EP1432408B8 - Pharmaceutical compositions comprising colloidal silicon dioxide - Google Patents

Pharmaceutical compositions comprising colloidal silicon dioxide Download PDF

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Publication number
EP1432408B8
EP1432408B8 EP02774661A EP02774661A EP1432408B8 EP 1432408 B8 EP1432408 B8 EP 1432408B8 EP 02774661 A EP02774661 A EP 02774661A EP 02774661 A EP02774661 A EP 02774661A EP 1432408 B8 EP1432408 B8 EP 1432408B8
Authority
EP
European Patent Office
Prior art keywords
silicon dioxide
colloidal silicon
pharmaceutical compositions
disintegrant
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP02774661A
Other languages
German (de)
French (fr)
Other versions
EP1432408B1 (en
EP1432408A1 (en
Inventor
Barbara Haeberlin
Andrea Kramer
Silvia Heuerding
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Pharma GmbH
Novartis AG
Original Assignee
Novartis Pharma GmbH Austria
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Novartis Pharma GmbH Austria, Novartis AG filed Critical Novartis Pharma GmbH Austria
Priority to DK09177889.4T priority Critical patent/DK2193788T3/en
Priority to SI200230928T priority patent/SI1432408T1/en
Priority to EP09177889.4A priority patent/EP2193788B1/en
Publication of EP1432408A1 publication Critical patent/EP1432408A1/en
Application granted granted Critical
Publication of EP1432408B1 publication Critical patent/EP1432408B1/en
Priority to CY20101101091T priority patent/CY1111119T1/en
Publication of EP1432408B8 publication Critical patent/EP1432408B8/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)

Abstract

A pharmaceutical composition comprising a macrolide solid dispersion, a disintegrant and colloidal silicon dioxide, wherein the composition comprises 1 to 5% colloidal silicon dioxide by weight.
EP02774661A 2001-09-28 2002-09-27 Pharmaceutical compositions comprising colloidal silicon dioxide Expired - Lifetime EP1432408B8 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DK09177889.4T DK2193788T3 (en) 2001-09-28 2002-09-27 Pharmaceutical compositions comprising colloidal silicon dioxide
SI200230928T SI1432408T1 (en) 2001-09-28 2002-09-27 Pharmaceutical compositions comprising colloidal silicon dioxide
EP09177889.4A EP2193788B1 (en) 2001-09-28 2002-09-27 Pharmaceutical compositions comprising colloidal silicon dioxide
CY20101101091T CY1111119T1 (en) 2001-09-28 2010-11-30 PHARMACEUTICAL PREPARATIONS CONTAINING COGLIDES

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0123400 2001-09-28
GBGB0123400.4A GB0123400D0 (en) 2001-09-28 2001-09-28 Organic compounds
PCT/EP2002/010890 WO2003028705A1 (en) 2001-09-28 2002-09-27 Pharmaceutical compositions comprising colloidal silicon dioxide

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP09177889.4A Division EP2193788B1 (en) 2001-09-28 2002-09-27 Pharmaceutical compositions comprising colloidal silicon dioxide
EP09177889.4 Division-Into 2009-12-03

Publications (3)

Publication Number Publication Date
EP1432408A1 EP1432408A1 (en) 2004-06-30
EP1432408B1 EP1432408B1 (en) 2010-10-27
EP1432408B8 true EP1432408B8 (en) 2011-03-02

Family

ID=9922916

Family Applications (2)

Application Number Title Priority Date Filing Date
EP02774661A Expired - Lifetime EP1432408B8 (en) 2001-09-28 2002-09-27 Pharmaceutical compositions comprising colloidal silicon dioxide
EP09177889.4A Expired - Lifetime EP2193788B1 (en) 2001-09-28 2002-09-27 Pharmaceutical compositions comprising colloidal silicon dioxide

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP09177889.4A Expired - Lifetime EP2193788B1 (en) 2001-09-28 2002-09-27 Pharmaceutical compositions comprising colloidal silicon dioxide

Country Status (30)

Country Link
US (4) US20040254210A1 (en)
EP (2) EP1432408B8 (en)
JP (2) JP2005507897A (en)
KR (1) KR100626785B1 (en)
CN (3) CN1561201A (en)
AR (2) AR036643A1 (en)
AT (1) ATE485813T1 (en)
BR (2) BRPI0212922B1 (en)
CA (1) CA2458455C (en)
CO (1) CO5390072A1 (en)
CY (2) CY1111119T1 (en)
DE (1) DE60238131D1 (en)
DK (2) DK2193788T3 (en)
EC (1) ECSP024323A (en)
ES (2) ES2560106T3 (en)
GB (1) GB0123400D0 (en)
HU (1) HU229991B1 (en)
IL (2) IL160498A0 (en)
MX (1) MXPA04002814A (en)
MY (1) MY150060A (en)
NO (1) NO333892B1 (en)
NZ (2) NZ531599A (en)
PE (1) PE20030602A1 (en)
PL (1) PL209704B1 (en)
PT (2) PT2193788E (en)
RU (1) RU2322970C2 (en)
SI (1) SI1432408T1 (en)
TW (1) TWI242449B (en)
WO (1) WO2003028705A1 (en)
ZA (1) ZA200401300B (en)

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GB0123400D0 (en) 2001-09-28 2001-11-21 Novartis Ag Organic compounds
BR0307544A (en) 2002-02-01 2004-12-07 Ariad Gene Therapeutics Inc Phosphorus-containing compounds, components and composition as well as their use by treatment methods
DE60324609D1 (en) * 2002-09-17 2008-12-18 Wyeth Corp GRANULATED FORMULATION OF RAPAMYCINESTER CCl-779
US20060035875A1 (en) * 2002-10-09 2006-02-16 Yukimasa Shiotsu Remedy for hormone-dependent cancer
DE10351448A1 (en) * 2003-11-04 2005-06-09 Bayer Healthcare Ag Flavor-containing drug formulations with improved pharmaceutical properties
WO2006131347A2 (en) * 2005-06-09 2006-12-14 Hansa Medical Ab Use of the ides proteinase (from s. pyogenes) for treating autoimmune diseases and graft rejection
CA2669415A1 (en) * 2006-11-14 2008-05-22 Ariad Pharmaceuticals, Inc. Solid dosage form comprising ap23573
EP4403221A3 (en) 2007-02-23 2024-10-09 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
CN103479584A (en) 2008-05-02 2014-01-01 吉里德科学公司 Use of solid carrier particles to improve the processability of pharmaceutical agent
CN101444503B (en) * 2008-12-31 2011-02-02 江苏大学 Efficient long-acting silibinin preparation and preparation method thereof
CN101439025B (en) * 2008-12-31 2011-05-11 江苏大学 Silymarin high-efficient long-acting preparation and production method thereof
CN101444494B (en) * 2008-12-31 2011-03-30 江苏大学 Insoluble drug high-efficiency long-acting sustained-release preparation and its preparation method
WO2010085520A1 (en) * 2009-01-21 2010-07-29 Mylan Inc. Disintegrable formulations of lanthanum carbonate
US8728516B2 (en) 2009-04-30 2014-05-20 Abbvie Inc. Stabilized lipid formulation of apoptosis promoter
TWI532484B (en) * 2009-06-08 2016-05-11 艾伯維有限公司 Solid dispersions containing an apoptosis-promoting agent
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