EP1392340A4 - Cytotoxic peptides and peptidomimetics based thereon, and methods for use thereof - Google Patents
Cytotoxic peptides and peptidomimetics based thereon, and methods for use thereofInfo
- Publication number
- EP1392340A4 EP1392340A4 EP02731181A EP02731181A EP1392340A4 EP 1392340 A4 EP1392340 A4 EP 1392340A4 EP 02731181 A EP02731181 A EP 02731181A EP 02731181 A EP02731181 A EP 02731181A EP 1392340 A4 EP1392340 A4 EP 1392340A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- cytotoxic peptides
- peptidomimetics based
- peptidomimetics
- cytotoxic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Psychiatry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28051501P | 2001-03-30 | 2001-03-30 | |
US28061501P | 2001-03-30 | 2001-03-30 | |
US280515P | 2001-03-30 | ||
US28105001P | 2001-04-02 | 2001-04-02 | |
US281050P | 2001-04-02 | ||
PCT/US2002/009649 WO2002092788A2 (en) | 2001-03-30 | 2002-03-29 | Cytotoxic peptides and peptidomimetics based thereon, and methods for use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1392340A2 EP1392340A2 (en) | 2004-03-03 |
EP1392340A4 true EP1392340A4 (en) | 2006-04-26 |
Family
ID=29740734
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02731181A Withdrawn EP1392340A4 (en) | 2001-03-30 | 2002-03-29 | Cytotoxic peptides and peptidomimetics based thereon, and methods for use thereof |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1392340A4 (en) |
AU (1) | AU2009227824A1 (en) |
CA (1) | CA2443160A1 (en) |
WO (1) | WO2002092788A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7544855B2 (en) | 2004-04-23 | 2009-06-09 | Buck Institute | Transgenic mouse whose genome comprises an APP having a mutation at amino acid 664 |
WO2019179985A1 (en) * | 2018-03-19 | 2019-09-26 | University Of Copenhagen | Inhibitors of mint and uses thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998015828A1 (en) * | 1996-10-07 | 1998-04-16 | Scios Inc. | Method to identify direct inhibitors of the beta-amyloid forming enzyme gamma-secretase |
-
2002
- 2002-03-29 EP EP02731181A patent/EP1392340A4/en not_active Withdrawn
- 2002-03-29 WO PCT/US2002/009649 patent/WO2002092788A2/en not_active Application Discontinuation
- 2002-03-29 CA CA002443160A patent/CA2443160A1/en not_active Abandoned
-
2009
- 2009-10-16 AU AU2009227824A patent/AU2009227824A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998015828A1 (en) * | 1996-10-07 | 1998-04-16 | Scios Inc. | Method to identify direct inhibitors of the beta-amyloid forming enzyme gamma-secretase |
Non-Patent Citations (9)
Title |
---|
COWAN CATHERINE M ET AL: "Caspases 3 and 9 send a pro-apoptotic signal from synapse to cell body in olfactory receptor neurons", JOURNAL OF NEUROSCIENCE, vol. 21, no. 18, 15 September 2001 (2001-09-15), pages 7099 - 7109, XP002368589, ISSN: 0270-6474 * |
DOVEY H F ET AL: "FUNCTIONAL GAMMA-SECRETASE INHIBITORS REDUCE BETA-AMYLOID PEPTIDE LEVELS IN BRAIN", JOURNAL OF NEUROCHEMISTRY, NEW YORK, NY, US, vol. 76, no. 1, January 2001 (2001-01-01), pages 173 - 181, XP001147446, ISSN: 0022-3042 * |
DUMANCHIN-NJOCK CECILE ET AL: "The caspase-derived C-terminal fragment of betaAPP induces caspase-independent toxicity and triggers selective increase of Abeta42 in mammalian cells", JOURNAL OF NEUROCHEMISTRY, vol. 78, no. 5, September 2001 (2001-09-01), pages 1153 - 1161, XP002353861, ISSN: 0022-3042 * |
GALVAN VERONICA ET AL: "Caspase cleavage of members of the amyloid precursor family of proteins", JOURNAL OF NEUROCHEMISTRY, vol. 82, no. 2, July 2002 (2002-07-01), pages 283 - 294, XP002368590, ISSN: 0022-3042 * |
LEBLANC ANDREA ET AL: "Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 33, 13 August 1999 (1999-08-13), pages 23426 - 23436, XP002353860, ISSN: 0021-9258 * |
LU D C ET AL: "A SECOND CYTOTOXIC PROTEOLYTIC PEPTIDE DERIVED FROM AMYLOID BETA-PROTEIN PRECURSOR", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 6, no. 4, April 2000 (2000-04-01), pages 397 - 404, XP000917557, ISSN: 1078-8956 * |
PALIGA K ET AL: "HUMAN AMYLOID PRECURSOR-LIKE PROTEIN 1 CDNA CLONING, ECTOPIC EXPRESSION IN COS-7 CELLS AND IDENTIFICATION OF SOLUBLE FORMS IN THE CEREBROSPINAL FLUID", EUROPEAN JOURNAL OF BIOCHEMISTRY, BERLIN, DE, vol. 250, no. 2, 1 December 1997 (1997-12-01), pages 354 - 363, XP000870182, ISSN: 0014-2956 * |
PINNIX I ET AL: "A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 276, no. 1, 5 January 2001 (2001-01-05), pages 481 - 487, XP002217635, ISSN: 0021-9258 * |
SPRECHER CINDY A ET AL: "Molecular cloning of the cDNA for a human amyloid precursor protein homolog: Evidence for a multigene family", BIOCHEMISTRY, vol. 32, no. 17, 1993, pages 4481 - 4486, XP002368588, ISSN: 0006-2960 * |
Also Published As
Publication number | Publication date |
---|---|
CA2443160A1 (en) | 2002-11-21 |
WO2002092788A9 (en) | 2004-05-06 |
AU2009227824A1 (en) | 2009-11-05 |
WO2002092788A3 (en) | 2003-12-18 |
WO2002092788A2 (en) | 2002-11-21 |
EP1392340A2 (en) | 2004-03-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20031028 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20060314 |
|
17Q | First examination report despatched |
Effective date: 20090723 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20091203 |