EP1315738A4 - Extended native chemical ligation - Google Patents

Extended native chemical ligation

Info

Publication number
EP1315738A4
EP1315738A4 EP01968707A EP01968707A EP1315738A4 EP 1315738 A4 EP1315738 A4 EP 1315738A4 EP 01968707 A EP01968707 A EP 01968707A EP 01968707 A EP01968707 A EP 01968707A EP 1315738 A4 EP1315738 A4 EP 1315738A4
Authority
EP
European Patent Office
Prior art keywords
chemical ligation
native chemical
extended native
extended
ligation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01968707A
Other languages
German (de)
French (fr)
Other versions
EP1315738A1 (en
Inventor
Paolo Botti
James A Bradburne
Stephen B H Kent
Donald W Low
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amylin Pharmaceuticals LLC
Original Assignee
Gryphon Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gryphon Therapeutics Inc filed Critical Gryphon Therapeutics Inc
Publication of EP1315738A1 publication Critical patent/EP1315738A1/en
Publication of EP1315738A4 publication Critical patent/EP1315738A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/80—Cytochromes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
EP01968707A 2000-09-08 2001-09-07 Extended native chemical ligation Withdrawn EP1315738A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23133900P 2000-09-08 2000-09-08
US231339P 2000-09-08
PCT/US2001/028172 WO2002020557A1 (en) 2000-09-08 2001-09-07 Extended native chemical ligation

Publications (2)

Publication Number Publication Date
EP1315738A1 EP1315738A1 (en) 2003-06-04
EP1315738A4 true EP1315738A4 (en) 2006-06-07

Family

ID=22868813

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01968707A Withdrawn EP1315738A4 (en) 2000-09-08 2001-09-07 Extended native chemical ligation

Country Status (12)

Country Link
EP (1) EP1315738A4 (en)
JP (2) JP2004508383A (en)
KR (1) KR20030061785A (en)
CN (1) CN1452632A (en)
AU (2) AU2001288937B2 (en)
BR (2) BR0113623A (en)
CA (1) CA2412298A1 (en)
ES (1) ES2360203T3 (en)
IL (1) IL154015A0 (en)
MX (1) MXPA03001450A (en)
WO (1) WO2002020557A1 (en)
ZA (3) ZA200300315B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4559219B2 (en) * 2002-06-10 2010-10-06 エミリン ファーマシューティカルズ インコーポレイテッド Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation
WO2004061094A1 (en) 2002-12-30 2004-07-22 Gryphon Therapeutics, Inc. Water-soluble thioester and selenoester compounds and methods for making and using the same
JP5014148B2 (en) * 2005-10-25 2012-08-29 独立行政法人理化学研究所 Method for producing peptide thioester
WO2011017837A1 (en) * 2009-08-12 2011-02-17 Xuechen Li Native chemical ligation at serine and threonine sites
FR2952058B1 (en) * 2009-10-29 2013-10-04 Centre Nat Rech Scient PROCESS FOR NATIVE LIGATION OF POLYPEPTIDES
CN115058426B (en) * 2022-05-16 2024-07-16 上海志药科技有限公司 Nucleic acid molecular probe for specifically recognizing SARS-CoV-19, screening method, detection product and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184344B1 (en) * 1995-05-04 2001-02-06 The Scripps Research Institute Synthesis of proteins by native chemical ligation
US6307018B1 (en) * 1996-12-24 2001-10-23 The Scripps Research Institute General chemical ligation
WO1998028434A1 (en) * 1996-12-24 1998-07-02 The Scripps Research Institute General chemical ligation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
S.J. BARK: "The ligation of unprotected peptide segments using auxiliary functional groups", PH.D. THESIS, 1997, The Scripps Research Institute - La Jolla, California, pages 1 - 148, XP001246730 *

Also Published As

Publication number Publication date
BR0113623A (en) 2004-06-22
WO2002020557A1 (en) 2002-03-14
ZA200300659B (en) 2004-03-05
AU2001288937B2 (en) 2005-04-28
CA2412298A1 (en) 2002-03-14
AU8893701A (en) 2002-03-22
MXPA03001450A (en) 2004-12-13
IL154015A0 (en) 2003-07-31
ES2360203T3 (en) 2011-06-01
ZA200300314B (en) 2004-02-04
ZA200300315B (en) 2004-02-04
KR20030061785A (en) 2003-07-22
CN1452632A (en) 2003-10-29
JP2008150393A (en) 2008-07-03
EP1315738A1 (en) 2003-06-04
JP2004508383A (en) 2004-03-18
BR0113579A (en) 2003-06-17

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20030129

AK Designated contracting states

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

A4 Supplementary search report drawn up and despatched

Effective date: 20060504

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 9/02 20060101ALI20060427BHEP

Ipc: C07K 7/06 20060101ALI20060427BHEP

Ipc: C07K 1/00 20060101AFI20020318BHEP

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: AMYLIN PHARMACEUTICALS, INC.

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: AMYLIN PHARMACEUTICALS, INC.

17Q First examination report despatched

Effective date: 20080221

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20080903