Definitions

• the present invention relates to a pre-dosed applicator with a benefit agent that ensures localised application of the agent to the target area while ensuring minimal contact with other oral tissues.
• Dental plaque is a non-mineralised microbial accumulation that adheres tenaciously to tooth surfaces. It is composed of an organic matrix derived from salivary glycoproteins and extracellular microbial products and cannot be removed by rinsing or water spray. It is common to all human populations, and if not regularly and thoroughly removed by proper brushing and allowed to accumulate on tooth surfaces, can lead to dental disease.
• Plaque is translucent or tooth coloured and hence not easily visible, therefore an individual is frequently not aware of plaque itself as well as the quantity and location in the mouth.
• One way for effective plaque control is to make a person aware of what plaque is and its effects on the surrounding tissues. This can be done by visually demonstrating plaque on one's teeth which would show the person that he/she does have bacterial deposits on teeth which might cause future damage and therefore cause concern and hence motivation for practising good oral hygiene. Using dye indicators known as plaque disclosing agents does this visual demonstrating of plaque.
• Disclosing agents that are currently available are organic dyes such as erythrosin dyes, fluorescent synthetic dyes which are invisible to the naked eye under normal daylight and only become visible by using light of proper wavelength, two tone dyes which differentiate between new and old plaque etc. Further typical disclosing agents include tartrazine yellow; patent Blue V; crystal violet; ruthenium red; 5- cyano-2, 3-ditolyltetrazolium chloride; amaranth; FDC Red 40; congo red; rosaniline; neutral red; safranine; FDC red 3; FDC blue 1; FDC green 3; Hercules green shade 3; fluorescein; red betamine; and yellow vulgaxanthine .
• organic dyes such as erythrosin dyes, fluorescent synthetic dyes which are invisible to the naked eye under normal daylight and only become visible by using light of proper wavelength, two tone dyes which differentiate between new and old plaque etc.
• Further typical disclosing agents include tartrazine yellow; patent Blue V; crystal violet;
• US4992256 (Colgate-Palmolive Co., 1991) teaches aqueous, aerosol spray, chewing gum, wafer and tablet form of active ingredient-FD & C red no.3 to detect dental plaque by naked eye under visible light conditions.
• US4431628 (Colgate-Palmolive Co., 1984) discloses a natural red dye from sugar beets formulated as a solution, tablet, gel, powder or aerosol for selectively staining said plaque formation on tooth surfaces without staining the adjacent oral tissues.
• the invention provides an applicator for a benefit agent, which applicator comprises a means for entraining said benefit agent in a liquid form, said means being liquid absorbable.
• said benefit agent is selected from the group consisting of sensitive teeth agents, anti-caries agents, anti-tartar agents, fresh breath agents, vitamins, flavours, plaque disclosing agents and mixtures thereof.
• a device thus provides the consumer with a means for specifically targeting an area of the oral cavity without using a large amount of said agent. It also provides the consumer with a means for specifically targeting an area needing attention.
• the prior art only being able to provide means for targeting the oral cavity as a whole.
• the antimicrobial agents which may provide an anti-tartar or anti gingivitis effect include: Triclosan, chlorhexidine, copper-, zinc- and stannous salts such as zinc citrate, zinc sulphate, zinc glycinate, sodium zinc citrate and stannous pyrophosphate, sanguinarine extract, metronidazole, quaternary ammonium compounds, such as cetylpyridinium chloride; bis-guanides, such as chlorhexidine digluconate, hexetidine, octenidine, alexidine; and halogenated bisphenolic compounds, such as 2,2' methylenebis- (4-chloro- 6-bromophenol) ; anti-inflammatory agents such as ibuprofen, flurbiprofen, aspirin, indomethacin etc.
• Triclosan chlorhexidine, copper-, zinc- and stannous salts such as zinc citrate, zinc sulphate, zinc glycinate, sodium zinc citrate and
• Anti-caries agents such as sodium- and stannous fluoride, aminefluorides, sodium monofluorophosphate, sodium trimeta phosphate and casein.
• the benefit agent according to the invention may also comprise any of the following ingredients:
• plaque buffers such as urea, calcium lactate, calcium glycerophosphate and strontium polyacrylates ;
• vitamins such as Vitamins A, C and E; plant extracts;
• desensitising agents e.g. potassium citrate, potassium chloride, potassium tartrate, potassium bicarbonate, potassium oxalate, potassium nitrate and strontium salts
• anti -calculus agents e.g. alkali-metal pyrophosphates, hypophosphite-containing polymers, organic phosphonates and phosphocitrates etc.
• biomolecules e.g. bacteriocins, antibodies, enzymes, etc.
• flavours e.g. peppermint and spearmint oils
• proteinaceous materials such as collagen
• pharmaceutically acceptable carriers e.g. starch, sucrose, water or water/alcohol systems etc.;
• surfactants such as anionic, nonionic, cationic and zwitterionic or amphoteric surfactants
• particulate abrasive materials such as silicas, aluminas, calcium carbonates, dicalciumphosphates, calcium pyrophosphates, hydroxyapatites, trimetaphosphates, insoluble hexametaphosphates and so on, including agglomerated particulate abrasive materials, usually in amounts between 3 and 60% by weight of the oral care composition.
• humectants such as glycerol, sorbitol, propyleneglycol , xylitol, lactitol etc.;
• binders and thickeners such as sodium carboxymethyl- cellulose, xanthan gum, gum arabic etc. as well as synthetic polymers such as polyacrylates and carboxyvinyl polymers such as Carbopol ® ;
• polymeric compounds which can enhance the delivery of active ingredients such as antimicrobial agents can also be included.
• examples of such polymers are copolymers of polyvinylmethylether with maleic anhydride and other similar delivery enhancing polymers, e.g. those described in DE-A-3,942,643 (Colgate); and
• the device according to the invention comprises the benefit agent is a level ranging from 0.0001 to 1%, preferably from 0.001 to 0.5% of the weight of the liquid absorbable part of the device after application of the agent.
• the agent is present in an amount ranging from 0.01 to 1%, preferably from 0.02 to 0.7% by weight of the liquid which is applied to the liquid absorbable part of the head before storage either as a dried device or a wet device which is suitably sealed.
• an applicator wherein a liquid absorbable material loaded with the benefit agent is provided on at least one end of the applicator and the said liquid absorbable material is preferably moistened prior to contacting the applicator onto the natural or artificial oral prostheses.
• the benefit agent may be in liquid form or even dried form so that it can be stored more easily. Dried applicators can be wetted immediately prior to use. Wet applicators may be stored in a sealed package so maintain freshness for use.
• the present invention provides a single or multiple use applicator capable of dispensing the required amount of plaque disclosing agent on to the natural or artificial oral prostheses.
• the applicator is provided with a liquid absorbable material that is loaded with the plaque disclosing agent in the liquid/solution form and is subsequently dried. It is particularly preferred that the drying is done by vacuum drying .
• plaque disclosing agents that may be used for the purpose of the invention are mercurochrome , bismark brown, erythrosin, fast green, fluorescein, two tone dye and basic fuschin, the most preferred agent being erythrosin.
• Preferred dyes include a combination of dyes such that a blue colour is obtained before the product has been used. Consumers prefer a blue colour to a red colour in devices such as those according to the invention. It is also advantageous to have a dye which actually changes colour on contact with plaque in the oral cavity such that there can be no mistake that the use of the product merely results in a transfer of dye. Preferably, the colour change results in a change from blue or green to pink.
• a preferable combination of dyes includes a combination of FDC Red No. 3 and FDC Blue No. 3.
• the ratio of the red to blue ranges from 150:1 to 1:15, more preferably from 50:1 to 1:5 and especially preferably from 8:1 to 1:1.
• the amount of FDC Red No. 3 ranges from 0.1 to 1.5% by weight of the dye applied to the device, more preferably from 0.3 to 1.5% and most preferably from 0.6 to 1.3%.
• the amount of FDC Blue No. 3 ranges from 0.01 to 1.8% by weight of the dye applied to the device, more preferably from 0.05 to 1.0% and most preferably from 0.1 to 0.5%.
• FDC Green No. 3 may also be used in this combination of dyes.
• the applicator may be designed for single or multiple use.
• the tip of the applicator is suitably sized and shaped to enable the use specifically on the teeth. It may vary in diameter from 1 mm To 10 mm, preferably from 2 mm to 8 mm and especially preferably from 2 mm to 6 mm.
• the head may be shaped circular, elliptical, tear drop shaped, conical, discoid, pear shaped, semicircular.
• a reservoir of the plaque disclosing agent such that the same may be made available for use on the oral prostheses as and when desired.
• the reservoir may be provided with the plaque disclosing agent in the solid or liquid form.
• the quantity of the dye required would be in the range lmg to lOmg and preferably lmg to 5mg.
• the tablet generally contains 12mg of the dye, a substantial amount of which gets wasted as the surrounding oral soft tissue also gets stained.
• the liquid absorbable material may be made of natural or synthetic material and may be chosen from cotton, sponge, or cloth or any absorbent material. Preferably, it also comprise an abrasive substance such as chalk, silica, perlite, pumice or any other commonly used oral care abrasive .
• the applicator is dried after the plaque disclosing agent is loaded on to the liquid absorbable part of the applicator by any suitable means and preferably by vacuum drying.
• the drying time is variable and may range from 3 to 4 hours and the temperature during drying may range from 60-80 degree Centigrade .
• the applicator may be packed suitably as single or multiple units .
• the applicator according to the invention may also be part of a kit comprising an oral care product in addition to the applicator.
• an oral care product in addition to the applicator.
• the user benefits from whiter teeth, fresher breath, reduced caries, reduced plaque build up and reduced gingivitis because of the motivational benefit of having the applicator in the same package as the oral care product .
• the oral care product can be a toothpaste, mouthwash, gel, powder or any other form of an oral care product commonly used in the art .
• Fig la and Fig lb describes the single use applicator.
• various other forms and shapes are disclosed.
• Fig la and Fig lb there is shaft (ST) that has a liquid absorbable head (LH) at one end as in Fig la and at both ends as in Fig lb.
• a reservoir is provided to enable multiple use.
• the liquid absorbable head was made of cotton and was loaded with 0.2ml of 2% erythrosin dye.
• the applicator was dried under vacuum for 3 hours at 80°C.
• Figure 3 is an applicator according to the invention which comprises as well as a liquid absorbable head (LH) and a shaft (ST) there is a finger hose (FS) enabling a finger to be inserted such that application can be made using a single finger. In this way the device can be used in the more hard to reach areas of the mouth.
• LH liquid absorbable head
• ST shaft
• FS finger hose
• Figure 4 is an applicator according to the invention which has a reservoir (R) which stores the liquid to be applied. In this way multiple use may be catered for.
• Figure 5 is an applicator comprising a shaft (ST) a liquid absorbable head (LH) and a toothpick.
• the toothpick in this case is at the end opposite the liquid absorbable head although this is not strictly necessary, albeit preferred.
• the bud is kept in contact with first dye FDC RED for 1 minute. This is followed by second dye FDC BLUE for 1 minute. The bud is then dried at 90 ° C for one hour.
• the bud colour was blue obtained by the combination of 0.6% FDC RED with 0.2% FDC BLUE .
• the colour obtained on application was blue and the plaque disclosed was pink.
• the plaque disclosing was found to be the best using 1.25%
• FDC RED with 0.2% FDC BLUE The colour of the bud was bluish green colour.
• a panel of trained volunteers was divided into two groups .
• One group was asked to use the applicator and the other to chew a erythrosin containing tablet before the first brushing for the day.
• the applicator having the loaded liquid absorbable head containing erythrosin at both ends were provided.
• the panellists were asked to moisten one end of the applicator and move it along the surface of the teeth viewing the same in front of a mirror for about a minute. The presence of the plaque is visible immediately.
• the tablet also revealed the plaque if any on the teeth.
• the panellists were asked to brush their teeth with a dentifrice and a brush as routine. At the end of brushing and rinsing the mouth with water the other end of the applicator was similarly used to disclose the plaque if any.

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• 2002
  • 2002-03-25 EP EP02722274A patent/EP1379195A1/de not_active Withdrawn

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