EP1365438A3 - Spectromètre de masse - Google Patents

Spectromètre de masse Download PDF

Info

Publication number
EP1365438A3
EP1365438A3 EP02257117A EP02257117A EP1365438A3 EP 1365438 A3 EP1365438 A3 EP 1365438A3 EP 02257117 A EP02257117 A EP 02257117A EP 02257117 A EP02257117 A EP 02257117A EP 1365438 A3 EP1365438 A3 EP 1365438A3
Authority
EP
European Patent Office
Prior art keywords
ions
fragment
ion trap
mass
collision cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP02257117A
Other languages
German (de)
English (en)
Other versions
EP1365438B1 (fr
EP1365438A2 (fr
Inventor
John Brian Hoyes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0211373.6A external-priority patent/GB0211373D0/en
Priority claimed from GB0222055A external-priority patent/GB2389704B/en
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Priority to EP08013533A priority Critical patent/EP2001039B1/fr
Publication of EP1365438A2 publication Critical patent/EP1365438A2/fr
Publication of EP1365438A3 publication Critical patent/EP1365438A3/fr
Application granted granted Critical
Publication of EP1365438B1 publication Critical patent/EP1365438B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/26Mass spectrometers or separator tubes
    • H01J49/34Dynamic spectrometers
    • H01J49/42Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205Device types
    • H01J49/421Mass filters, i.e. deviating unwanted ions without trapping
    • H01J49/4215Quadrupole mass filters
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/004Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/26Mass spectrometers or separator tubes
    • H01J49/34Dynamic spectrometers
    • H01J49/42Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426Methods for controlling ions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Electron Tubes For Measurement (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
EP02257117A 2002-05-17 2002-10-14 Spectromètre de masse comprenant un spectromètre à mobilité ionique et un filtre de masse Expired - Lifetime EP1365438B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08013533A EP2001039B1 (fr) 2002-05-17 2002-10-14 Spectromètre de masse

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0211373 2002-05-17
GBGB0211373.6A GB0211373D0 (en) 2002-05-17 2002-05-17 Mass spectrometer
GBGB0212641.5A GB0212641D0 (en) 2002-05-17 2002-05-31 Mass spectrometer
GB0212641 2002-05-31
GB0222055 2002-09-23
GB0222055A GB2389704B (en) 2002-05-17 2002-09-23 Mass Spectrometer

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP08013533A Division EP2001039B1 (fr) 2002-05-17 2002-10-14 Spectromètre de masse
EP08013533.8 Division-Into 2008-07-28

Publications (3)

Publication Number Publication Date
EP1365438A2 EP1365438A2 (fr) 2003-11-26
EP1365438A3 true EP1365438A3 (fr) 2006-04-12
EP1365438B1 EP1365438B1 (fr) 2010-09-08

Family

ID=29407326

Family Applications (2)

Application Number Title Priority Date Filing Date
EP08013533A Expired - Lifetime EP2001039B1 (fr) 2002-05-17 2002-10-14 Spectromètre de masse
EP02257117A Expired - Lifetime EP1365438B1 (fr) 2002-05-17 2002-10-14 Spectromètre de masse comprenant un spectromètre à mobilité ionique et un filtre de masse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP08013533A Expired - Lifetime EP2001039B1 (fr) 2002-05-17 2002-10-14 Spectromètre de masse

Country Status (3)

Country Link
EP (2) EP2001039B1 (fr)
CA (1) CA2407957C (fr)
GB (1) GB2390478B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2390478B (en) * 2002-05-17 2004-06-02 Micromass Ltd Mass spectrometer
US7064319B2 (en) * 2003-03-31 2006-06-20 Hitachi High-Technologies Corporation Mass spectrometer
DE102004014582B4 (de) * 2004-03-25 2009-08-20 Bruker Daltonik Gmbh Ionenoptische Phasenvolumenkomprimierung
GB0408751D0 (en) 2004-04-20 2004-05-26 Micromass Ltd Mass spectrometer
GB0424426D0 (en) 2004-11-04 2004-12-08 Micromass Ltd Mass spectrometer
GB0801309D0 (en) * 2008-01-24 2008-03-05 Micromass Ltd Mass spectrometer
GB201319952D0 (en) * 2013-11-12 2013-12-25 Micromass Ltd Methods of isolating ions
EP3069376A2 (fr) * 2013-11-12 2016-09-21 Micromass UK Limited Procédé d'isolement d'ions
US11049709B2 (en) * 2013-11-12 2021-06-29 Micromass Uk Limited Ion trap mass spectrometers with space charge control
GB201410346D0 (en) * 2014-06-11 2014-07-23 Micromass Ltd Two dimensional msms acquisition modes
CN108735571B (zh) 2014-06-11 2020-07-17 英国质谱公司 二维ms/ms采集模式
US9147565B1 (en) * 2014-12-30 2015-09-29 Morpho Detection, Llc Ion mobility spectrometer and method of using the same
CN111710588B (zh) * 2015-04-23 2023-09-26 英国质谱公司 在离子阱中分离离子
US10832897B2 (en) * 2018-10-19 2020-11-10 Thermo Finnigan Llc Methods and devices for high-throughput data independent analysis for mass spectrometry using parallel arrays of cells
CN109755096B (zh) * 2018-12-31 2020-11-06 聚光科技(杭州)股份有限公司 筛选式飞行时间质谱仪及检测方法
US11293898B2 (en) 2020-02-06 2022-04-05 Thermo Finnigan Llc Duty cycle improvement for a mass spectrometer using ion mobility separation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000070335A2 (fr) * 1999-05-17 2000-11-23 Advanced Research & Technology Institute Mobilite des ions et spectrometre de masse
US20020014586A1 (en) * 1997-06-02 2002-02-07 Clemmer David E. Instrument for separating ions in time as functions of preselected ion mobility and ion mass

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5689111A (en) * 1995-08-10 1997-11-18 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer
US6498342B1 (en) * 1997-06-02 2002-12-24 Advanced Research & Technology Institute Ion separation instrument
EP1057209B1 (fr) * 1998-01-23 2011-11-23 PerkinElmer Health Sciences, Inc. Spectrometrie de masse a guide d'ions multipolaire
CA2391060C (fr) * 2001-06-21 2011-08-09 Micromass Limited Spectrometre de masse
GB2390478B (en) * 2002-05-17 2004-06-02 Micromass Ltd Mass spectrometer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020014586A1 (en) * 1997-06-02 2002-02-07 Clemmer David E. Instrument for separating ions in time as functions of preselected ion mobility and ion mass
WO2000070335A2 (fr) * 1999-05-17 2000-11-23 Advanced Research & Technology Institute Mobilite des ions et spectrometre de masse

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HARDEN C S ET AL: "DETECTION OF METHYL ISOCYANATE IN AIR WITH THE USE OF HAND-HELD IONMOBILITY SPECTROMETERS", August 1997, FIELD ANALYTICAL CHEMISTRY AND TECHNOLOGY, WILEY, NEW YORK, NY,, US, PAGE(S) 285-294, ISSN: 1086-900X, XP000944904 *

Also Published As

Publication number Publication date
EP1365438B1 (fr) 2010-09-08
GB2390478B (en) 2004-06-02
CA2407957C (fr) 2010-12-14
GB0321698D0 (en) 2003-10-15
EP1365438A2 (fr) 2003-11-26
EP2001039B1 (fr) 2012-03-28
CA2407957A1 (fr) 2003-11-17
GB2390478A (en) 2004-01-07
EP2001039A1 (fr) 2008-12-10

Similar Documents

Publication Publication Date Title
EP1365438A3 (fr) Spectromètre de masse
EP1315196A3 (fr) Spectromètre de masse
EP1789989B1 (fr) Spectromètre de masse
GB0216438D0 (en) Comprehensive tandem time of flight mass spectrometer and method of use
WO2007148115A3 (fr) Spectromètre de masse
EP1467398A3 (fr) Spectromètre de masse.
US7312442B2 (en) Enhanced gradient multipole collision cell for higher duty cycle
JP2008524789A5 (fr)
EP2442351A3 (fr) Procédé de spectrométrie de masse et appareil
GB2402260B (en) All mass MS/MS method and apparatus
WO2004051225A3 (fr) Processus pour concevoir des separateurs de masse et des pieges a ions, procedes pour produire des separateurs de masse et des pieges a ions, spectrometres de masse, pieges a ions et procedes pour analyser des echantillons
EP1006559A3 (fr) Méthode de balayage MS/MS pour un dispositif de spectrométrie de masse en tandem comprenant un quadrupole suivi d' un temps de vol
CA2349416A1 (fr) Amelioration des methodes de balayage ms/ms pour spectrometre de masse tandem quadripolaire/a temps de vol
WO2000017908A3 (fr) Reduction de charge en spectrometrie de masse avec electrospray
WO2011127091A1 (fr) Procédé d'amélioration de la résolution en masse sur une gamme de masses limitée pour la spectrométrie à temps de vol
EP1630852A2 (fr) Spectromètre de masse à piège d'ions avec l'extraction d'ions avec balayage de temporisation
US8389931B2 (en) Method for sequencing peptides and proteins using metastable-activated dissociation mass spectrometry
EP1378930A3 (fr) Spectromètre de masse
GB2389704A (en) An ion mobility spectrometer coupled to a scanning mass filter and fragmentation cell
US8263932B2 (en) Mass-analyzing method
WO2007140400A3 (fr) Procédé pour faire fonctionner un instrument de séparation d'ions
Berkout Fragmentation of peptide ions via interaction with metastable atoms
WO2013061145A1 (fr) Procédé et appareil d'interruption de réactions ion-ion
AU2011237721A1 (en) Method for enhancement of mass resolution over a limited mass range for time-of-flight spectrometry

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: MICROMASS UK LIMITED

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

17P Request for examination filed

Effective date: 20060718

AKX Designation fees paid

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

17Q First examination report despatched

Effective date: 20080109

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

RIC1 Information provided on ipc code assigned before grant

Ipc: H01J 49/42 20060101AFI20100210BHEP

Ipc: G01N 27/64 20060101ALI20100210BHEP

RTI1 Title (correction)

Free format text: MASS SPECTROMETER COMPRISING AN ION MOBILITY SPECTROMETER AND A MASS FILTER

RBV Designated contracting states (corrected)

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GR IE IT LI LU MC NL PT SE SK TR

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GR IE IT LI LU MC NL PT SE SK TR

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REF Corresponds to:

Ref document number: 60237581

Country of ref document: DE

Date of ref document: 20101021

Kind code of ref document: P

REG Reference to a national code

Ref country code: NL

Ref legal event code: VDEP

Effective date: 20100908

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100908

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100908

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100908

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100908

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101209

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100908

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110110

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100908

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100908

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100908

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20101031

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100908

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101219

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100908

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20101031

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20101031

26N No opposition filed

Effective date: 20110609

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100908

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 60237581

Country of ref document: DE

Effective date: 20110609

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20101014

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100908

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20101014

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100908

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101208

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 14

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 15

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 16

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 17

REG Reference to a national code

Ref country code: DE

Ref legal event code: R082

Ref document number: 60237581

Country of ref document: DE

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20210922

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20210921

Year of fee payment: 20

REG Reference to a national code

Ref country code: DE

Ref legal event code: R071

Ref document number: 60237581

Country of ref document: DE