonylamino)-benzyl)-6-(3-methoxy-4-fluor- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (isoxazol-5-carbonylamino) benzyl) -6- (3-methoxy-4-difluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (isoxazole-5-carbonylamino) benzyl) -6- (3-methoxy-4-fluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lsoxazol-5-carbonylamino)-benzyl)-6-(3-difluormethoxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (isoxazol-5-carbonylamino) benzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lsoxazol-5-carbonylamino)-benzyl)-6-(3-trifluormethoxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (isoxazole-5-carbonylamino) benzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lsoxazol-5-carbonylamino)-benzyl)-6-(3-fluormethoxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-(lsoxazol-5-carbonylamino)-benzyl)-6-(3-methoxy-4-ethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (isoxazole-5-carbonylamino) benzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (isoxazole-5-carbonylamino) benzyl) -6- (3-methoxy-4-ethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lsoxazol-5-carbonylamino)-benzyl)-6-(3-ethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-(lsoxazol-5-carbonylamino)-benzyl)-6-(3-hydroxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (isoxazole-5-carbonylamino) benzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (isoxazole-5-carbonylamino) benzyl) -6- (3-hydroxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lsoxazol-5-carbonylamino)-benzyl)-6-(4-methylsulfonylphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (isoxazole-5-carbonylamino) benzyl) -6- (4-methylsulfonylphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lsoxazol-5-carbonylamino)-benzyl)-6-(4-methylenoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (isoxazole-5-carbonylamino) benzyl) -6- (4-methyleneoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lsoxazol-5-carbonylamino)-benzyl)-6-(3-cyclopentyloxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (isoxazol-5-carbonylamino) benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(lsoxazol-5-carbonylamino)-benzyl)-6-(3-cyclopentyloxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (isoxazole-5-carbonylamino) benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lsoxazol-5-carbonylamino)-phenethyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (isoxazol-5-carbonylamino) phenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(lsoxazol-5-carbonylamino)-phenethyl)-6-(3,4-dimethoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydro-ρyridazin-3-on;2- (4- (isoxazole-5-carbonylamino) phenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on, F. 196°;3- (4- (isoxazole-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one, mp 196 °;
3-(3-(lsoxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (3- (isoxazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(2-(lsoxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (2- (isoxazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4- (isoxazole-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(3-(lsoxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (3- (isoxazole-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(2-(lsoxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (2- (isoxazole-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4-trifluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4-difluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (isoxazole-5-carbonylamino) benzyl) -5- (3-methoxy-4-trifluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine-2- one; 3- (4- (isoxazole-5-carbonylamino) benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4-fluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-difluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (isoxazole-5-carbonylamino) benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one; 3- (4- (isoxazol-5-carbonylamino) benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-trifluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (isoxazol-5-carbonylamino) benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-fluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (isoxazol-5-carbonylamino) benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4-ethoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (isoxazole-5-carbonylamino) benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-ethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (isoxazole-5-carbonylamino) benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-hydroxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (isoxazole-5-carbonylamino) benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(4-methylsulfonylphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (isoxazol-5-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(4-methylenoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (isoxazole-5-carbonylamino) benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (isoxazole-5-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine-2- one;
3-(3-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;
3-(4-(lsoxazol-5-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)-3- (3- (isoxazole-5-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxy-phenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine-2- one; 3- (4- (isoxazole-5-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -
3,6-dihydro-1 ,3,4-thiadiazin-2-on;3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(lsoxazol-5-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)-3- (4- (isoxazole-5-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (isoxazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-( lsoxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)- 3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(2-(lsoxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (3- (isoxazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1,3,4-oxadiazin-2-one; 3- (2- (isoxazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(lsoxazol-5-carbonyIamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(3-(lsoxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (isoxazole-5-carbonyamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (3- (isoxazole-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-(lsoxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (2- (isoxazole-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4-trifluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (isoxazole-5-carbonylamino) benzyl) -5- (3-methoxy-4-trifluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4-difluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (isoxazole-5-carbonylamino) benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4-fluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (isoxazole-5-carbonylamino) benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-difluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (isoxazol-5-carbonylamino) benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-trifluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (isoxazol-5-carbonylamino) benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-fluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (isoxazol-5-carbonylamino) benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4-ethoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (isoxazole-5-carbonylamino) benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-ethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-hydroxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (isoxazole-5-carbonylamino) benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one; 3- (4- (isoxazole-5-carbonylamino) benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(4-methylsulfonylphenyl)-3- (4- (isoxazole-5-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(4-methylenoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (isoxazole-5-carbonylamino) benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(3-(lsoxazol-5-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (isoxazole-5-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one; 3- (3- (isoxazole-5-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(lsoxazoI-5-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)- 3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-(lsoxazol-5-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)-3- (4- (isoxazoI-5-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1,3,4-oxadiazin-2-one; 3- (4- (isoxazole-5-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
2-(4-(Oxazol-5-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (oxazol-5-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(Oxazol-5-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (Oxazol-5-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-(Oxazol-5-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4, 5-tetrahydro-pyridazin-3-on;2- (2- (oxazol-5-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Oxazol-5-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (Oxazol-5-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(Oxazol-5-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (Oxazol-5-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-(Oxazol-5-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (2- (oxazol-5-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Oxazol-5-carbonylamino)-benzyl)-6-(3-methoxy-4-thfluor- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (Oxazol-5-carbonylamino) benzyl) -6- (3-methoxy-4-thfluoromethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Oxazol-5-carbonylamino)-benzyl)-6-(3-methoxy-4-difluor- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (Oxazol-5-carbonylamino) benzyl) -6- (3-methoxy-4-difluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Oxazol-5-carbonylamino)-benzyl)-6-(3-methoxy-4-fluor- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;
2-(4-(Oxazol-5-carbonylamino)-benzyl)-6-(3-difluormethoxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (Oxazol-5-carbonylamino) benzyl) -6- (3-methoxy-4-fluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (Oxazol-5-carbonylamino) benzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Oxazol-5-carbonylamino)-benzyl)-6-(3-trifluormethoxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (Oxazol-5-carbonylamino) benzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Oxazol-5-carbonylamino)-benzyl)-6-(3-fluormethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (Oxazol-5-carbonylamino) benzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Oxazol-5-carbonylamino)-benzyl)-6-(3-methoxy-4-ethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyhdazin-3-on; 2-(4-(Oxazol-5-carbonylamino)-benzyl)-6-(3-ethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (Oxazol-5-carbonylamino) benzyl) -6- (3-methoxy-4-ethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyhdazin-3-one; 2- (4- (Oxazol-5-carbonylamino) benzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Oxazol-5-carbonylamino)-benzyl)-6-(3-hydroxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-(Oxazol-5-carbonylamino)-benzyl)-6-(4-methylsulfonylphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (Oxazol-5-carbonylamino) benzyl) -6- (3-hydroxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4- (Oxazol-5-carbonylamino) benzyl) -6- (4-methylsulfonylphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Oxazol-5-carbonylamino)-benzyl)-6-(4-methylenoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (Oxazol-5-carbonylamino) benzyl) -6- (4-methyleneoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Oxazol-5-carbonylamino)-benzyl)-6-(3-cyclopentyloxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (Oxazol-5-carbonylamino) benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(Oxazol-5-carbonylamino)-benzyl)-6-(3-cyclopentyloxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (Oxazol-5-carbonylamino) benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Oxazol-5-carbonylamino)-phenethyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (oxazol-5-carbonylamino) phenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Oxazol-5-carbonylamino)-phenethyl)-6-(3,4-dimethoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (Oxazol-5-carbonylamino) phenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(3-(Oxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (3- (Oxazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(2-(Oxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (2- (Oxazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;
3-(3-(Oxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (3- (Oxazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(2-(Oxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (2- (Oxazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4-trifluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (oxazole-5-carbonylamino) benzyl) -5- (3-methoxy-4-trifluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine-2- one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4-difluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4-fluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one; 3- (4- (oxazole-5-carbonylamino) benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3-difluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3-trifluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3-fluormethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4-ethoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3-ethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3-hydroxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (oxazole-5-carbonylamino) benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(4-methylsulfonylphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(4-methylenoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(3-(Oxazol-5-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (3- (Oxazol-5-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Oxazol-5-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)- 3,6-dihydro-1 ,3,4-thiadiazin-2-on;
3-(4-(Oxazol-5-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)-3- (4- (Oxazol-5-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1,3,4-thiadiazin-2-one; 3- (4- (oxazole-5-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -
6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-(Oxazol-5-carbonylamino )-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (3- (Oxazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-(Oxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (2- (Oxazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-(Oxazol-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(2-(Oxazoi-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (3- (Oxazol-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (2- (Oxazoi-5-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4-trifluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (3-methoxy-4-trifluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4-difluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (oxazole-5-carbonylamino) benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(Oxazoi-5-carbonylamino)-benzyl)-5-(3-methoxy-4-fiuor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Oxazoi-5-carbonylamino) benzyl) -5- (3-methoxy-4-fluorous methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3-difluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3-trifluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3-fluormethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3-methoxy-4-ethoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (oxazole-5-carbonylamino) benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3-ethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3-hydroxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(4-methylsulfonylphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one; 3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(4-methylenoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Oxazol-5-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (Oxazol-5-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxy-phenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(3-(Oxazol-5-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-(Oxazol-5-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)-3- (3- (Oxazol-5-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one; 3- (4- (oxazole-5-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -
3,6-dihydro-1 ,3,4-oxadiazin-2-on;3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Oxazol-5-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 2-(4-(Pyrimidin-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-3- (4- (Oxazol-5-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 2- (4- (pyrimidine-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -
2,3,4, 5-tetrahydro-pyridazin-3-on;2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(Pyrimidin-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4, 5-tetrahydro-pyridazin-3-on;2- (3- (pyrimidin-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-(Pyrimidin-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (2- (pyrimidin-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrimidin-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrimidin-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(Pyrimidin-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (pyrimidine-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-(Pyrimidin-2-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (2- (pyrimidine-2-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrimidin-2-carbonylamino)-benzyl)-6-(3-methoxy-4-trifluor- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrimidin-2-carbonylamino) benzyl) -6- (3-methoxy-4-trifluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrimidin-2-carbonylamino)-benzyl)-6-(3-methoxy-4-difluor- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrimidin-2-carbonylamino) benzyl) -6- (3-methoxy-4-difluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrimidin-2-carbonylamino)-benzyl)-6-(3-methoxy-4-fluor- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrimidin-2-carbonylamino) benzyl) -6- (3-methoxy-4-fluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrimidin-2-carbonylamino)-benzyl)-6-(3-difluormethoxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;
2-(4-(Pyrimidin-2-carbonylamino)-benzyl)-6-(3-trifluormethoxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyhdazin-3-on;2- (4- (pyrimidin-2-carbonylamino) benzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (pyrimidine-2-carbonylamino) benzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyhdazin-3-one;
2-(4-(Pyrimidin-2-carbonylamino)-benzyl)-6-(3-fluormethoxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrimidin-2-carbonylamino) benzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrimidin-2-carbonylamino)-benzyl)-6-(3-methoxy-4-ethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrimidin-2-carbonylamino) benzyl) -6- (3-methoxy-4-ethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrimidin-2-carbonylamino)-benzyl)-6-(3-ethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-(Pyrimidin-2-carbonylamino)-benzyl)-6-(3-hydroxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrimidin-2-carbonylamino) benzyl) -6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (pyrimidin-2-carbonylamino) benzyl) -6- (3-hydroxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrimidin-2-carbonylamino)-benzyl)-6-(4-methylsulfonylphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-(Pyrimidin-2-carbonylamino)-benzyl)-6-(4-methylenoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrimidine-2-carbonylamino) benzyl) -6- (4-methylsulfonylphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (pyrimidine-2-carbonylamino) benzyl) -6- (4-methyleneoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrimidin-2-carbonylamino)-benzyl)-6-(3-cyclopentyloxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrimidin-2-carbonylamino) benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(Pyrimidin-2-carbonylamino)-benzyl)-6-(3-cyclopentyloxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (pyrimidin-2-carbonylamino) benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrimidin-2-carbonylamino)-phenethyl)-6-(3,4-dimethoxy- phenyl)-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrimidin-2-carbonylamino) phenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrimidin-2-carbonylamino)-phenethyl)-6-(3,4-dimethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrimidine-2-carbonylamino) phenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)- 3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrimidin-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1,3,4-thiadiazin-2-one;
3-(3-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)- 3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (3- (pyrimidin-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1,3,4-thiadiazin-2-one;
3-(2-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)- 3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (2- (pyrimidin-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1,3,4-thiadiazin-2-one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrimidin-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(3-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;
3-(2-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (3- (pyrimidin-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (2- (pyrimidin-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-methoxy-4-trifluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrimidine-2-carbonylamino) benzyl) -5- (3-methoxy-4-trifluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine-2- one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-methoxy-4-difluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrimidine-2-carbonylamino) benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-methoxy-4-fluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(Pyrimidin-2-carbonylamino)-benzyi)-5-(3-difluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrimidine-2-carbonylamino) benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one; 3- (4- (pyrimidin-2-carbonylamino) -benzyi) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-trifluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-fluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrimidin-2-carbonylamino) benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4- (pyrimidin-2-carbonylamino) benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-methoxy-4-ethoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrimidine-2-carbonylamino) benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-ethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrimidine-2-carbonylamino) benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-hydroxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrimidine-2-carbonylamino) benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(4-methylsulfonylphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrimidin-2-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(4-methylenoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrimidin-2-carbonylamino) benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrimidine-2-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(3-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (3- (pyrimidine-2-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine-2- one;
3-(4-(Pyrimidin-2-carbonylamino)-phenethyl)-5-(3,4-dimethoxy- phenyl)-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrimidin-2-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Pyrimidin-2-carbonylamino)-phenethyl)-5-(3,4-dimethoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3- (4- (pyrimidin-2-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4- (pyrimidine-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -
3,6-dihydro-1 ,3,4-oxadiazin-2-on;3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3- (3- (pyrimidine-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -
3,6-dihydro-1 ,3,4-oxadiazin-2-on;3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3- (2- (pyrimidine-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -
3,6-dihydro-1 ,3,4-oxadiazin-2-on;3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(3-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrimidin-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (3- (pyrimidin-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-methoxy-4-trifluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (2- (pyrimidin-2-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4- (pyrimidine-2-carbonylamino) benzyl) -5- (3-methoxy-4-trifluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-methoxy-4-difluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrimidine-2-carbonylamino) benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-methoxy-4-fluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrimidine-2-carbonylamino) benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-difluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrimidin-2-carbonylamino) benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-trifluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrimidin-2-carbonylamino) benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-fluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrimidin-2-carbonylamino) benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-methoxy-4-ethoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrimidine-2-carbonylamino) benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-ethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrimidine-2-carbonylamino) benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-hydroxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrimidine-2-carbonylamino) benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(4-methylsulfonylphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(4-methylenoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrimidin-2-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4- (pyrimidine-2-carbonylamino) benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-cyclopentyIoxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrimidine-2-carbonylamino) -benzyl) -5- (3-cyclopentiyoxy-4-methoxy-phenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(3-(Pyrimidin-2-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (3- (pyrimidine-2-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Pyrimidin-2-carbonylamino)-phenethyl)-5-(3,4-dimethoxy- phenyl)-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-(Pyrimidin-2-carbonylamino)-phenethyl)-5-(3,4-dimethoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrimidin-2-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4- (pyrimidin-2-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
2-(4-(Pyrazol-3-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-py dazin-3-on; 2-(3-(Pyrazol-3-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-2- (4- (pyrazol-3-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropy-dazin-3-one; 2- (3- (pyrazole-3-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -
2,3,4,5-tetrahydro-pyridazin-3-on;2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-(Pyrazol-3-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (2- (pyrazol-3-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrazol-3-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrazol-3-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(Pyrazol-3-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (pyrazol-3-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(2-(Pyrazol-3-carbonylamino)-benzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (2- (pyrazol-3-carbonylamino) benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrazol-3-carbonylamino)-benzyl)-6-(3-methoxy-4-trifluor- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrazol-3-carbonylamino) benzyl) -6- (3-methoxy-4-trifluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrazol-3-carbonylamino)-benzyl)-6-(3-methoxy-4-difluor- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrazol-3-carbonylamino) benzyl) -6- (3-methoxy-4-difluoro-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrazol-3-carbonylamino)-benzyl)-6-(3-methoxy-4-fluor- methoxypheny -δ-ethyl^^^.δ-tetrahydro-pyridazin-S-on;2- (4- (pyrazole-3-carbonylamino) benzyl) -6- (3-methoxy-4-fluoro-methoxypheny -δ-ethyl ^^^. Δ-tetrahydro-pyridazin-S-one;
2-(4-(Pyrazol-3-carbonylamino)-benzyl)-6-(3-difluormethoxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrazol-3-carbonylamino) benzyl) -6- (3-difluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrazol-3-carbonylamino)-benzyl)-6-(3-trifluormethoxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;
2-(4-(Pyrazol-3-carbonylamino)-benzyl)-6-(3-fluormethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrazol-3-carbonylamino) benzyl) -6- (3-trifluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (pyrazol-3-carbonylamino) benzyl) -6- (3-fluoromethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrazol-3-carbonylamino)-benzyl)-6-(3-methoxy-4-ethoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrazol-3-carbonylamino) benzyl) -6- (3-methoxy-4-ethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrazol-3-carbonylamino)-benzy.)-6-(3-ethoxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (Pyrazol-3-carbonylamino) benzy.) - 6- (3-ethoxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one ;
2-(4-(Pyrazol-3-carbonylamino)-benzyl)-6-(3-hydroxy-4-methoxy- phenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-(Pyrazol-3-carbonylamino)-benzyl)-6-(4-methylsulfonylphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrazole-3-carbonylamino) benzyl) -6- (3-hydroxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2- (4- (pyrazol-3-carbonylamino) benzyl) -6- (4-methylsulfonylphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrazol-3-carbonyIamino)-benzyl)-6-(4-methylenoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-(Pyrazol-3-carbonylamino)-benzyl)-6-(3-cyclopentyloxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrazole-3-carbonyamino) benzyl) -6- (4-methyleneoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4- (pyrazol-3-carbonylamino) benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-(Pyrazol-3-carbonylamino)-benzyl)-6-(3-cyclopentyloxy-4- methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (3- (pyrazol-3-carbonylamino) benzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrazol-3-carbonylamino)-phenethyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrazol-3-carbonylamino) phenethyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-(Pyrazol-3-carbonylamino)-phenethyl)-6-(3,4-dimethoxyphenyl)- 5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4- (pyrazol-3-carbonylamino) phenethyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrazol-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(3-(Pyrazol-3-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (3- (pyrazol-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(2-(Pyrazol-3-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (2- (pyrazol-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrazol-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(3-(Pyrazol-3-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (3- (pyrazol-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(2-(Pyrazol-3-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-methoxy-4-trifluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (2- (pyrazol-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4- (pyrazole-3-carbonylamino) benzyl) -5- (3-methoxy-4-trifluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazine-2- one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-methoxy-4-difluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrazole-3-carbonylamino) benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-methoxy-4-fluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrazole-3-carbonylamino) benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-difluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-trifIuormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrazol-3-carbonylamino) benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4- (pyrazol-3-carbonylamino) benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-fluormethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-methoxy-4-ethoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrazole-3-carbonylamino) benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one; 3- (4- (pyrazole-3-carbonylamino) benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-ethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrazole-3-carbonylamino) benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-hydroxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrazole-3-carbonylamino) benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(4-methylsulfonylphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrazol-3-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(4-methylenoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrazol-3-carbonylamino) benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrazole-3-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(3-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (3- (pyrazole-3-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazine-2- one;
3-(4-(Pyrazol-3-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)- 3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrazol-3-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1,3,4-thiadiazin-2-one;
3-(4-(Pyrazol-3-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4- (pyrazol-3-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on;
3-(3-(Pyrazol-3-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrazol-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (3- (pyrazol-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(2-(Pyrazol-3-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (2- (pyrazol-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrazol-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(3-(Pyrazol-3-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(2-(Pyrazol-3-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (3- (pyrazol-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (2- (pyrazol-3-carbonylamino) benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-methoxy-4-trifluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-methoxy-4-difluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrazole-3-carbonylamino) benzyl) -5- (3-methoxy-4-trifluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one; 3- (4- (pyrazole-3-carbonylamino) benzyl) -5- (3-methoxy-4-difluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-methoxy-4-fluor- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrazole-3-carbonylamino) benzyl) -5- (3-methoxy-4-fluoro-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-difluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrazol-3-carbonylamino) benzyl) -5- (3-difluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-trifluormethoxy-4- methoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrazol-3-carbonylamino) benzyl) -5- (3-trifluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-fluormethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrazole-3-carbonylamino) benzyl) -5- (3-fluoromethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-oxadiazine-2- one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-methoxy-4-ethoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrazole-3-carbonylamino) benzyl) -5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-ethoxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrazole-3-carbonylamino) benzyl) -5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-hydroxy-4-methoxy- phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrazole-3-carbonylamino) benzyl) -5- (3-hydroxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(4-methylsulfonylphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrazol-3-carbonylamino) benzyl) -5- (4-methylsulfonylphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(4-methylenoxyphenyl)-6- ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;
3-(4-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (4- (pyrazol-3-carbonylamino) benzyl) -5- (4-methyleneoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 3- (4- (pyrazole-3-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(3-(Pyrazol-3-carbonylamino)-benzyl)-5-(3-cyclopentyloxy-4- methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on;3- (3- (pyrazole-3-carbonylamino) benzyl) -5- (3-cyclopentyloxy-4-methoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazine-2- one;
3-(4-(Pyrazol-3-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)-3- (4- (pyrazole-3-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) -
3,6-dihydro-1 ,3,4-oxadiazin-2-on;3,6-dihydro-1, 3,4-oxadiazin-2-one;
3-(4-(Pyrazol-3-carbonylamino)-phenethyl)-5-(3,4-dimethoxyphenyl)- 6-ethyl-3,6-dihydro-1 ,3,4-oxadiazin-2-on; 2-(3-Nicotinoylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5- tetrahydropyridazin-3-on, F. 204°;3- (4- (pyrazol-3-carbonylamino) phenethyl) -5- (3,4-dimethoxyphenyl) - 6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one; 2- (3-nicotinoylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one, mp 204 °;
2-(4-lsonicotinoylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)- 2,3,4,5-tetrahydropyridazin-3-on, Hydrochlorid F. 252°; 2-(4-Pyrazincarbonylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2- (4-isonicotinoylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) - 2,3,4,5-tetrahydropyridazin-3-one, hydrochloride mp 252 °; 2- (4-Pyrazincarbonylaminobenzyl) -6- (3-ethoxy-4-methoxyphenyl) -
2,3,4,5-tetrahydropyridazin-3-on, F. 202°;2,3,4,5-tetrahydropyridazin-3-one, mp 202 °;
2-(4-(lsoxazol-5-carbonylamino)-benzyl)-6-(3-ethoxy-4-methoxy- phenyl)-2,3,4,5-tetrahydropyridazin-3-on, F. 192°;2- (4- (isoxazole-5-carbonylamino) benzyl) -6- (3-ethoxy-4-methoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one, mp 192 °;
2-(4-Nicotinoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)- 2,3,4,5-tetrahydropyridazin-3-on, F. 205°2- (4-Nicotinoylaminobenzyl) -6- (3-cyclopentyloxy-4-methoxyphenyl) - 2,3,4,5-tetrahydropyridazin-3-one, mp 205 °
2-(4-Nicotinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetra- hydropyridazin-3-on, Hydrochlorid F. 212°;2- (4-nicotinoylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one, hydrochloride F. 212 °;
d) Verbindungen, offenbart in EP 0 539 806 B1 , ausgewählt aus derd) compounds disclosed in EP 0 539 806 B1 selected from the
Gruppegroup
5-(3-Methoxy-4-difluormethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4- thiadiazin-2-on, F. 97°; 5-(3-Methoxy-4-trifluormethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4- thiadiazin-2-on;5- (3-methoxy-4-difluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one, mp 97 °; 5- (3-methoxy-4-trifluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
5-(3-Methoxy-4-trifluormethoxyphenyl)-6-methyl-3,6-dihydro-1 ,3,4- thiadiazin-2-on;5- (3-methoxy-4-trifluoromethoxyphenyl) -6-methyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
5-(3-Methoxy-4-difluormethoxyphenyl)-6-methyl-3,6-dihydro-1 ,3,4- 4. . .. . n thιadιazιn-2-on;
5-[3-Methoxy-4-(1 , 1 ,2,2-tetraf luorethoxy)-phenyl]-6-ethyl-3,6-dihydro-5- (3-methoxy-4-difluoromethoxyphenyl) -6-methyl-3,6-dihydro-1, 3,4. 4 , ... n thιadιazιn-2-one; 5- [3-methoxy-4- (1, 1, 2,2-tetrafluoroethoxy) phenyl] -6-ethyl-3,6-dihydro-
1 ,3,4-thiadiazin-2-on;1, 3,4-thiadiazin-2-one;
5-(3-Methoxy-4-chlormethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4- thiadiazin-2-on;5- (3-methoxy-4-chloromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
5-(3-Methoxy-4-chlormethoxyphenyl)-6-methyl-3,6-dihydro-1 ,3,4- thiadiazin-2-on;5- (3-methoxy-4-chloromethoxyphenyl) -6-methyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
5-(3-Methoxy-4-pentachlorethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4- thiadiazin-2-on; 5-(3-Methoxy-4-trifluormethoxyphenyl)-6-propyl-3,6-dihydro-1 ,3,4- thiadiazin-2-on;5- (3-methoxy-4-pentachloroethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 5- (3-methoxy-4-trifluoromethoxyphenyl) -6-propyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
5-(3-Methoxy-4-difluormethoxyphenyl)-6-propyl-3,6-dihydro-1 ,3,4- thiadiazin-2-on; 5-[3-Methoxy-4-(1 ,1 ,2,-trifluorethoxy)-phenyl]-6-ethyl-3,6-dihydro-5- (3-methoxy-4-difluoromethoxyphenyl) -6-propyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 5- [3-methoxy-4- (1, 1, 2, -trifluoroethoxy) phenyl] -6-ethyl-3,6-dihydro-
1 ,3,4-thiadiazin-2-on;1, 3,4-thiadiazin-2-one;
5-[3-Methoxy-4-(1 , 1 ,2,-trif luorethoxy)-phenyl]-6-methyl-3,6-dihydro- 1 ,3,4-thiadiazin-2-on;5- [3-methoxy-4- (1, 1, 2, -trifluoroethoxy) phenyl] -6-methyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
5-(3-Methoxy-4-difluormethoxyphenyl)-3,6-dihydro-1 ,3,4-thiadiazin-2- on, F. 120°;5- (3-methoxy-4-difluoromethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one, mp 120 °;
5-(3-Methoxy-4-trifluormethoxyphenyl)-3,6-dihydro-1 ,3,4-thiadiazin-2- on;5- (3-methoxy-4-trifluoromethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
5-(4-Trifluormethoxyphenyl)-3,6-dihydro-1 ,3,4-thiadiazin-2-on; 5-[3-Methoxy-4-(1 ,1 ,2,2-tetraf luorethoxy)-phenyl]-3,6-dihydro-1 ,3,4- thiadiazin-2-on;5- (4-trifluoromethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one; 5- [3-methoxy-4- (1, 1, 2,2-tetrafluoroethoxy) phenyl] -3,6-dihydro-1, 3,4-thiadiazin-2-one;
5-(3-Methoxy-4-chlormethoxyphenyl)-3,6-dihydro-1 ,3,4-thiadiazin-2- on; 5-(3-Methoxy-4-trichlormethoxyphenyl)-3,6-dihydro-1 ,3,4-thiadiazin-2- on;5- (3-methoxy-4-chloromethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one; 5- (3-methoxy-4-trichloromethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
5-(3-Methoxy-4-pentachlorethoxyphenyl)-3,6-dihydro-1 ,3,4-thiadiazin- 2-on;5- (3-methoxy-4-pentachloroethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
5-(4-DifIuormethoxyphenyl)-3,6-dihydro-1 ,3,4-thiadiazin-2-on;5- (4-difluoromethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
5-[3-Methoxy-4-(1 ,1 ,2,2,3-pentafluorpropoxy)-phenyl]-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on;
5-[Bis-3,4-(difluormethoxy)-phenyl]-3,6-dihydro-1 ,3,4-thiadiazin-2-on;5- [3-methoxy-4- (1, 1, 2,2,3-pentafluoropropoxy) phenyl] -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 5- [bis-3,4- (difluoromethoxy) phenyl] -3,6-dihydro-1, 3,4-thiadiazin-2-one;
5-[Bis-3,4-(dichlormethoxy)-phenyl]-3,6-dihydro-1 ,3,4-thiadiazin-2-on;5- [bis-3,4- (dichloromethoxy) phenyl] -3,6-dihydro-1, 3,4-thiadiazin-2-one;
5-[Bis-3,4-(1 ,2-difluorethoxy)-phenyl]-3,6-dihydro-1 ,3,4-thiadiazin-2- on;5- [bis-3,4- (1,2-difluoroethoxy) phenyl] -3,6-dihydro-1,3,4-thiadiazin-2-one;
5-[3-Ethoxy-4-(1 ,1 ,2,2,-tetrafluorethoxy)-phenyl]-3,6-dihydro-1 ,3,4- thiadiazin-2-on;5- [3-ethoxy-4- (1, 1, 2,2, -tetrafluoroethoxy) phenyl] -3,6-dihydro-1, 3,4-thiadiazin-2-one;
5-[3-Methoxy-4-(1 ,2,2,-trichlorethoxy)-phenyl]-3,6-dihydro-1 ,3,4- thiadiazin-2-on; 5-[4-(2,2,2-Trifluorethoxy)-phenyl]-6-ethyl-3,6-dihydro-1 ,3,4- thiadiazin-2-on, F. 102°;5- [3-methoxy-4- (1, 2,2, -trichloroethoxy) phenyl] -3,6-dihydro-1, 3,4-thiadiazin-2-one; 5- [4- (2,2,2-trifluoroethoxy) phenyl] -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one, mp 102 °;
5-[3-Methoxy-4-(2,2,2-trifluorethoxy)-phenyl]-6-ethyl-3,6-dihydro- 1 ,3,4-thiadiazin-2-on, F. 123-125°; 5-[3-Methoxy-4-(2,2,2-trifluorethoxy)-phenyl]-3,6-dihydro-1 ,3,4- thiadiazin-2-on, F. 120°;5- [3-Methoxy-4- (2,2,2-trifluoroethoxy) phenyl] -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one, mp 123-125 ° ; 5- [3-methoxy-4- (2,2,2-trifluoroethoxy) phenyl] -3,6-dihydro-1, 3,4-thiadiazin-2-one, mp 120 °;
5-[3-(2,2,2-Trifluorethoxy)-4-methoxy-phenyl]-6-ethyl-3,6-dihydro- 1 ,3,4-thiadiazin-2-on, F. 120-121 °;5- [3- (2,2,2-Trifluoroethoxy) -4-methoxy-phenyl] -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one, mp 120-121 ° ;
5-(3-Difluormethoxy-4-methoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4- thiadiazin-2-on, F. 105°;5- (3-difluoromethoxy-4-methoxy-phenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one, mp 105 °;
e) Verbindungen, offenbart in EP 0 618 201 A1 , ausgewählt aus der Gruppe 3-Dimethylaminopropyl-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-e) Compounds disclosed in EP 0 618 201 A1, selected from the group 3-dimethylaminopropyl-5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-
1 ,3,4-thiadiazinon-2-on, F. 175°;1, 3,4-thiadiazinon-2-one, mp 175 °;
3-Dimethylaminopropyl-5-(3-methoxy-4-trifluormethoxy-phenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazinon-2-on; 3-Dimethylaminopropyl-5-(3-methoxy-4-difluormethoxy-phenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazinon-2-on;3-dimethylaminopropyl-5- (3-methoxy-4-trifluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one; 3-dimethylaminopropyl-5- (3-methoxy-4-difluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Dimethylaminopropyl-5-(3-methoxy-4-fluormethoxy-phenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-thiadiazinon-2-on;3-dimethylaminopropyl-5- (3-methoxy-4-fluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Dimethylaminopropyl-5-(4-methoxy-3-difluormethoxy-phenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazinon-2-on;
3-Dimethylaminopropyl-5-[4-methoxy-3-(2,2,2-trifluorethoxy)-phenyl]-3-dimethylaminopropyl-5- (4-methoxy-3-difluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one; 3-dimethylaminopropyl-5- [4-methoxy-3- (2,2,2-trifluoroethoxy) phenyl] -
6-ethyl-3,6-dihydro-1 ,3,4-thiadiazinon-2-on;6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Dimethylaminopropyl-5-(4-methoxy-3-fluormethoxy-phenyl)-6-ethyl-3-dimethylaminopropyl-5- (4-methoxy-3-fluoromethoxy-phenyl) -6-ethyl-
3,6-dihydro-1 ,3,4-thiadiazinon-2-on;3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Dimethylaminopropyl-5-(3-methoxy-4-ethoxy-phenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazinon-2-on;3-dimethylaminopropyl-5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Dimethylaminopropyl-5-(4-methoxy-3-ethoxy-phenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazinon-2-on; 3-Dimethylaminopropyl-5-(3-methoxy-4-hydroxy-phenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazinon-2-on;3-dimethylaminopropyl-5- (4-methoxy-3-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one; 3-dimethylaminopropyl-5- (3-methoxy-4-hydroxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Dimethylaminopropyl-5-(3,4-dimethoxy-phenyl)-3,6-dihydro-1 ,3,4- thiadiazinon-2-on; 2-Dimethylaminoethyl-5-(3,4-dimethoxy-phenyl)-6-ethyl-3,6-dihydro-3-dimethylaminopropyl-5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazinon-2-one; 2-dimethylaminoethyl-5- (3,4-dimethoxy-phenyl) -6-ethyl-3,6-dihydro-
1 ,3,4-thiadiazinon-2-on;1, 3,4-thiadiazinon-2-one;
2-Dimethylaminoethyl-5-(3-methoxy-4-trifluormethoxy-phenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-thiadiazinon-2-on;2-dimethylaminoethyl-5- (3-methoxy-4-trifluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
2-Dimethylaminoethyl-5-(3-methoxy-4-difluormethoxy-phenyl)-6-ethyl-2-dimethylaminoethyl-5- (3-methoxy-4-difluoromethoxy-phenyl) -6-ethyl-
3,6-dihydro-1 ,3,4-thiadiazinon-2-on;3,6-dihydro-1, 3,4-thiadiazinon-2-one;
2-Dimethylaminoethyl-5-(3-methoxy-4-fluormethoxy-phenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-thiadiazinon-2-on;2-dimethylaminoethyl-5- (3-methoxy-4-fluoromethoxy-phenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
2-Dimethylaminoethyl-5-(4-methoxy-3-difluormethoxy-phenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-thiadiazinon-2-on;2-dimethylaminoethyl-5- (4-methoxy-3-difluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
2-Dimethylaminoethyl-5-(4-methoxy-3-fluormethoxy-phenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-thiadiazinon-2-on;2-dimethylaminoethyl-5- (4-methoxy-3-fluoromethoxy-phenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
2-Dimethylaminoethyl-5-(3-methoxy-4-ethoxy-phenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazinon-2-on;2-dimethylaminoethyl-5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
2-Dimethylaminoethyl-5-(4-methoxy-3-ethoxy-phenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazinon-2-on;2-dimethylaminoethyl-5- (4-methoxy-3-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
2-Dimethylaminoethyl-5-(4-methoxy-3-hydroxy-phenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazinon-2-on;2-dimethylaminoethyl-5- (4-methoxy-3-hydroxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Morpholinopropyl-5-[3-methoxy-4-(1 ,1 ,2,2,3-pentafluorpropoxy)- phenyl]-6-ethyl-3,6-dihydro-1 ,3,4-thiadiazinon-2-on;
3-Dimethylaminopropyl-5-[3,4-bis-(difluormethoxy)-phenyl]-3,6- dihydro-1 ,3,4-thiadiazinon-2-on;3-morpholinopropyl-5- [3-methoxy-4- (1,1,2,3,3-pentafluoropropoxy) phenyl] -6-ethyl-3,6-dihydro-1,3,4-thiadiazinone-2- one; 3-dimethylaminopropyl-5- [3,4-bis (difluoromethoxy) phenyl] -3,6-dihydro-1,3,4-thiadiazinon-2-one;
3-Dimethylaminopropyl-5-[3-methoxy-4-(1 ,1 ,2-trifluorethoxy)-phenyl]-3-dimethylaminopropyl-5- [3-methoxy-4- (1, 1, 2-trifluoroethoxy) phenyl] -
3,6-dihydro-1 ,3,4-thiadiazinon-2-on;3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Dimethylamιnopropyl-5-[3,4-bis-(chlormethoxy)-phenyl]-3,6-dihydro-3-Dimethylamιnopropyl-5- [3,4-bis (chloromethoxy) phenyl] -3,6-dihydro-
1 ,3,4-thiadiazinon-2-on;1, 3,4-thiadiazinon-2-one;
3-Morpholinopropyl-5-(3-methoxy-4-fluormethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazinon-2-on; 3-Morpholinopropyl-5-(3-methoxy-4-trifluormethoxyphenyl)-6-ethyl-3-morpholinopropyl-5- (3-methoxy-4-fluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one; 3-morpholinopropyl-5- (3-methoxy-4-trifluoromethoxyphenyl) -6-ethyl-
3,6-dihydro-1 ,3,4-thiadiazinon-2-on;3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Piperidinopropyl-5-(3-methoxy-4-difluormethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazinon-2-on; 3-Morpholinopropyl-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-3-piperidinopropyl-5- (3-methoxy-4-difluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one; 3-morpholinopropyl-5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-
1 ,3,4-thiadiazinon-2-on;1, 3,4-thiadiazinon-2-one;
3-Piperidinopropyl-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4- thiadiazinon-2-on;3-piperidinopropyl-5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Pyrrolidinopropyl-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro- 1 ,3,4-thiadiazinon-2-on;3-pyrrolidinopropyl-5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Morpholinopropyl-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazinon-2-on;3-morpholinopropyl-5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Piperidinopropyl-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro- 1 ,3,4-thiadiazinon-2-on;3-piperidinopropyl-5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Pyrrolidinopropyl-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazinon-2-on;3-pyrrolidinopropyl-5- (3-methoxy-4-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Morpholinopropyl-5-(4-methoxy-3-ethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazinon-2-on;3-morpholinopropyl-5- (4-methoxy-3-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Piperidinopropyl-5-(4-methoxy-3-ethoxyphenyl)-6-ethyl-3,6-dihydro- 1 ,3,4-thiadiazinon-2-on;3-piperidinopropyl-5- (4-methoxy-3-ethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Morpholinopropyl-5-(3-methoxy-4-difluormethoxyphenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-thiadiazinon-2-on;3-morpholinopropyl-5- (3-methoxy-4-difluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Piperidinopropyl-5-(4-methoxy-3-difluormethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazinon-2-on;
3-Piperidinopropyl-5-[3-(2,2,2-trifluorethoxy)-4-methoxyphenyl]-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazinon-2-on;3-piperidinopropyl-5- (4-methoxy-3-difluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one; 3-piperidinopropyl-5- [3- (2,2,2-trifluoroethoxy) -4-methoxyphenyl] -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Morpholinopropyl-5-[3-(2,2,2-trifluorethoxy)-4-methoxyphenyl]-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazinon-2-on;3-morpholinopropyl-5- [3- (2,2,2-trifluoroethoxy) -4-methoxyphenyl] -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
2-Morpholinoethyl-5-(3-methoxy-4-fluormethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazinon-2-on;2-morpholinoethyl-5- (3-methoxy-4-fluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
2-Morpholinoethyl-5-(3-methoxy-4-trifluormethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazinon-2-on;2-morpholinoethyl-5- (3-methoxy-4-trifluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
f) Verbindungen, offenbart in DE 196 04 388 A1 , ausgewählt aus der Gruppef) compounds disclosed in DE 196 04 388 A1 selected from the group
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)-propylester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- (N , N-diethylamino) propyl;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diethylamino)-ethylester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (N , N-diethylamino) ethyl ester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diisopropylamino)-ethylester, Hydrochlorid, F. 218°;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (N , N-diisopropylamino) ethyl ester, hydrochloride, mp 218 °;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-carbaminsäure-6-(N,N-dimethylamino)-hexylester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 6- (N , N-dimethylamino) hexyl;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-dimethylamino)-1 -methyl- ethylester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (N , N-dimethylamino) -1-methyl ethyl ester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-carbaminsäure-(1 -methyl-4-piperidyl)-ester, F. 183°; N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin-N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid- (1-methyl -4-piperidyl) ester, mp 183 °; N- [4- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazine
3-ylmethyl)-phenyl]-carbaminsäure-(4-hydroxy-1-piperidyl)-ethylester;3-ylmethyl) -phenyl] carbamic acid (4-hydroxy-1-piperidyl) ethyl ester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadi- azin-3-ylmethyl)-phenyl]-carbaminsäure-2-morpholino-ethylester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- morpholino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-carbaminsäure-3-morpholino-propylester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-carbaminsäure-2-thiomorpholino-ethylester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3-morpholino- propyl; N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid-2-thiomorpholino- ethyl ester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin-N- [4- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazine
3-ylmethyl)-phenyl]-carbaminsäure-3-thiomorpholino-propylester;3-ylmethyl) -phenyl] -carbamic acid 3-thiomorpholino-propyl ester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadi- azin-3-ylmethyl)-phenyl]-carbaminsäure-2-piperazino-ethylester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- piperazino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-carbaminsäure-3-piperazino-propylester; N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin-N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid-3-piperazino- propyl; N- [4- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazine
3-ylmethyl)-phenyl]-carbaminsäure-2-pyrrolidino-ethylester;3-ylmethyl) -phenyl] -carbamic acid 2-pyrrolidino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-carbaminsäure-3-pyrrolidino-propylester; N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin-N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid-3-pyrrolidino- propyl; N- [3- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazine
3-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)-propylester, Hydrochlorid, F. 161 °;3-ylmethyl) phenyl] carbamic acid 3- (N, N-diethylamino) propyl ester, hydrochloride, mp 161 °;
N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diethylamino)-ethylester;N- [3- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (N , N-diethylamino) ethyl ester;
N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diisopropylamino)-ethylester;N- [3- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (N , N-diisopropylamino) ethyl;
N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-carbaminsäure-6-(N,N-dimethylamino)-hexylester; N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin-N- [3- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 6- (N , N-dimethylamino) hexyl; N- [3- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazine
3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-dimethylamino)-1-methyl- ethylester;3-ylmethyl) phenyl] carbamic acid 2- (N, N-dimethylamino) -1-methylethyl ester;
N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-carbaminsäure-(1 -methyl-4-piperidyl)-ester;N- [3- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid- (1-methyl -4-piperidyl) ester;
N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thia- diazin-3-ylmethyl)-phenyl]-carbaminsäure-2-morpholino-ethylester;N- [3- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thia-diazin-3-ylmethyl) phenyl] carbamic acid 2- morpholino-ethyl ester;
N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-carbaminsäure-3-morpholino-propylester;N- [3- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid-3-morpholino- propyl;
N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-carbaminsäure-2-thiomorpholino-ethylester;
N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin-N- [3- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid-2-thiomorpholino- ethyl ester; N- [3- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazine
3-ylmethyl)-phenyl]-carbaminsäure-3-thiomorpholino-propylester;3-ylmethyl) -phenyl] -carbamic acid 3-thiomorpholino-propyl ester;
N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin-N- [3- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazine
3-ylmethyl)-phenyl]-carbaminsäure-2-piperazino-ethylester;3-ylmethyl) -phenyl] -carbamic acid 2-piperazino-ethyl ester;
N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin-N- [3- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazine
3-ylmethyl)-phenyl]-carbaminsäure-3-piperazino-propylester;3-ylmethyl) -phenyl] -carbamic acid 3-piperazino-propyl ester;
N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-carbaminsäure-2-pyrrolidino-ethylester; N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadi- azin-3-ylmethyl)-phenyl]-carbaminsäure-3-pyrrolidino-propylester;N- [3- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid-2-pyrrolidino- ethyl ester; N- [3- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- pyrrolidino-propyl ester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4-thia- diazin-3-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)- propylester;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thia-diazin-3-ylmethyl) phenyl] carbamic acid - 3- (N, N-diethylamino) propyl ester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4-thia- diazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diethylamino)-ethylester;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thia-diazin-3-ylmethyl) phenyl] carbamic acid - 2- (N, N-diethylamino) ethyl ester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4-thia- diazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diisopropylamino)- ethylester;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thia-diazin-3-ylmethyl) phenyl] carbamic acid - 2- (N, N-diisopropylamino) ethyl ester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4-thia- diazin-3-ylmethyl)-phenyl]-carbaminsäure-6-(N,N-dimethylamino)- hexylester; N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4-thia- diazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-dimethylamino)-1-methyl- ethylester;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thia-diazin-3-ylmethyl) phenyl] carbamic acid - 6- (N, N-dimethylamino) hexyl ester; N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thia-diazin-3-ylmethyl) phenyl] carbamic acid - 2- (N, N-dimethylamino) -1-methylethyl ester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4-thia- diazin-3-ylmethyl)-phenyl]-carbaminsäure-(1 -methyl-4-piperidyl)-ester, F. 153;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thia-diazin-3-ylmethyl) phenyl] carbamic acid - (1-methyl-4-piperidyl) ester, m.p. 153;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4-thia- diazin-3-ylmethyl)-phenyl]-carbaminsäure-2-morpholino-ethylester;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thia-diazin-3-ylmethyl) phenyl] carbamic acid - 2-morpholino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4-thia- diazin-3-ylmethyl)-phenyl]-carbaminsäure-3-morpholino-propylester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4-thia- diazin-3-ylmethyl)-phenyl]-carbaminsäure-2-thiomorpholino-ethylester;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thia-diazin-3-ylmethyl) phenyl] carbamic acid - 3-morpholino-propyl; N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thia-diazin-3-ylmethyl) phenyl] carbamic acid - 2-thiomorpholino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4-thia- diazin-3-ylmethyl)-phenyl]-carbaminsäure-3-thiomorpholino-propylester;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thia-diazin-3-ylmethyl) phenyl] carbamic acid - 3-thiomorpholino-propyl ester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4-thia- diazin-3-ylmethyl)-phenyl]-carbaminsäure-2-piperazino-ethylester;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thia-diazin-3-ylmethyl) phenyl] carbamic acid - 2-piperazino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4-thia- diazin-3-ylmethyl)-phenyl]-carbaminsäure-3-piperazino-propylester; N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4-thia- diazin-3-ylmethyl)-phenyl]-carbaminsäure-2-pyrrolidino-ethylester;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thia-diazin-3-ylmethyl) phenyl] carbamic acid - 3-piperazino-propyl ester; N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thia-diazin-3-ylmethyl) phenyl] carbamic acid - 2-pyrrolidino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-pyrrolidino-propylester; N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)- propylester;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- pyrrolidino-propyl ester; N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid - 3- (N, N-diethylamino) propyl ester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diethylamino)- ethylester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid - 2- (N, N-diethylamino) ethyl ester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diisopropylamino)- ethylester; N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-6-(N,N-dimethylamino)- hexylester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid - 2- (N, N-diisopropylamino) ethyl ester; N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid - 6- (N, N-dimethylamino) hexyl ester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-dimethylamino)-1 - methyl-ethylester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid - 2- (N, N-dimethylamino) -1-methyl-ethyl ester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-(1-methyl-4-piperidyl)-ester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid - (1-methyl-4-piperidyl) ester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1 ,3,4- thia-diazin-3-ylmethyl)-phenyl]-carbaminsäure-2-morpholino-ethylester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-morpholino-propylester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thia-diazin-3-ylmethyl) phenyl] - carbamic acid 2-morpholino-ethyl ester; N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid - 3-morpholino-propyl;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-thiomorpholino-ethylester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid - 2-thiomorpholino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-thiomorpholino-propyl- ester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid - 3-thiomorpholino-propyl ester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-piperazino-ethylester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid - 2-piperazino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-piperazino-propylester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid - 3-piperazino-propyl ester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-pyrrolidino-ethylester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid - 2-pyrrolidino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-pyrrolidino-propylester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid - 3-pyrrolidino-propyl ester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)- propylester;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] - carbamic acid 3- (N, N-diethylamino) propyl ester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diethylamino)- ethylester; N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H-N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] - carbamic acid 2- (N, N-diethylamino) ethyl ester; N- [4- (3,6-dihydro-5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N- diisopropylamino)-ethylester;1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (N, N-diisopropylamino) ethyl ester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-6-(N,N-dimethylamino)- hexylester;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] - carbamic acid 6- (N, N-dimethylamino) hexyl ester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H-N- [4- (3,6-dihydro-5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-dimethylamino)-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (N, N-dimethylamino) -
1 -methyl-ethylester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H-1-methyl-ethyl ester; N- [4- (3,6-dihydro-5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-(1 -methyl-4-piperidyl)- ester;1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid (1-methyl-4-piperidyl) ester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H-N- [4- (3,6-dihydro-5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-2-oxo-2H-
1 ,3,4-thia-diazin-3-ylmethyl)-phenyl]-carbaminsäure-2-morpholino- ethylester;1, 3,4-thia-diazin-3-ylmethyl) -phenyl] -carbamic acid-2-morpholino-ethyl ester;
-2-oxo-2H-1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3- morpholino-propylester; N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H--2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3-morpholino-propyl ester; N- [4- (3,6-dihydro-5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-thiomorpholino-ethyl- ester;1, 3,4-thiadiazin-3-ylmethyl) -phenyl] -carbamic acid-2-thiomorpholino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-thiomorpholino- propylester;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] - 3-thiomorpholino-propyl carbamate;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-piperazino- ethylester;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] - carbamic acid 2-piperazino ethyl ester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-piperazino- propylester;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] - 3-piperazino-propyl carbamic acid;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-pyrrolidino- ethylester;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] - carbamic acid 2-pyrrolidino ethyl ester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-pyrrolidino- propylester;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -6-ethyl-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] - 3-pyrrolidinopropyl carbamic acid;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)- propylester;N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- (N, N-diethylamino) propyl ester;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diethylamino)- ethylester;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (N, N-diethylamino) ethyl ester; N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-ρhenyl]-carbaminsäure-2-(N,N- diisopropylamino)-ethylester;1, 3,4-thiadiazin-3-ylmethyl) -phenyl] carbamic acid 2- (N, N-diisopropylamino) ethyl ester;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-6-(N,N-dimethylamino)- hexylester;1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 6- (N, N-dimethylamino) hexyl ester;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-dimethylamino)- 1 -methyl-ethylester;N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (N, N-dimethylamino) -1-methyl-ethyl ester;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-(1 -methyl-4-piperidyl)- ester; N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-Dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid- (1st -methyl-4-piperidyl) ester; N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thia-diazin-3-ylmethyl)-phenyl]-carbaminsäure-2-morpholino- ethylester;1, 3,4-thia-diazin-3-ylmethyl) -phenyl] -carbamic acid-2-morpholino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-morpholino- propylester;N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- morpholino propyl ester;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-thiomorpholino-ethyl- ester; N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- thiomorpholino ethyl ester; N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-thiomorpholino- propylester;1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3-thiomorpholino propyl ester;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-piperazino- ethylester;N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- piperazino ethyl ester;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-piperazino- propylester;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3-piperazino propyl ester; N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-pyrrolidino- ethylester;1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2-pyrrolidino ethyl ester;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-pyrrolidino- propylester.1, 3,4-thiadiazin-3-ylmethyl) -phenyl] -carbamic acid-3-pyrrolidinopropyl ester.
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)- propylester;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- (N, N-diethylamino) propyl ester;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diethylamino)- ethylester; N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diisopropylamino)- ethylester;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (N, N-diethylamino) ethyl ester; N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (N, N-diisopropylamino) ethyl ester;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-6-(N,N-dimethylamino)- hexylester;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 6- (N, N-dimethylamino) hexyl ester;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-dimethylamino)-1 - methyl-ethylester;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (N, N-dimethylamino) -1-methyl-ethyl ester;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-(1 -methyl-4-piperidyl)-ester;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid- (1st -methyl-4-piperidyl) ester;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-morpholino-ethylester;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- morpholino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-morpholino-propylester;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- morpholino-propyl;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-thiomorpholino-ethylester;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-thiomorpholino-propyl- ester;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- thiomorpholino-ethyl ester; N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- thiomorpholino propyl ester;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-piperazino-ethylester;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- piperazino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-piperazino-propylester;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- piperazino-propyl ester;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-pyrrolidino-ethylester;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- pyrrolidino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-pyrrolidino-propylester;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- pyrrolidino-propyl ester;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)- propylester;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- (N, N-diethylamino) propyl ester;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diethylamino)- ethylester;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (N, N-diethylamino) ethyl ester;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diisopropylamino)- ethylester;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (N, N-diisopropylamino) ethyl ester;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-6-(N,N-dimethylamino)- hexylester;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 6- (N, N-dimethylamino) hexyl ester;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-dimethylamino)-1 - methyl-ethylester;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (N, N-dimethylamino) -1-methyl-ethyl ester;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-(1 -methyl-4-piperidyl)-ester;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid- (1st -methyl-4-piperidyl) ester;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-morpholino-ethylester;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- morpholino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-morpholino-propylester;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-thiomorpholino-ethylester;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- morpholino-propyl; N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- thiomorpholino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-thiomorpholino-propyl- ester;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- thiomorpholino propyl ester;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-piperazino-ethylester;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- piperazino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-piperazino-propylester;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- piperazino-propyl ester;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-pyrrolidino-ethylester;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- pyrrolidino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-pyrrolidino-propylester;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- pyrrolidino-propyl ester;
N-[4-(3,6-Dihydro-5-(3-fluormethoxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)- propylester;N- [4- (3,6-Dihydro-5- (3-fluoromethoxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- (N, N-diethylamino) propyl ester;
N-[4-(3,6-Dihydro-5-(3-fluormethoxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diethylamino)- ethylester;N- [4- (3,6-Dihydro-5- (3-fluoromethoxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (N, N-diethylamino) ethyl ester;
N-[4-(3,6-Dihydro-5-(3-fluormethoxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diisopropyl- amino)-ethylester;N- [4- (3,6-Dihydro-5- (3-fluoromethoxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (N, N-diisopropylamino) ethyl ester;
N-[4-(3,6-Dihydro-5-(3-fluormethoxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-6-(N,N-dimethylamino)- hexylester; N-[4-(3,6-Dihydro-5-(3-fluormethoxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-Dihydro-5- (3-fluoromethoxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 6- (N, N-dimethylamino) hexyl ester; N- [4- (3,6-dihydro-5- (3-fluoromethoxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-dimethylamino)- 1-methyl-ethylester;1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (N, N-dimethylamino) -1-methyl-ethyl ester;
N-[4-(3,6-Dihydro-5-(3-fluormethoxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-(1 -methyl-4-piperidyl)- ester;
N-[4-(3,6-Dihydro-5-(3-fluormethoxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-Dihydro-5- (3-fluoromethoxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid- (1st -methyl-4-piperidyl) ester; N- [4- (3,6-dihydro-5- (3-fluoromethoxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thia-diazin-3-ylmethyl)-phenyl]-carbaminsäure-2-morpholino- ethylester;1, 3,4-thia-diazin-3-ylmethyl) -phenyl] -carbamic acid-2-morpholino-ethyl ester;
N-[4-(3,6-Dihydro-5-(3-fluormethoxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-dihydro-5- (3-fluoromethoxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-morpholino- propylester;1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3-morpholino-propyl ester;
N-[4-(3,6-Dihydro-5-(3-fluormethoxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-thiomorpholino-ethyl- ester;N- [4- (3,6-Dihydro-5- (3-fluoromethoxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- thiomorpholino ethyl ester;
N-[4-(3,6-Dihydro-5-(3-fluormethoxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-thiomorpholino- propylester; N-[4-(3,6-Dihydro-5-(3-fluormethoxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-Dihydro-5- (3-fluoromethoxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- thiomorpholino propyl ester; N- [4- (3,6-dihydro-5- (3-fluoromethoxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-piperazino- ethylester;1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2-piperazinoethyl ester;
N-[4-(3,6-Dihydro-5-(3-fluormethoxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-piperazino- propylester;N- [4- (3,6-Dihydro-5- (3-fluoromethoxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- piperazino propyl ester;
N-[4-(3,6-Dihydro-5-(3-fluormethoxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-pyrrolidino- ethylester; N-[4-(3,6-Dihydro-5-(3-fluormethoxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-Dihydro-5- (3-fluoromethoxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- pyrrolidino ethyl ester; N- [4- (3,6-dihydro-5- (3-fluoromethoxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-pyrrolidino- propylester;1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3-pyrrolidinopropyl ester;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-2-morpholino-acetamid;N- [4- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-morpholinoacetamide;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-2-(N,N-diethylamino)-acetamid;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (N, N diethylamino) acetamide;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-2-(N,N-diisopropylamino)-acetamid;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (N, N -diisopropylamino) -acetamide;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-thiomorpholino-acetamid;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin-N- [4- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-thiomorpholinoacetamide; N- [4- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazine
3-ylmethyl)-phenyl]-2-piperidino-acetamid;3-ylmethyl) phenyl] -2-piperidino-acetamide;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin-N- [4- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazine
3-ylmethyl)-phenyl]-2-(4-hydroxy-piperidino)-acetamid;3-ylmethyl) phenyl] -2- (4-hydroxy-piperidino) -acetamide;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin-N- [4- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazine
3-ylmethyl)-phenyl]-2-piperazino-acetamid;3-ylmethyl) phenyl] -2-piperazino-acetamide;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-2-(4-methyl-piperazino)-acetamid; N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin-N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (4-methyl piperazino) -acetamide; N- [4- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazine
3-ylmethyl)-phenyl]-2-pyrrolidino-acetamid;3-ylmethyl) phenyl] -2-pyrrolidino-acetamide;
N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-2-(4-morpholinyl)-acetamid; N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin-N- [3- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (4-morpholinyl ) -acetamide; N- [3- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazine
3-ylmethyl)-phenyl]-2-(N,N-diethylamino)-acetamid;3-ylmethyl) phenyl] -2- (N, N-diethylamino) acetamide;
N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-2-(N,N-diisopropylamino)-acetamid;N- [3- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (N, N -diisopropylamino) -acetamide;
N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-thiomorpholino-acetamid;N- [3- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-thiomorpholinoacetamide;
N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-2-piperidino-acetamid;N- [3- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-piperidinoacetamide;
N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-2-(4-hydroxy-piperidino)-acetamid;N- [3- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (4-hydroxy piperidino) -acetamide;
N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-2-piperazino-acetamid;N- [3- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-piperazinoacetamide;
N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-2-(4-methyl-piperazino)-acetamid;N- [3- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (4-methyl piperazino) -acetamide;
N-[3-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-2-pyrrolidino-acetamid;N- [3- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-pyrrolidino-acetamide;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-3-(4-morpholinyl)-propionsäureamid;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3- (4-morpholinyl ) -propionsäureamid;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-3-(N,N-diethylamino)-propionsäureamid;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin-N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3- (N, N diethylamino) -propionsäureamid; N- [4- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazine
3-ylmethyl)-phenyl]-3-(N,N-diisopropylamino)-propionsäureamid;3-ylmethyl) -phenyl] -3- (N, N-diisopropylamino) -propionsäureamid;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin-N- [4- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazine
3-ylmethyl)-phenyl]-3-thiomorpholino-propionsäureamid;3-ylmethyl) -phenyl] -3-thiomorpholino-propionamide;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin-N- [4- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazine
3-ylmethyl)-phenyl]-3-piperidino-propionsäureamid;3-ylmethyl) -phenyl] -3-piperidino-propionamide;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-3-(4-hydroxy-piperidino)-propionsäureamid; N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin-N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3- (4-hydroxy piperidino) -propionsäureamid; N- [4- (3,6-dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazine
3-ylmethyl)-phenyl]-3-piperazino-propionsäureamid;3-ylmethyl) -phenyl] -3-piperazino-propionamide;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-3-pyrrolidino-propionsäureamid; N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-(4-morpholinyl)-acetamid;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3-pyrrolidino-propionic acid amide; N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (4th -morpholinyl) -acetamide;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-(N,N-diethylamino)-acetamid;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (N , N-diethylamino) acetamide;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-(N,N-diisopropylamino)-acetamid;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (N , N-diisopropylamino) -acetamide;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-thiomorpholino-acetamid;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-thiomorpholino- acetamide;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-piperidino-acetamid;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-piperidino- acetamide;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-(4-hydroxy-piperidino)-acetamid;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (4th -hydroxy-piperidino) -acetamide;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-piperazino-acetamid;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-piperazino- acetamide;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-pyrrolidino-acetamid;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-pyrrolidino- acetamide;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-(4-morpholinyl)-acetamid;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (4th -morpholinyl) -acetamide;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-(N,N-diethylamino)-acetamid;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-(N,N-diisopropylamino)-acetamid;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (N , N-diethylamino) acetamide; N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (N , N-diisopropylamino) -acetamide;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-thiomorpholino-acetamid;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-thiomorpholino- acetamide;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-piperidino-acetamid;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-piperidino- acetamide;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-(4-hydroxy-piperidino)-acetamid; N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-piperazino-acetamid;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (4th -hydroxy-piperidino) -acetamide; N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-piperazino- acetamide;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-pyrrolidino-acetamid; N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-(4-morpholinyl)-acetamid;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-pyrrolidino- acetamide; N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (4th -morpholinyl) -acetamide;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-(N,N-diethylamino)-acetamid;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (N , N-diethylamino) acetamide;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-(N,N-diisopropylamino)-acetamid;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (N , N-diisopropylamino) -acetamide;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-thiomorpholino-acetamid;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-thiomorpholino- acetamide;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-piperidino-acetamid;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-piperidino- acetamide;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-(4-hydroxy-piperidino)-acetamid;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (4th -hydroxy-piperidino) -acetamide;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-piperazino-acetamid;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-piperazino- acetamide;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-2-pyrrolidino-acetamid;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-pyrrolidino- acetamide;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-2-(4-morpholinyl)-acetamid;N- [4- (3,6-Dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] -2- (4th -morpholinyl) -acetamide;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-2-(N,N-diethylamino)-acetamid;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-Dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] -2- (N , N-diethylamino) acetamide; N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-2-(N,N-diisopropylamino)-acetamid;1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2- (N, N-diisopropylamino) acetamide;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-2-thiomorpholino-acetamid;1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-thiomorpholino-acetamide;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thiadiazin-3-yImethyl)-phenyl]-2-piperidino-acetamid;1, 3,4-thiadiazin-3-yimethyl) phenyl] -2-piperidino-acetamide;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-2-(4-hydroxy-piperidino)-acetamid; N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-Dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] -2- (4th -hydroxy-piperidino) -acetamide; N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-2-pyrrolidino-acetamid;1, 3,4-thiadiazin-3-ylmethyl) phenyl] -2-pyrrolidino-acetamide;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-(4-morpholinyl)-propionsäureamid; N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-(N,N-diethylamino)-propionsäureamid;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3- (4th -morpholinyl) -propionsäureamid; N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3- (N , N-diethylamino) -propionsäureamid;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-(N,N-diisopropylamino)-propionsäureamid;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3- (N , N-diisopropylamino) -propionsäureamid;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-thiomorpholino-propionsäure-amid;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3-thiomorpholino- propionic acid amide;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-piperidino-propionsäureamid;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3-piperidino- propionamide;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-(4-hydroxy-piperidino)-propionsäureamid;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3- (4th -hydroxy-piperidino) -propionsäureamid;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-piperazino-propionsäureamid;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3-piperazino- propionamide;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-pyrrolidino-propionsäureamid;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3-pyrrolidino- propionamide;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-(4-morpholinyl)-propionsäureamid;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3- (4th -morpholinyl) -propionsäureamid;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-(N,N-diethylamino)-propionsäureamid;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3- (N , N-diethylamino) -propionsäureamid;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-(N,N-diisopropylamino)-propionsäureamid;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-thiomorpholino-propionsäureamid;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3- (N , N-diisopropylamino) -propionsäureamid; N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3-thiomorpholino- propionamide;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-piperidino-propionsäureamid;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3-piperidino- propionamide;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-(4-hydroxy-piperidino)-propionsäureamid;N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3- (4th -hydroxy-piperidino) -propionsäureamid;
N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-piperazino-propionsäureamid; N-[4-(3,6-Dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-pyrrolidino-propionsäureamid.N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3-piperazino- propionamide; N- [4- (3,6-Dihydro-5- (3-propoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3-pyrrolidino- propionamide.
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-(4-morpholinyl)-propionsäureamid; N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-(N,N-diethylamino)-propionsäureamid;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3- (4th -morpholinyl) -propionsäureamid; N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3- (N , N-diethylamino) -propionsäureamid;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 l3,4- thiadiazin-3-ylmethyl)-phenyl]-3-(N,N-diisopropylamino)-propionsäureamid;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1 L 3,4-thiadiazin-3-ylmethyl) phenyl] -3- (N , N-diisopropylamino) -propionsäureamid;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-thiomorpholino-propionsäureamid;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3-thiomorpholino- propionamide;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-piperidino-propionsäureamid;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3-piperidino- propionamide;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-(4-hydroxy-piperidino)-propionsäureamid;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3- (4th -hydroxy-piperidino) -propionsäureamid;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-piperazino-propionsäureamid;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3-piperazino- propionamide;
N-[4-(3,6-Dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-3-pyrrolidino-propionsäureamid;N- [4- (3,6-Dihydro-5- (3-isopropoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3-pyrrolidino- propionamide;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-3-(4-morpholinyI)-propionsäure-amid;N- [4- (3,6-Dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] -3- (4th -morpholinyI) -propionic acid amide;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-3-(N,N-diethylamino)-propionsäure- amid;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-Dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] -3- (N , N-diethylamino) propionic acid amide; N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-3-(N,N-diisopropylamino)-propion- säureamid;1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3- (N, N-diisopropylamino) propionic acid amide;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-3-thiomorpholino-propionsäureamid;1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3-thiomorpholino-propionic acid amide;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-3-piperidino-propionsäure-amid;N- [4- (3,6-Dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] -3-piperidino- propionic acid amide;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-3-(4-hydroxy-piperidino)-propionsäure- amid;N- [4- (3,6-Dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] -3- (4th -hydroxy-piperidino) -propionic acid amide;
N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H- 1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-3-piperazino-propionsäure-amid; N-[4-(3,6-Dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-Dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl) phenyl] -3-piperazino- propionic acid amide; N- [4- (3,6-dihydro-5- (3-cyclopentyloxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-3-pyrrolidino-propionsäureamid;1, 3,4-thiadiazin-3-ylmethyl) phenyl] -3-pyrrolidino-propionic acid amide;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)-propylester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid-3- (N, N-diethylamino ) -propyl ester;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diethylamino)-ethylester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N, N-diethylamino ) -ethyl ester;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diisopropylamino)-ethylester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N, N-diisopropylamino ) -ethyl ester;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-carbaminsäure-6-(N,N-dimethylamino)-hexylester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 6- (N, N-dimethylamino ) hexyl;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-carbaminsäure-2-(N,N-dimethylamino)-1-methyl- ethylester; N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-carbaminsäure-(1-methyl-4-piperidyl)-ester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N, N-dimethylamino ) -1-methylethyl ester; N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid- (1-methyl-4-piperidyl ) ester;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-carbaminsäure-(4-hydroxy-1-piperidyl)-ethylester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid- (4-hydroxy-1-piperidyl ) -ethyl ester;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin- 2- ylmethyl)-phenyl]-carbaminsäure-2-morpholino-ethylester;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-carbaminsäure-3-morpholino-propylester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 2-morpholino-ethyl ester; N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 3-morpholino-propyl ester;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-carbaminsäure-2-thiomorpholino-ethylester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 2-thiomorpholino-ethyl ester;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-carbaminsäure-3-thiomorpholino-propylester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 3-thiomorpholino-propyl ester;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-carbaminsäure-2-piperazino-ethylester; N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-carbaminsäure-3-piperazino-propylester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 2-piperazino-ethyl ester; N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-piperazino-propyl ester;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-carbaminsäure-2-pyrrolidino-ethylester; N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-carbaminsäure-3-pyrrolidino-propylester.N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 2-pyrrolidino-ethyl ester; N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 3-pyrrolidino-propyl ester.
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)- propylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3- (N, N -diethylamino) - propyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diethylamino)- ethylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N, N -diethylamino) - ethyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diisopropylamino)- ethylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N, N -diisopropylamino) - ethyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-6-(N,N-dimethylamino)- hexylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 6- (N, N -dimethylamino) - hexyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-dimethylamino)-1- methyl-ethylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N, N -dimethylamino) -1-methyl-ethyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-(1-methyl-4-piperidyl)-ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-morpholino-ethylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid- (1-methyl-4 -piperidyl) ester; N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-morpholino-ethyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-morpholino-propylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-morpholino-propyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-thiomorpholino-ethylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-thiomorpholino-ethyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-thiomorpholino-propylester; N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-piperazino-ethylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-thiomorpholino-propyl ester; N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-piperazinoethyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-piperazino-propylester; N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-pyrrolidino-ethylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-piperazino-propyl ester; N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-pyrrolidinoethyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-pyrrolidino-propylester.N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-pyrrolidino propyl ester.
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)- propylester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3- (N , N-diethylamino) propyl ester;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diethylamino)- ethylester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N , N-diethylamino) - ethyl ester;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diisopropylamino)- ethylester; N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-6-(N,N-dimethylamino)- hexylester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N , N-diisopropylamino) - ethyl ester; N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 6- (N , N-dimethylamino) hexyl ester;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-dimethylamino)-1 - methyl-ethylester;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-(1-methyl-4-piperidyl)-ester; N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-morpholino-ethyl- es- ter;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N , N-dimethylamino) -1 - methyl ethyl ester; N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid (1-methyl -4-piperidyl) ester; N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-morpholino- ethyl ester;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-morpholino-propylester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-morpholino- propyl;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-thiomorpholino-ethylester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-thiomorpholino- ethyl ester;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-thiomorpholino-propylester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-thiomorpholino- propyl;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-piperazino-ethylester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-piperazino- ethyl ester;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-piperazino-propylester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-piperazino propyl;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-pyrrolidino-ethylester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-pyrrolidino- ethyl ester;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-pyrrolidino-propylester;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-pyrrolidino- propyl;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)- propylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3- (N, N-diethylamino) propyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diethylamino)- ethylester; N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diisopropylamino)- ethylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N, N-diethylamino) ethyl ester; N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N, N-diisopropylamino) ethyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-6-(N,N-dimethylamino)- hexylester;
N-[4-(6-(3-Ethoxy-4-methoxyρhenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-dimethylamino)-1 - methyl-ethylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 6- (N, N-dimethylamino) hexyl ester; N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N, N-dimethylamino) -1-methyl-ethyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-(1 -methyl-4-piperidyl)-ester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid- (1st -methyl-4-piperidyl) ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-morpholino-ethylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2- morpholino-ethyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-morpholino-propylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3- morpholino-propyl;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-thiomorpholino-ethylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2- thiomorpholino-ethyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-thiomorpholino-propylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3- thiomorpholino-propyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-piperazino-ethylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2- piperazino-ethyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-piperazino-propylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3- piperazino-propyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-pyrrolidino-ethylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2- pyrrolidino-ethyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-pyrrolidino-propylester; N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5- tetrahydro-pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethyl- amino)-propylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3- pyrrolidino-propyl ester; N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid-3- (N, N -diethylamino) propyl ester;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2, 3,4,5- tetrahydro-pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diethyl- amino)-ethylester;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2, 3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N, N -diethylamino) ethyl ester;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5- tetrahydro-pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-(N,N- diisopropylamino)-ethylester;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5- tetrahydro-pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-6-(N,N- dimethylamino)-hexylester;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N, N - diisopropylamino) ethyl ester; N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 6- (N, N - dimethylamino) hexyl ester;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5- 5 tetrahydro-pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-(N,N- dimethylamino)-1 -methyl-ethylester;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5- 5 tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N, N-dimethylamino) -1-methyl-ethyl ester;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5- tetrahydro-pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-(1 -methyl-4- 10 piperidyl)-ester;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid- (1-methyl-4 - 10 piperidyl) esters;
N-[4-(6-(3-Cyc.opentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5- tetrahydro-pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-morpholino- ethylester; __, 5 N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5- tetrahydro-pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-morpholino- propylester;N- [4- (6- (3-Cyc.opentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 2-morpholino- ethyl ester; __, 5 N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid-3-morpholino - propyl ester;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5- tetrahydro-pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-thiomorpholino-N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid-2-thiomorpholino-
20 ethylester;20 ethyl esters;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5- tetrahydro-pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-thiomorpholino- propylester; 5 N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5- tetrahydro-pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-piperazino- ethylester;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 3-thiomorpholino-propyl ester; 5 N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 2-piperazinoethyl ester ;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5- 0 tetrahydro-pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-piperazino- propylester;N- [4- (6- (3-cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5 0-tetrahydro-pyridazin-2-ylmethyl) -phenyl] -carbamic acid 3-propyl piperazino ;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2, 3,4,5- tetrahydro-pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-pyrrolidino- ethylester; 5
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyr)-3-oxo-2,3,4,5- tetrahydro-pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-pyrrolidino- propylester;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2, 3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 2-pyrrolidinoethyl ester; 5 N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyr) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid-3-pyrrolidinopropyl ester;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)- propylester;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3- (N, N -diethylamino) - propyl ester;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diethylamino)- ethylester;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N, N -diethylamino) - ethyl ester;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diisopropylamino)- ethylester; N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-6-(N,N-dimethylamino)- hexylester;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N, N -diisopropylamino) - ethyl ester; N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 6- (N, N -dimethylamino) - hexyl ester;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-dimethylamino)-1 - methyl-ethylester;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N, N -dimethylamino) -1 - methyl ethyl ester;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-(1-methyl-4-piperidyl)-ester; N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-morpholino-ethylester;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid- (1-methyl-4 -piperidyl) ester; N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-morpholino-ethyl ester;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-morpholino-propylester;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-morpholino-propyl ester;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-thiomorpholino-ethylester;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-thiomorpholino-ethyl ester;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-thiomorpholino-propylester;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-thiomorpholino-propyl ester;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-piperazino-ethylester;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-piperazinoethyl ester;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-piperazino-propylester;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-pyrrolidino-ethylester;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-piperazino-propyl ester; N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-pyrrolidinoethyl ester;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-pyrrolidino-propylester;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-pyrrolidino propyl ester;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)- propylester;N- [4- (6- (3-Isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3- (N, N -diethylamino) - propyl ester;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diethylamino)- ethylester;N- [4- (6- (3-Isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N, N -diethylamino) - ethyl ester;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-diisopropylamino)- ethylester;N- [4- (6- (3-Isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N, N -diisopropylamino) - ethyl ester;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-6-(N,N-dimethylamino)- hexylester;N- [4- (6- (3-Isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 6- (N, N -dimethylamino) - hexyl ester;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-(N,N-dimethylamino)-1- methyl-ethylester;N- [4- (6- (3-Isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2- (N, N -dimethylamino) -1-methyl-ethyl ester;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-(1-methyl-4-piperidyl)-ester; N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-morpholino-ethylester;N- [4- (6- (3-Isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid- (1-methyl-4 -piperidyl) ester; N- [4- (6- (3-isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-morpholino-ethyl ester;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-morpholino-propylester; N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-thiomorpholino-ethylester;N- [4- (6- (3-Isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-morpholino-propyl ester; N- [4- (6- (3-isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-thiomorpholino-ethyl ester;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-thiomorpholino-propylester;N- [4- (6- (3-Isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-thiomorpholino-propyl ester;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-piperazino-ethylester;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-piperazino-propylester;N- [4- (6- (3-isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-piperazinoethyl ester; N- [4- (6- (3-isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-piperazino-propyl ester;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-pyrrolidino-ethylester;N- [4- (6- (3-Isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-pyrrolidinoethyl ester;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-pyrrolidino-propylester;N- [4- (6- (3-Isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-pyrrolidinopropyl ester;
N-[4-(6-(3-Fluormethoxy-4-methoxyphenyl 3-0X0-2, 3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3- N,N-diethylamino)- propylester;N- [4- (6- (3-fluoromethoxy-4-methoxyphenyl 3-0X0-2, 3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid-3N, N-diethylamino) - propyl ester;
N-[4-(6-(3-Fluormethoxy-4-methoxyphenyl -3-0X0-2, 3,4, 5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2- N,N-diethylamino)- ethylester;N- [4- (6- (3-Fluoromethoxy-4-methoxyphenyl -3-0X0-2, 3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid-2N, N-diethylamino ) - ethyl ester;
N-[4-(6-(3-Fluormethoxy-4-methoxyphenyl 3-0X0-2, 3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2 N,N-diisopropylamino)- ethylester;N- [4- (6- (3-fluoromethoxy-4-methoxyphenyl 3-0X0-2, 3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid-2 N, N-diisopropylamino) - ethyl ester;
N-[4-(6-(3-Fluormethoxy-4-methoxyphenyl -3-0X0-2, 3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyI]-carbaminsäure-6- N,N-dimethylamino)- hexylester;N- [4- (6- (3-Fluoromethoxy-4-methoxyphenyl -3-0X0-2, 3,4,5-tetrahydropyridazin-2-ylmethyl) phenyI] carbamic acid-6N, N-dimethylamino ) - hexyl ester;
N-[4-(6-(3-Fluormethoxy-4-methoxyphenyl -3-0X0-2, 3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2- N,N-dimethylamino)-1- methyl-ethylester;N- [4- (6- (3-Fluoromethoxy-4-methoxyphenyl -3-0X0-2, 3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid-2N, N-dimethylamino ) -1-methyl-ethyl ester;
N-[4-(6-(3-Fluormethoxy-4-methoxyphenyl -3-0X0-2, 3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-(1 - methyl-4-piperidyl)-ester;N- [4- (6- (3-fluoromethoxy-4-methoxyphenyl -3-0X0-2, 3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid- (1-methyl-4- piperidyl) ester;
N-[4-(6-(3-Fluormethoxy-4-methoxyphenyl 3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-morpholino-ethylester;N- [4- (6- (3-fluoromethoxy-4-methoxyphenyl 3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-morpholino-ethyl ester;
N-[4-(6-(3-Fluormethoxy-4-methoxyphenyl -3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-morpholino-propylester;N- [4- (6- (3-Fluoromethoxy-4-methoxyphenyl -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-morpholino-propyl ester;
N-[4-(6-(3-Fluormethoxy-4-methoxyphenyl -3-0X0-2, 3, 4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-thiomorpholino-ethylesterN- [4- (6- (3-Fluoromethoxy-4-methoxyphenyl -3-0X0-2, 3, 4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-thiomorpholino-ethyl ester
N-[4-(6-(3-Fluormethoxy-4-methoxyphenyl 3-0x0-2, 3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-thiomorpholino-propylester;
N-[4-(6-(3-Fluormethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-piperazino-ethylester;N- [4- (6- (3-fluoromethoxy-4-methoxyphenyl 3-0x0-2, 3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-thiomorpholino-propyl ester; N- [4- (6- (3-fluoromethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-piperazinoethyl ester;
N-[4-(6-(3-Fluormethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-piperazino-propylester;N- [4- (6- (3-fluoromethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3-piperazino-propyl ester;
N-[4-(6-(3-Fluormethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-2-pyrrolidino-ethylester;N- [4- (6- (3-fluoromethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 2-pyrrolidinoethyl ester;
N-[4-(6-(3-Fluormethoxy-4-methoxyphenyl)-3-oxo-2, 3,4,5- tetrahydro-pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-pyrrolidino- propylester.N- [4- (6- (3-Fluoromethoxy-4-methoxyphenyl) -3-oxo-2, 3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid 3-pyrrolidinopropyl ester.
N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-(4-morpholinyl)-acetamid, F. 150°;N- [4- (6- (3-ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2- (4-morpholinyl) - acetamide, m.p. 150 °;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-(N,N-diethylamino)-acetamid;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2- (N, N-diethylamino ) -acetamide;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-(N,N-diisopropylamino)-acetamid;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2- (N, N-diisopropylamino ) -acetamide;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-thiomorpholino-acetamid;N- [4- (6- (3-ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2-thiomorpholinoacetamide;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-piperidino-acetamid;N- [4- (6- (3-ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2-piperidinoacetamide;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-(4-hydroxy-piperidino)-acetamid; N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-piperazino-acetamid;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2- (4-hydroxy-piperidino ) -acetamide; N- [4- (6- (3-ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2-piperazinoacetamide;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-pyrrolidino-acetamid; N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-2-(4-morpholinyl)-acetamid;N- [4- (6- (3-ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2-pyrrolidino-acetamide; N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] -2- (4-morpholinyl) acetamide;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-2-(N,N-diethylamino)-acetamid;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] -2- (N, N-diethylamino) - acetamide;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-2-(N,N-diisopropylamino)-acetamid;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] -2- (N, N-diisopropylamino) - acetamide; N- [4- (6- (3,4-dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin
2-ylmethyl)-phenyl]-2-thiomorpholino-acetamid;2-ylmethyl) phenyl] -2-thiomorpholino-acetamide;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-2-piperidino-acetamid;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] -2-piperidinoacetamide;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-2-(4-hydroxy-piperidino)-acetamid;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] -2- (4-hydroxy-piperidino) - acetamide;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-2-piperazino-acetamid; N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-2-pyrrolidino-acetamid;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] -2-piperazinoacetamide; N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] -2-pyrrolidino-acetamide;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-3-(4-morpholinyl)-propionsäureamid; N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-3-(N,N-diethylamino)-propionsäureamid;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] -3- (4-morpholinyl) propionic acid amide; N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] -3- (N, N-diethylamino) - propionamide;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-3-(N,N-diisopropylamino)-propionsäureamid;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] -3- (N, N-diisopropylamino) - propionamide;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-N- [4- (6- (3,4-dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin
2-ylmethyl)-phenyl]-3-thiomorpholino-propionsäureamid;2-ylmethyl) -phenyl] -3-thiomorpholino-propionamide;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-3-piperidino-propionsäureamid;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] -3-piperidino-propionic acid amide;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-3-(4-hydroxy-piperidino)-propionsäureamid;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] -3- (4-hydroxy-piperidino) - propionamide;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-3-piperazino-propionsäureamid;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] -3-piperazino-propionic acid amide;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-3-pyrrolidino-propionsäureamid;N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] -3-pyrrolidino-propionic acid amide;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-(4-morpholinyl)-acetamid;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2- (4-morpholinyl) - acetamide;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-(N,N-diethylamino)-acetamid;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2- (N, N-diethylamino ) -acetamide;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-(N,N-diisopropylamino)-acetamid;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-thiomorpholino-acetamid;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2- (N, N-diisopropylamino ) -acetamide; N- [4- (6- (3-propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2-thiomorpholinoacetamide;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-piperidino-acetamid;N- [4- (6- (3-propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2-piperidinoacetamide;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-(4-hydroxy-piperidino)-acetamid;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2- (4-hydroxy-piperidino ) -acetamide;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-2-piperazino-acetamid; N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-pyrrolidino-acetamid;N- [4- (6- (3-propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) -2-piperazinoacetamide; N- [4- (6- (3-propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2-pyrrolidino-acetamide;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-(4-morpholinyl)-acetamid; N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-(N,N-diethylamino)-acetamid;N- [4- (6- (3-isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2- (4-morpholinyl) - acetamide; N- [4- (6- (3-Isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2- (N, N-diethylamino ) -acetamide;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-(N,N-diisopropylamino)-acetamid;N- [4- (6- (3-Isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2- (N, N-diisopropylamino ) -acetamide;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-thiomorpholino-acetamid;N- [4- (6- (3-isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2-thiomorpholino-acetamide;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-piperidino-acetamid;N- [4- (6- (3-isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2-piperidinoacetamide;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-(4-hydroxy-piperidino)-acetamid;N- [4- (6- (3-Isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2- (4-hydroxy-piperidino ) -acetamide;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-2-piperazino-acetamid;N- [4- (6- (3-isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) -2-piperazinoacetamide;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-pyrrolidino-acetamid;N- [4- (6- (3-isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2-pyrrolidino-acetamide;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetra- hydro-pyridazin-2-ylmethyl)-phenyl]-2-(4-morpholinyl)-acetamid;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetra-hydro-pyridazin-2-ylmethyl) phenyl] -2- (4-morpholinyl ) -acetamide;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2, 3,4,5- tetrahydro-pyridazin-2-ylmethyl)-phenyl]-2-(N,N-diethylamino)-acetamid;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5- tetrahydro-pyridazin-2-ylmethyl)-phenyl]-2-(N,N-diisopropylamino)- acetamid;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2, 3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] -2- (N, N-diethylamino ) -acetamide; N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] -2- (N, N-diisopropylamino ) - acetamide;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetra- hydro-pyridazin-2-ylmethyl)-phenyl]-2-thiomorpholino-acetamid;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetra-hydro-pyridazin-2-ylmethyl) phenyl] -2-thiomorpholino-acetamide;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetra- hydro-pyridazin-2-ylmethyl)-phenyl]-2-piperidino-acetamid;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetra-hydro-pyridazin-2-ylmethyl) phenyl] -2-piperidinoacetamide;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetra- hydro-pyridazin-2-ylmethyl)-phenyl]-2-(4-hydroxy-piperidino)-acetamid;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetra-hydro-pyridazin-2-ylmethyl) phenyl] -2- (4-hydroxy piperidino) -acetamide;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetra- hydro-pyridazin-2-ylmethyl)-2-piperazino-acetamid;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetra-hydro-pyridazin-2-ylmethyl) -2-piperazinoacetamide;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetra- hydro-pyridazin-2-ylmethyl)-phenyl]-2-pyrrolidino-acetamid;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetra-hydro-pyridazin-2-ylmethyl) phenyl] -2-pyrrolidino-acetamide;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-3-(4-morpholinyl)-propionsäureamid;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -3- (4-morpholinyl) - propionamide;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-3-(N,N-diethylamino)-propionsäureamid;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -3- (N, N-diethylamino ) -propionsäureamid;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-3-(N,N-diisopropylamino)-propionsäureamid;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -3- (N, N-diisopropylamino ) -propionsäureamid;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyhdazin-2-ylmethyl)-phenyl]-3-thiomorpholino-propionsäure amid; N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyhdazin-2-ylmethyl)-phenyl]-3-piperidino-propionsäureamid;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyhdazin-2-ylmethyl) phenyl] -3-thiomorpholino-propionic acid amide; N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyhdazin-2-ylmethyl) phenyl] -3-piperidino-propionic acid amide;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-3-(4-hydroxy-piperidino)-propion-säureamid; N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyhdazin-2-ylmethyl)-phenyl]-3-piperazino-propionsäureamid;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -3- (4-hydroxy-piperidino ) -propionic acid amide; N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyhdazin-2-ylmethyl) phenyl] -3-piperazino-propionic acid amide;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyhdazin-2-ylmethyl)-phenyl]-3-pyrrolidino-propionsäureamid;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyhdazin-2-ylmethyl) phenyl] -3-pyrrolidino-propionic acid amide;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-3-(4-morpholinyl)-propionsäureamid;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-3-(N,N-diethylamino)-propionsäureamid;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -3- (4-morpholinyl) - propionamide; N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -3- (N, N-diethylamino ) -propionsäureamid;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-3-(N,N-diisopropylamino)-propionsäureamid;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -3- (N, N-diisopropylamino ) -propionsäureamid;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-3-thiomorpholino-propionsäure amid;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -3-thiomorpholino-propionic acid amide;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-3-piperidino-propionsäureamid; N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- py dazin-2-ylmethyl)-phenyl]-3-(4-hydroxy-piperidino)-propion-säureamid;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -3-piperidino-propionic acid amide; N- [4- (6- (3-propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropy-dazin-2-ylmethyl) phenyl] -3- (4-hydroxy- piperidino) propionic acid amide;
N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-3-piperazino-propionsäureamid; N-[4-(6-(3-Propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-3-pyrroiidino-propionsäureamid;N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -3-piperazino-propionic acid amide; N- [4- (6- (3-Propoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -3-pyrroidino propionic acid amide;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-3-(4-morpholinyl)-propionsäureamid;N- [4- (6- (3-isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -3- (4-morpholinyl) - propionamide;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-3-(N,N-diethylamino)-propionsäureamid;N- [4- (6- (3-Isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -3- (N, N-diethylamino ) -propionsäureamid;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-3-(N,N-diisopropylamino)-propionsäureamid;N- [4- (6- (3-Isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -3- (N, N-diisopropylamino ) -propionsäureamid;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-3-thiomorpholino-propionsäureamid;N- [4- (6- (3-isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -3-thiomorpholino-propionic acid amide;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-3-piperidino-propionsäureamid;N- [4- (6- (3-isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -3-piperidino-propionic acid amide;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-3-(4-hydroxy-piperidino)-propionsäureamid;N- [4- (6- (3-Isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -3- (4-hydroxy-piperidino ) -propionsäureamid;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-3-piperazino-propionsäureamid;N- [4- (6- (3-isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -3-piperazino-propionic acid amide;
N-[4-(6-(3-lsopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-3-pyrrolidino-propionsäureamid;N- [4- (6- (3-isopropoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -3-pyrrolidino-propionic acid amide;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetra- hydro-pyridazin-2-ylmethyl)-phenyl]-3-(4-morpholinyl)-propionsäureamid;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5- tetrahydro-pyridazin-2-ylmethyl)-phenyl]-3-(N,N-diethylamino)- propionsäureamid;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetra-hydro-pyridazin-2-ylmethyl) phenyl] -3- (4-morpholinyl ) -propionsäureamid; N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] -3- (N, N-diethylamino ) - propionic acid amide;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5- tetrahydro-pyridazin-2-ylmethyl)-phenyl]-3-(N,N-diisopropylamino)-propion- säureamid;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] -3- (N, N-diisopropylamino ) -propionic acid amide;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetra- hydro-pyridazin-2-ylmethyl)-phenyl]-3-thiomorpholino-propionsäureamid; N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetra- hydro-pyridazin-2-ylmethyl)-phenyl]-3-piperidino-propionsäureamid;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetra-hydro-pyridazin-2-ylmethyl) phenyl] -3-thiomorpholino-propionic acid amide; N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetra-hydro-pyridazin-2-ylmethyl) phenyl] -3-piperidino-propionic acid amide;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetra- hydro-pyridazin-2-ylmethyl)-phenyl]-3-(4-hydroxy-piperidino)-propionsäure- amid;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetra-hydro-pyridazin-2-ylmethyl) phenyl] -3- (4-hydroxy -piperidino) -propionic acid amide;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetra- hydro-pyridazin-2-ylmethyl)-phenyl]-3-piperazino-propionsäureamid;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetra-hydro-pyridazin-2-ylmethyl) phenyl] -3-piperazino-propionic acid amide;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetra- hydro-pyridazin-2-ylmethyl)-phenyl]-3-pyrrolidino-propionsäure-amid;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetra-hydro-pyridazin-2-ylmethyl) phenyl] -3-pyrrolidino-propionic acid- amide;
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)-propylester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- (N , N-diethylamino) propyl;
und/oder ihrer physiologisch unbedenklichen Salze zur Herstellung eines Arzneimittels zur Behandlung von Osteoporose, Tumoren, Tumormetastasen, Atherosklerose, rheumatoide Arthritis, multiple Sklerose, Diabetes mellitus, ulzerative Kolitis und AIDS.and / or their physiologically acceptable salts for the manufacture of a medicament for the treatment of osteoporosis, tumors, tumor metastases, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, ulcerative colitis and AIDS.
Gegenstand der Erfindung ist insbesondere die Verwendung von a) Verbindungen, offenbart in EP 0 738 715 A2, ausgewählt aus der GruppeThe invention relates in particular to the use of a) compounds disclosed in EP 0 738 715 A2, selected from the group
2-(4-Ethoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahyd ro-pyridazin-3-on ;2- (4-ethoxycarbonylaminobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-Methylsulfonamidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydro-pyridazin-3-on;
2-(3-Acetamidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro- pyridazin-3-on;2- (3-methylsulfonamidobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one; 2- (3-acetamidobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydropyridazin-3-one;
2-(4-Trifluoracetamidobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2- (4-Trifluoracetamidobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydro-pyridazin-3-on;2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Ethoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2- (4-Ethoxycarbonylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-
2,3,4, 5-tetrahydro-pyridazin-3-on;2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Methoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2- (4-Methoxycarbonylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydro-pyridazin-3-on; 2-(4-Butyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahydro-pyridazin-3-on; b) Verbindungen, offenbart in EP 0 723 962 B1 , ausgewählt aus der Gruppe 3-(4-Nitrobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4- thiadiazin-2-on;2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4-butyrylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; b) Compounds disclosed in EP 0 723 962 B1, selected from the group 3- (4-nitrobenzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4- thiadiazin-2-one;
3-(4-Aminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1 ,3,4- thiadiazin-2-on;3- (4-aminobenzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Trifluoroacetamidobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (4-trifluoroacetamidobenzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Acetamidobenzyl)-5-(3,4-dimethoxy-phenyl)-3,6-dihydro-1 ,3,4- thiadiazin-2-on;3- (4-acetamidobenzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Methoxybenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro- 1 ,3,4-thiadiazin-2-one;3- (4-methoxybenzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(2,6-Dichlorobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro- 1 ,3,4-thiadiazin-2-on; c) Verbindungen, offenbart in EP 0 763 534 A1 , ausgewählt aus der Gruppe3- (2,6-dichlorobenzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; c) compounds disclosed in EP 0 763 534 A1 selected from the group
3-(4-Picolinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (4-picolinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro- 1 ,3,4-thiadiazin-2-on;3- (4-Picolinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro- 1 ,3,4-thiadiazin-2-on;
3-(4-lsonicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-3- (4-nicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4-lsonicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-
1 ,3,4-thiadiazin-2-on;1, 3,4-thiadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-oxadiazin-2-on;3- (4-nicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-oxadiazin-2-one;
2-(4-Nicotinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5- tetrahyd ro-pyridazin-3-on ; d) Verbindungen, offenbart in EP 0 539 806 B1 , ausgewählt aus der2- (4-nicotinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; d) compounds disclosed in EP 0 539 806 B1 selected from the
Gruppe 5-(3-Methoxy-4-difluormethoxy-phenyl)-6-ethyl-3,6-dihydro-1 ,3,4- thiadiazin-2-on;Group 5- (3-methoxy-4-difluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
5-(3-Methoxy-4-difluormethoxy-phenyl)-3,6-dihydro-1 ,3,4-thiadiazin-2- on; e) Verbindungen, offenbart in EP 0 618 201 A1 , ausgewählt aus der Gruppe5- (3-methoxy-4-difluoromethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one; e) compounds disclosed in EP 0 618 201 A1 selected from the group
3-Dimethylaminopropyl-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro- 1 ,3,4-thiadiazinon-2-on;3-dimethylaminopropyl-5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;
3-Dimethylaminopropyl-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1 ,3,4- thiadiazinon-2-on;3-dimethylaminopropyl-5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Dimethylaminoethyl-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro- 1 ,3,4-thiadiazinon-2-on;3-dimethylaminoethyl-5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Piperidinopropyl-5-(3-methoxy-4-difluormethoxy-phenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-thiadiazinon-2-on;3-piperidinopropyl-5- (3-methoxy-4-difluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Morpholinopropyl-5-(3-methoxy-4-difluormethoxy-phenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-thiadiazinon-2-on; f) Verbindungen, offenbart in DE 196 04 388 A1 , ausgewählt aus der Gruppe3-morpholinopropyl-5- (3-methoxy-4-difluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one; f) compounds disclosed in DE 196 04 388 A1 selected from the group
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4-thiadiazin- 3-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)-propylester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- (N , N-diethylamino) propyl;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)- propylester;
N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazin-2- ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethyl-amino)-propylester; N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)- propylester;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- (N, N-diethylamino) propyl ester; N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydro-pyridazin-2-ylmethyl) phenyl] carbamic acid-3- (N, N-diethyl amino) propyl ester; N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3- (N, N -diethylamino) - propyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-(4-methylpiperazino)-acetamid;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2- (4-methylpiperazino) - acetamide;
N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetra- hydro-pyridazin-2-ylmethyl)-phenyl]-2-(4-methylpiperazino)-acetamid;N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetra-hydro-pyridazin-2-ylmethyl) phenyl] -2- (4-methylpiperazino ) -acetamide;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(4-methyl-piperazino)- acetamid;N- [4- (3,6-Dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (4-methyl-piperazino) acetamide;
und/oder ihrer physiologisch unbedenklichen Salze zur Herstellung eines Arzneimittels zur Behandlung von Osteoporose, Tumoren, Tumormetastasen, Atherosklerose, rheumatoide Arthritis, multiple Sklerose, Diabetes mellitus, ulzerative Kolitis und AIDS.
and / or their physiologically acceptable salts for the manufacture of a medicament for the treatment of osteoporosis, tumors, tumor metastases, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, ulcerative colitis and AIDS.
Claims
1. Verwendung von1. Use of
a) Verbindungen der Formel I, offenbart in EP 0 738 715 A2,a) compounds of the formula I, disclosed in EP 0 738 715 A2,
worinwherein
R1 und R2 jeweils unabhängig voneinander H oder A,R 1 and R 2 are each independently H or A,
R3 und R4 jeweils unabhängig voneinander -OH, -OR10, -S-R10, -SO-R10, -S02-R10, Hai, Methylendioxy, -N02, -NH2, -NHR10 oder -NR10R11,R 3 and R 4 each independently of one another -OH, -OR 10 , -SR 10 , -SO-R 10 , -S0 2 -R 10 , shark, methylenedioxy, -N0 2 , -NH 2 , -NHR 10 or -NR 10 R 11 ,
R5 einen unsubstituierten oder ein- oder zweifach durch R6 und/oder R7 substituierten Phenylrest,R 5 is a phenyl radical which is unsubstituted or mono- or disubstituted by R 6 and / or R 7 ,
Q fehlt oder Alkylen mit 1-6 C-Atomen,Q is absent or alkylene with 1-6 C atoms,
R6 und R7 jeweils unabhängig voneinander -NH2, -NR8R9, -NHR10, -NR10R11, -NO2. Hai, -CN, -OA, -COOH oder -COOA,R 6 and R 7 each independently of one another -NH 2 , -NR 8 R 9 , -NHR 10 , -NR 10 R 11 , -NO 2. Hai, -CN, -OA, -COOH or -COOA,
R8 und R9 jeweils unabhängig voneinander H, Acyl mit 1-8 C- Atomen, das durch 1 -5 F- und/oder Cl-Atome substituiert sein kann, -COOA, -SO-A, -S02A, -CONH2) -CONHA, -CONA2, -CO-COOH, -CO-COOA,R 8 and R 9 each independently of one another are H, acyl having 1-8 C atoms, which can be substituted by 1 -5 F and / or Cl atoms, -COOA, -SO-A, -S0 2 A, - CONH 2) -CONHA, -CONA 2 , -CO-COOH, -CO-COOA,
-CO-CONH2, -CO-CONHA oder -CO-CONA2,-CO-CONH 2 , -CO-CONHA or -CO-CONA 2 ,
A Alkyl mit 1 bis 6 C-Atomen, das durch 1 -5 F- und/oderA alkyl with 1 to 6 carbon atoms, which is represented by 1 -5 F and / or
Cl-Atome substituiert sein kann, R10 und R1 jeweils unabhängig voneinander A, Cycloalkyl mit 3-7 C- Atomen, Methylencycloalkyl mit 4-8 C-Atomen oder Al- kenyl mit 2-8 C-Atomen undCl atoms can be substituted, R 10 and R 1 are each independently A, cycloalkyl with 3-7 C atoms, methylene cycloalkyl with 4-8 C atoms or alkenyl with 2-8 C atoms and
Hai F. CI, Br oder I bedeuten,Hai F. CI, Br or I mean
b) Verbindungen der Formel I, offenbart in EP 0 723 962 B1 ,b) compounds of the formula I, disclosed in EP 0 723 962 B1,
worinwherein
R1 und R2 jeweils unabhängig voneinander H oder A,R 1 and R 2 are each independently H or A,
R3 und R4 jeweils unabhängig voneinander -OH, -OR10, -S-R10,R 3 and R 4 each independently of one another -OH, -OR 10 , -SR 10 ,
-SO-R10, -SO2-R10, Hai, Methylendioxy, -N02, -NH2l -SO-R 10 , -SO2-R 10 , shark, methylenedioxy, -N0 2 , -NH 2l
-NHR10 oder -NR10R11, R5 einen unsubstituierten oder ein- oder zweifach durch R6 7 und/oder R substituierten Phenylrest,-NHR 10 or -NR 10 R 11 , R 5 is an unsubstituted or mono- or disubstituted by R 6 7 and / or R phenyl radical,
Q fehlt oder Alkylen mit 1 -6 C-Atomen,Q is absent or alkylene with 1 -6 C atoms,
R6 und R7 jeweils unabhängig voneinander -NH2, -NR8R9, -NHR10, -NR10R11, -N02) Hai, -CN, -OA, -COOH oder -COOA, R8 und R9 jeweils unabhängig voneinander H, Acyl mit 1 -8 C-R 6 and R 7 each independently of one another -NH 2 , -NR 8 R 9 , -NHR 10 , -NR 10 R 11 , -N0 2) shark, -CN, -OA, -COOH or -COOA, R 8 and R 9 each independently of one another H, acyl with 1 -8 C-
Atomen, das durch 1-5 F- und/oder Cl-Atome substituiert sein kann, -COOA, -SO-A, -S02A, -CONH2, -CONHA, -CONA2, -CO-COOH, -CO-COOA,Atoms, which can be substituted by 1-5 F and / or Cl atoms, -COOA, -SO-A, -S0 2 A, -CONH2, -CONHA, -CONA 2 , -CO-COOH, -CO- COOA,
-CO-CONH2, -CO-CONHA oder -CO-CONA2, A Alkyl mit 1 bis 6 C-Atomen, das durch 1-5 F- und/oder-CO-CONH2, -CO-CONHA or -CO-CONA 2 , A alkyl with 1 to 6 carbon atoms, which is replaced by 1-5 F and / or
Cl-Atome substituiert sein kann, R10 und R11 jeweils unabhängig voneinander A, Cycloalkyl mit 3-7 C-Cl atoms can be substituted, R 10 and R 11 are each independently A, cycloalkyl with 3-7 C-
Atomen, Methylencycloalkyl mit 4-8 C-Atomen oderAtoms, methylene cycloalkyl with 4-8 C atoms or
Alkenyl mit 2-8 C-Atomen undAlkenyl with 2-8 C atoms and
Hai F, Cl, Br oder I bedeuten,Shark F, Cl, Br or I mean
Verbindungen der Formel I, offenbart in EP 0 763 534 A1 ,Compounds of formula I, disclosed in EP 0 763 534 A1,
worin wherein
B einen aromatischen Heterocyclus mit 1 bis 4 N-, O- und/oder S-Atomen, über N oder C gebunden, der un- substituiert oder ein-, zwei- oder dreifach durch Hai, A und/oder OA substituiert sein kann, und auch an einen Benzol- oder Pyridinring kondensiert sein kann,B is an aromatic heterocycle with 1 to 4 N, O and / or S atoms, bonded via N or C, which may be unsubstituted or substituted once, twice or three times by shark, A and / or OA, and can also be fused to a benzene or pyridine ring,
Q fehlt oder Alkylen mit 1 -6 C-Atomen, X CH2, S oder O,Q is absent or alkylene with 1 -6 C atoms, X CH 2 , S or O,
R1 und R2 jeweils unabhängig voneinander H oder A,R 1 and R 2 are each independently H or A,
R3 und R4 jeweils unabhängig voneinander -OH, OR5, -S-R5, -SO-R5, -S02-R5, Hai, Methylendioxy, -N02, -NH2, -NHR5 oder -NR5R6,R 3 and R 4 each independently of one another -OH, OR 5 , -SR 5 , -SO-R 5 , -S0 2 -R 5 , shark, methylenedioxy, -N0 2 , -NH 2 , -NHR 5 or -NR 5 R 6 ,
R5 und R6 jeweils unabhängig voneinander A, Cycloalkyl mit 3-7 C-Atomen, Methylencycloalkyl mit 4-8 C-Atomen oderR 5 and R 6 are each independently A, cycloalkyl with 3-7 C atoms, methylene cycloalkyl with 4-8 C atoms or
Alkenyl mit 2-8 C-Atomen, A Alkyl mit 1 bis 10 C-Atomen, das durch 1 bis 5 F- und/oder Cl-Atome substituiert sein kann und Hai F,CI, Broder I bedeuten,Alkenyl with 2-8 C atoms, A alkyl with 1 to 10 C atoms, which can be substituted by 1 to 5 F and / or Cl atoms and mean Shark F, CI, Broder I,
d) Verbindungen der Formel I, offenbart in EP 0539806 B1 ,d) compounds of the formula I, disclosed in EP 0539806 B1,
worinwherein
R1 und R2 jeweils unabhängig voneinander H oder A,R 1 and R 2 are each independently H or A,
R3 H, OA oder 0-CmH2m+ι-nXn.R 3 H, OA or 0-C m H 2m + ι-nXn.
R -0-CmH2m-(-1-nXn.R -0-C m H 2 m - (- 1-nXn.
X F oder Cl,X F or Cl,
A Alkyl mit 1 -6 C-Atomen, m 1,2, 3, 4, 5 oder 6 und n 1,2,3,4,5,6,7,8,9, 10, 11, 12 oder 13 bedeuten,A is alkyl with 1 -6 carbon atoms, m 1, 2, 3, 4, 5 or 6 and n 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13 .
e) Verbindungen der Formel I, offenbart in EP 0618201 A1 ,e) compounds of the formula I, disclosed in EP 0618201 A1,
worin wherein
R1 und R2 jeweils unabhängig voneinander H oder A,R 1 and R 2 are each independently H or A,
R3 und R4 jeweils unabhängig voneinander OH, OA, SA, SOA,R 3 and R 4 each independently of one another OH, OA, SA, SOA,
S02A, Hai, Methylendioxy, Cycloalkyloxy mit 3-7 C-S0 2 A, shark, methylenedioxy, cycloalkyloxy with 3-7 C-
Atomen oder 0-CmH2m+ι-kFk,Atoms or 0-C m H 2m + ι- k F k ,
Rs -NR _.6bRn7' oder -N (CH2)n,R s -NR _.6 b R n 7 'or -N (CH 2 ) n ,
wobei eine CH2-Gruppe auch durch Sauerstoff ersetzt sein kann,a CH 2 group can also be replaced by oxygen,
R6 und R7 jeweils unabhängig voneinander H oder A,R 6 and R 7 each independently of one another are H or A,
Q Alkylen mit 1-6 C-Atomen, A Alkyl mit 1 -6 C-Atomen,Q alkylene with 1-6 C atoms, A alkyl with 1 -6 C atoms,
Hai F, Cl, Br oder I, m 1 , 2, 3, 4, 5 oder 6, n 3, 4, 5 oder 6, k 1 , 2, 3, 4, 5, 6, 7, 8, 9, 10, 1 1 , 12 oder 13 bedeuten,Shark F, Cl, Br or I, m 1, 2, 3, 4, 5 or 6, n 3, 4, 5 or 6, k 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 1 1, 12 or 13 mean
Verbindungen der Formel I, offenbart in DE 196 04 388 A1 ,Compounds of the formula I, disclosed in DE 196 04 388 A1,
worin wherein
R1 und R2 jeweils unabhängig voneinander H oder A, R3 und R4 jeweils unabhängig voneinander -OH, OA, -S-A,R 1 and R 2 are each independently H or A, R 3 and R 4 are each independently -OH, OA, -SA,
-SO-A, -S02-A, Hai, Methylendioxy, -N02, -NH2, -NHA oder -NAA', A und A' jeweils unabhängig voneinander Alkyl mit 1 bis 10 C--SO-A, -S0 2 -A, shark, methylenedioxy, -N0 2 , -NH 2 , -NHA or -NAA ', A and A' each independently of one another alkyl with 1 to 10 C-
Atomen, das durch 1 bis 5 F- und/oder Cl-Atome substituiert sein kann, Cycloalkyl mit 3-7 C-Atomen oder Me- thylencycloalkyl mit 4-8 C-Atomen,Atoms which can be substituted by 1 to 5 F and / or Cl atoms, cycloalkyl with 3-7 C atoms or methylene cycloalkyl with 4-8 C atoms,
B -Y-R5 oder -O-Y-R5,B -YR 5 or -OYR 5 ,
Q fehlt oder Alkylen mit 1 -4 C-Atomen,Q is absent or alkylene with 1 -4 C atoms,
Y fehlt oder Alkylen mit 1 -10 C-Atomen, X CH2 oder S,Y is absent or alkylene with 1 -10 C atoms, X CH 2 or S,
R5 NH2, NHA, NAA1 oder einen unsubstituierten oder einfach durch A oder OH substituierten gesättigten 3-8- gliedrigen Heterocyclus mit mindestens einem N-Atom, worin zusätzlich weitere CH2-Gruppen durch NH, NA, S oder O ersetzt sein können, Hai F, Cl, Br oder I bedeuten,R 5 NH 2 , NHA, NAA 1 or an unsubstituted or simply substituted by A or OH saturated 3-8-membered heterocycle with at least one N atom, in which additional CH 2 groups are replaced by NH, NA, S or O. can mean shark F, Cl, Br or I,
und/oder ihrer physiologisch unbedenklichen Salze zur Herstellung eines Arzneimittels zur Behandlung von Osteoporose, Tumoren, Tumormetastasen, Atherosklerose, rheumatoide Arthritis, multiple Sklerose, Diabetes mellitus, ulzerative Kolitis und AIDS.and / or their physiologically acceptable salts for the manufacture of a medicament for the treatment of osteoporosis, tumors, tumor metastases, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, ulcerative colitis and AIDS.
2. Verwendung nach Anspruch 1 von2. Use according to claim 1 of
a) Verbindungen, offenbart in EP 0 738 715 A2, ausgewählt aus der Gruppea) compounds disclosed in EP 0 738 715 A2 selected from the group
2-(4-Ethoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)- 2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-ethoxycarbonylaminobenzyl) -6- (3,4-dimethoxyphenyl) - 2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-Methylsulfonamidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydro-pyridazin-3-on;2- (3-methylsulfonamidobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one;
2-(3-Acetamidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5- tetrahydro-pyridazin-3-on; 2-(4-Trifluoracetamidobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2- (3-acetamidobenzyl) -6- (3,4-dimethoxyphenyl) -2,3,4,5-tetrahydro-pyridazin-3-one; 2- (4-Trifluoracetamidobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydro-pyridazin-3-on;2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Ethoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-ethoxycarbonylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Methoxycarbonylaminobenzy.)-6-(3,4-dimethoxyphenyl)-5- ethyl-2,3,4,5-tetrahydro-pyridazin-3-on;2- (4-methoxycarbonylaminobenzy.) - 6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one;
2-(4-Butyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl- 2,3,4,5-tetrahydro-pyridazin-3-on; b) Verbindungen, offenbart in EP 0 723 962 B1 , ausgewählt aus der Gruppe2- (4-butyrylaminobenzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-2,3,4,5-tetrahydro-pyridazin-3-one; b) compounds disclosed in EP 0 723 962 B1 selected from the group
3-(4-Nitrobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro- 1 ,3,4-thiadiazin-2-on; 3-(4-Aminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-3- (4-nitrobenzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4-aminobenzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-
1 ,3,4-thiadiazin-2-on;1, 3,4-thiadiazin-2-one;
3-(4-Trifluoroacetamidobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-trifluoroacetamidobenzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Acetamidobenzyl)-5-(3,4-dimethoxy-phenyl)-3,6-dihydro-3- (4-Acetamidobenzyl) -5- (3,4-dimethoxy-phenyl) -3,6-dihydro-
1 ,3,4-thiadiazin-2-on;1, 3,4-thiadiazin-2-one;
3-(4-Methoxybenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-one;3- (4-methoxybenzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(2,6-Dichlorobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazin-2-on; c) Verbindungen, offenbart in EP 0763 534 A1 , ausgewählt aus der3- (2,6-dichlorobenzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one; c) compounds disclosed in EP 0763 534 A1 selected from the
Gruppegroup
3-(4-Picolinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl- 3,6-dihydro-1 ,3,4-thiadiazin-2-on;3- (4-picolinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Picolinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (4-picolinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-Nicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on;3- (4-nicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one;
3-(4-lsonicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-3,6- dihydro-1 ,3,4-thiadiazin-2-on; 3-(4-Nicotinoylamino-benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3- (4-isonicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one; 3- (4-nicotinoylamino-benzyl) -5- (3,4-dimethoxyphenyl) -6-ethyl-
3,6-dihydro-1 ,3,4-oxadiazin-2-on;3,6-dihydro-1, 3,4-oxadiazin-2-one;
2-(4-Nicotinoylamino-benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2- (4-nicotinoylamino-benzyl) -6- (3,4-dimethoxyphenyl) -5-ethyl-
2,3,4,5-tetrahydro-pyridazin-3-on; d) Verbindungen, offenbart in EP 0 539 806 B1 , ausgewählt aus der2,3,4,5-tetrahydro-pyridazin-3-one; d) compounds disclosed in EP 0 539 806 B1 selected from the
Gruppegroup
5-(3-Methoxy-4-difluormethoxy-phenyl)-6-ethyl-3,6-dihydro- 1 ,3,4-thiadiazin-2-on; 5-(3-Methoxy-4-difluormethoxy-phenyl)-3,6-dihydro-1 ,3,4- thiadiazin-2-on; e) Verbindungen, offenbart in EP 0 618 201 A1 , ausgewählt aus der Gruppe 3-Dimethylaminopropyl-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazinon-2-on;5- (3-methoxy-4-difluoromethoxy-phenyl) -6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one; 5- (3-methoxy-4-difluoromethoxy-phenyl) -3,6-dihydro-1, 3,4-thiadiazin-2-one; e) Compounds disclosed in EP 0 618 201 A1, selected from the group 3-dimethylaminopropyl-5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2- one;
3-Dimethylaminopropyl-5-(3,4-dimethoxyphenyl)-3,6-dihydro- 1 ,3,4-thiadiazinon-2-on;3-dimethylaminopropyl-5- (3,4-dimethoxyphenyl) -3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Dimethylaminoethyl-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6- dihydro-1 ,3,4-thiadiazinon-2-on;3-dimethylaminoethyl-5- (3,4-dimethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Piperidinopropyl-5-(3-methoxy-4-difluormethoxy-phenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazinon-2-on;3-piperidinopropyl-5- (3-methoxy-4-difluoromethoxyphenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one;
3-Morpholinopropyl-5-(3-methoxy-4-difluormethoxy-phenyl)-6- ethyl-3,6-dihydro-1 ,3,4-thiadiazinon-2-on; f) Verbindungen, offenbart in DE 196 04388 A1 , ausgewählt aus der Gruppe3-morpholinopropyl-5- (3-methoxy-4-difluoromethoxy-phenyl) -6-ethyl-3,6-dihydro-1, 3,4-thiadiazinon-2-one; f) compounds disclosed in DE 196 04388 A1 selected from the group
N-[4-(3,6-Dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1 ,3,4- thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)- propylester;N- [4- (3,6-Dihydro-5- (3,4-dimethoxyphenyl) -2-oxo-2H-1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- (N , N-diethylamino) propyl ester;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethyl- amino)-propylester; N-[4-(6-(3,4-Dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethyl-amino)- propylester;1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 3- (N, N-diethylamino) propyl ester; N- [4- (6- (3,4-Dimethoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3- (N, N-diethyl -amino) - propyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-carbaminsäure-3-(N,N-diethylamino)- propylester;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] carbamic acid 3- (N, N -diethylamino) - propyl ester;
N-[4-(6-(3-Ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydro- pyridazin-2-ylmethyl)-phenyl]-2-(4-methylpiperazino)-acetamid; N-[4-(6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetra- hydro-pyridazin-2-ylmethyl)-phenyl]-2-(4-methylpiperazino)-acetamid;N- [4- (6- (3-Ethoxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl) phenyl] -2- (4-methylpiperazino) - acetamide; N- [4- (6- (3-Cyclopentyloxy-4-methoxyphenyl) -3-oxo-2,3,4,5-tetra-hydro-pyridazin-2-ylmethyl) phenyl] -2- (4-methylpiperazino ) -acetamide;
N-[4-(3,6-Dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-N- [4- (3,6-dihydro-5- (3-ethoxy-4-methoxyphenyl) -2-oxo-2H-
1 ,3,4-thiadiazin-3-ylmethyl)-phenyl]-carbaminsäure-2-(4-methyl- piperazino)-acetamid;1, 3,4-thiadiazin-3-ylmethyl) phenyl] carbamic acid 2- (4-methylpiperazino) acetamide;
und/oder ihrer physiologisch unbedenklichen Salze zur Herstellung eines Arzneimittels zur Behandlung von Osteoporose, Tumoren, Tumormetastasen, Atherosklerose, rheumatoide Arthritis, multiple Skle- rose, Diabetes mellitus, ulzerative Kolitis und AIDS.and / or their physiologically acceptable salts for the manufacture of a medicament for the treatment of osteoporosis, tumors, tumor metastases, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, ulcerative colitis and AIDS.
Verwendung nach Anspruch 1 oder 2 zur Herstellung eines Arzneimittels zur Behandlung neoplastischer Schädigungen.Use according to claim 1 or 2 for the manufacture of a medicament for the treatment of neoplastic damage.
Verwendung nach Anspruch 1 oder 2 zur Herstellung eines Arzneimittels zur Behandlung präcancerogener Schädigungen.Use according to claim 1 or 2 for the manufacture of a medicament for the treatment of precancerogenic damage.
Verwendung nach Anspruch 1 oder 2 zur Herstellung eines Arzneimittels zur Regulierung von Apoptose in menschlichen Zellen. Use according to claim 1 or 2 for the manufacture of a medicament for regulating apoptosis in human cells.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10150517 | 2001-10-12 | ||
DE10150517A DE10150517A1 (en) | 2001-10-12 | 2001-10-12 | Medicaments containing pyridazinone, thiadiazinone or oxadiazinone derivatives, used e.g. for treatment of osteoporosis, tumors, atherosclerosis, rheumatoid arthritis or multiple sclerosis |
PCT/EP2002/010507 WO2003032993A1 (en) | 2001-10-12 | 2002-09-19 | Use of phosphorodiesterase iv inhibitors |
Publications (1)
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EP1435958A1 true EP1435958A1 (en) | 2004-07-14 |
Family
ID=7702358
Family Applications (1)
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---|---|---|---|
EP02777150A Withdrawn EP1435958A1 (en) | 2001-10-12 | 2002-09-19 | Use of phosphorodiesterase iv inhibitors |
Country Status (15)
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US (1) | US20040235845A1 (en) |
EP (1) | EP1435958A1 (en) |
JP (1) | JP2005505604A (en) |
KR (1) | KR20050028900A (en) |
CN (1) | CN1564687A (en) |
AR (1) | AR037741A1 (en) |
AU (1) | AU2002338734B2 (en) |
CA (1) | CA2460135C (en) |
CZ (1) | CZ2004457A3 (en) |
DE (1) | DE10150517A1 (en) |
HU (1) | HUP0401641A3 (en) |
MX (1) | MXPA04002639A (en) |
NO (1) | NO20041938L (en) |
SK (1) | SK1652004A3 (en) |
WO (1) | WO2003032993A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
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US7776893B2 (en) | 2003-09-05 | 2010-08-17 | Nycomed Gmbh | Use of PDE4 inhibitors for the treatment of diabetes mellitus |
WO2005075437A1 (en) * | 2004-02-04 | 2005-08-18 | Altana Pharma Ag | Pyridazinone derivatives and their use as pde4 inhibitors |
DE602005005638T2 (en) | 2004-02-04 | 2009-05-14 | Nycomed Gmbh | 2- (Piperidin-4-Yl) -4,5-Dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors |
WO2006094933A1 (en) | 2005-03-08 | 2006-09-14 | Nycomed Gmbh | Roflumilast for the treatment of diabetes mellitus |
DE102005055354A1 (en) * | 2005-11-21 | 2007-10-31 | Merck Patent Gmbh | Substituted 5-phenyl-3,6-dihydro-2-oxo-6H- [1,3,4] thiadiazines |
DE102005055355A1 (en) * | 2005-11-21 | 2007-10-31 | Merck Patent Gmbh | thiadiazine derivatives 3,6-dihydro-2-oxo-6H- [1,3,4] |
KR20090047546A (en) * | 2006-09-07 | 2009-05-12 | 니코메드 게엠베하 | Combination treatment for diabetes mellitus |
BR112015019276A2 (en) | 2013-02-19 | 2017-07-18 | Pfizer | azabenzimidazole compounds as inhibitors of pde4 isoenzymes for the treatment of snc disorders and other disorders |
US10131669B2 (en) | 2014-07-24 | 2018-11-20 | Pfizer Inc. | Pyrazolopyrimidine compounds |
DK3177624T3 (en) | 2014-08-06 | 2019-07-01 | Pfizer | IMIDAZOPYRIDAZINE COMPOUNDS |
RU2626677C1 (en) * | 2016-03-09 | 2017-07-31 | Федеральное государственное автономное образовательное учреждение высшего образования "Уральский федеральный университет имени первого Президента России Б.Н. Ельцина" | Application of pharmaceutical composition of 2-morpholino-5-phenyl-6h-1,3,4-thiadiazine with ascorbic acid as means for alloxan diabetes correction |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
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DE4134893A1 (en) * | 1991-10-23 | 1993-04-29 | Merck Patent Gmbh | THIADIAZINONE |
DE4310699A1 (en) * | 1993-04-01 | 1994-10-06 | Merck Patent Gmbh | Thiadiazinone |
US5786354A (en) * | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation |
DE19502699A1 (en) * | 1995-01-28 | 1996-08-01 | Merck Patent Gmbh | Arylalkyl-thiadiazinones |
DE19514568A1 (en) * | 1995-04-20 | 1996-10-24 | Merck Patent Gmbh | Arylalkyl pyridazinones |
DE19533975A1 (en) * | 1995-09-14 | 1997-03-20 | Merck Patent Gmbh | Arylalkyl diazinones |
GB9525262D0 (en) * | 1995-12-11 | 1996-02-07 | Bayer Ag | Heterocyclylcarbonyl substituted benzofuranyl-ureas |
DE19604388A1 (en) * | 1996-02-07 | 1997-08-14 | Merck Patent Gmbh | New aryl-alkyl diazinone derivatives |
US5948911A (en) * | 1998-11-20 | 1999-09-07 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure to thienopyrimidine derivatives |
-
2001
- 2001-10-12 DE DE10150517A patent/DE10150517A1/en not_active Withdrawn
-
2002
- 2002-09-19 US US10/492,367 patent/US20040235845A1/en not_active Abandoned
- 2002-09-19 HU HU0401641A patent/HUP0401641A3/en unknown
- 2002-09-19 EP EP02777150A patent/EP1435958A1/en not_active Withdrawn
- 2002-09-19 MX MXPA04002639A patent/MXPA04002639A/en not_active Application Discontinuation
- 2002-09-19 CZ CZ2004457A patent/CZ2004457A3/en unknown
- 2002-09-19 CA CA2460135A patent/CA2460135C/en not_active Expired - Fee Related
- 2002-09-19 SK SK165-2004A patent/SK1652004A3/en not_active Application Discontinuation
- 2002-09-19 AU AU2002338734A patent/AU2002338734B2/en not_active Ceased
- 2002-09-19 KR KR1020047005415A patent/KR20050028900A/en not_active Application Discontinuation
- 2002-09-19 WO PCT/EP2002/010507 patent/WO2003032993A1/en not_active Application Discontinuation
- 2002-09-19 CN CNA028198638A patent/CN1564687A/en active Pending
- 2002-09-19 JP JP2003535796A patent/JP2005505604A/en active Pending
- 2002-10-11 AR ARP020103824A patent/AR037741A1/en not_active Application Discontinuation
-
2004
- 2004-05-11 NO NO20041938A patent/NO20041938L/en unknown
Non-Patent Citations (1)
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See references of WO03032993A1 * |
Also Published As
Publication number | Publication date |
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CA2460135C (en) | 2010-08-24 |
SK1652004A3 (en) | 2005-05-05 |
MXPA04002639A (en) | 2004-06-07 |
US20040235845A1 (en) | 2004-11-25 |
JP2005505604A (en) | 2005-02-24 |
AR037741A1 (en) | 2004-12-01 |
KR20050028900A (en) | 2005-03-23 |
CN1564687A (en) | 2005-01-12 |
CZ2004457A3 (en) | 2005-04-13 |
CA2460135A1 (en) | 2003-04-24 |
HUP0401641A3 (en) | 2007-02-28 |
HUP0401641A2 (en) | 2004-11-29 |
NO20041938L (en) | 2004-05-11 |
DE10150517A1 (en) | 2003-04-17 |
AU2002338734B2 (en) | 2007-11-08 |
WO2003032993A1 (en) | 2003-04-24 |
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