EP1355612A1 - Reconstitution device and method of use - Google Patents

Reconstitution device and method of use

Info

Publication number
EP1355612A1
EP1355612A1 EP20020705953 EP02705953A EP1355612A1 EP 1355612 A1 EP1355612 A1 EP 1355612A1 EP 20020705953 EP20020705953 EP 20020705953 EP 02705953 A EP02705953 A EP 02705953A EP 1355612 A1 EP1355612 A1 EP 1355612A1
Authority
EP
European Patent Office
Prior art keywords
receptacle
pressure
lumen
receiver
source
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20020705953
Other languages
German (de)
French (fr)
Inventor
Richard Spero
Adam Hagmann
Terry E. Laas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter International Inc filed Critical Baxter International Inc
Publication of EP1355612A1 publication Critical patent/EP1355612A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2058—Connecting means having multiple connecting ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2072—Venting means for internal venting

Definitions

  • Many drugs administered to patients comprise a compound of medicament components mixed shortly before use. Oftentimes it is necessary to store these substances in separate receptacles until use. Reconstitution of the compound may require the mixing of a liquid-phase component and a solid-phase component, or the mixing of two liquid- phase components. Commonly, the solid-phase component is in powder form to permit stable storing of a component.
  • the receptacles used to store these components may be constructed of glass, plastic, or other suitable material.
  • One way currently used to reconstitute material requires a first component to be injected with a syringe into a receptacle containing a second component.
  • a syringe having a needle attached thereto is inserted through the rubber membrane top of a receptacle containing a first liquid-phase component, and the liquid-phase component is withdrawn into the syringe barrel.
  • the needle is then removed from the liquid-phase component receptacle.
  • the needle of the syringe is inserted through the rubber membrane top of the second liquid-phase or solid-phase component receptacle, and the liquid-phase component is injected from the syringe barrel into the second receptacle.
  • the second receptacle is shaken to mix the components. Thereafter, a needle, attached to a syringe, is inserted through the rubber membrane top, the component mixture is drawn into the syringe barrel, and the needle is removed from the receptacle. The component mixture may then be administered.
  • An improvement to this process is the subject of U.S. Pat. No. 5,445,631 , entitled "Fluid Delivery System", to Tadatoshi et al.
  • the device of that invention includes a double-ended spike containing a lumen. The problem created by the device disclosed therein failed to address pressurize equalization between the individual component containers. As a result, the rate of material transfer is in constant fluctuation due to thermodynamic issues.
  • the present invention discloses a method and apparatus for reconstituting a multiple component material. More particularly, the present invention discloses a method and apparatus utilizing an operator-controlled pressurization differential to transfer and reconstitute solutions.
  • the individual components may comprise liquid-liquid, or liquid-solid mixtures.
  • the present invention is especially useful for reconstituting a fibrinogen-based tissue sealant.
  • Another use of the present invention involves the reconstitution of multiple component chemotherapy drugs.
  • the present invention in its broadest sense should not be construed to be limited to any particular multiple component materials, although particular examples may be shown and disclosed.
  • a first receptacle receiver having at least a material flow lumen and a pressure lumen in communication therewith is in fluid communication with a second receptacle receiver through said material flow lumen.
  • a user-controllable source of positive pressure is used to create a pressurization differential between the first and second receptacles, thereby resulting in transfer of the materials.
  • a first receptacle receiver having at least a material flow lumen in communication therewith is in fluid communication through said material flow lumen with a second receptacle receiver having a pressure lumen in communication therewith.
  • a user-controllable source of negative pressure is used to create a pressurization differential between the first and second receptacles, thereby resulting in a material transfer.
  • Also disclosed in the present invention is a method of reconstituting a solution, comprising the steps of creating fluid communication between a first receptacle and a second receptacle, and creating a pressure differential between said first receptacle and said second receptacle, thereby causing the contents of the first receptacle to flow into said second receptacle.
  • Fig. 1 is a side elevation view of an embodiment of the reconstitution device of the present invention
  • FIG. 2 is a side view of the reconstitution device illustrated in Fig. 1 ;
  • Fig. 3 is a side cross-sectional view of the reconstitution device illustrated in Fig. 1 ;
  • Fig. 4 is a side cross-sectional view of the reconstitution device of the present invention utilizing a syringe to provide a pressure differential;
  • FIG. 5 is a side view of another embodiment of the reconstitution device of the present invention having an enclosed first receptacle receiver
  • Fig. 6 is a side cross-sectional view of the reconstitution device illustrated in Fig. 5;
  • Fig. 7 is a side elevation view of another embodiment of the reconstitution device of the present invention.
  • Fig. 8 is a side view of the reconstitution device illustrated in Fig. 7 having a first receptacle and second receptacle connected to the device;
  • Fig. 9 is a side cross-sectional view of the reconstitution device illustrated in Fig. 7 showing the device prior to use; and [0021] Fig. 10 is a side cross-sectional view of the reconstitution device illustrated in Fig. 7 showing the device in use.
  • the reconstitution device of the present invention is used to facilitate the transfer of components between separate component receptacles. More particularly, the present invention permits the user to create a pressure differential between a first component receptacle and a second component receptacle, thereby enabling efficient material transfer between receptacles.
  • the present invention enables the operator to transfer material from commercially available component receptacles with increased user safety. In addition to increasing safety, the present invention greatly reduces the likelihood of material contamination.
  • the present invention is simple and inexpensive to manufacture and utilizes existing component receptacles. It is anticipated as being within the scope of the present invention to produce a reconstitution device capable of functionally coupling with a plurality of component receptacles in a plurality of sizes.
  • Figure 1 shows an apparatus 10 for reconstituting a multiple component material having a first receptacle receiver 12, a second receptacle receiver 14, a device body 16 positioned therebetween, and a vacuum device interface 18.
  • the apparatus 10 may be constructed of a plurality of materials, including, without limitation, polyethylene, polypropylene, polystyrene, or a like material.
  • the apparatus 10 comprises a first receptacle receiver 12 having a first receptacle stop 20 and receptacle support members 22a and 22b terminating in receptacle locking members 24a and 24b.
  • a first receptacle orifice 26 is formed by the first receptacle stop 20 and may include receptacle support members 22a and 22b. If desired, alternate embodiments of the present invention may be manufactured without the receptacle support members 22a and 22b.
  • a first component cannula 28 Positioned within the first receptacle orifice 26 is a first component cannula 28 having a first pointed tip 30 and a first component withdrawal port 32.
  • the second receptacle receiver 14 comprises a second receptacle stop 34 and a second component cannula 36 having a second pointed tip 38 and disposing a vacuum port 40 and a transfer port 42.
  • a device body 16 Interposed between the first receptacle receiver 12 and the second receptacle receiver 14 is a device body 16 having a pressurization interface 18 positioned thereon.
  • Figure 3 shows a sectional view of the present invention.
  • the pressurization interface 18 forms a pressurization orifice 44, which is in communication with the pressurization port 40 through pressurization lumen 46 located within the second cannula 36.
  • the transfer lumen 50 located adjacent to the pressurization lumen 46 within the second cannula 36, terminates at the transfer port 42 and is in communication with the withdrawal port 32 located on the first cannula 28.
  • Figure 4 shows the present invention using a syringe 56 as a pressurization device.
  • the syringe 56 comprises a syringe body 62, a syringe distal tip 64, a syringe plunger 66, and a syringe pusher 68.
  • the syringe distal tip 64 is positioned within the pressurization orifice 44 formed by the pressurization interface 18.
  • a first receptacle 58 is positioned within the first receptacle receiver 12 such that receptacle locking members 24a and 24b securely position the first receptacle 58 within the receptacle orifice 26.
  • a second receptacle 60 is positioned within the second receptacle receiver 14.
  • first cannula 28 and the second cannula 36 may be manufactured from a plurality of materials, including, without limitation, polyethylene, polypropylene, polystyrene, stainless steel, or a like material.
  • the reconstitution device 110 includes a first receptacle receiver 112, a second receptacle receiver 114, a device body 116 positioned therebewteen, and a vacuum device interface 118.
  • the present embodiment may be manufactured in a plurality of sizes and shapes to accommodate various component receptacles.
  • the present embodiment includes an encapsulated first receptacle receiver 112, formed by first receptacle stop 120 and a continuous receptacle support member 122 defining a first receptacle orifice 126.
  • At least one receptacle locking member 124 is positioned on the receptacle support member 122 and located within the first receptacle orifice 126.
  • the multiple internal lumen configuration of the present embodiment is similar to the previous embodiment.
  • the pressurization interface 118 forms a pressurization orifice 144, which is in communication with the pressurization port 144 through the pressurization lumen 146 located within the second cannula 136.
  • the transfer lumen 150 located adjacent to the pressurization lumen 146 within the second cannula 136, terminates at the transfer port 142 and is in communication with the withdrawal port 132 located on the first cannula 128 located within the first receptacle orifice 126.
  • FIG. 7 and 8 shows a third embodiment of the present invention.
  • the apparatus 210 comprises a first receptacle receiver 212, a second receptacle receiver 214, and a device body 216 positioned therebewteen.
  • the present embodiment may be manufactured in a plurality of sizes and shapes to accommodate various component receptacles.
  • the first receptacle receiver 212 comprises a first receptacle stop 220 and a first receptacle support member 222 terminating with at least one receptacle locking member 224.
  • a first receptacle orifice 226 is formed by the first receptacle stop 220 and the first receptacle support member 222.
  • the first receptacle orifice 226 comprises a first multi-lumen component cannula 228 having a first pointed tip 230, a first component withdrawal port 232 and a pressurization port 234.
  • the second receptacle receiver 214 comprises a second receptacle stop 236 and a second receptacle support member 238.
  • a second receptacle orifice 240 is formed by the second receptacle stop 236 and the second receptacle support member 238.
  • a pressurization piston 242 which sealably interacts with the second receptacle support member 238, is slidably positioned within the second receptacle orifice 240, thereby forming a compression chamber 244.
  • a cannula port 246 is positioned on the pressurization piston 242.
  • At least one pressure transfer port 248 is located on the second receptacle stop 236.
  • the second multi-lumen cannula 250 is connected to the second receptacle stop 236 and comprises a pointed tip 252, a material transfer port 254 and a venting port 256.
  • the device body 216 positioned between the first receptacle receiver 212 and the second receptacle receiver 214, comprises a pressurization lumen 258, a material transfer lumen 260, a venting lumen 262, and a venting orifice 264.
  • the pressurization lumen 258 is in fluid communication with the pressurization port 234 located on the first cannula 228 and the pressure transfer port 248 located within the compression chamber 244.
  • the material transfer lumen 260 is in fluid communication with the first component withdrawal port 236 and the material transfer port 254.
  • the venting lumen 262 is in fluid communication with the venting port 256 and a venting orifice 264 located on the device body 216.
  • the present invention comprises various methods for reconstituting a multiple component material. More specifically, the method permits the reconstitution of a material from multiple component receptacles which are in fluid communication. An operator controlled pressure differential is created to effect a transfer of materials between the receptacles.
  • a first method of reconstitution which can be practiced with the apparatus shown in Figures 1-6, utilizes a negative pressure formed in the second receptacle 60.
  • the method may be practiced by the introduction of a positive pressure introduced to the first receptacle 58, followed by the introduction of a negative pressure into the second receptacle 60.
  • a first receptacle 58 is positioned within the first receptacle receiver 12, wherein the first cannula 28 is in fluid communication with the material stored therein.
  • a second receptacle 60 is positioned within the second receptacle receiver 14, such that the second cannula 36 is located within the second receptacle 60.
  • a syringe 56 may be coupled to the pressurization interface 18, wherein the syringe distal tip 64 is positioned within the pressurization orifice 44.
  • alternative instruments may be used to create a pressure differential, including, for example, a mechanical vacuum device.
  • a pressure differential is created within the second receptacle 60 as the syringe plunger 66 is retracted from the syringe barrel 62.
  • the negative pressure differential created within the second receptacle results in the first component traversing the transfer lumen 50 and entering the second receptacle 60.
  • the user may first inject air into the second receptacle 60 with the syringe 56.
  • the injected gas causes a positive pressure differential, which equalizes within the first receptacle 58 and second receptacle 60.
  • the subsequent retraction of the syringe plunger 66 results in the creation of a negative pressure differential within the second receptacle 60.
  • FIG. 7-10 Yet another embodiment of the method of reconstituting a material is disclosed herein. This embodiment may be practiced by utilizing the apparatus disclosed in Figures 7-10 which comprises positioning a first receptacle 266 within the first receptacle orifice 226 formed on the first receptacle receiver 212, wherein the first multi-lumen cannula 228 is located within the first receptacle 266 and in communication with material stored therein.
  • a second receptacle 268 is positioned within the second receptacle orifice 240 and contacts the pressurization piston 242.
  • the user forcibly advances the second receptacle receiver 214 over the second receptacle 268, resulting in the insertion of the second multi-lumen cannula 250 into the second receptacle 266.
  • advancement of the second receptacle receiver 214 over the second receptacle 268 advances the pressurization piston 242 towards the second receptacle stop 236, thereby decreasing the effective volume of the compression chamber 244.
  • the ambient gas being displaced by the compression chamber's decreasing volume is directed into the first receptacle 266 through the pressurization lumen 258.
  • a pressurization differential is created between the first and second receptacles, wherein the first receptacle 266 incurs a positive pressure.
  • the pressure differential results in the first component contained within the first receptacle 266 traversing the withdrawal port 232 and the transfer lumen 260, thereby entering the second receptacle 268 through the material transfer port 254.
  • the second receptacle 268 utilizes the venting port 256 connected to the venting orifice 264 to equalize pressure within the second receptacle 268.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Extraction Or Liquid Replacement (AREA)

Abstract

A method and apparatus for reconstituting a multiple component material is disclosed. More particularly, the present invention discloses an apparatus utilizing an operator controllable pressurization device to generate a pressure differential between two receptacles attached to the device. The receptacles may contain individual components of a multiple component material, and may include liquid-liquid or liquid-solid compounds. The apparatus includes a material transfer lumen attacheble to a first and second component receptacle. A pressurization lumen is connected to one of the component receptacles to facilitate material transfer. One embodiment of the present invention utilizes a negative pressure differential created in the second receptacle to facilitate transfer. In another embodiment, a positive pressure is created in the first receptacle to force material transfer between the two receptacles.

Description

RECONSTITUTION DEVICE AND METHOD OF USE
BACKGROUND OF THE INVENTION THE DEVICE
[0001] Many drugs administered to patients comprise a compound of medicament components mixed shortly before use. Oftentimes it is necessary to store these substances in separate receptacles until use. Reconstitution of the compound may require the mixing of a liquid-phase component and a solid-phase component, or the mixing of two liquid- phase components. Commonly, the solid-phase component is in powder form to permit stable storing of a component. The receptacles used to store these components may be constructed of glass, plastic, or other suitable material.
[0002] One way currently used to reconstitute material requires a first component to be injected with a syringe into a receptacle containing a second component. For example, a syringe having a needle attached thereto is inserted through the rubber membrane top of a receptacle containing a first liquid-phase component, and the liquid-phase component is withdrawn into the syringe barrel. The needle is then removed from the liquid-phase component receptacle. Subsequently, the needle of the syringe is inserted through the rubber membrane top of the second liquid-phase or solid-phase component receptacle, and the liquid-phase component is injected from the syringe barrel into the second receptacle. The second receptacle is shaken to mix the components. Thereafter, a needle, attached to a syringe, is inserted through the rubber membrane top, the component mixture is drawn into the syringe barrel, and the needle is removed from the receptacle. The component mixture may then be administered. [0003] An improvement to this process is the subject of U.S. Pat. No. 5,445,631 , entitled "Fluid Delivery System", to Tadatoshi et al. The device of that invention includes a double-ended spike containing a lumen. The problem created by the device disclosed therein failed to address pressurize equalization between the individual component containers. As a result, the rate of material transfer is in constant fluctuation due to thermodynamic issues.
[0004] These problems were addressed in WO 96/29112, entitled "Fluid Control Device", to Handelman et al. The Handelman device utilizes pressurized component vials storing their contents under a high vacuum to create a pressure differential.
[0005] With respect to these devices, it is desirable to have a system capable of reconstituting a multiple component material using commercially available component storage receptacles. Additionally, it is desirable to have a reconstitution system wherein the operator may control the rate of reconstitution. Yet another problem associated with drug reconstitution is that some drugs, e.g. drugs used for chemotherapy, may be hazardous to hospital personnel. It is, thus, also desirable to have a reconstitution device and method that reduces or eliminates the possibility of inadvertent needle sticks.
BRIEF SUMMARY OF THE INVENTION
[0006] The present invention discloses a method and apparatus for reconstituting a multiple component material. More particularly, the present invention discloses a method and apparatus utilizing an operator-controlled pressurization differential to transfer and reconstitute solutions. The individual components may comprise liquid-liquid, or liquid-solid mixtures. For example, the present invention is especially useful for reconstituting a fibrinogen-based tissue sealant. Another use of the present invention involves the reconstitution of multiple component chemotherapy drugs. In sum, the present invention in its broadest sense should not be construed to be limited to any particular multiple component materials, although particular examples may be shown and disclosed.
[0007] In one embodiment, a first receptacle receiver having at least a material flow lumen and a pressure lumen in communication therewith is in fluid communication with a second receptacle receiver through said material flow lumen. A user-controllable source of positive pressure is used to create a pressurization differential between the first and second receptacles, thereby resulting in transfer of the materials.
[0008] In yet another embodiment, a first receptacle receiver having at least a material flow lumen in communication therewith is in fluid communication through said material flow lumen with a second receptacle receiver having a pressure lumen in communication therewith. A user-controllable source of negative pressure is used to create a pressurization differential between the first and second receptacles, thereby resulting in a material transfer.
[0009] Also disclosed in the present invention is a method of reconstituting a solution, comprising the steps of creating fluid communication between a first receptacle and a second receptacle, and creating a pressure differential between said first receptacle and said second receptacle, thereby causing the contents of the first receptacle to flow into said second receptacle.
[0010] Other objects, features, and advantages of the present invention will become apparent from a consideration of the following detailed description. BRIEF DESCRIPTION OF THE DRAWINGS
[0011] The apparatus of the present invention will be explained in more detail by way of the accompanying drawings, wherein:
[0012] Fig. 1 is a side elevation view of an embodiment of the reconstitution device of the present invention;
[0013] Fig. 2 is a side view of the reconstitution device illustrated in Fig. 1 ;
[0014] Fig. 3 is a side cross-sectional view of the reconstitution device illustrated in Fig. 1 ;
[0015] Fig. 4 is a side cross-sectional view of the reconstitution device of the present invention utilizing a syringe to provide a pressure differential;
[0016] Fig. 5 is a side view of another embodiment of the reconstitution device of the present invention having an enclosed first receptacle receiver;
[0017] Fig. 6 is a side cross-sectional view of the reconstitution device illustrated in Fig. 5;
[0018] Fig. 7 is a side elevation view of another embodiment of the reconstitution device of the present invention;
[0019] Fig. 8 is a side view of the reconstitution device illustrated in Fig. 7 having a first receptacle and second receptacle connected to the device;
[0020] Fig. 9 is a side cross-sectional view of the reconstitution device illustrated in Fig. 7 showing the device prior to use; and [0021] Fig. 10 is a side cross-sectional view of the reconstitution device illustrated in Fig. 7 showing the device in use.
DETAILED DESCRIPTION OF THE INVENTION
[0022] Disclosed herein is a detailed description of various illustrated embodiments of the present invention. This description is not to be taken in a limiting sense, but is made merely for the purpose of illustrating the general principles of the invention. The section titles and overall organization of the present detailed description are for the purpose of convenience only and are not intended to limit the present invention.
[0023] The reconstitution device of the present invention is used to facilitate the transfer of components between separate component receptacles. More particularly, the present invention permits the user to create a pressure differential between a first component receptacle and a second component receptacle, thereby enabling efficient material transfer between receptacles. The present invention enables the operator to transfer material from commercially available component receptacles with increased user safety. In addition to increasing safety, the present invention greatly reduces the likelihood of material contamination. As those skilled in the art will appreciate, the present invention is simple and inexpensive to manufacture and utilizes existing component receptacles. It is anticipated as being within the scope of the present invention to produce a reconstitution device capable of functionally coupling with a plurality of component receptacles in a plurality of sizes.
[0024] Figure 1 shows an apparatus 10 for reconstituting a multiple component material having a first receptacle receiver 12, a second receptacle receiver 14, a device body 16 positioned therebetween, and a vacuum device interface 18. As those skilled in the art will appreciate the present invention may be manufactured in a plurality of sizes to accommodate a variety of receptacle sizes. The apparatus 10 may be constructed of a plurality of materials, including, without limitation, polyethylene, polypropylene, polystyrene, or a like material.
[0025] As shown in Figure 2, the apparatus 10 comprises a first receptacle receiver 12 having a first receptacle stop 20 and receptacle support members 22a and 22b terminating in receptacle locking members 24a and 24b. A first receptacle orifice 26 is formed by the first receptacle stop 20 and may include receptacle support members 22a and 22b. If desired, alternate embodiments of the present invention may be manufactured without the receptacle support members 22a and 22b. Positioned within the first receptacle orifice 26 is a first component cannula 28 having a first pointed tip 30 and a first component withdrawal port 32. The second receptacle receiver 14 comprises a second receptacle stop 34 and a second component cannula 36 having a second pointed tip 38 and disposing a vacuum port 40 and a transfer port 42. Interposed between the first receptacle receiver 12 and the second receptacle receiver 14 is a device body 16 having a pressurization interface 18 positioned thereon.
[0026] Figure 3 shows a sectional view of the present invention. As shown in Figure 3, the pressurization interface 18 forms a pressurization orifice 44, which is in communication with the pressurization port 40 through pressurization lumen 46 located within the second cannula 36. The transfer lumen 50, located adjacent to the pressurization lumen 46 within the second cannula 36, terminates at the transfer port 42 and is in communication with the withdrawal port 32 located on the first cannula 28. [0027] Figure 4 shows the present invention using a syringe 56 as a pressurization device. The syringe 56 comprises a syringe body 62, a syringe distal tip 64, a syringe plunger 66, and a syringe pusher 68. The syringe distal tip 64 is positioned within the pressurization orifice 44 formed by the pressurization interface 18. A first receptacle 58 is positioned within the first receptacle receiver 12 such that receptacle locking members 24a and 24b securely position the first receptacle 58 within the receptacle orifice 26. A second receptacle 60 is positioned within the second receptacle receiver 14. As shown in Figure 4, locating the first receptacle 58 within the first receptacle receiver 12 results in the first pointed tip 30 of the first cannula 28 piercing the sealing material (not shown) of the first receptacle 58, thereby positioning the first cannula 28 within the first receptacle 58. Likewise, locating the second receptacle 60 within the second receptacle receiver 14 results in the second pointed tip 38 of the second cannula 36 piercing the sealing material (not shown) of the second receptacle 60, thereby positioning the second cannula 36 within the second receptacle 60. The first cannula 28 and the second cannula 36 may be manufactured from a plurality of materials, including, without limitation, polyethylene, polypropylene, polystyrene, stainless steel, or a like material.
[0028] A second embodiment of the present invention is illustrated in Figures 5 and 6. The reconstitution device 110 includes a first receptacle receiver 112, a second receptacle receiver 114, a device body 116 positioned therebewteen, and a vacuum device interface 118. Like the previous embodiment, the present embodiment may be manufactured in a plurality of sizes and shapes to accommodate various component receptacles. The present embodiment includes an encapsulated first receptacle receiver 112, formed by first receptacle stop 120 and a continuous receptacle support member 122 defining a first receptacle orifice 126. At least one receptacle locking member 124 is positioned on the receptacle support member 122 and located within the first receptacle orifice 126.
[0029] As shown in Figures 5 and 6, the multiple internal lumen configuration of the present embodiment is similar to the previous embodiment. The pressurization interface 118 forms a pressurization orifice 144, which is in communication with the pressurization port 144 through the pressurization lumen 146 located within the second cannula 136. The transfer lumen 150, located adjacent to the pressurization lumen 146 within the second cannula 136, terminates at the transfer port 142 and is in communication with the withdrawal port 132 located on the first cannula 128 located within the first receptacle orifice 126.
[0030] Figures 7 and 8 shows a third embodiment of the present invention. The apparatus 210 comprises a first receptacle receiver 212, a second receptacle receiver 214, and a device body 216 positioned therebewteen. Like the previous embodiment, the present embodiment may be manufactured in a plurality of sizes and shapes to accommodate various component receptacles.
[0031] Figures 9 and 10 show the present embodiment during various stages of use The first receptacle receiver 212 comprises a first receptacle stop 220 and a first receptacle support member 222 terminating with at least one receptacle locking member 224. A first receptacle orifice 226 is formed by the first receptacle stop 220 and the first receptacle support member 222. The first receptacle orifice 226 comprises a first multi-lumen component cannula 228 having a first pointed tip 230, a first component withdrawal port 232 and a pressurization port 234. The second receptacle receiver 214 comprises a second receptacle stop 236 and a second receptacle support member 238. A second receptacle orifice 240 is formed by the second receptacle stop 236 and the second receptacle support member 238. A pressurization piston 242, which sealably interacts with the second receptacle support member 238, is slidably positioned within the second receptacle orifice 240, thereby forming a compression chamber 244. A cannula port 246 is positioned on the pressurization piston 242. At least one pressure transfer port 248 is located on the second receptacle stop 236. The second multi-lumen cannula 250 is connected to the second receptacle stop 236 and comprises a pointed tip 252, a material transfer port 254 and a venting port 256. The device body 216, positioned between the first receptacle receiver 212 and the second receptacle receiver 214, comprises a pressurization lumen 258, a material transfer lumen 260, a venting lumen 262, and a venting orifice 264. The pressurization lumen 258 is in fluid communication with the pressurization port 234 located on the first cannula 228 and the pressure transfer port 248 located within the compression chamber 244. The material transfer lumen 260 is in fluid communication with the first component withdrawal port 236 and the material transfer port 254. The venting lumen 262 is in fluid communication with the venting port 256 and a venting orifice 264 located on the device body 216.
[0032] The present invention comprises various methods for reconstituting a multiple component material. More specifically, the method permits the reconstitution of a material from multiple component receptacles which are in fluid communication. An operator controlled pressure differential is created to effect a transfer of materials between the receptacles.
[0033] A first method of reconstitution, which can be practiced with the apparatus shown in Figures 1-6, utilizes a negative pressure formed in the second receptacle 60. Alternatively, the method may be practiced by the introduction of a positive pressure introduced to the first receptacle 58, followed by the introduction of a negative pressure into the second receptacle 60. For example, a first receptacle 58 is positioned within the first receptacle receiver 12, wherein the first cannula 28 is in fluid communication with the material stored therein. A second receptacle 60 is positioned within the second receptacle receiver 14, such that the second cannula 36 is located within the second receptacle 60. A syringe 56, for example, may be coupled to the pressurization interface 18, wherein the syringe distal tip 64 is positioned within the pressurization orifice 44. It should be understood that alternative instruments may be used to create a pressure differential, including, for example, a mechanical vacuum device. A pressure differential is created within the second receptacle 60 as the syringe plunger 66 is retracted from the syringe barrel 62. The negative pressure differential created within the second receptacle results in the first component traversing the transfer lumen 50 and entering the second receptacle 60. Alternatively, the user may first inject air into the second receptacle 60 with the syringe 56. The injected gas causes a positive pressure differential, which equalizes within the first receptacle 58 and second receptacle 60. The subsequent retraction of the syringe plunger 66 results in the creation of a negative pressure differential within the second receptacle 60. Those skilled in the art will appreciate the present embodiment provides for the reconstitution of a multiple component material without introducing an ambient gas or material, thereby reducing the likelihood of contamination.
[0034] Yet another embodiment of the method of reconstituting a material is disclosed herein. This embodiment may be practiced by utilizing the apparatus disclosed in Figures 7-10 which comprises positioning a first receptacle 266 within the first receptacle orifice 226 formed on the first receptacle receiver 212, wherein the first multi-lumen cannula 228 is located within the first receptacle 266 and in communication with material stored therein. A second receptacle 268 is positioned within the second receptacle orifice 240 and contacts the pressurization piston 242. The user forcibly advances the second receptacle receiver 214 over the second receptacle 268, resulting in the insertion of the second multi-lumen cannula 250 into the second receptacle 266. Simultaneously, advancement of the second receptacle receiver 214 over the second receptacle 268 advances the pressurization piston 242 towards the second receptacle stop 236, thereby decreasing the effective volume of the compression chamber 244. The ambient gas being displaced by the compression chamber's decreasing volume is directed into the first receptacle 266 through the pressurization lumen 258. A pressurization differential is created between the first and second receptacles, wherein the first receptacle 266 incurs a positive pressure. The pressure differential results in the first component contained within the first receptacle 266 traversing the withdrawal port 232 and the transfer lumen 260, thereby entering the second receptacle 268 through the material transfer port 254. During the reconstitution procedure the second receptacle 268 utilizes the venting port 256 connected to the venting orifice 264 to equalize pressure within the second receptacle 268.
[0035] In closing, it is noted that specific illustrative embodiments of the invention have been disclosed hereinabove. However, it is to be understood that the invention is not limited to these specific embodiments. Accordingly, the invention is not limited to the precise embodiments described in detail hereinabove. Those skilled in the art will appreciate the benefits advanced by the present invention. For example, no material transfer between the receptacles will occur until a pressure differential is established. Also, with respect to the first disclosed embodiment, the material transfer occurs within a sealed environment, therefor the likelihood of contamination is greatly reduced. With respect to the claims, it is applicant's intention that the claims not be interpreted in accordance with the sixth paragraph of 35 U.S.C. § 112 unless the term "means" is used followed by a functional statement. Further, with respect to the claims, it should be understood that any of the claims described below can be combined for the purposes of the invention.

Claims

What is claimed is:
1. A reconstitution device, comprising:
a first receptacle receiver having at least a material flow lumen in communication therewith;
a second receptacle receiver connected to said first receptacle receiver, said second receptacle receiver in communication with said material flow lumen;
a pressure lumen in communication with at least one of said first receptacle receiver and said second receptacle receiver; and
a user-controllable source of pressure in fluid communication with said pressure lumen.
2. The reconstitution device of claim 1 , wherein the pressure source is a source of positive pressure.
3. The reconstitution device of claim 2, further comprising a chamber between said first receptacle receiver and said second receptacle receiver and wherein said pressure source comprises a piston residing in said chamber and said pressure lumen is in fluid communication with said chamber.
4. The reconstitution device of claim 3, wherein said chamber is capable of compression, thereby introducing a positive pressure to said first receptacle through said pressure lumen.
5. The reconstitution device of claim 1 , wherein the pressure source is a source of negative pressure.
6. The reconstitution device of claim 5, wherein the negative pressure source is a syringe.
7. The reconstitution device of claim 5, wherein the negative pressure source is an external vacuum source.
8. The reconstitution device of claim 1 , wherein the pressure source is a source of positive pressure created in a first receptacle and a source of negative pressure created in a second receptacle.
9. A reconstitution device, comprising:
a first receptacle receiver having at least a material flow lumen in communication therewith;
a second receptacle receiver connected to said first receptacle receiver and in communication with said material flow lumen;
a pressure lumen in communication with said second receptacle receiver; and
a user-controllable source of pressure in fluid communication with said pressure lumen.
10. The reconstitution device of claim 9, wherein said pressure source is a source of negative pressure.
11. The reconstitution device of claim 10, wherein the negative pressure source is a syringe connected to the device through an externally accessible orifice in communication with said pressure lumen.
12. The reconstitution device of claim 9, wherein said first receptacle receiver comprises a first receptacle stop and at least first receptacle support member attached thereto.
13. The reconstitution device of claim 12, wherein at least one receptacle locking member is positioned on said first receptacle support member.
14. A reconstitution device, comprising:
a first receptacle receiver having at least a material flow lumen in communication therewith;
a second receptacle receiver connected to said first receptacle receiver and in communication with said material flow lumen;
a pressure lumen in communication with said first receptacle receiver; and
a user-controllable source of pressure in fluid communication with said pressure lumen.
15. The reconstitution device of claim 14, wherein the pressure source is a source of positive pressure.
16. The reconstitution device of claim 15, further comprising a chamber between said first receptacle receiver and said second receptacle receiver and wherein said pressure source comprises a piston residing in said chamber and said pressure lumen is in fluid communication with said chamber.
17. The reconstitution device of claim 16, wherein said chamber is capable of compression, thereby introducing a positive pressure to said first receptacle through said pressure lumen.
18. A method of reconstituting a solution, said method comprising the steps of: creating fluid communication between a first receptacle and a second receptacle; and
creating a pressure differential between said first receptacle and said second receptacle, thereby causing the contents of the first receptacle to flow into said second receptacle.
19. The method of claim 18, wherein the step of creating a pressure differential comprises the step of positively pressurizing the first receptacle.
20. The method of claim 18, wherein the step of creating a pressure differential comprises the step of negatively pressurizing the second receptacle.
21. The method of claim 18, wherein the step of creating a pressure differential comprises the steps of positively pressurizing the first receptacle and negatively pressurizing the second receptacle.
22. A method of reconstituting a solution, said method comprising the steps of:
creating fluid communication between a first receptacle and a second receptacle; and
positively pressurizing the first receptacle, thereby causing the contents of the first receptacle to flow into said second receptacle.
23. A method of reconstituting a solution, said method comprising the steps of:
creating fluid communication between a first receptacle and a second receptacle; and
negatively pressurizing the second receptacle, thereby causing the contents of the first receptacle to flow into said second receptacle.
EP20020705953 2001-02-02 2002-01-25 Reconstitution device and method of use Withdrawn EP1355612A1 (en)

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US776351 2001-02-02
US09/776,351 US6474375B2 (en) 2001-02-02 2001-02-02 Reconstitution device and method of use
PCT/US2002/002089 WO2002062288A1 (en) 2001-02-02 2002-01-25 Reconstitution device and method of use

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JP (1) JP2004524082A (en)
AU (1) AU2002240070B2 (en)
CA (1) CA2435339C (en)
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WO (1) WO2002062288A1 (en)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL114960A0 (en) * 1995-03-20 1995-12-08 Medimop Medical Projects Ltd Flow control device
US20030010717A1 (en) * 2001-07-13 2003-01-16 Nx Stage Medical, Inc. Systems and methods for handling air and/or flushing fluids in a fluid circuit
DE502004005171D1 (en) * 2003-03-06 2007-11-22 Csl Behring Gmbh Transfer device, in particular for medical fluids
US7470265B2 (en) * 2003-03-20 2008-12-30 Nxstage Medical, Inc. Dual access spike for infusate bags
US6948522B2 (en) * 2003-06-06 2005-09-27 Baxter International Inc. Reconstitution device and method of use
IL160891A0 (en) 2004-03-16 2004-08-31 Auto-mix needle
IL161660A0 (en) 2004-04-29 2004-09-27 Medimop Medical Projects Ltd Liquid drug delivery device
US7998106B2 (en) * 2004-05-03 2011-08-16 Thorne Jr Gale H Safety dispensing system for hazardous substances
US20060184103A1 (en) * 2005-02-17 2006-08-17 West Pharmaceutical Services, Inc. Syringe safety device
US7905868B2 (en) 2006-08-23 2011-03-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
ES2371557T3 (en) 2005-08-11 2012-01-05 Medimop Medical Projects Ltd. TRANSFER DEVICES OF LIQUID DRUGS FOR A RIGHT PRESSURE ADJUSTMENT TO FAILURE IN MEDICINAL ROADS.
US8529502B2 (en) 2006-04-24 2013-09-10 Novo Nordisk Healthcare Ag Transfer system for forming a drug solution from a lyophilized drug
EP2540276B1 (en) 2006-05-25 2016-03-16 Bayer Healthcare LLC Method of assembling a reconstitution device
US7806265B2 (en) * 2006-07-12 2010-10-05 Mobius Therapeutics, Llc Apparatus and method for reconstituting a pharmaceutical and preparing the reconstituted pharmaceutical for transient application
EP2101711A1 (en) * 2006-11-30 2009-09-23 Medi-Physics, Inc. Dual-lumen needle with an elongate notch opening
IL182605A0 (en) 2007-04-17 2007-07-24 Medimop Medical Projects Ltd Fluid control device with manually depressed actuator
US8597243B2 (en) 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8434528B2 (en) * 2007-04-30 2013-05-07 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US7963954B2 (en) 2007-04-30 2011-06-21 Medtronic Minimed, Inc. Automated filling systems and methods
WO2008136845A2 (en) * 2007-04-30 2008-11-13 Medtronic Minimed, Inc. Reservoir filling, bubble management, and infusion medium delivery systems and methods with same
US8613725B2 (en) * 2007-04-30 2013-12-24 Medtronic Minimed, Inc. Reservoir systems and methods
EP2188004A4 (en) 2007-08-21 2015-06-17 Yukon Medical Llc Vial access and injection system
WO2009038860A2 (en) 2007-09-18 2009-03-26 Medeq Llc Medicament mixing and injection apparatus
IL186290A0 (en) 2007-09-25 2008-01-20 Medimop Medical Projects Ltd Liquid drug delivery devices for use with syringe having widened distal tip
US20120156794A1 (en) * 2008-03-19 2012-06-21 Florian Schweigert Method for the extraction and detection of fat-soluble components from biological materials
JP5685522B2 (en) 2008-04-01 2015-03-18 ユーコン・メディカル，リミテッド・ライアビリティ・カンパニー Duplex container fluid transfer device
CN102202636A (en) * 2008-05-30 2011-09-28 优诺医疗有限公司 Reservoir filling device
DE112009002513T5 (en) * 2008-10-20 2012-01-19 The Yokohama Rubber Co., Ltd. Reservoir for puncture sealant and puncture repair equipment
JP5432176B2 (en) * 2008-11-21 2014-03-05 テルモ株式会社 Connector
USD641080S1 (en) 2009-03-31 2011-07-05 Medimop Medical Projects Ltd. Medical device having syringe port with locking mechanism
JP5685579B2 (en) 2009-04-14 2015-03-18 ユーコン・メディカル，リミテッド・ライアビリティ・カンパニー Fluid transfer device
CN104287966B (en) * 2009-05-04 2017-03-15 瓦莱里塔斯公司 Fluid conveying device
USD616984S1 (en) 2009-07-02 2010-06-01 Medimop Medical Projects Ltd. Vial adapter having side windows
CA2768985C (en) 2009-07-29 2020-03-10 Icu Medical, Inc. Fluid transfer devices and methods of use
USD630732S1 (en) 2009-09-29 2011-01-11 Medimop Medical Projects Ltd. Vial adapter with female connector
IL201323A0 (en) 2009-10-01 2010-05-31 Medimop Medical Projects Ltd Fluid transfer device for assembling a vial with pre-attached female connector
AU2010310457B2 (en) 2009-10-23 2015-07-02 Amgen Inc. Vial adapter and system
IL202070A0 (en) 2009-11-12 2010-06-16 Medimop Medical Projects Ltd Inline liquid drug medical device
IL202069A0 (en) 2009-11-12 2010-06-16 Medimop Medical Projects Ltd Fluid transfer device with sealing arrangement
CN102781396B (en) 2010-02-24 2015-01-07 麦迪麦珀医疗工程有限公司 Liquid drug transfer device with vented vial adapter
WO2011104711A1 (en) 2010-02-24 2011-09-01 Medimop Medical Projects Ltd Fluid transfer assembly with venting arrangement
USD655017S1 (en) 2010-06-17 2012-02-28 Yukon Medical, Llc Shroud
USD669980S1 (en) 2010-10-15 2012-10-30 Medimop Medical Projects Ltd. Vented vial adapter
IL209290A0 (en) 2010-11-14 2011-01-31 Medimop Medical Projects Ltd Inline liquid drug medical device having rotary flow control member
EP2465558A1 (en) 2010-12-17 2012-06-20 Weibel CDS AG Device for removing a liquid from a container
MX341790B (en) 2011-03-31 2016-09-02 Amgen Inc Vial adapter and system.
US11338081B2 (en) * 2011-04-04 2022-05-24 Jihad Mustapha Fluid mixing device
IL212420A0 (en) 2011-04-17 2011-06-30 Medimop Medical Projects Ltd Liquid drug transfer assembly
USD681230S1 (en) 2011-09-08 2013-04-30 Yukon Medical, Llc Shroud
IL215699A0 (en) 2011-10-11 2011-12-29 Medimop Medical Projects Ltd Liquid drug reconstitution assemblage for use with iv bag and drug vial
AU2012324021A1 (en) 2011-12-22 2013-07-11 Icu Medical, Inc. Fluid transfer devices and methods of use
USD737436S1 (en) 2012-02-13 2015-08-25 Medimop Medical Projects Ltd. Liquid drug reconstitution assembly
USD720451S1 (en) 2012-02-13 2014-12-30 Medimop Medical Projects Ltd. Liquid drug transfer assembly
USD674088S1 (en) 2012-02-13 2013-01-08 Medimop Medical Projects Ltd. Vial adapter
IL219065A0 (en) 2012-04-05 2012-07-31 Medimop Medical Projects Ltd Fluid transfer device with manual operated cartridge release arrangement
USD769444S1 (en) 2012-06-28 2016-10-18 Yukon Medical, Llc Adapter device
IL221635A0 (en) 2012-08-26 2012-12-31 Medimop Medical Projects Ltd Drug vial mixing and transfer device for use with iv bag and drug vial
IL221634A0 (en) 2012-08-26 2012-12-31 Medimop Medical Projects Ltd Universal drug vial adapter
EP2872100B1 (en) 2012-09-13 2017-03-29 Medimop Medical Projects Ltd Telescopic female drug vial adapter
US20140124087A1 (en) * 2012-11-08 2014-05-08 Nordson Corporation Fluid delivery assemblies for withdrawing biomaterial fluid from a vial and for dispensing the biomaterial fluid, fluid control devices therefor, and related methods
USD734868S1 (en) 2012-11-27 2015-07-21 Medimop Medical Projects Ltd. Drug vial adapter with downwardly depending stopper
WO2014085258A1 (en) * 2012-11-29 2014-06-05 Board Of Regents, The University Of Texas System Robotic infusion mixer and transportable cartridge
US10022301B2 (en) 2013-03-15 2018-07-17 Becton Dickinson and Company Ltd. Connection system for medical device components
IL225734A0 (en) 2013-04-14 2013-09-30 Medimop Medical Projects Ltd Ready-to-use drug vial assemblages including drug vial and drug vial closure having fluid transfer member, and drug vial closure therefor
CN105228676B (en) 2013-05-10 2018-01-05 麦迪麦珀医疗工程有限公司 Include the medical treatment device of the vial adapter with inline dry kit
US9321545B2 (en) * 2013-07-09 2016-04-26 Pharmac, Llc Apparatus for mixing and transferring medications
USD767124S1 (en) 2013-08-07 2016-09-20 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
USD765837S1 (en) 2013-08-07 2016-09-06 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
CN205626622U (en) 2013-08-07 2016-10-12 麦迪麦珀医疗工程有限公司 Liquid transfer device that is used together with infusion container
JP6280216B2 (en) * 2013-11-06 2018-02-14 ベクトン ディキンソン アンド カンパニー リミテッド Adapter for small bottle access device
CN105873633B (en) 2013-11-06 2019-08-27 贝克顿·迪金森有限公司 Attachment device for Medical Devices
CN105792793B (en) 2013-11-06 2020-08-14 贝克顿·迪金森有限公司 Liquid-tight transfer system with connector
JP6438022B2 (en) 2013-11-06 2018-12-12 ベクトン ディキンソン アンド カンパニー リミテッド System for sealed transfer of fluid including a locking member
EP3065810B1 (en) 2013-11-06 2020-01-01 Becton, Dickinson and Company Ltd. Medical connector having locking engagement
AU2014353184B2 (en) 2013-11-25 2017-08-17 Icu Medical, Inc. Methods and system for filling IV bags with therapeutic fluid
USD794183S1 (en) 2014-03-19 2017-08-08 Medimop Medical Projects Ltd. Dual ended liquid transfer spike
JP6700194B2 (en) 2014-04-16 2020-05-27 ベクトン ディキンソン アンド カンパニー リミテッド Fluid transfer device
EP3134058B1 (en) 2014-04-21 2020-03-18 Becton Dickinson and Company Limited Fluid transfer device and packaging therefor
CA2946562C (en) 2014-04-21 2019-03-26 Becton Dickinson and Company Limited System with adapter for closed transfer of fluids
ES2925687T3 (en) 2014-04-21 2022-10-19 Becton Dickinson & Co Ltd Syringe adapter with disconnect feedback mechanism
BR112016024684B1 (en) 2014-04-21 2022-06-28 Becton Dickinson and Company Limited SYSTEM FOR CLOSED FLUID TRANSFER AND SYRINGE ADAPTER
JP6735677B2 (en) 2014-04-21 2020-08-05 ベクトン ディキンソン アンド カンパニー リミテッド System for closed transfer of fluids and membrane construction for its use
ES2865138T3 (en) 2014-04-21 2021-10-15 Becton Dickinson & Co Ltd Vial stabilizer base with attachable vial adapter
IL273763B2 (en) 2014-04-21 2023-10-01 Becton Dickinson & Co Ltd Fluid transfer device and packaging therefor
BR112016024683B1 (en) 2014-04-21 2021-12-21 Becton Dickinson and Company Limited SYRINGE ADAPTER WITH COMPOUND MOTION DISENGAGEMENT AND METHOD
CA159103S (en) * 2014-04-29 2015-06-01 Bayer Animal Health Gmbh Transfer device
USD757933S1 (en) 2014-09-11 2016-05-31 Medimop Medical Projects Ltd. Dual vial adapter assemblage
US9937292B2 (en) * 2014-12-09 2018-04-10 Medtronic Minimed, Inc. Systems for filling a fluid infusion device reservoir
BR112017013534B1 (en) 2015-01-05 2021-12-21 Medimop Medical Projects Ltd. ASSEMBLING THE DOUBLE BOTTLE ADAPTER FOR USE WITH ONE MEDICATION BOTTLE AND ONE LIQUID BOTTLE
US10413662B2 (en) * 2015-05-14 2019-09-17 Carefusion 303, Inc. Priming apparatus and method
BR122020014232B1 (en) * 2015-06-19 2022-10-25 Takeda Pharmaceutical Company Limited COMBINATION DEVICE TO COMBINE A FLUID FROM A CONTAINER UNIT
CN113143759B (en) 2015-07-16 2024-01-30 西部制药服务以色列有限公司 Liquid drug transfer device for secure telescopic snap-fit on an injection vial
USD801522S1 (en) 2015-11-09 2017-10-31 Medimop Medical Projects Ltd. Fluid transfer assembly
JP6523569B2 (en) 2015-11-25 2019-06-05 ウエスト・ファーマ．サービシーズ・イスラエル，リミテッド Dual vial adapter assembly comprising a vial adapter having a self sealing access valve
BE1023649B1 (en) * 2015-12-03 2017-06-06 Trasis S.A. PERFORATING NEEDLE FOR FLASK WITH SEPTUM
EP3383343A4 (en) 2015-12-04 2019-07-10 ICU Medical, Inc. Systems methods and components for transferring medical fluids
WO2017095818A1 (en) 2015-12-04 2017-06-08 Carefusion 303, Inc. Manifold for automatic drug compounder
IL245800A0 (en) 2016-05-24 2016-08-31 West Pharma Services Il Ltd Dual vial adapter assemblages including identical twin vial adapters
IL245803A0 (en) 2016-05-24 2016-08-31 West Pharma Services Il Ltd Dual vial adapter assemblages including vented drug vial adapter and vented liquid vial adapter
IL246073A0 (en) * 2016-06-06 2016-08-31 West Pharma Services Il Ltd Fluid transfer devices for use with drug pump cartridge having slidable driving plunger
US9956143B2 (en) * 2016-06-14 2018-05-01 Pharmac, Llc Syringe apparatus for transferring liquids into and out of a vial having a septum
USD851745S1 (en) 2016-07-19 2019-06-18 Icu Medical, Inc. Medical fluid transfer system
WO2018022640A1 (en) 2016-07-25 2018-02-01 Icu Medical, Inc. Systems, methods, and components for trapping air bubbles in medical fluid transfer modules and systems
IL247376A0 (en) 2016-08-21 2016-12-29 Medimop Medical Projects Ltd Syringe assembly
USD832430S1 (en) 2016-11-15 2018-10-30 West Pharma. Services IL, Ltd. Dual vial adapter assemblage
IL249408A0 (en) 2016-12-06 2017-03-30 Medimop Medical Projects Ltd Liquid transfer device for use with infusion liquid container and pincers-like hand tool for use therewith for releasing intact drug vial therefrom
US11701301B2 (en) 2017-03-06 2023-07-18 All India Institute Of Medical Sciences (Aiims) Device, method and kit for the reconstitution of a solid or semi solid pharmaceutical composition
IL251458A0 (en) 2017-03-29 2017-06-29 Medimop Medical Projects Ltd User actuated liquid drug transfer devices for use in ready-to-use (rtu) liquid drug transfer assemblages
IL254802A0 (en) 2017-09-29 2017-12-31 Medimop Medical Projects Ltd Dual vial adapter assemblages with twin vented female vial adapters
US11752069B2 (en) * 2017-11-27 2023-09-12 Healios K. K. Method for transferring cellular medicine using a cellular medicine transfer system
JP1630477S (en) 2018-07-06 2019-05-07
KR20210068500A (en) 2018-10-03 2021-06-09 다케다 야쿠힌 고교 가부시키가이샤 Packaging for multiple containers
AU2019352873A1 (en) * 2018-10-03 2021-05-06 Takeda Pharmaceutical Company Limited Pooling device for single or multiple medical containers
USD923812S1 (en) 2019-01-16 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
JP1648075S (en) 2019-01-17 2019-12-16
WO2020157719A1 (en) 2019-01-31 2020-08-06 West Pharma. Services Il, Ltd Liquid transfer device
WO2020180507A1 (en) * 2019-03-01 2020-09-10 Skin NY Dermatology, PLLC Vial adapter for drawing drugs from a vial
KR102157609B1 (en) * 2019-03-05 2020-09-18 김용현 Drug mixing device, drug mixing kit comprising the same and method for manufacturing the same
CA3135248C (en) 2019-04-30 2024-01-02 Yossi Bar-El Liquid transfer device with dual lumen iv spike
US11590057B2 (en) 2020-04-03 2023-02-28 Icu Medical, Inc. Systems, methods, and components for transferring medical fluids
USD956958S1 (en) 2020-07-13 2022-07-05 West Pharma. Services IL, Ltd. Liquid transfer device
CN114307828B (en) * 2021-12-08 2022-10-04 深圳传世生物医疗有限公司 Puncture liquid feeding method and device and puncture liquid feeding blending equipment

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2584397A (en) * 1945-10-03 1952-02-05 Louis K Pitman Apparatus for transferring liquid from one container to another
NL296017A (en) 1962-08-03 1900-01-01
US4038981A (en) 1974-07-26 1977-08-02 Burron Medical Products, Inc. Electronically controlled intravenous infusion set
US4252159A (en) 1979-04-02 1981-02-24 Maki Eugene B Dosage device
US4246932A (en) 1979-10-18 1981-01-27 Burron Medical, Inc. Multiple additive valve assembly
US4378013A (en) 1980-09-23 1983-03-29 Burron Medical Inc. Flow controller for IV chamber
US4433974A (en) 1981-06-17 1984-02-28 Baxter Travenol Laboratories, Inc. Mixing system for parenteral liquids
US4516967A (en) 1981-12-21 1985-05-14 Kopfer Rudolph J Wet-dry compartmental syringe
US4434820A (en) 1982-05-05 1984-03-06 Glass John P Syringe loader and method
US4401432A (en) 1982-05-26 1983-08-30 Boris Schwartz Storage, mixing and filtering receptacle for syringe
ATE27907T1 (en) 1982-10-27 1987-07-15 Duphar Int Res INJECTION SYRINGE WITH TELESCOPIC CONNECTION BETWEEN SYRINGE BODY AND MEDICATION CONTAINER.
EP0126718A3 (en) 1983-05-20 1985-10-23 Bengt Gustavsson A device for transferring a substance from one vessel to another and further to the intended application
IT1173370B (en) 1984-02-24 1987-06-24 Erba Farmitalia SAFETY DEVICE TO CONNECT A SYRINGE TO THE MOUTH OF A BOTTLE CONTAINING A DRUG OR A TUBE FOR DISPENSING THE SYRINGE DRUG
US4543101A (en) 1984-03-28 1985-09-24 Adria Laboratories, Inc. Valve device to aid in reconstituting injectable powders
DE3522645A1 (en) 1985-06-25 1987-01-08 Hausmann Ag Labor METHOD AND DEVICE FOR STERILY MIXING PARENTERAL LIQUIDS TO BE DELIVERED
US4675020A (en) 1985-10-09 1987-06-23 Kendall Mcgaw Laboratories, Inc. Connector
US4662878A (en) 1985-11-13 1987-05-05 Patents Unlimited Ltd. Medicine vial adaptor for needleless injector
US4722733A (en) 1986-02-26 1988-02-02 Intelligent Medicine, Inc. Drug handling apparatus and method
IT1201801B (en) 1986-08-04 1989-02-02 Pietro Cosmai MIXER LOADER FOR TRANSCUTANEOUS INJECTORS
IE60235B1 (en) 1986-09-18 1994-06-15 Kabi Pharmacia Ab "Connector and disposable assembly utilising said connector"
US4900322A (en) 1986-09-22 1990-02-13 Adams James D Blood component pooling valve and kit
US4729401A (en) 1987-01-29 1988-03-08 Burron Medical Inc. Aspiration assembly having dual co-axial check valves
NL8800529A (en) 1987-04-06 1988-11-01 Duphar Int Res Liq.-transferring needle unit
US4787898A (en) 1987-05-12 1988-11-29 Burron Medical Inc. Vented needle with sideport
US4768568A (en) 1987-07-07 1988-09-06 Survival Technology, Inc. Hazardous material vial apparatus providing expansible sealed and filter vented chambers
JPH021277A (en) 1988-03-31 1990-01-05 Fujisawa Pharmaceut Co Ltd Infusion container
ATE111725T1 (en) 1990-01-08 1994-10-15 Becton Dickinson France DOUBLE CHAMBER STORAGE AND TRANSFER BOTTLE.
US5045081A (en) 1990-01-16 1991-09-03 Dysarz Edward D Trap in barrel one handed retractable vial filling device
US5114411A (en) 1990-11-19 1992-05-19 Habley Medical Technology Corporation Multi-chamber vial
US5188615A (en) 1990-11-19 1993-02-23 Habley Medical Technology Corp. Mixing vial
US5360410A (en) 1991-01-16 1994-11-01 Senetek Plc Safety syringe for mixing two-component medicaments
US5304165A (en) 1991-12-09 1994-04-19 Habley Medical Technology Corporation Syringe-filling medication dispenser
CA2093560C (en) 1992-04-10 2005-06-07 Minoru Honda Fluid container
JP2605345Y2 (en) 1992-05-01 2000-07-10 株式会社大塚製薬工場 Drug container
JPH05317383A (en) 1992-05-19 1993-12-03 Nissho Corp Solution container equipped with means for communicating with chemical container
US5330426A (en) 1992-08-13 1994-07-19 Science Incorporated Mixing and delivery syringe assembly
US5531683A (en) 1992-08-13 1996-07-02 Science Incorporated Mixing and delivery syringe assembly
JPH06239352A (en) 1993-02-05 1994-08-30 Nissho Corp Solution injection set
CA2158159A1 (en) 1993-05-05 1994-11-10 David F. Negrotti Modular laboratory equipment and coupling system
US5397303A (en) 1993-08-06 1995-03-14 River Medical, Inc. Liquid delivery device having a vial attachment or adapter incorporated therein
US5466220A (en) 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device
US5526853A (en) 1994-08-17 1996-06-18 Mcgaw, Inc. Pressure-activated medication transfer system
US5613291A (en) 1995-01-25 1997-03-25 Becton, Dickinson And Company Method for providing a sterility seal in a medicinal storage bottle
IL114960A0 (en) 1995-03-20 1995-12-08 Medimop Medical Projects Ltd Flow control device
JPH11514248A (en) 1995-03-21 1999-12-07 セレックス・リミテッド・パートナーシップ Vascular access device
US5876372A (en) 1995-03-22 1999-03-02 Abbott Laboratories Syringe system accomodating seperate prefilled barrels for two constituents
US5603695A (en) 1995-06-07 1997-02-18 Erickson; Kim Device for alkalizing local anesthetic injection medication
FR2738550B1 (en) 1995-09-11 1997-11-07 Biodome DEVICE FOR SEALING A CONTAINER ITSELF CLOSED, ASSEMBLY FOR PROVIDING A PRODUCT COMPRISING SUCH A CONTAINER AND SUCH A SEALING DEVICE
WO1997020536A1 (en) 1995-12-06 1997-06-12 Gabriel Meyer Device for preparing a medicinal solution reconstituted from two components
US5944709A (en) 1996-05-13 1999-08-31 B. Braun Medical, Inc. Flexible, multiple-compartment drug container and method of making and using same
US5928213A (en) 1996-05-13 1999-07-27 B. Braun Medical, Inc. Flexible multiple compartment medical container with preferentially rupturable seals
AU3561297A (en) 1996-07-11 1998-02-09 Pharmacia & Upjohn Ab Method and device for sealing and connecting a container
US5873872A (en) 1996-09-17 1999-02-23 Becton Dickinson And Company Multipositional resealable vial connector assembly for efficient transfer of liquid
US5925029A (en) 1997-09-25 1999-07-20 Becton, Dickinson And Company Method and apparatus for fixing a connector assembly onto a vial with a crimp cap
US5954696A (en) 1997-12-15 1999-09-21 B. Braun Medical, Inc. Pressure infusion pump
US6003566A (en) 1998-02-26 1999-12-21 Becton Dickinson And Company Vial transferset and method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO02062288A1 *

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AU2002240070B2 (en) 2006-01-05
US6474375B2 (en) 2002-11-05
WO2002062288A1 (en) 2002-08-15
US20020104584A1 (en) 2002-08-08
CA2435339A1 (en) 2002-08-15
CA2435339C (en) 2010-04-06
JP2004524082A (en) 2004-08-12
MXPA03006948A (en) 2004-05-24

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