EP1390012A4 - Nouvelles methodes et compositions d'administration de macromolecules aux voies respiratoires ou via celles-ci - Google Patents

Nouvelles methodes et compositions d'administration de macromolecules aux voies respiratoires ou via celles-ci

Info

Publication number
EP1390012A4
EP1390012A4 EP02728994A EP02728994A EP1390012A4 EP 1390012 A4 EP1390012 A4 EP 1390012A4 EP 02728994 A EP02728994 A EP 02728994A EP 02728994 A EP02728994 A EP 02728994A EP 1390012 A4 EP1390012 A4 EP 1390012A4
Authority
EP
European Patent Office
Prior art keywords
compositions
respiratory tract
novel methods
delivering macromolecules
macromolecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02728994A
Other languages
German (de)
English (en)
Other versions
EP1390012A1 (fr
Inventor
Adrian Bot
Luis A Dellamary
Dan Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of EP1390012A1 publication Critical patent/EP1390012A1/fr
Publication of EP1390012A4 publication Critical patent/EP1390012A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
EP02728994A 2001-04-26 2002-04-26 Nouvelles methodes et compositions d'administration de macromolecules aux voies respiratoires ou via celles-ci Withdrawn EP1390012A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28689101P 2001-04-26 2001-04-26
US286891P 2001-04-26
PCT/US2002/013145 WO2002087542A1 (fr) 2001-04-26 2002-04-26 Nouvelles methodes et compositions d'administration de macromolecules aux voies respiratoires ou via celles-ci

Publications (2)

Publication Number Publication Date
EP1390012A1 EP1390012A1 (fr) 2004-02-25
EP1390012A4 true EP1390012A4 (fr) 2009-10-28

Family

ID=23100607

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02728994A Withdrawn EP1390012A4 (fr) 2001-04-26 2002-04-26 Nouvelles methodes et compositions d'administration de macromolecules aux voies respiratoires ou via celles-ci

Country Status (3)

Country Link
EP (1) EP1390012A4 (fr)
JP (1) JP2004528339A (fr)
WO (1) WO2002087542A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
AU2003291527A1 (en) * 2002-12-31 2004-07-29 Nektar Therapeutics Antibody-containing particles and compositions
AU2009246217B2 (en) 2008-05-15 2013-01-10 Novartis Ag Pulmonary delivery of a fluoroquinolone
CN101926770B (zh) * 2009-06-25 2013-07-10 浙江海正药业股份有限公司 载药脂质体及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996019197A1 (fr) * 1994-12-22 1996-06-27 Astra Aktiebolag Preparations d'aerosols a base de peptides et de proteines
WO1998031346A1 (fr) * 1997-01-16 1998-07-23 Massachusetts Institute Of Technology Preparation de particules pour inhalation
WO1999016422A1 (fr) * 1997-09-29 1999-04-08 Inhale Therapeutic Systems, Inc. Preparations stabilisees pour aerosols-doseurs
WO2000000215A1 (fr) * 1998-06-29 2000-01-06 Inhale Therapeutic Systems, Inc. Systemes administration de particules et procedes d'utilisation
WO2001085137A2 (fr) * 2000-05-10 2001-11-15 Inhale Therapeutic Systems, Inc. Compositions pharmaceutiques en poudre stables a base de lipides et d'ions de metaux pour l'adminsitration de medicaments et mode d'utilisation
WO2001085136A2 (fr) * 2000-05-10 2001-11-15 Alliance Pharmaceutical Corporation Poudres a base de phospholipides permettant de distribuer un medicament

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8603812D0 (sv) * 1986-09-12 1986-09-12 Draco Ab Administration of liposomes to mammals
JPH05500229A (ja) * 1991-04-12 1993-01-21 東レ株式会社 固体ポリペプチド微粒子のエアロゾル製剤とその製造方法
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
EP1210069B1 (fr) * 1999-08-25 2004-12-29 Advanced Inhalation Research, Inc. Grandes particules poreuses susceptibles d'etre obtenues par le sechage par atomisation et aptes a l'administration pulmonaire

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996019197A1 (fr) * 1994-12-22 1996-06-27 Astra Aktiebolag Preparations d'aerosols a base de peptides et de proteines
WO1998031346A1 (fr) * 1997-01-16 1998-07-23 Massachusetts Institute Of Technology Preparation de particules pour inhalation
WO1999016422A1 (fr) * 1997-09-29 1999-04-08 Inhale Therapeutic Systems, Inc. Preparations stabilisees pour aerosols-doseurs
WO1999016421A1 (fr) * 1997-09-29 1999-04-08 Inhale Therapeutic Systems, Inc. Preparations bioactives stabilisees et leur procedes d'utilisation
WO2000000215A1 (fr) * 1998-06-29 2000-01-06 Inhale Therapeutic Systems, Inc. Systemes administration de particules et procedes d'utilisation
WO2001085137A2 (fr) * 2000-05-10 2001-11-15 Inhale Therapeutic Systems, Inc. Compositions pharmaceutiques en poudre stables a base de lipides et d'ions de metaux pour l'adminsitration de medicaments et mode d'utilisation
WO2001085136A2 (fr) * 2000-05-10 2001-11-15 Alliance Pharmaceutical Corporation Poudres a base de phospholipides permettant de distribuer un medicament

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DELLAMARY L A ET AL: "HOLLOW POROUS PARTICLES IN METERED DOSE INHALERS", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS, NEW YORK, NY, US, vol. 17, no. 2, 1 February 2000 (2000-02-01), pages 168 - 174, XP009034216, ISSN: 0724-8741 *
See also references of WO02087542A1 *

Also Published As

Publication number Publication date
EP1390012A1 (fr) 2004-02-25
JP2004528339A (ja) 2004-09-16
WO2002087542A1 (fr) 2002-11-07

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20031126

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: NOVARTIS AG

A4 Supplementary search report drawn up and despatched

Effective date: 20090928

17Q First examination report despatched

Effective date: 20100222

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20100706