EP1372630A2 - Agent destine au traitement de la vessie hyperactive - Google Patents

Agent destine au traitement de la vessie hyperactive

Info

Publication number
EP1372630A2
EP1372630A2 EP02728597A EP02728597A EP1372630A2 EP 1372630 A2 EP1372630 A2 EP 1372630A2 EP 02728597 A EP02728597 A EP 02728597A EP 02728597 A EP02728597 A EP 02728597A EP 1372630 A2 EP1372630 A2 EP 1372630A2
Authority
EP
European Patent Office
Prior art keywords
compound
inactivating
slowly
type
bladder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02728597A
Other languages
German (de)
English (en)
Other versions
EP1372630A4 (fr
Inventor
Tsuyoshi Kyowa Hakko Kogyo Co. Ltd. YAMAGATA
Kaoru Head Of.Kyowa Hakko Kogyo Co. Ltd. ATSUKI
Tetsuji Kyowa Hakko Kogyo Co. Ltd. OHNO
Shiro Kyowa Hakko Kogyo Co. Ltd SHIRAKURA
William C. Degroat
Adrian Sculporeanu
Akira Kyowa Hakko Kogyo Co. Ltd. KARASAWA
Naoki Yoshimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
University of Pittsburgh
Original Assignee
Kyowa Hakko Kogyo Co Ltd
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd, University of Pittsburgh filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of EP1372630A2 publication Critical patent/EP1372630A2/fr
Publication of EP1372630A4 publication Critical patent/EP1372630A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder

Definitions

  • Table 7 shows the activity of Compound 1 upon membrane potential in DRG cells. It showed that Compound 1 increases slowly-inactivating A-type K + currents, namely increases outward currents to effect hyperpolarization (a negative change of membrane potential ) . This activity suggests reduction of excitability of DRG cells . Based on the results of Test Examples 1 and 2, it was revealed that Compound 1 has an activity of increasing slowly-inactivating A-type K + currents.
  • a cystometry test was carried out.
  • the rat was put in a Ballman cage (Natsume Seisakusho), a three way cock was connected to the bladder catheter, one end of the cock was connected to a pressure transducer (Nihon Kohden) and the other end was connected to a 50 L capacity syringe (Terumo) arranged to an infusion pump (Harvard Apparatus) for physiological saline injection.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un agent destiné au traitement de la vessie hyperactive. Cet agent comprend, comme principe actif, un composé présentant une activité d'ouverture de canal K+ de type A à inactivation lente ou un sel acceptable sur le plan pharmaceutique de celui-ci, ainsi qu'un procédé de balayage d'agents destinés au traitement de la vessie hyperactive consistant à mesurer une activité d'ouverture de canal K+ de type A à inactivation lente comme un indice.
EP02728597A 2001-03-30 2002-03-29 Agent destine au traitement de la vessie hyperactive Withdrawn EP1372630A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27969801P 2001-03-30 2001-03-30
US279698P 2001-03-30
PCT/US2002/009577 WO2002078523A2 (fr) 2001-03-30 2002-03-29 Agent destine au traitement de la vessie hyperactive

Publications (2)

Publication Number Publication Date
EP1372630A2 true EP1372630A2 (fr) 2004-01-02
EP1372630A4 EP1372630A4 (fr) 2005-03-23

Family

ID=23070051

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02728597A Withdrawn EP1372630A4 (fr) 2001-03-30 2002-03-29 Agent destine au traitement de la vessie hyperactive

Country Status (4)

Country Link
EP (1) EP1372630A4 (fr)
JP (1) JP2005506296A (fr)
CA (1) CA2442437A1 (fr)
WO (1) WO2002078523A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2388898B (en) * 2002-04-02 2005-10-05 Inverness Medical Ltd Integrated sample testing meter

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0979821A1 (fr) * 1997-04-15 2000-02-16 Kyowa Hakko Kogyo Co., Ltd. Composes tricycliques

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0979821A1 (fr) * 1997-04-15 2000-02-16 Kyowa Hakko Kogyo Co., Ltd. Composes tricycliques

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GRANT T L ET AL: "ANILIDE TERTIARY CARBINOLS: A NOVEL SERIES OF K+ CHANNEL OPENERS" TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, vol. 15, no. 11, 1 November 1994 (1994-11-01), pages 402-404, XP000566910 ISSN: 0165-6147 *
See also references of WO02078523A2 *

Also Published As

Publication number Publication date
EP1372630A4 (fr) 2005-03-23
JP2005506296A (ja) 2005-03-03
CA2442437A1 (fr) 2002-10-10
WO2002078523A2 (fr) 2002-10-10
WO2002078523A3 (fr) 2003-07-24

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20031029

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

A4 Supplementary search report drawn up and despatched

Effective date: 20050209

RIC1 Information provided on ipc code assigned before grant

Ipc: 7C 07D 495/04 B

Ipc: 7A 61P 13/10 B

Ipc: 7A 61K 31/18 A

17Q First examination report despatched

Effective date: 20050601

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20051012