EP1310229A4 - Method of manufacturing seamless capsule - Google Patents

Method of manufacturing seamless capsule

Info

Publication number
EP1310229A4
EP1310229A4 EP01956914A EP01956914A EP1310229A4 EP 1310229 A4 EP1310229 A4 EP 1310229A4 EP 01956914 A EP01956914 A EP 01956914A EP 01956914 A EP01956914 A EP 01956914A EP 1310229 A4 EP1310229 A4 EP 1310229A4
Authority
EP
European Patent Office
Prior art keywords
nozzle
liquid
capsule shell
shell material
curing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP01956914A
Other languages
German (de)
French (fr)
Other versions
EP1310229B1 (en
EP1310229A1 (en
Inventor
Hiroyuki Nakajima
Masayoshi Yamazaki
Takeshi Nakamura
Tsukasa Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to EP08169858A priority Critical patent/EP2052710B1/en
Publication of EP1310229A1 publication Critical patent/EP1310229A1/en
Publication of EP1310229A4 publication Critical patent/EP1310229A4/en
Application granted granted Critical
Publication of EP1310229B1 publication Critical patent/EP1310229B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]

Abstract

Disclosed is a seamless capsule manufacturing method formed by encapsulating a filler material with a capsule shell material, said method comprising: a step of preparing a concentric multiple nozzle having a center nozzle and an annular nozzle concentrically surrounding the center nozzle; a step of preparing a tubular member in which a curing liquid for curing a liquid capsule shell material by coming into contact with the capsule shell material flows, and said tubular member having a vertical portion which extends vertically and has an open upper end; a step of supplying a liquid filler material to the center nozzle of the concentric multiple nozzle, and supplying a liquid capsule shell material to the annular nozzle of the concentric multiple nozzle; a step of forming a concentric columnar composite flow which includes the flow of the liquid filler material discharged from the center nozzle and the flow of the liquid capsule shell material discharged from the annular nozzle and flowing around the flow of the filler material, and cutting the composite flow from the end thereof to form a droplet; and a step of introducing the droplet into the curing liquid in the vertical portion of the tubular member such that the position of introduction is misaligned relative to the center of the vertical portion, and curing the capsule shell material of the droplet by coming into contact with the curing liquid.
EP01956914A 2000-08-17 2001-08-16 Method of manufacturing seamless capsule Expired - Lifetime EP1310229B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08169858A EP2052710B1 (en) 2000-08-17 2001-08-16 Seamless capsule manufacturing method

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000247878 2000-08-17
JP2000247878 2000-08-17
PCT/JP2001/007054 WO2002013755A1 (en) 2000-08-17 2001-08-16 Method of manufacturing seamless capsule

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP08169858A Division EP2052710B1 (en) 2000-08-17 2001-08-16 Seamless capsule manufacturing method

Publications (3)

Publication Number Publication Date
EP1310229A1 EP1310229A1 (en) 2003-05-14
EP1310229A4 true EP1310229A4 (en) 2007-08-01
EP1310229B1 EP1310229B1 (en) 2009-12-23

Family

ID=18737880

Family Applications (2)

Application Number Title Priority Date Filing Date
EP01956914A Expired - Lifetime EP1310229B1 (en) 2000-08-17 2001-08-16 Method of manufacturing seamless capsule
EP08169858A Expired - Lifetime EP2052710B1 (en) 2000-08-17 2001-08-16 Seamless capsule manufacturing method

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP08169858A Expired - Lifetime EP2052710B1 (en) 2000-08-17 2001-08-16 Seamless capsule manufacturing method

Country Status (7)

Country Link
US (1) US7112292B2 (en)
EP (2) EP1310229B1 (en)
JP (1) JP4778639B2 (en)
AT (2) ATE452618T1 (en)
AU (1) AU2001278747A1 (en)
DE (1) DE60140874D1 (en)
WO (1) WO2002013755A1 (en)

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JPWO2005041658A1 (en) * 2003-10-31 2007-11-29 アース製薬株式会社 Gel material
JP2008535644A (en) 2005-03-04 2008-09-04 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ Method and apparatus for the formation of multiple emulsions
US20100266685A1 (en) * 2005-08-16 2010-10-21 Symrise Gmbh & Co. Kg Seamless Coated Spherical Filled Capsules
JP5593022B2 (en) * 2008-10-20 2014-09-17 フロイント産業株式会社 Seamless capsule manufacturing equipment
FR2939012B1 (en) 2008-12-01 2015-03-27 Capsum PROCESS FOR MANUFACTURING A SERIES OF CAPSULES, AND ASSOCIATED SERIES OF CAPSULES
JP4822299B2 (en) * 2009-06-19 2011-11-24 富士カプセル株式会社 Soft capsule and method for producing the same
BR112012004719A2 (en) 2009-09-02 2016-04-05 Harvard College multiple emulsions created by blasting and other techniques
FR2955257B1 (en) * 2010-01-15 2012-06-01 Capsum METHOD OF MANUFACTURING CAPSULES WITH CONTROLLED FALL HEIGHT.
BR112013029729A2 (en) 2011-05-23 2017-01-24 Basf Se emulsion control including multiple emulsions
CN103764265A (en) 2011-07-06 2014-04-30 哈佛学院院长等 Multiple emulsions and techniques for the formation of multiple emulsions
GB201113775D0 (en) 2011-08-10 2011-09-21 British American Tobacco Co Capsule formation
GB201113776D0 (en) 2011-08-10 2011-09-21 British American Tobacco Co Capsule formation
GB201113774D0 (en) * 2011-08-10 2011-09-21 British American Tobacco Co Capsule formation
CN102556921A (en) * 2012-02-23 2012-07-11 浙江大学 Liquid dropping funnel
JP6058923B2 (en) * 2012-06-28 2017-01-11 フロイント産業株式会社 Seamless capsule manufacturing method and seamless capsule manufacturing apparatus
AU2015329446B2 (en) * 2014-10-06 2017-03-16 Fuji Capsule Co., Ltd. Method of manufacturing enteric soft capsule
AU2015329445B2 (en) * 2014-10-06 2017-11-30 Fuji Capsule Co., Ltd. Method of manufacturing enteric seamless soft capsule
JP6780194B2 (en) * 2016-09-26 2020-11-04 国立研究開発法人農業・食品産業技術総合研究機構 Microcapsule manufacturing equipment
CN107951722A (en) * 2016-10-17 2018-04-24 烟台百药泰中药科技有限公司 A kind of fast preparation method of seamless capsule and pill
CN106333377A (en) * 2016-10-24 2017-01-18 四川鑫康源生物科技有限公司 Drip preparation device and drip preparation method for preparing capsule health care product
JP6884369B2 (en) * 2016-12-28 2021-06-09 三生医薬株式会社 Seamless capsule
KR101824075B1 (en) * 2017-03-31 2018-01-31 정수영 Seamless capsule vibrator
CN108272119A (en) * 2018-02-07 2018-07-13 南昌大学 A kind of device preparing microcapsules by temperature control solidification
CN108160014A (en) * 2018-02-07 2018-06-15 南昌大学 It is a kind of to prepare double casing microcapsules device
US11173461B2 (en) * 2018-03-22 2021-11-16 Lawrence Livermore National Security, Llc Fabricating structured particles through rapid hardening and tailored collection methods
WO2019198835A1 (en) * 2018-04-13 2019-10-17 富士カプセル株式会社 Soft capsule assemblage and composition for oral administration comprising same
CN114572436A (en) * 2020-12-01 2022-06-03 上海烟草集团有限责任公司 High-speed forming device for blasting beads
WO2023062109A1 (en) 2021-10-13 2023-04-20 Wm19 Holding Ag Oral formulations comprising nicotine salt
KR102421317B1 (en) * 2022-01-06 2022-07-15 박순영 Seamless Capsule Manufacturing Machine

Citations (3)

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GB544507A (en) * 1939-07-17 1942-04-16 Robert Pauli Scherer Method of and apparatus for shaping plastic capsules and for forming compound capsules
US2799897A (en) * 1952-05-26 1957-07-23 Trifax N V Method for producing seamless filled capsules
EP0778083A1 (en) * 1995-12-07 1997-06-11 Freund Industrial Co., Ltd. Seamless capsule and method for manufacturing the same

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JPS5946540A (en) 1982-09-09 1984-03-15 Toshiba Corp Turbidimeter
JPS59112833A (en) * 1982-12-17 1984-06-29 Nippon Carbide Ind Co Ltd Apparatus for preparing seamless filled capsule
JPH0640953B2 (en) * 1986-01-27 1994-06-01 フロイント産業株式会社 Capsule manufacturing method and device
JP2722223B2 (en) * 1988-10-31 1998-03-04 東レ・ダウコーニング・シリコーン株式会社 Manufacturing method of silicone rubber capsule
ATE89766T1 (en) * 1989-01-31 1993-06-15 Coletica USE OF SOLUTIONS CONTAINING ATELOCOLLAGEN AND POLYHOLOSIDES, E.G. GLYCOSAMINOGLYCAN, FOR THE MANUFACTURE OF MICROCAPSULES THE MICROCAPSULES OBTAINED THEN AND PROCESSES FOR THEIR MANUFACTURE; PREPARATIONS CONTAINING FOOD, MEDICATIONS OR COSMETIC COMPOSITIONS.
JP3159724B2 (en) 1991-04-19 2001-04-23 フロイント産業株式会社 Seamless capsule manufacturing method and apparatus
JP3091254B2 (en) 1991-05-14 2000-09-25 フロイント産業株式会社 Seamless capsule manufacturing equipment
US5186948A (en) * 1991-05-28 1993-02-16 Freund Inphachem Inc. Apparatus for manufacturing seamless capsules
US5232712A (en) * 1991-06-28 1993-08-03 Brown University Research Foundation Extrusion apparatus and systems
JPH05317387A (en) 1992-05-01 1993-12-03 Sansho Kaken Kk Manufacture of complex capsule body
JPH0810313A (en) * 1994-07-01 1996-01-16 Freunt Ind Co Ltd Manufacture of seamless capsule
US5650232A (en) * 1994-10-07 1997-07-22 Warner-Lambert Company Method for making seamless capsules
US5888538A (en) * 1995-03-29 1999-03-30 Warner-Lambert Company Methods and apparatus for making seamless capsules
JP3667045B2 (en) 1997-09-10 2005-07-06 森下仁丹株式会社 Multiple soft capsules for removing bad breath and method for producing the same
JPH11188079A (en) 1997-12-26 1999-07-13 Kao Corp Method of manufacturing seamless capsule grain
JP2001000509A (en) 1999-06-25 2001-01-09 Kao Corp Production of capsule particle
JP3392780B2 (en) 1999-06-28 2003-03-31 花王株式会社 Capsule particle production equipment
JP4610727B2 (en) 1999-12-20 2011-01-12 中外製薬株式会社 Seamless capsule manufacturing method
TWI227170B (en) 1999-12-20 2005-02-01 Chugai Pharmaceutical Co Ltd The process for preparation of seamless capsules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB544507A (en) * 1939-07-17 1942-04-16 Robert Pauli Scherer Method of and apparatus for shaping plastic capsules and for forming compound capsules
US2799897A (en) * 1952-05-26 1957-07-23 Trifax N V Method for producing seamless filled capsules
EP0778083A1 (en) * 1995-12-07 1997-06-11 Freund Industrial Co., Ltd. Seamless capsule and method for manufacturing the same

Also Published As

Publication number Publication date
ATE544440T1 (en) 2012-02-15
EP1310229B1 (en) 2009-12-23
JP2002136576A (en) 2002-05-14
EP2052710A2 (en) 2009-04-29
US20030180485A1 (en) 2003-09-25
US7112292B2 (en) 2006-09-26
EP2052710A3 (en) 2010-11-03
JP4778639B2 (en) 2011-09-21
ATE452618T1 (en) 2010-01-15
WO2002013755A1 (en) 2002-02-21
EP2052710B1 (en) 2012-02-08
DE60140874D1 (en) 2010-02-04
AU2001278747A1 (en) 2002-02-25
EP1310229A1 (en) 2003-05-14

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