EP1317248A1 - Procede cosmetique - Google Patents

Procede cosmetique

Info

Publication number
EP1317248A1
EP1317248A1 EP00963409A EP00963409A EP1317248A1 EP 1317248 A1 EP1317248 A1 EP 1317248A1 EP 00963409 A EP00963409 A EP 00963409A EP 00963409 A EP00963409 A EP 00963409A EP 1317248 A1 EP1317248 A1 EP 1317248A1
Authority
EP
European Patent Office
Prior art keywords
skin
protease
cosmetic
enzyme
cosmetic method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00963409A
Other languages
German (de)
English (en)
Inventor
Conor James O'prey
Marina Trani
David John Weisgerber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of EP1317248A1 publication Critical patent/EP1317248A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A61K2800/884—Sequential application

Definitions

  • the present invention relates to the use of cosmetic compositions comprising a protease enzyme and a polyhydric alcohol for improving skin hydration, skin softness and skin smoothness.
  • Skin is made up of several layers of cells which coat and protect the keratin and collagen fibrous proteins that form the skeleton, of its structure.
  • the outermost of these layers, referred to as the stratum corneum is known to be composed of 25nm protein bundles surrounded by 8nm thick layers.
  • Anionic surfactants and organic solvents typically penetrate the stratum corneum membrane and, by delipidization (i.e. removal of the lipids from the stratum corneum), destroy its integrity. This destruction of the skin surface topography leads to a rough feel and may eventually permit the surfactant or solvent to interact with the keratin, creating irritation.
  • Dry, itchy or flaky skin may also result from the failure to maintain a proper water gradient across the stratum corneum.
  • Most of the water needed to maintain the water gradient which is sometimes considered to be the stratum corneum's plasticizer, comes from inside the body. If the humidity is too low, such as in a cold climate, insufficient water remains in the outer layers of the stratum corneum to properly plasticize the tissue, and the skin begins to scale and becomes itchy.
  • protease enzymes function primarily by providing a desquamatory action to the cosmetic composition. It is believed that the proteases remove damaged (e.g. dry) skin cells on the surface of the skin, thereby reducing the rough feel associated therewith. The protease removes the effect of prior damage to the skin, giving the skin a fresher, more youthful appearance and feel.
  • Disclosures describing cosmetic compositions comprising protease enzymes have to date focussed on stabilising the enzyme within the composition. These disclosures include encapsulating the enzymes prior to inclusion within the cosmetic composition (GB 1,255,284 and JP 10-251122); buffering the cosmetic composition such that the enzyme remains inactive until used (WO 97/47238); and using precursors or other actives within the composition to stabilise the enzyme (EP 0710478 and SU 1690764).
  • the favoured approach in the art for stabilising protease enzymes in cosmetic compositions is to dramatically reduce water availability within the composition by formulating the aqueous phase of any composition with very high levels of polyhydric alcohol such as glycerine, disclosed in JP 1283213, JP 3294211.
  • a cosmetic method for providing improved skin hydration comprising topically applying to the skin a protease enzyme, and simultaneously or sequentially, topically applying to the skin a polyhydric alcohol.
  • a cosmetic method for providing improved skin hydration comprising topically applying to the skin a polyhydric alcohol, and simultaneously or sequentially, topically applying to the skin a protease enzyme.
  • a cosmetic method for providing improved skin hydration comprising topically applying to the skin a cosmetic composition comprising (a) from about 0.0001% to about 1%, by weight, of protease enzyme; and (b) from about 0.1% to about 20%>, by weight, of polyhydric alcohol.
  • a cosmetic method for providing improved skin hydration comprising topically applying to the skin a first cosmetic composition comprising from about 0.0001% to about 1%, by weight, of protease enzyme, and either simultaneously or sequentially applying to the skin a second cosmetic composition comprising from about 0.1% to about 20%>, by weight, of polyhydric alcohol.
  • the methods of the present invention provide significant improvements in skin hydration, skin softness and skin smoothness benefits.
  • enzyme as used herein means the enzyme, wild-type or variant, either er se, or chemically modified by the conjugation of polymer moieties.
  • protease enzyme refers to any enzyme whose substrate is a protein.
  • wild-type refers to an enzyme produced by unmutated hosts.
  • variant means an enzyme having an amino acid sequence which differs from that of the wild-type enzyme due to the genetic mutation of the host producing that enzyme.
  • enzyme activity refers to the activity of 20 ⁇ l of enzyme solution (50ppm) when reacted with the surface of a suitable proteinaceous substrate disc of diameter 1cm, at room temperature over a 30 minute time period.
  • suitable activity is defined as greater than 20% of reaction complete within 30minutes, preferably greater than 50%, more preferably greater than 75%. By using this measure it is defined that enzyme buffers of less than pH 5.5 are not suitable for use with this enzyme.
  • skin hydration refers to an improvement in skin moisture content which can be determined either by technical measures such as by use of a corneometer etc, or expert visual measures for example Fitzpatrick skin dryness scale or by consumer self assessment.
  • the "water activity a w " of a medium containing water is the ratio of the water vapour pressure of the product "P H2O product” to the vapour pressure of pure water “P H20 pure” at the same temperature. It can also be expressed as the ratio of the number of molecules of water “N H2O " to the total number of molecules
  • the methods of the present invention comprise applying to the skin a protease enzyme together with a polyhydric alcohol.
  • the protease enzyme and the polyhydric alcohol can be delivered to the skin either simultaneously or sequentially.
  • a cosmetic method for providing improved skin hydration comprising topically applying to the skin a protease enzyme and simultaneously or sequentially topically applying to the skin a polyhydric alcohol.
  • a cosmetic method for providing improved skin hydration comprising topically applying to the skin a polyhydric alcohol and simultaneously or sequentially topically applying to the skin a protease enzyme.
  • the protease enzyme and the polyhydric alcohol are delivered sequentially for two separate cosmetic compositions.
  • sequentially it is meant that the two compositions are deliver one after the other, in any order, where the second composition is added within 1 hour of delivery of the first composition.
  • the enzyme composition is applied to the skin first.
  • the polyhydric alcohol composition is added before the buffer solution from the enzyme composition has evaporated.
  • a cosmetic method for providing improved skin hydration comprising topically applying to the skin a cosmetic composition comprising from about 0.0001% to about 1%, preferably from about 0.001% to about 0.5% and most preferably from about 0.005% to about 0.1%, by weight, of protease enzyme and from about 0.1% to about 20%, preferably from about 0.5% to about 18%, more preferably from about 2% to about 15% and even more preferably from about 5% to about 12%o, by weight, of polyhydric alcohol.
  • polyhydric alcohol and the protease enzyme can be delivered to the skin from separate cosmetic compositions.
  • a cosmetic method for providing improved skin hydration comprising topically applying to the skin a first cosmetic composition comprising a protease enzyme and simultaneously or sequentially topically applying to the skin a second cosmetic composition comprising polyhydric alcohol.
  • compositions herein are suitable for topical application to the skin or hair.
  • the compositions can be in the form of creams, lotions, gels, and the like.
  • the cosmetic compositions herein are in the form of an emulsion of one or more oil phases in an aqueous continuous phase.
  • An essential component used in the methods of the present invention is a protease enzyme.
  • protease enzymes are classified under the Enzyme Classification number E.C. 3.4 (Carboxylic Ester Hydrolases) in accordance with the Recommendations (1992) of the International Union of Biochemistry and Molecular Biology (IUBMB).
  • Useful proteases are also described in PCT publications: WO 95/30010 published November 9, 1995 by The Procter & Gamble Company; WO 95/30011 published November 9, 1995 by The Procter & Gamble Company; WO 95/29979 published November 9, 1995 by The Procter & Gamble Company.
  • Preferred protease enzymes for use herein are subtilisin, chymotrypsin and elastase-type protease enzymes.
  • subtilisin-type protease enzymes are naturally produced by Bacillus alcalophilus, Bacillus amyloliquefaciens, Bacillus amylosaccharicus, Bacillus licheniformis, Bacillus lentus and Bacillus subtilis microorganisms.
  • a particularly preferred substilisin-type enzyme is bacterial serine protease enzyme, and variants thereof, obtained from Bacillus amyloliquefaciens, Bacillus licheniformis and/or
  • Bacillus subtilis including Novo Industries A/S Alcalase®, Esperase® , Savinase® (Copenhagen, Denmark), Gist-brocades' Maxatase®, Maxacal® and Maxapem 15®
  • protease enzymes and variants thereof, obtained from Bacillus amyloliquefaciens.
  • Bacillus amyloliquefaciens One known enzyme is BPN'.
  • the wild-type BPN' from Bacillus amyloliquefaciens is characterized by the amino acid sequence:
  • Gly at position Glyl 66 is replaced with Asn, Ser, Lys, Arg, His, Gin,
  • the Gly at position Glyl 69 is replaced with Ser; the Met at position Met222 is replaced with Gin, Phe, Cys, His, Asn, Glu, Ala or Thr; or
  • Met222 is replaced with Cys; or c.) the Gly at position Glyl 60 is replaced with Ala and the Met at position
  • Met222 is replaced with Ala.
  • Protease B is disclosed by Genencor International, hie. (San Francisco, California) European Patent EP-B-251,446 (granted December 28, 1994 and published January 7, 1988) as characterized by the wild- type BP amino acid with the mutations in one or more of the following amino acids: Tyr21, Thr22, Ser24, Asp36, Ala 45, Ala48, Ser49, Met50, His67, Ser87, Lys94, Val95, Gly97, SerlOl, Glyl 02, Glyl 03, Ilel07, Glyl 10, Met 124, Glyl27, Glyl28, Prol29, Leul35, Lysl70, Tyrl71, Prol72, Aspl97, Met 199, Ser 204, Lys213, Tyr214, Gly215, and Ser221; or two or more of the amino acids listed above and Asp32, Ser33, Tyrl04, Alal52, Asnl55, Glul
  • protease D Another preferred BPN' variant protease, hereafter referred to as "Protease D", is described in WO 95/10615 published April 20, 1995 by Genencor International as characterized by the wild-type BPN' amino acid with mutation to position Asn76, in combination with mutations in one or more other amino acid positions selected from the group consisting of Asp99, SerlOl, Glnl03, Tyrl04, Serl05, Ilel07, Asnl09, Asnl23, Leul26, Glyl27, Glyl28, Leul35, Glul56, Glyl66, Glul95, Aspl97, Ser204, Gln206, Pro210, Ala216, Tyr217, Asn218, Met222, Ser260, Lys265, and/or Ala274.
  • Protease F Another preferred BPN variant protease, hereafter referred to as "Protease F", is described in U.S. Patent Number 4,760,025, issued to Estell, et al. on July 26, 1988 as characterized by the wild-type BPN' amino acid with mutation to one or more amino acid positions selected from the group consisting of Asp32, Ser33, His64, Tyrl04, Asnl55, Glul56, Glyl 66, Glyl69, Phel89, Tyr217, and Met222.
  • Preferred proteolytic enzymes are selected from the group consisting of Alcalase®, BPN', Protease A, Protease B, Protease D, and Protease F, and mixtures thereof. Protease F is most preferred.
  • compositions for use herein comprise from about 0.0001%> to about 1%, more preferably from about 0.001% to about 0.5%, even more preferably from about 0.005% to about 0.1%, by weight, of protease enzyme.
  • compositions for use herein comprise at least one polyhydric alcohol in a concentration of from about 0.1% to about 20%, preferably from about 0.5% to about 18%, more preferably from about 2% to about 15%, and even more preferably from about 5% to about 12% by weight, of the polyhydric alcohol, or mixtures thereof.
  • a polyhydric alcohol is considered any organic compound comprising two, or more, alcohol functions or alkoxylated derivatives thereof.
  • the composition has the form of an oil in water emulsion, that the polyhydric alcohol is present in the continuous phase.
  • Suitable polyhydric alcohols for use herein include polyalkylene glycols and more preferably alkylene polyols and their derivatives, including propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol and derivatives thereof, sorbitol, hydroxypropyl sorbitol, erythritol, threitol, pentaerythritol, xylitol, glucitol, mannitol, hexylene glycol, butylene glycol (e.g., 1,3-butylene glycol), hexane triol (e.g., 1,2,6- hexanetriol), trimethylol propane, neopentyl glycol, glycerine, ethoxylated glycerine, propane- 1,3 diol, propoxylated glycerine and mixtures thereof.
  • the alkoxylated derivatives of any of the above polyhydric alcohols
  • Preferred polyhydric alcohols of the present invention are selected from glycerine, butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, hexane triol, ethoxylated glycerine and propoxylated glycerine, and mixtures thereof.
  • Most preferred polyhydric alcohols for use in the present invention are glycerine, butylene glycol, propylene glycol, polyethylene glycol and mixtures thereof.
  • compositions used herein can comprise a wide variety of optional ingredients.
  • compositions of the present invention comprise a safe and effective amount of a dermatologically acceptable carrier, suitable for topical application to the skin or hair within which the essential materials and optional other materials are incorporated to enable the essential materials and optional components to be delivered to the skin or hair at an appropriate concentration.
  • the carrier can thus act as a diluent, dispersant, solvent, or the like for the essential components which ensures that they can be applied to and distributed evenly over the selected target at an appropriate concentration.
  • the carrier can be solid, semi-solid or liquid. Highly preferred carriers are liquid or semi- solid, such as creams, lotions and gels. Preferably the carrier is in the form of a lotion, cream or a gel, more preferably one which has a sufficient thickness or yield point to prevent the particles from sedimenting.
  • the carrier can itself be inert or it can possess dermatological benefits of its own.
  • the carrier should also be physically and chemically compatible with the essential components described herein, and should not unduly impair stability, efficacy or other use benefits associated with the compositions of the present invention.
  • the type of carrier ultilised in the present invention depends on the type of product form desired for the composition.
  • the topical compositions useful in the subject invention may be made into a wide variety of product forms such as are known in the art. These include, but are not limited to, lotions, creams, gels, sticks, ointments, pastes and mousses. These product forms may comprise several types of carriers including, but not limited to, solutions, emulsions, and gels.
  • Preferred carriers contain a dermatologically acceptable, hydrophilic diluent.
  • Suitable hydrophilic diluents include water, organic hydrophilic diluents such as Ci - C 4 monohydric alcohols and low molecular weight glycols and polyols, including propylene glycol, polyethylene glycol (e.g. of MW 200-600), polypropylene glycol (e.g.
  • the diluent is preferably liquid. Water is an especially preferred diluent.
  • the composition preferably comprises at least about 20% of the hydrophilic diluent.
  • Preferred carriers comprise an emulsion comprising a hydrophilic phase, especially an aqueous phase, and a hydrophobic phase e.g., a lipid, oil or oily material.
  • a hydrophilic phase will be dispersed in the hydrophobic phase, or vice versa, to form respectively hydrophilic or hydrophobic dispersed and continuous phases, depending on the composition ingredients, h emulsion technology
  • the term "dispersed phase” is a term well-known to one skilled in the art which means that the phase exists as small particles or droplets that are suspended in and surrounded by a continuous phase.
  • the dispersed phase is also known as the internal or discontinuous phase.
  • the emulsion may be or comprise (e.g., in a triple or other multi-phase emulsion) an oil-in-water emulsion or a water-in-oil emulsion such as a water-in-silicone emulsion.
  • Oil-in- water emulsions typically comprise from about 1% to about 60% (preferably about 1% to about 30%) of the dispersed hydrophobic phase and from about 1% to about 99% (preferably from about 40% to about 90%) of the continuous hydrophilic phase; water-in- oil emulsions typically comprise from about 1% to about 98% (preferably from about 40% to about 90%)) of the dispersed hydrophilic phase and from about 1% to about 50% (preferably about 1% to about 30%) of the continuous hydrophobic phase.
  • Preferred compositions herein are oil-in-water emulsions.
  • compositions herein comprise a skin care active at a level from about 0.1% to about 20%, preferably from about 1% to about 10%, more preferably from about 2% to about 8%, by weight.
  • the skin care active for use herein is selected from a vitamin B 3 component, panthenol, vitamin E, vitamin E acetate, retinol, retinyl propionate, retinyl palmitate, retinoic acid, vitamin C, theobromine, ⁇ -hydroxyacid, farnesol, phytantriol, salicylic acid, and mixtures thereof.
  • the preferred skin care active for use herein from the viewpoint of providing improved skin hydration is a vitamin B 3 component.
  • compositions of the present invention preferably comprise from about 0.01%> to about 20%), more preferably from about 0.1 % to about 15%, even more preferably from about 0.5% to about 10%, and still more preferably from about 1% to about 8%, most preferably from about 1.5% to about 6%, of the vitamin B3 compound.
  • vitamin B3 compound means a compound having the formula:
  • R is - CO ⁇ 2 (i.e., niacinamide), - COOH (i.e., nicotinic acid) or - CH2OH (i.e., nicotinyl alcohol); derivatives thereof; and salts of any of the foregoing.
  • exemplary derivatives of the foregoing vitamin B3 compounds include nicotinic acid esters, including non-vasodilating esters of nicotinic acid, nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxide and niacinamide N-oxide.
  • Suitable esters of nicotinic acid include nicotinic acid esters of C1 -C22 . preferably Ci-
  • non-vasodilating means that the ester does not commonly yield a visible flushing response after application to the skin in the subject compositions (the majority of the general population would not experience a visible flushing response, although such compounds may cause vasodilation not visible to the naked eye).
  • Non-vasodilating esters of nicotinic acid include tocopherol nicotinate and inositol hexanicotinate; tocopherol nicotinate is preferred.
  • a more complete description of vitamin B3 compounds is given in WO 98/22085.
  • vitamin B3 compounds are well known in the art and are commercially available from a number of sources, e.g., the Sigma Chemical Company (St.
  • vitamin B3 compounds may be used herein.
  • Preferred vitamin B3 compounds are niacinamide and tocopherol nicotinate. Niacinamide is more preferred.
  • retinoid includes all natural and/or synthetic analogs of Vitamin A or retinol-like compounds which possess the biological activity of Vitamin A in the skin as well as the geometric isomers and stereoisomers of these compounds.
  • the retinoid is preferably retinol, retinol esters (e.g., C2 - C22 alkyl esters of retinol, including retinyl palmitate, retinyl acetate, retinyl proprionate), retinal, and/or retinoic acid (including all-trans retinoic acid and/or 13-cis-retinoic acid), more preferably retinoids other than retinoic acid.
  • retinol esters e.g., C2 - C22 alkyl esters of retinol, including retinyl palmitate, retinyl acetate, retinyl proprionate
  • retinal and/or retinoic acid (including all-trans retinoic acid and/or 13-cis-retinoic acid)
  • retinoic acid including all-trans retinoic acid and/or 13-cis-retinoic acid
  • Preferred retinoids are retinol, retinyl palmitate, retinyl acetate, retinyl proprionate, retinal, retinoic acid and combinations thereof. More preferred are retinol, retinoic propionate, retinoic acid and retinyl palmitate.
  • the retinoid may be included as the substantially pure material, or as an extract obtained by suitable physical and/or chemical isolation from natural (e.g., plant) sources.
  • compositions preferably contain from or about 0.005% to or about 2%, more preferably 0.01% to about 2% retinoid.
  • Retinol is most preferably used in an amount of from or about 0.01% to or about 0.15%; retinol esters are most preferably used in an amount of from about 0.01% to about 2% (e.g., about 1%).
  • compositions suitable for use in the present invention comprise a vitamin complex consisting of from about 1% to about 5%, by weight, of vitamin B 3 compound or its derivatives; and from about 0.1 %> to about 1%, by weight, of a retinol compound or its derivatives in conjunction with from about 0.1% to about 1%, by weight, panthenol or its derivatives.
  • compositions of the present invention may comprise additional humectants which are preferably present at a level of from about 0.01% to about 20%, more preferably from about 0.1% to about 15% and especially from about 0.5% to about 10%.
  • Preferred humectants include, but are not limited to, compounds selected from urea, D or DL panthenol, calcium pantothenate, royal jelly, panthetine, pantotheine, panthenyl ethyl ether, pangamic acid, pyridoxin, pantoyl lactose Vitamin B complex, hexane - 1, 2, 6, - triol, guanidine or its derivatives.
  • Highly preferred humectants are urea, panthenol and mixtures thereof. The above listed compounds may be incorporated singly or in combination.
  • Suitable additional humectants useful herein are sodium 2-pyrrolidone-5-carboxylate (NaPCA), guanidine; glycolic acid and glycolate salts (e.g. ammonium and quaternary alkyl ammonium); lactic acid and lactate salts (e.g. ammonium and quaternary alkyl ammonium); aloe vera in any of its variety of forms (e.g., aloe vera gel); hyaluronic acid and derivatives thereof (e.g., salt derivatives such as sodium hyaluronate); lactamide monoethanolamine; acetamide monoethanolamine; urea; panthenol and derivatives thereof; and mixtures thereof.
  • NaPCA sodium 2-pyrrolidone-5-carboxylate
  • guanidine glycolic acid and glycolate salts
  • lactic acid and lactate salts e.g. ammonium and quaternary alkyl ammonium
  • aloe vera in any of
  • At least part (up to about 5% by weight of composition) of an additional humectant can be incorporated in the form of an admixture with a particulate cross-linked hydrophobic acrylate or methacrylate copolymer, itself preferably present in an amount of from about 0.1% to about 10%, which can be added either to the aqueous or disperse phase.
  • This copolymer is particularly valuable for reducing shine and controlling oil while helping to provide effective moisturization benefits and is described in further detail by WO96/03964, incorporated herein by reference.
  • Preferred additional humectants are selected from urea, panthenol and mixtures thereof.
  • the oil in water emulsions of the present invention generally comprise from about ⁇ % to about 20%, preferably from about 1.5% to about 15%, more preferably from about 0.1% to about 8%, especially from about 0.5% to about 5% of a dermatologically acceptable emollient.
  • Emollients tend to lubricate the skin, increase the smoothness and suppleness of the skin, prevent or relieve dryness of the skin, and/or protect the skin.
  • Emollients are typically water-immiscible, oily or waxy materials and emollients with high molecular weights can confer tacky properties to a topical composition.
  • suitable emollients are known and may be used herein. Sagarin, Cosmetics, Science and Technology, 2nd Edition, Vol.
  • Suitable branched chain hydrocarbons for use herein are selected from isopentacontaoctactane, petrolatum, and mixtures thereof. Suitable for use herein are branched chain aliphatic hydrocarbons sold under the trade name Permethyl (RTM) and commercially available from Presperse Inc., P.O. Box 735, South Plainfield, N.J. 07080, U.S.A. ii) C1 -C30 alcohol esters of C1 -C30 carboxylic acids, C12-15 alkyl benzoates, and of
  • C2-C30 dicarboxylic acids e.g. isononyl isononanoate, isostearyl neopentanoate. isodecyl octanoate, isodecyl isononanoate, tridecyl isononanoate, myristyl octanoate, octyl pelargonate, octyl isononanoate, myristyl myristate, myristyl neopentanoate, myristyl octanoate, isopropyl myristate, myristyl propionate, isopropyl stearate, isopropyl isostearate, methyl isostearate, behenyl behenate, dioctyl maleate, diisopropyl adipate, and diisopropyl dilinoleate and mixtures thereof.
  • Ci -C30 mono- and poly- esters of sugars and related materials are derived from a sugar or polyol moiety and one or more carboxylic acid moieties. Depending on the constituent acid and sugar, these esters can be in either liquid or solid form at room temperature.
  • Examples include: glucose tetraoleate, the galactose tetraesters of oleic acid, the sorbitol tetraoleate, sucrose tetraoleate, sucrose pentaoleate, sucrose hexaoleate, sucrose heptaoleate, sucrose octaoleate, sorbitol hexaester in which the carboxylic acid ester moieties are palmitoleate and arachidate in a 1 :2 molar ratio, and the octaester of sucrose wherein the esterifying carboxylic acid moieties are laurate, linoleate and behenate in a 1:3:4 molar ratio.
  • Other materials include cottonseed oil or soybean oil fatty acid esters of sucrose. Other examples of such materials are described in WO 96/16636, incorporated by reference herein. A particularly preferred material is known by the INCI name sucrose polycottonseedate iv) Vegetable oils and hydrogenated vegetable oils. Examples of vegetable oils and hydrogenated vegetable oils include safflower oil, coconut oil, cottonseed oil, menhaden oil, palm kernel oil, palm oil, peanut oil, soybean oil, rapeseed oil, linseed oil, rice bran oil, pine oil, sesame oil, sunflower seed oil, partially and fully hydrogenated oils from the foregoing sources, and mixtures thereof v) Soluble or colloidally-soluble moisturising agents.
  • hylaronic acid and starch-grafted sodium polyacrylates such as Sanwet (RTM) EVI-IOOO, EVI-1500 and EVI-2500 available from Celanese Superabsorbent Materials, Portsmith, VA, USA and described in USA-A-4,076,663.
  • Preferred emollients for use herein are isohexadecane, isooctacontane, petrolatum, isononyl isononanoate, isodecyl octanoate, isodecyl isononanoate, tridecyl isononanoate, myristyl octanoate, octyl isononanoate, myristyl myristate, methyl isostearate, isopropyl isostearate, C12-15 alkyl benzoates and mixtures thereof.
  • Particularly preferred emollients for use herein are isohexadecane, isononyl isononanoate, methyl isostearate, isopropyl isostearate, petrolatum, or mixtures thereof. Due to its poor skin feel properties castor oil is not a preferred emollient for use herein.
  • Em ulsifiers/Surfactants Em ulsifiers/Surfactants
  • compositions herein preferably contain an emulsifier and/or surfactant, generally to help disperse and suspend the disperse phase within the continuous aqueous phase.
  • a surfactant may also be useful if the product is intended for skin cleansing.
  • emulsifiers will be referred to under the term 'surfactants', thus 'surfactant(s)' will be used to refer to surface active agents whether used as emulsifiers or for other surfactant purposes such as skin cleansing.
  • Known or conventional surfactants can be used in the composition, provided that the selected agent is chemically and physically compatible with essential components of the composition, and provides the desired characteristics. Suitable surfactants include non-silicone derived materials, and mixtures thereof.
  • compositions of the present invention preferably comprise from about 0.05% to about 15% of a surfactant or mixture of surfactants.
  • the exact surfactant or surfactant mixture chosen will depend upon the pH of the composition and the other components present.
  • Preferred surfactants are nonionic.
  • nonionic surfactants that are useful herein are those that can be broadly defined as condensation products of long chain alcohols, e.g.
  • Cg_3o alcohols with sugar or starch polymers ie glycosides.
  • Other useful nonionic surfactants include the condensation products of alkylene oxides with fatty acids (i.e. alkylene oxide esters of fatty acids). These materials have the general formula
  • RCO(X) n OH wherein R is a C10-.30 alkyl group, X is -OCH2CH2- (i.e. derived from ethylene glycol or oxide) or -OCH2CHCH3- (i.e. derived from propylene glycol or oxide), and n is an integer from about 6 to about 200.
  • Other nonionic surfactants are the condensation products of alkylene oxides with 2 moles of fatty acids (i.e. alkylene oxide diesters of fatty acids). These materials have the general formula RCO(X) n OOCR wherein R is a Ci 0-.30 alkyl group, X is -OCH2CH2-(i.e.
  • An emulsifier for use herein is most preferably a fatty acid ester blend based on a mixture of sorbitan fatty acid ester and sucrose fatty acid ester, especially a blend of sorbiton stearate and sucrose cocoate. This is commercially available from ICI under the trade name Arlatone 2121. Even further suitable examples include a mixture of cetearyl alcohols, cetearyl glucosides such as those available under the trade name Montanov 68 from Seppic and Emulgade PL68/50 available from Henkel..
  • hydrophilic surfactants useful herein can alternatively or additionally include any of a wide variety of cationic, anionic, zwitterionic, and amphoteric surfactants such as are known in the art. See, e.g., McCutcheon's, Deter ents and Emulsifiers, North American Edition (1986), published by Allured Publishing Corporation; U.S. Patent No. 5,011,681 to Ciotti et al, issued April 30, 1991; U.S. Patent No. 4,421,769 to Dixon et al., issued December 20, 1983; and U.S. Patent No. 3,755,560 to Dickert et al., issued August 28, 1973. A wide variety of anionic surfactants are also useful herein.
  • Exemplary anionic surfactants include the alkoyl isethionates (e.g., C12 - C30), alkyl and alkyl ether sulfates and salts thereof, alkyl and alkyl ether phosphates and salts thereof, alkyl methyl taurates (e.g., Cj2 - C30), and soaps (e.g., alkali metal salts, e.g., sodium or potassium salts) of fatty acids.
  • alkoyl isethionates e.g., C12 - C30
  • alkyl and alkyl ether sulfates and salts thereof alkyl and alkyl ether phosphates and salts thereof
  • alkyl methyl taurates e.g., Cj2 - C30
  • soaps e.g., alkali metal salts, e.g., sodium or potassium salts
  • amphoteric and zwitterionic surfactants are also useful herein.
  • amphoteric and zwitterionic surfactants which can be used in the compositions of the present invention are those which are broadly described as derivatives of aliphatic secondary and tertiary amines in which the aliphatic radical can be straight or branched chain and wherein one of the aliphatic substituents contains from about 8 to about 22 carbon atoms (preferably Cg - Ci g) and one contains an anionic water solubilising group, e.g., carboxy, sulfonate, sulfate, phosphate, or phosphonate.
  • alkyl imino acetates examples are alkyl imino acetates, and iminodialkanoates and aminoalkanoates, imidazolinium and ammonium derivatives.
  • suitable amphoteric and zwitterionic surfactants are those selected from the group consisting of betaines, sultaines, hydroxysultaines, and branched and unbranched alkanoyl sarcosinates, and mixtures thereof.
  • Preferred emulsions of the present invention include a silicone containing emulsifier or surfactant.
  • silicone emulsifiers are useful herein. These silicone emulsifiers are typically organically modified organopolysiloxanes, also known to those skilled in the art as silicone surfactants.
  • Useful silicone emulsifiers include dimethicone copolyols. These materials are polydimethyl siloxanes which have been modified to include polyether side chains such as polyethylene oxide chains, polypropylene oxide chains, mixtures of these chains, and polyether chains containing moieties derived from both ethylene oxide and propylene oxide.
  • dimethicone copolyols examples include alkyl-modified dimethicone copolyols, i.e., compounds which contain C2-C30 pendant side chains.
  • Still other useful dimethicone copolyols include materials having various cationic, anionic, amphoteric, and zwitterionic pendant moieties.
  • compositions of the present invention can comprise at least one polymeric thickening agent.
  • the polymeric thickening agents useful herein preferably have a number average molecular weight of greater than 20,000, more preferably greater than 50,000 and especially greater than 100,000.
  • compositions of the present invention may comprise from about 0.01% to about 10%, preferably from about 0.1% to about 8% and most preferably from about 0.5% to about 5% by weight of the composition of the polymeric thickening agent, or mixtures thereof.
  • Preferred polymer thickening agents for use herein include non-ionic thickening agents and anionic thickening agents, or mixtures thereof.
  • Suitable non-ionic thickening agents include polyacrylamide polymers, crosslinked poly(N-vinylpyrrolidones), polysaccharides, natural or synthetic gums, polyvinylpyrrolidone, and polyvinylalcohol.
  • Suitable anionic thickening agents include acrylic acid/ethyl acrylate copolymers, carboxyvinyl polymers and crosslinked copolymers of alkyl vinyl ethers and maleic anhydride.
  • Particularly preferred thickening agents for use herein are the non-ionic polyacrylamide polymers such as polyacrylamide and isoparaffm and laureth-7, available under the trade name Sepigel 305 from Seppic Corporation, and acrylic acid/ethyl acrylate copolymers and the carboxyvinyl polymers sold by the B.F. Goodrich Company under the trade mark of Carbopol resins, or mixtures thereof.
  • Suitable Carbopol resins may be hydrophobically modified, and other suitable resins are described in WO98/22085, or mixtures thereof.
  • compositions preferably comprise, at least one silicone oil phase.
  • Silicone oil phase(s) generally comprises from about 0.1% to about 20%, preferably from about 0.5% to about 10%, more preferably from about 0.5% to about 5%, of the composition.
  • The, or each, silicone oil phase preferably comprises one or more silicone components. Silicone components can be fluids, including straight chain, branched and cyclic silicones.
  • Suitable silicone fluids useful herein include silicones inclusive of polyalkyl siloxane fluids, polyaryl siloxane fluids, cyclic and linear polyalkylsiloxanes, polyalkoxylated silicones, amino and quaternary ammonium modified silicones, polyalkylaryl siloxanes or a polyether siloxane copolymer and mixtures thereof.
  • the silicone fluids can be volatile or non-volatile.
  • Silicone fluids generally have a weight average molecular weight of less than about 200,000. Suitable silicone fluids have a molecular weight of about 100,000 or less, preferably about 50,000 or less, most preferably about 10,000 or less.
  • the silicone fluid is selected from silicone fluids having a weight average molecular weight in the range from about 100 to about 50,000 and preferably from about 200 to about 40,000.
  • silicone fluids have a viscosity ranging from about 0.65 to about 600,000 mm ⁇ .s'l, preferably from about 0.65 to about 10,000 m ⁇ .s'l at 25°C. The viscosity can be measured by means of a glass capillary viscometer as set forth in Dow Corning Corporate Test Method CTM0004, July 29, 1970.
  • Suitable polydimethyl siloxanes that can be used herein include those available, for example, from the General Electric Company as the SF and Viscasil (RTM) series and from Dow Corning as the Dow Corning 200 series.
  • essentially non-volatile polyalkylarylsiloxanes for example, polymethylphenylsiloxanes, having viscosities of about 0.65 to 30,000 mm ⁇ .s"! at 25°C.
  • siloxanes are available, for example, from the General Electric Company as SF 1075 methyl phenyl fluid or from Dow Corning as 556 Cosmetic Grade Fluid.
  • Cyclic polydimethylsiloxanes suitable for use herein are those having a ring structure incorporating from about 3 to about 7 (CH3)2SiO moieties.
  • the silicone fluid is selected from dimethicone, decamethylcyclopentasiloxane, octamethylcyclotetrasiloxane, phenyl methicone, and mixtures thereof.
  • Silicone gums can also be used herein.
  • the term "silicone gum” herein means high molecular weight silicones having a weight average molecular weight in excess of about 200,000 and preferably from about 200,000 to about 4,000,000. Iincluded are non- volatile polyalkyl and polyaryl siloxane gums.
  • a silicone oil phase comprises a silicone gum or a mixture of silicones including the silicone gum.
  • silicone gums typically have a viscosity at 25°C in excess of about 1,000,000 m ⁇ s-!.
  • the silicone gums include dimethicones as described by Petrarch and others including US- A-4, 152,416, May 1 , 1979 to Spitzer, et al, and Noll, Walter, Chemistry and
  • silicone gums include polydimethylsiloxane, (polydimethylsiloxane)(methylvinylsiloxane) copolymer, poly(dimethylsiloxane)- (diphenyl)(methylvinylsiloxane) copolymer and mixtures thereof.
  • Preferred silicone gums for use herein are silicone gums having a molecular weight of from about 200,000 to about 4,000,000 selected from dimethiconol, and dimethicone and mixtures thereof.
  • a silicone phase herein preferably comprises a silicone gum incorporated into the composition as part of a silicone gum-fluid blend.
  • the silicone gum When the silicone gum is incorporated as part of a silicone gum-fluid blend, the silicone gum preferably constitutes from about 5% to about 40%), especially from about 10% to 20% by weight of the silicone gum-fluid blend.
  • Suitable silicone gum-fluid blends herein are mixtures consisting essentially of:
  • a carrier which is a silicone fluid, the carrier having a viscosity from about 0.65 mm ⁇ .s"! to about 100 mm s'l,
  • the ratio of i) to ii) is from about 10:90 to about 20:80 and wherein said silicone gum-based component has a final viscosity of from about 100 mm ⁇ .s'l to about 100,000 mm ⁇ .s'l, preferably from 500 mm ⁇ .s'l to about 10,000 m ⁇ .s"!,
  • An especially preferred silicone-gum fluid blend based component for use in the compositions herein is a dimethiconol gum having a molecular weight of from about 200,000 to about 4,000,000 along with a silicone fluid carrier with a viscosity of about
  • crosslinked polyorganosiloxane polymers are crosslinked polyorganosiloxane polymers, optionally dispersed in a fluid carrier.
  • the crosslinked polyorganosiloxane polymers together with its carrier (if present) comprises 0.1% to about 20%>, preferably from about 0.5% to about 10%, more preferably from about 0.5% to about 5% of the composition.
  • Such polymers comprise polyorganosiloxane polymers crosslinked by a crosslinking agent. Suitable crosslinking agents are disclosed in WO98/22085. Examples of suitable polyorganosiloxane polymers for use herein include methyl vinyl dimethicone, methyl vinyl diphenyl dimethicone and methyl vinyl phenyl methyl diphenyl dimethicone.
  • crosslinked polyorganosiloxane polymers for use herein are silicone vinyl crosspolymer mixtures available under the tradename KSG supplied by Shinetsu Chemical Co., Ltd, for example KSG-15, KSG-16, KSG-17, KSG-18. These materials contain a combination of crosslinked polyorganosiloxane polymer and silicone fluid. Particularly preferred for use herein especially in combination with the organic amphiphilic emulsifier material is KSG-18.
  • KSG-15, KSG- 16, KSG-17 and KSG-18 are cyclomethicone dimethicone/vinyl dimethicone crosspolymer, dimethicone dimethicone/vinyl dimethicone crosspolymer, cyclomethicone dimethicone/vinyl dimethicone crosspolymer and phenyl trimethicone dimethicone/phenyl vinyl dimethicone crosspolymer, respectively.
  • silicone components suitable for use in a silicone oil phase herein includes polydiorganosiloxane-polyoxyalkylene copolymers containing at least one polydiorganosiloxane segment and at least one polyoxyalkylene segment.
  • Suitable polydiorganosiloxane segments and copolymers thereof are disclosed in WO98/22085.
  • Suitable polydiorganosiloxane-polyalkylene copolymers are available commercially under the tradenames Belsil (RTM) from Wacker-Chemie GmbH, Geschafts Symposium S, Postfach D-8000 Kunststoff 22 and Abil (RTM) from Th.
  • a particularly preferred copolymer fluid blend for use herein includes Dow Coming DC3225C which has the CTFA designation Dimethicone/Dimethicone copolyol.
  • compositions of the present invention preferably comprise an organic sunscreen.
  • Suitable sunscreens can have UVA absorbing properties, UVB absorbing properties or a mixture thereof.
  • the exact amount of the sunscreen active will vary depending upon the desired Sun Protection Factor, ie the "SPF" of the composition as well as the desired level of UV protection.
  • the compositions of the present invention preferably comprise an SPF of at least 10, preferably at least 15.
  • SPF is a commonly used measure of photoprotection of a sunscreen against erythema.
  • the SPF is defined as a ratio of the ultraviolet energy required to produce minimal erythema on protected skin to that required to products the same minimal erythema on unprotected skin in the same individual. See Federal Register, 43, No 166, pp.
  • Amounts of the sunscreen used are typically from about 2% to about 20%, more typically from about 4% to about 14%.
  • Suitable sunscreens include, but are not limited to, those found in the CTFA International Cosmetic Ingredient Dictionary and Handbook, 7 l edition, volume 2 pp. 1672, edited by Wenninger and McEwen (The Cosmetic, Toiletiy, and Fragrance Association, Inc., Washington, D. C, 1997).
  • compositions of the present invention preferably comprise a UVA absorbing sunscreen actives which absorb UV radiation having a wavelength of from about 320nm to about 400nm.
  • Suitable UVA absorbing sunscreen actives are selected from dibenzoylmethane derivatives, anthranilate derivatives such as methylanthranilate and homomethyl, 1-N-acetylanthranilate, and mixtures thereof. Examples of dibenzoylmethane sunscreen actives are described in US Patent No 4,387,089 issued to Depolo; and in Sunscreens: Development, Evaluation, and Regulatory Aspects edited by N. J. Lowe and N. A. Shaath, Marcel Dekker, fric (1990).
  • the UVA absorbing sunscreen active is preferably present in an amount to provide broad spectrum UVA protection either independently, or in combination with, other UV protective actives which may be present in the composition.
  • Preferred UVA sunscreen actives are dibenzoylmethane sunscreen actives and their derivatives. They include, but are not limited to, those selected from 2- methyldibenzoylmethane, 4-methyldibenzoylmethane, 4-isopropyldibenzoylmethane, 4- tert-butyldibenzoylmethane, 2, 4-dimethyldibenzoylmetha ⁇ e, 2, 5- dimethyldibenzoylmethane, 4, 4'-diisopropylbenzoylmethane, 4-(l, l-dimethylethyl)-4'- methoxydibenzoylmethane, 2-methyl-5-isopropyl-4'-methoxydibenzoylmethane, 2- methyl-5-tert-butyl-4'-methoxy-dibenzoylmethane, 2, 4-dimethyl-4'- methoxydibenzoylmethane, 2, 6-dimethyl
  • Preferred dibenzoyl sunscreen actives include those selected from 4-(l, l-dimethylethyl)-4'-methoxydibenzoylmethane, 4-isopropyldibenzoylmethane, and mixtures thereof.
  • a more preferred sunscreen active is 4-(l, l-dimethylethyl)-4'- methoxydibenzoylmethane.
  • the sunscreen active 4-(l, l-dimethylethyl)-4'-methoxydibenzoylmethane which is also known as butyl methoxydibenzoylmethane or Avobenzone, is commercially available under the names of Parsol® 1789 from Givaudan Roure (International) S. A. (Basel, Switzerland) and Eusolex® 9020 from Merck & Co., fric (Whitehouse Station, NJ).
  • the sunscreen 4-isoproplydibenzoylmethane which is also known as isopropyldibenzoylmethane, is commercially available from Merck under the name of Eusolex® 8020.
  • compositions of the present invention preferably further comprise a UVB sunscreen active which absorbs UV radiation having a wavelength of from about 290nm to abut 320nm.
  • the compositions comprise an amount of the UVB sunscreen active which is safe and effective to provide UVB protection either independently, or in combination with, other UV protective actives which may be present in the compositions.
  • the compositions preferably comprise from about 0.1% to abut 16%, more preferably from about 0.1% to about 12%, and most preferably from about 0.5% to about 8% by weight, of UVB absorbing organic sunscreen.
  • UVB sunscreen actives are suitable for use herein.
  • organic sunscreen actives are described in US Patent No 5,087,372 issued February 11, 1992 to Haffey et al.; and US Patent Nos 5,073,371 and 5,073,372 both issued on December 17, 1991 to Turner et al. and Segarin, et al., at Chapter V-H, pages 189 et seq., of Cosmetics Science and Technology.
  • Still other useful sunscreens are those disclosed in U.S. Patent No. 4,937,370, to Sabatelli, issued June 26, 1990; and U.S. Patent No. 4,999,186, to Sabatelli et al., issued March 12, 1991.
  • Preferred UVB sunscreen actives are selected from 2-ethylhexyl-2-cyano-3, 2-ethylhexyl N,N-dimethyl-p- aminobenzoate, p-aminobenzoic acid, oxybenzone, homomenthyl salicylate, octyl salicylate, 4,4'-methoxy-t-butyldibenzoylmethane, 4-isopropyl dibenzoylmethane, 3- benzylidene camphor, 3-(4-methylbenzylidene) camphor, 3 -diphenylacrylate (referred to as octocrylene), 2-phenyl-benzimidazole-5-sulphonic acid (PBSA), cinnamates and their derivatives such as 2-ethylhexyl-p-methoxycinnamate and octyl-p-methoxycinnamate, TEA salicylate, octyldimethyl PABA
  • Preferred organic sunscreen actives are 2-ethylhexyl-2-cyano-3, 3- diphenylacrylate (referred to as octocrylene), 2-phenyl- benzimidazole-5-sulphonic acid (PBSA), octyl-p-methoxycinnamate, and mixtures thereof. Salt and acid neutralised forms of the acidic sunscreens are also useful herein.
  • An agent may also be added to any of the compositions useful in the present invention to stabilise the UNA sunscreen to prevent it from photo-degrading on exposure to UN radiation and thereby maintaining its UVA protection efficacy.
  • Suitable stabilising agents include, but are not limited to, those described in US Patents ⁇ os 5,972,316; 5,968,485; 5,935,556; 5,827,508 and Patent WO 00/06110.
  • Preferred examples of stabilising agents for use in the present invention include 2-ethylhexyl-2- cyano-3, 3 -diphenylacrylate (referred to as octocrylene), ethyl-2-cyano-3, 3- diphenylacrylate, 2-ethylhexyl-3, 3 -diphenylacrylate, ethyl-3, 3-bis(4- methoxyphenyl)acrylate, and mixtures thereof.
  • 2-ethylhexyl-2-cyano-3, 3- diphenylacrylate is most preferred.
  • compositions useful in the present invention may also be added to any of the compositions useful in the present invention to improve the skin substantivity of those compositions, particularly to enhance their resistance to being washed off by water, or rubbed off.
  • a preferred agent which will provide this benefit is a copolymer of ethylene and acrylic acid. Compositions comprising this copolymer are disclosed in U.S. Patent 4,663,157, Brock, issued May 5, 1987.
  • addition to the organic sunscreens compositions of the present invention can additionally comprise inorganic physical sunblocks.
  • suitable physical sunblocks are described in CTFA International Cosmetic Ingredient Dictionary, 6 th Edition, 1995, pp. 1026-28 and 1103, Sayre, R. M. et al., "Physical Sunscreens", J. Soc. Cosmet. Chem., vol 41, no 2, pp. 103-109 (1990).
  • Preferred inorganic physical sunblocks are zinc oxide and titanium dioxide, and mixtures thereof.
  • the physical sunblocks are present in an amount such that the present compositions are transparent on the skin (ie non- hitening), preferably less than or equal to about 5%.
  • titanium dioxide When used, titanium dioxide is used, it can have an anatase, rutile, or amorphous structure.
  • Physical sunblock particles eg titanium dioxide and zinc oxide, can be uncoated or coated with a variety of materials including but not limited to amino acids, aluminium compounds such as alumina, aluminium stearate, aluminium laurate, and the like; carboxylic acids and their salts eg stearic acid and its salts; phospholipids such as lecithin; organic silicone compounds; inorganic silicone compounds such as silica and silicates; and mixtures thereof.
  • a preferred titanium dioxide is commercially available from Tayca (Japan) and is distributed by Tri-K Industries (Emerson, NJ) under the MT micro-ionised series (eg MT 100SAS).
  • compositions of the present invention preferably comprise from about 0.1% to about 10%, more preferably from about 0.1% to about 4%, and most preferably from about 0.5% to about 2.5%, by weight, of inorganic sunscreen.
  • optional ingredients such as neutralising agents, perfumes, and colouring agents, can also be added to the compositions herein. It is preferred that any additional ingredients enhance the skin softness / smoothness benefits of the product. In addition it is preferred that any such ingredients do not negatively impact the aesthetic properties of the product. As such high levels of proteins such as collagen and elastin are not preferred in compositions useful in the present invention.
  • compositions of the invention can also contain from about 0.01% to about 10%, preferably from about 0.1%o to about 5% of a panthenol moisturizer.
  • the panthenol moisturizer can be selected from D-panthenol ([R]-2,4-dihydroxy-N-[3-hydroxypropyl)]- 3,3-dimethylbutamide), DL-panthenol, calcium pantothenate, royal jelly, panthetine, pantotheine, panthenyl ethyl ether, pangamic acid, pyridoxin, and pantoyl lactose.
  • compositions of the present invention additionally comprise a salt selected from alkali metal and alkaline earth metal salts, and mixtures thereof, preferably sodium, calcium and magnesium salts, and mixtures thereof.
  • compositions herein preferably comprise from about 5ppm to about 500 ppm of the salt, based on the amount of metal ion.
  • compositions herein may comprise additional enzymes selected from lipases, phosphohpases, glycosidases, lactoperoxidases and cellulases, and mixtures thereof.
  • Neutralizing agents suitable for use in neutralizing acidic group containing hydrophilic gelling agents herein include sodium hydroxide, potassium hydroxide, ammonium hydroxide, monoethanolamine, diethanolamine, amino methyl propanol, tris-buffer and triethanolamine.
  • keratolytic agents include keratolytic agents; water-soluble or solubilizable preservatives preferably at a level of from about 0.1% to about 5%>, such as Germall 115, methyl, ethyl, propyl and butyl esters of hydroxybenzoic acid, benzyl alcohol, DMDM hydantoin iodopropanyl butylcarbanate available under the trade name Glydant Plus from Lonza, EDTA, Euxyl (RTM) K400, Bromopol (2-bromo-2-nitropropane-l,3-diol) and phenoxypropanol; anti-bacterials such as hgasan (RTM) and phenoxyethanol (preferably at levels of from 0.1 %> to about 5%); soluble or colloidally-soluble moisturising agents such as hylaronic acid and starch-grafted sodium polyacrylates such as Sanwet (RTM) EVI-IOOO, IM
  • alpha hydroxy acids examples include glycolic acid, lactic acid, malic acid, citric acid, glycolic acid in conjunction with ammonium glycolate, alpha-hydroxy ethanoic acid, alpha-hydroxyoctanoic acid, alpha-hydroxycaprylic acid, hydroxycaprylic acid, mixed fruit acid, tri-alpOha hydroxy fruit acids, triple fruit acid, sugar cane extract, alpha hydroxy and botanical comprise, 1-alpha hydroxy acid and glycomer in crosslinked fatty acids alpha nutrium.
  • Preferred examples of alpha hydroxy acids are glycolic acid and lactic acid. It is preferred that alpha hydroxy acids are used in levels of upto 10%>.
  • compositions of the present invention can additionally comprise from about 0.1% to about 5% by weight of aluminium starch octenylsuccinate.
  • Aluminium starch octenylsuccinate is the aluminium salt of the reaction product of octenylsuccinic anhydride with starch and is commercially available under the trade name from Dry Flo National Starch & Chemical Ltd. Dry Flo is useful herein from the viewpoint of skin feel and application characteristics.
  • a safe and effective amount of an anti-inflammatory agent may be added to the compositions of the subject invention, preferably from about 0.1% to about 5%, more preferably from about 0.1% to about 2%, of the composition.
  • the anti-inflammatory agent enhances the skin appearance benefits of the present invention, e.g., such agents contribute to a more uniform and acceptable skin tone or colour.
  • the exact amount of anti-inflammatory agent to be used in the compositions will depend on the particular anti- inflammatory agent utilised since such agents vary widely in potency.
  • compositions of the subject invention can further include an anti-oxidant/radical scavenger.
  • the anti-oxidant/radical scavenger is especially useful for providing protection against UV radiation which can cause increased scaling or texture changes in the stratum corneum and against other environmental agents which can cause skin damage. Suitable amounts are from about 0.1% to about 10%, more preferably from about 1% to about 5%, of the composition.
  • Anti-oxidants/radical scavengers such as ascorbic acid (vitamin C) and its salts.
  • a chelating agent is especially useful for providing protection against UV radiation which can contribute to excessive scaling or skin texture changes and against other environmental agents which can cause skin damage.
  • a suitable amount is from about 0.01% to about 1%, more preferably from about 0.05% to about 0.5%, of the composition.
  • Exemplary chelators that are useful herein are disclosed in U.S. Patent No. 5,487,884, incorporated herein by reference.
  • Preferred chelators useful in compositions of the subject invention are ethylenediamine tetraacetic acid (EDTA), furildioxime, and derivatives thereof.
  • compositions of the present invention can also comprise a skin lightening agent.
  • the compositions preferably comprise from about 0.1% to about 10%>, more preferably from about 0.2% to about 5%, also preferably from about 0.5%> to about 2%, of a skin lightening agent.
  • Suitable skin lightening agents include those known in the art, including kojic acid, arbutin, ascorbic acid and derivatives thereof, e.g., magnesium ascorbyl phosphate.
  • Further skin lightening agents suitable for use herein also include those described in WO 95/34280 and WO 95/23780; each incorporated herein by reference.
  • water-soluble or solubilizable preservatives preferably at a level of from about 0.1% to about 5%, such as Germall 115, methyl, ethyl, propyl and butyl esters of hydroxybenzoic acid, benzyl alcohol, DMDM hydantoin iodopropanyl butylcarbanate available under the trade name Glydant Plus from Lonza, EDTA, Euxyl (RTM) K400, Bromopol (2-bromo-2-nitropropane-l,3-diol) and phenoxypropanol; anti- bacterials such as rgasan (RTM) and phenoxyethanol (preferably at levels of from 0.1% to about 5%).
  • Antibacterial agents such as TCC/TCS, also known as triclosan and trichlorocarbon are also useful in compositions of the present invention.
  • compositions of the present invention comprise particulate materials having a refractive index of from about 1.3 to about 1.7, the particulate materials being dispersed in the composition and having a median particle size of from about 2 to about 30 ⁇ m.
  • the parti culates useful herein have relatively narrow distributions, by which is meant that more than 50% of the particles fall within 3 ⁇ m either side of the respective median value.
  • Suitable particulate materials are organic or organosilicone and preferably organosilicone polymers.
  • Preferred particles are free-flowing, solid, materials.
  • solid is meant that the particles are not hollow. The void at the centre of hollow particles can have an adverse effect on refractive index and therefore the visual effects of the particles on either skin or the composition.
  • Suitable organic particulate materials include those made of polymethylsilsesquioxane, referenced above, polyamide, polythene, polyacrylonitrile, polyacrylic acid, polymethacrylic acid, polystyrene, polytetrafluoroethylene (PTFE) and poly(vinylidene chloride). Copolymers derived from monomers of the aforementioned materials can also be used. Inorganic materials include silica and boron nitride.
  • Tospearl® 145 which has a median particle size of about 4.5 ⁇ m and EA-209® from Kobo which is an ethylene / acrylic acid copolymer having a median particle size of about 10 ⁇ m, Nylon- 12 available under the trade name Orgasol 2002 from Elf Atochem, France, or mixtures thereof.
  • suitable pigments are titanium dioxide, predispersed titanium dioxide from Kobo e.g. Kobo GWL75CAP, iron oxides, acyglutamate iron oxides, ultramarine blue, D&C dyes, carmine, and mixtures thereof. Depending upon the type of composition, a mixture of pigments will normally be used.
  • the preferred pigments for use herein from the viewpoint of moisturisation, skin feel, skin appearance and emulsion compatibility are treated pigments.
  • the pigments can be treated with compounds such as amino acids, silicones, lecithin and ester oils.
  • the pH of the compositions herein is in the range from about 6.1 to about 10.0, preferably from about 7.0 to about 9.0, more preferably from about 8.0 to about 9.0 and even more preferably from about 8.0 to about 8.6. It is preferred that the pH of the final composition is adjusted by addition of acidic, basic or buffer salts as necessary.
  • the cosmetic compositions herein preferably have a water activity greater than 0.85, more preferably greater than 0.9, and most preferably greater than 0.95.
  • compositions of the invention are generally in emulsion form and are preferably formulated so as to have a product viscosity of at least about 4,000 mPa.s and preferably in the range from about 4,000 to about 1,000,000 mPa.s, more preferably from about 8,000 to about 350,000 mPa.s and especially from about 10,000 to about 250,000 mPa.s and even more especially from about 10,000 to about 150,000 mPa.s (25°C, neat, Brookfield RVT, T Spindle at 5 rpms and Heliopath Stand).
  • compositions of the present invention are prepared by standard techniques well known to those skilled in the art. In general the aqueous phase and/ or the oil phase would be prepared separately, with materials of similar phase partitioning being added in any order. If the final product is an emulsion, the two phases will then be combined with vigorous stirring. Any ingredients in the formulation with high volatility, or which are susceptible to hydrolysis at high temperatures, can be added with gentle stirring towards the end of the process, post emulsification if applicable.
  • compositions were prepared based on the formulations described above. Study participants were treated with 0.1-2 micrograms of enzyme solutions (examples 1-3) per square cm followed by 0.8-2 micrograms of polyhydric alcohol composition (examples 4- 8) over a total skin area of 35 square cm. Skin hydrations levels were then measured over time using a comeometer.
  • the cosmetic methods used in the above examples display excellent skin hydration, skin softness and skin smoothness benefits.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne un procédé cosmétique améliorant l'hydratation de la peau par application topique d'enzyme protéase, avec application topique simultanée ou séquentielle d'alcool polyhydrique. L'invention concerne également un procédé cosmétique améliorant l'hydratation de la peau par application topique d'alcool polyhydrique, avec application topique simultanée ou séquentielle d'enzyme protéase. L'invention concerne par ailleurs un procédé cosmétique améliorant l'hydratation de la peau par application topique d'une composition cosmétique renfermant: a) entre environ 0,0001 % et environ 1 %, en poids, d'enzyme protéase; et b) entre environ 0,1 % et environ 20 %, en poids, d'alcool polyhydrique. Enfin, l'invention concerne un procédé cosmétique améliorant l'hydratation de la peau par application topique d'une première composition cosmétique renfermant entre environ 0,0001 % et environ 1 %, en poids, d'enzyme protéase, et par application topique simultanée ou séquentielle d'une seconde composition cosmétique renfermant entre environ 0,1 % et environ 20 %, en poids, d'alcool polyhydrique.
EP00963409A 2000-09-13 2000-09-13 Procede cosmetique Withdrawn EP1317248A1 (fr)

Applications Claiming Priority (1)

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PCT/US2000/025084 WO2002022101A1 (fr) 2000-09-13 2000-09-13 Procede cosmetique

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EP1317248A1 true EP1317248A1 (fr) 2003-06-11

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EP (1) EP1317248A1 (fr)
JP (1) JP2004508392A (fr)
CN (1) CN1454078A (fr)
AU (1) AU2000274825A1 (fr)
MX (1) MXPA03002168A (fr)
WO (1) WO2002022101A1 (fr)

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FR2842209B1 (fr) 2002-07-09 2007-11-23 Nouvelle protease aspartique dite saspase et son utilisation dans le domaine cosmetique et therapeutique
KR100558751B1 (ko) * 2004-10-18 2006-03-14 주식회사 태평양 피부보습용 화장료 조성물
KR102055895B1 (ko) * 2018-07-31 2020-01-22 박병희 신규한 바실러스 리케니포미스 및 이의 용도
KR102055890B1 (ko) * 2018-07-31 2020-01-22 박병희 신규한 바실러스 아밀로리퀘파시엔스 및 이의 용도
WO2022154247A1 (fr) * 2021-01-15 2022-07-21 주식회사 엘지생활건강 Composition pour améliorer l'exfoliation de cellules mortes ou l'état de la peau

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JPS5879913A (ja) * 1981-11-09 1983-05-13 Taizo Ayukawa ヘアトニツク組成物
US5741518A (en) * 1992-08-03 1998-04-21 L'oreal Composition composed of an aqueous dispersion of stabilized vesicles of nonionic amphiphilic lipids
FR2737116B1 (fr) * 1995-07-25 1997-08-22 Oreal Composition stable contenant un actif cosmetique et/ou dermatologique sensible a l'eau
CN1140261C (zh) * 1996-01-31 2004-03-03 科斯莫弗姆有限公司 含有稳定生物有效化合物的组合物的应用
FR2755368B1 (fr) * 1996-11-04 1999-03-19 Oreal Composition rincable pour le soin de la peau
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FR2780645B1 (fr) * 1998-07-06 2000-08-11 Oreal Produit pour application topique contenant une lipase, un precurseur de vitamine et un alcool gras
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IE990934A1 (en) * 1999-11-08 2002-04-03 Procter & Gamble Cosmetic Compositions
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JP2004508392A (ja) 2004-03-18
CN1454078A (zh) 2003-11-05
WO2002022101A1 (fr) 2002-03-21
MXPA03002168A (es) 2003-07-24
AU2000274825A1 (en) 2002-03-26

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