ZA200307030B - Applicator. - Google Patents
Applicator. Download PDFInfo
- Publication number
- ZA200307030B ZA200307030B ZA200307030A ZA200307030A ZA200307030B ZA 200307030 B ZA200307030 B ZA 200307030B ZA 200307030 A ZA200307030 A ZA 200307030A ZA 200307030 A ZA200307030 A ZA 200307030A ZA 200307030 B ZA200307030 B ZA 200307030B
- Authority
- ZA
- South Africa
- Prior art keywords
- applicator
- agents
- plaque
- teeth
- agent
- Prior art date
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- 235000012736 patent blue V Nutrition 0.000 description 1
- 239000004177 patent blue V Substances 0.000 description 1
- 239000010451 perlite Substances 0.000 description 1
- 235000019362 perlite Nutrition 0.000 description 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical compound [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920002432 poly(vinyl methyl ether) polymer Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 229960003975 potassium Drugs 0.000 description 1
- AVTYONGGKAJVTE-OLXYHTOASA-L potassium L-tartrate Chemical compound [K+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O AVTYONGGKAJVTE-OLXYHTOASA-L 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 229940094025 potassium bicarbonate Drugs 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 239000001472 potassium tartrate Substances 0.000 description 1
- 229940111695 potassium tartrate Drugs 0.000 description 1
- 235000011005 potassium tartrates Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 239000008262 pumice Substances 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 239000001044 red dye Substances 0.000 description 1
- OARRHUQTFTUEOS-UHFFFAOYSA-N safranin Chemical compound [Cl-].C=12C=C(N)C(C)=CC2=NC2=CC(C)=C(N)C=C2[N+]=1C1=CC=CC=C1 OARRHUQTFTUEOS-UHFFFAOYSA-N 0.000 description 1
- 229940084560 sanguinarine Drugs 0.000 description 1
- YZRQUTZNTDAYPJ-UHFFFAOYSA-N sanguinarine pseudobase Natural products C1=C2OCOC2=CC2=C3N(C)C(O)C4=C(OCO5)C5=CC=C4C3=CC=C21 YZRQUTZNTDAYPJ-UHFFFAOYSA-N 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
- YKOLYTVUIVUUDY-UHFFFAOYSA-K sodium;zinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Na+].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YKOLYTVUIVUUDY-UHFFFAOYSA-K 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 159000000008 strontium salts Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000000979 synthetic dye Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- 229940071566 zinc glycinate Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 235000009529 zinc sulphate Nutrition 0.000 description 1
- 239000011686 zinc sulphate Substances 0.000 description 1
- UOXSXMSTSYWNMH-UHFFFAOYSA-L zinc;2-aminoacetate Chemical compound [Zn+2].NCC([O-])=O.NCC([O-])=O UOXSXMSTSYWNMH-UHFFFAOYSA-L 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
B WO 02/083026 PCT/EP02/03413
APPLICATOR
The present invention relates to a pre-dosed applicator with a benefit agent that ensures localised application of the agent to the target area while ensuring minimal contact with other oral tissues.
Dental plague is a non-mineralised microbial accumulation that adheres tenaciously to tooth surfaces. It is composed of an organic matrix derived from salivary glycoproteins and extracellular microbial products and cannot be removed by rinsing or water spray. It is common to all human populations, and if not regularly and thoroughly removed by proper brushing and allowed to accumulate on tooth surfaces, can lead to dental disease.
Plaque is translucent or tooth coloured and hence not easily visible, therefore an individual is frequently not aware of plaque itself as well as the quantity and location in the mouth. One way for effective plaque control is to make a person aware of what plaque is and its effects on the surrounding tissues. This can be done by visually demonstrating plague on one’s teeth which would show the person that he/she does have bacterial deposits on teeth which might cause future damage and therefore cause concern and hence motivation for practising good oral hygiene. Using . dye indicators known as plaque disclosing agents does this * visual demonstrating of plaque.
Disclosing agents that are currently available are organic dyes such as erythrosin dyes, fluorescent synthetic dyes
- 2 = which are invisible to the naked eye under normal daylight and only become visible by using light of proper wavelength, two tone dyes which differentiate between new and old plaque etc. Further typical disclosing agents include tartrazine yellow; patent Blue V; crystal violet; ruthenium red; 5- cyano-2, 3-ditolyltetrazolium chloride; amaranth; FDC Red 40; congo red; rosaniline; neutral red; safranine; FDC red 3; FDC blue 1; FDC green 3; Hercules green shade 3; fluorescein; red betamine; and yellow vulgaxanthine. -
Conventional methods of applying these disclosing agents are either as a solution or as disclosing tablets. These methods have the disadvantages in that there is non-discriminatory staining of gingival tissues and lips and the colour remains on the tissue surfaces even after rinsing and disappears gradually. This is one factor that prevents people from using disclosing agents routinely.
US4992256 (Colgate-Palmolive Co., 1991) teaches aqueous, aerosol spray, chewing gum, wafer and tablet form of active ingredient-FD & C red no.3 to detect dental plaque by naked eye under visible light conditions.
US4431628 (Colgate-Palmolive Co., 1984) discloses a natural red dye from sugar beets formulated as a solution, tablet, gel, powder or aerosol for selectively staining said plaque . formation on tooth surfaces without staining the adjacent - oral tissues.
Other forms of the product such as chewable tablet, wafer, powder, lozenges, aerosol, liquid concentrate are also known where various known plaque disclosing actives have been incorporated.
However, there is no effective teaching for selective application of the plaque disclosing agent on the teeth for the purpose without staining the neighbouring oral soft tissue and lips.
It has now been possible to dispense selective amounts of the plaque disclosing agent using an applicator on the teeth by which the plaque, pellicle, germs and bacteria is selectively stained without staining the neighbouring oral soft tissue and lips. This applicator is more effective than the commonly used method of application of dye by disclosing tablets or solution. It is convenient to use and is very economical.
Thus according to a first aspect the invention provides an applicator for a benefit agent, which applicator comprises a means for entraining said benefit agent in a liquid form, said means being liquid absorbable. Preferably, said benefit agent is selected from the group consisting of sensitive : teeth agents, anti-caries agents, anti-tartar agents, fresh breath agents, vitamins, flavours, plaque disclosing agents and mixtures thereof. . A device according to the invention thus provides the consumer with a means for specifically targeting an area of the oral cavity without using a large amount of said agent.
It also provides the consumer with a means for specifically targeting an area needing attention. The prior art only being able to provide means for targeting the oral cavity as a whole. 4
The antimicrobial agents, which may provide an anti-tartar or anti gingivitis effect include: Triclosan, chlorhexidine, copper-, zinc- and stannous salts such as zinc citrate, zinc sulphate, zinc glycinate, sodium zinc citrate and stannous pyrophosphate, sanguinarine extract, metronidazole, quaternary ammonium compounds, such as cetylpyridinium chloride; bis-guanides, such as chlorhexidine digluconate, hexetidine, octenidine, alexidine; and halogenated bisphenolic compounds, such as 2,2' methylenebis- (4-chloro- 6 -bromophenol) ; anti-inflammatory agents such as ibuprofen, flurbiprofen, aspirin, indomethacin etc.
Anti-caries agents such as sodium- and stannous fluoride, aminefluorides, sodium monofluorophosphate, sodium trimeta phosphate and casein.
The benefit agent according to the invention may also comprise any of the following ingredients: plaque buffers such as urea, calcium lactate, calcium glycerophosphate and strontium polyacrylates; vitamins such as Vitamins A, C and E; plant extracts; desensitising agents, e.g. potassium citrate, potassium ! chloride, potassium tartrate, potassium bicarbonate, potassium oxalate, potassium nitrate and strontium salts;
anti-calculus agents, e.g. alkali-metal pyrophosphates, hypophosphite-containing polymers, organic phosphonates and . phosphocitrates etc.;
5 biomolecules, e.g. bacteriocins, antibodies, enzymes, etc.; flavours, e.g. peppermint and spearmint oils; proteinaceous materials such as collagen;
preservatives; opacifying agents; colouring agents; pH-adjusting agents; sweetening agents;
pharmaceutically acceptable carriers, e.g. starch, sucrose, water or water/alcohol systems etc. ; surfactants, such as anionic, nonionic, cationic and zwitterionic or amphoteric surfactants; . particulate abrasive materials such as silicas, aluminas, calcium carbonates, dicalciumphosphates, calcium ’ pyrophosphates, hydroxyapatites, trimetaphosphates, insoluble hexametaphosphates and so on, including agglomerated particulate abrasive materials, usually in
- & - amounts between 3 and 60% by weight of the oral care composition. humectants such as glycerol, sorbitol, propyleneglycol, xylitol, lactitol etc.; binders and thickeners such as sodium carboxymethyl- cellulose, xanthan gum, gum arabic etc. as well as synthetic polymers such as polyacrylates and carboxyvinyl polymers such as Carbopol®; polymeric compounds which can enhance the delivery of active ingredients such as antimicrobial agents can also be included. Examples of such polymers are copolymers of polyvinylmethylether with maleic anhydride and other similar delivery enhancing polymers, e.g. those described in
DE-A-3,942,643 (Colgate); and buffers and salts to buffer the pH and ionic strength of the oral care composition.
Preferably the benefit agent is present in an amount capable of providing the necessary benefit. However, this may be far short of the required level necessary in a toothpaste to achieve the same effect. Accordingly, the device according to the invention comprises the benefit agent is a level . ranging from 0.0001 to 1%, preferably from 0.001 to 0.5% of the weight of the liquid absorbable part of the device after application of the agent. Alternatively, the agent is present in an amount ranging from 0.01 to 1%, preferably from 0.02 to 0.7% by weight of the liquid which is applied to the liquid absorbable part of the head before storage either as a dried device or a wet device which is suitably sealed.
According to a preferred aspect of the invention there is provided an applicator wherein a liquid absorbable material loaded with the benefit agent is provided on at least one end of the applicator and the said liquid absorbable material is preferably moistened prior to contacting the applicator onto the natural or artificial oral prostheses.
The benefit agent may be in liquid form or even dried form so that it can be stored more easily. Dried applicators can be wetted immediately prior to use. Wet applicators may be stored in a sealed package so maintain freshness for use.
According to a preferred aspect the present invention provides a single or multiple use applicator capable of dispensing the required amount of plaque disclosing agent on to the natural or artificial oral prostheses.
According to another preferred aspect of the invention the applicator is provided with a liquid absorbable material that is loaded with the plaque disclosing agent in the liquid/solution form and is subsequently dried. It is particularly preferred that the drying is done by vacuum . drying. ’ The different plaque disclosing agents that may be used for the purpose of the invention are mercurochrome, bismark brown, erythrosin, fast green, fluorescein, two tone dye and basic fuschin, the most preferred agent being erythrosin.
Preferred dyes include a combination of dyes such that a blue colour is obtained before the product has been used.
Consumers prefer a blue colour to a red colour in devices such as those according to the invention. It is also advantageous to have a dye which actually changes colour on contact with plague in the oral cavity such that there can be no mistake that the use of the product merely results in a transfer of dye. Preferably, the colour change results in a change from blue or green to pink.
A preferable combination of dyes includes a combination of
FDC Red No. 3 and FDC Blue No. 3. Preferably the ratio of the red to blue ranges from 150:1 to 1:15, more preferably from 50:1 to 1:5 and especially preferably from 8:1 to 1:1.
The amount of FDC Red No. 3 ranges from 0.1 to 1.5% by weight of the dye applied to the device, more preferably from 0.3 to 1.5% and most preferably from 0.6 to 1.3%. The amount of FDC Blue No. 3 ranges from 0.01 to 1.8% by weight of the dye applied to the device, more preferably from 0.05 to 1.0% and most preferably from 0.1 to 0.5%. FDC Green No. 3 may also be used in this combination of dyes.
The applicator may be designed for single or multiple use. ‘ The tip of the applicator is suitably sized and shaped to enable the use specifically on the teeth. It may vary in diameter from 1 mm To 10 mm, preferably from 2 mm to 8 mm and especially preferably from 2 mm to 6 mm. The head may be shaped circular, elliptical, tear drop shaped, conical,
- a - discoid, pear shaped, semicircular. When designed for multiple use there is provided a reservoir of the plaque disclosing agent such that the same may be made available for use on the oral prostheses as and when desired. The reservoir may be provided with the plaque disclosing agent in the solid or liquid form.
In single use applicators a known and required quantity is provided as a part of the liquid absorbable material on the applicator. For one application on the entire set of teeth the quantity of the dye required would be in the range 1mg to 10mg and preferably 1lmg to 5mg. The tablet generally contains 12mg of the dye, a substantial amount of which gets wasted as the surrounding oral soft tissue also gets stained.
The liquid absorbable material may be made of natural or synthetic material and may be chosen from cotton, sponge, or cloth or any absorbent material. Preferably, it also comprise an abrasive substance such as chalk, silica, perlite, pumice or any other commonly used oral care abrasive.
The applicator is dried after the plaque disclosing agent is loaded on to the liquid absorbable part of the applicator by any suitable means and preferably by vacuum drying. The : drying time is variable and may range from 3 to 4 hours and the temperature during drying may range from 60-80 degree
Centigrade.
to WO 02/083026 PCT/EP02/03413
The applicator may be packed suitably as single or multiple units. 0)
If we reduce the quantity it may not be sufficiently available to stain the teeth and hence a certain amount of over dosing becomes essential which however, leads to the other problem of soft tissue staining. The applicator will preferentially be used on the teeth and thus the quantity of the material used is appropriate.
In a further aspect the applicator according to the invention may also be part of a kit comprising an oral care product in addition to the applicator. In such a kit the user benefits from whiter teeth, fresher breath, reduced caries, reduced plaque build up and reduced gingivitis because of the motivational benefit of having the applicator in the same package as the oral care product. The oral care product can be a toothpaste, mouthwash, gel, powder or any other form of an oral care product commonly used in the art.
The invention will now be illustrated by the following non- limiting examples.
Description and preparation of the applicator:
Fig la and Fig 1b describes the single use applicator. In
Fig 2a and Fig 2b, various other forms and shapes are disclosed. In Fig la and Fig 1b, there is shaft (ST) that has a liquid absorbable head (LH) at one end as in Fig la
I 4 So B
A WO 02/083026 PCT/EP02/03413 and at both ends as in Fig lb. A reservoir is provided to enable multiple use. The liquid absorbable head was made of . cotton and was loaded with 0.2ml of 2% erythrosin dye. The applicator was dried under vacuum for 3 hours at 80°C.
Figure 3 is an applicator according to the invention which comprises as well as a liquid absorbable head (LH) and a shaft (ST) there is a finger hose (FS) enabling a finger to be inserted such that application can be made using a single finger. In this way the device can be used in the more hard to reach areas of the mouth.
Figure 4 is an applicator according to the invention which has a reservoir (R) which stores the liquid to be applied.
In this way multiple use may be catered for.
Figure 5 is an applicator comprising a shaft (ST) a liquid absorbable head (LH) and a toothpick. The toothpick in this case is at the end opposite the liquid absorbable head although this is not strictly necessary, albeit preferred.
Combination dyes
The bud is kept in contact with first dye FDC RED for 1 minute. This is followed by second dye FDC BLUE for 1 minute. The bud is then dried at 90 ° C for one hour.
A
To WO 02/083026 PCT/EP02/03413
FDC Red No.3 FDC Blue No.3 | Colour on bud |Disclosing
CT en
A EL cB
ET LA cca cB
CONCLUSIONS
The bud colour was blue obtained by the combination of 0.6%
FDC RED with 0.2% FDC BLUE .The colour obtained on application was blue and the plaque disclosed was pink.
The plaque disclosing was found to be the best using 1.25%
FDC RED with 0.2% FDC BLUE. The colour of the bud was bluish green colour.
Testing of the efficiency of the applicator:
A panel of trained volunteers was divided into two groups.
One group was asked to use the applicator and the other to chew a erythrosin containing tablet before the first brushing for the day. The applicator having the loaded liquid absorbable head containing erythrosin at both ends were provided. The panellists were asked to moisten one end of the applicator and move it along the surface of the teeth s WO 02/083026 PCT/EP02/03413 viewing the same in front of a mirror for about a minute.
The presence of the plaque is visible immediately. The tablet also revealed the plaque if any on the teeth. The panellists were asked to brush their teeth with a dentifrice and a brush as routine. At the end of brushing and rinsing the mouth with water the other end of the applicator was similarly used to disclose the plaque if any.
There was minimal or no stain on the oral soft tissue when the applicator according to the invention was used but a deep red stain was visible when the tablet containing erythrosin was chewed and it lasted for about 2 hours.
However, disclosure of the plaque on the teeth guided the brushing operation in both cases to the same extent. '
Claims (8)
1. Applicator for applying a benefit agent to teeth, said applicator comprising a handle and a liquid absorbable part.
2. Applicator according to claim 1, wherein the benefit agent is selected from the group consisting of sensitive teeth agents, anti-caries agents, anti-tartar agents, fresh breath agents, vitamins, flavours, plaque disclosing agents and mixtures thereof.
3. Applicator according to claim 1 or 2, wherein the benefit agent is a plaque disclosing agent.
4. Applicator according to claim 1, wherein the applicator comprises a handle and an applicator head, the head
. comprising a liquid absorbable material for absorbing a Plaque disclosing solution.
5. Applicator according to claim 4 comprising a dried plaque disclosing material in the applicator head.
6. Use of an applicator according to any of claims 1, 3 or 4 for applying plaque disclosing material to the teeth by
: . 23 first wetting the applicator and then applying to the teeth.
7. A kit comprising an applicator according to any one of o claims 1 to 5 and a toothpaste.
8. An applicator for applying a benefit agent to teeth substantially as herein described with reference to any one of Figures la and 1b, or 2a and 2b, or 3 or 4 or 5 of the accompanying drawings. Amended Sheet — 2004-1) -3
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN348MU2001 | 2001-04-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200307030B true ZA200307030B (en) | 2004-12-06 |
Family
ID=34586957
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200307030A ZA200307030B (en) | 2001-04-18 | 2003-09-09 | Applicator. |
Country Status (1)
Country | Link |
---|---|
ZA (1) | ZA200307030B (en) |
-
2003
- 2003-09-09 ZA ZA200307030A patent/ZA200307030B/en unknown
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