EP1392340A4 - Zytotoxische peptide und darauf basierende peptidomimetika und verfahren zur verwendung davon - Google Patents

Zytotoxische peptide und darauf basierende peptidomimetika und verfahren zur verwendung davon

Info

Publication number
EP1392340A4
EP1392340A4 EP02731181A EP02731181A EP1392340A4 EP 1392340 A4 EP1392340 A4 EP 1392340A4 EP 02731181 A EP02731181 A EP 02731181A EP 02731181 A EP02731181 A EP 02731181A EP 1392340 A4 EP1392340 A4 EP 1392340A4
Authority
EP
European Patent Office
Prior art keywords
methods
cytotoxic peptides
peptidomimetics based
peptidomimetics
cytotoxic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02731181A
Other languages
English (en)
French (fr)
Other versions
EP1392340A2 (de
Inventor
Dale Bredesen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Buck Institute for Research on Aging
Original Assignee
Buck Institute for Research on Aging
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Buck Institute for Research on Aging filed Critical Buck Institute for Research on Aging
Publication of EP1392340A2 publication Critical patent/EP1392340A2/de
Publication of EP1392340A4 publication Critical patent/EP1392340A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
EP02731181A 2001-03-30 2002-03-29 Zytotoxische peptide und darauf basierende peptidomimetika und verfahren zur verwendung davon Withdrawn EP1392340A4 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US28051501P 2001-03-30 2001-03-30
US28061501P 2001-03-30 2001-03-30
US280515P 2001-03-30
US28105001P 2001-04-02 2001-04-02
US281050P 2001-04-02
PCT/US2002/009649 WO2002092788A2 (en) 2001-03-30 2002-03-29 Cytotoxic peptides and peptidomimetics based thereon, and methods for use thereof

Publications (2)

Publication Number Publication Date
EP1392340A2 EP1392340A2 (de) 2004-03-03
EP1392340A4 true EP1392340A4 (de) 2006-04-26

Family

ID=29740734

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02731181A Withdrawn EP1392340A4 (de) 2001-03-30 2002-03-29 Zytotoxische peptide und darauf basierende peptidomimetika und verfahren zur verwendung davon

Country Status (4)

Country Link
EP (1) EP1392340A4 (de)
AU (1) AU2009227824A1 (de)
CA (1) CA2443160A1 (de)
WO (1) WO2002092788A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7544855B2 (en) 2004-04-23 2009-06-09 Buck Institute Transgenic mouse whose genome comprises an APP having a mutation at amino acid 664
WO2019179985A1 (en) * 2018-03-19 2019-09-26 University Of Copenhagen Inhibitors of mint and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998015828A1 (en) * 1996-10-07 1998-04-16 Scios Inc. Method to identify direct inhibitors of the beta-amyloid forming enzyme gamma-secretase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998015828A1 (en) * 1996-10-07 1998-04-16 Scios Inc. Method to identify direct inhibitors of the beta-amyloid forming enzyme gamma-secretase

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
COWAN CATHERINE M ET AL: "Caspases 3 and 9 send a pro-apoptotic signal from synapse to cell body in olfactory receptor neurons", JOURNAL OF NEUROSCIENCE, vol. 21, no. 18, 15 September 2001 (2001-09-15), pages 7099 - 7109, XP002368589, ISSN: 0270-6474 *
DOVEY H F ET AL: "FUNCTIONAL GAMMA-SECRETASE INHIBITORS REDUCE BETA-AMYLOID PEPTIDE LEVELS IN BRAIN", JOURNAL OF NEUROCHEMISTRY, NEW YORK, NY, US, vol. 76, no. 1, January 2001 (2001-01-01), pages 173 - 181, XP001147446, ISSN: 0022-3042 *
DUMANCHIN-NJOCK CECILE ET AL: "The caspase-derived C-terminal fragment of betaAPP induces caspase-independent toxicity and triggers selective increase of Abeta42 in mammalian cells", JOURNAL OF NEUROCHEMISTRY, vol. 78, no. 5, September 2001 (2001-09-01), pages 1153 - 1161, XP002353861, ISSN: 0022-3042 *
GALVAN VERONICA ET AL: "Caspase cleavage of members of the amyloid precursor family of proteins", JOURNAL OF NEUROCHEMISTRY, vol. 82, no. 2, July 2002 (2002-07-01), pages 283 - 294, XP002368590, ISSN: 0022-3042 *
LEBLANC ANDREA ET AL: "Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 33, 13 August 1999 (1999-08-13), pages 23426 - 23436, XP002353860, ISSN: 0021-9258 *
LU D C ET AL: "A SECOND CYTOTOXIC PROTEOLYTIC PEPTIDE DERIVED FROM AMYLOID BETA-PROTEIN PRECURSOR", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 6, no. 4, April 2000 (2000-04-01), pages 397 - 404, XP000917557, ISSN: 1078-8956 *
PALIGA K ET AL: "HUMAN AMYLOID PRECURSOR-LIKE PROTEIN 1 CDNA CLONING, ECTOPIC EXPRESSION IN COS-7 CELLS AND IDENTIFICATION OF SOLUBLE FORMS IN THE CEREBROSPINAL FLUID", EUROPEAN JOURNAL OF BIOCHEMISTRY, BERLIN, DE, vol. 250, no. 2, 1 December 1997 (1997-12-01), pages 354 - 363, XP000870182, ISSN: 0014-2956 *
PINNIX I ET AL: "A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 276, no. 1, 5 January 2001 (2001-01-05), pages 481 - 487, XP002217635, ISSN: 0021-9258 *
SPRECHER CINDY A ET AL: "Molecular cloning of the cDNA for a human amyloid precursor protein homolog: Evidence for a multigene family", BIOCHEMISTRY, vol. 32, no. 17, 1993, pages 4481 - 4486, XP002368588, ISSN: 0006-2960 *

Also Published As

Publication number Publication date
AU2009227824A1 (en) 2009-11-05
WO2002092788A3 (en) 2003-12-18
WO2002092788A2 (en) 2002-11-21
EP1392340A2 (de) 2004-03-03
WO2002092788A9 (en) 2004-05-06
CA2443160A1 (en) 2002-11-21

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