EP1308504A1 - Apparatus for the incubation and storage especially for samples of organic material - Google Patents

Apparatus for the incubation and storage especially for samples of organic material Download PDF

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Publication number
EP1308504A1
EP1308504A1 EP02021917A EP02021917A EP1308504A1 EP 1308504 A1 EP1308504 A1 EP 1308504A1 EP 02021917 A EP02021917 A EP 02021917A EP 02021917 A EP02021917 A EP 02021917A EP 1308504 A1 EP1308504 A1 EP 1308504A1
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EP
European Patent Office
Prior art keywords
heat transfer
incubation
storage device
transfer medium
heat
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Granted
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EP02021917A
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German (de)
French (fr)
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EP1308504B1 (en
Inventor
Marion Dr. Kauschke
Dieter Bidlingmaier
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Thermo Electron LED GmbH
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Kendro Laboratory Products GmbH
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/14—Incubators; Climatic chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L1/00—Enclosures; Chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid

Definitions

  • the invention relates to an incubation and storage device, in particular for samples organic material.
  • Devices of the type mentioned are used in biology and medicine for example to to store organic materials under defined external conditions.
  • Temperature-adjustable incubation devices or storage facilities are used in medicine Storage of fabrics use.
  • the electrical heating elements are on the outside of the inner container Incubation device applied or in rare cases arranged in the interior.
  • the Cooling takes place via the refrigerant evaporator, for example directly in the interior are arranged. Alternatively, part of the indoor air is bypassed to the evaporator led and cooled before the cooled air returned to the interior of the Incubation device is supplied.
  • a disadvantage of this known solution is that the two are separate Systems of heating and cooling of the incubation device are only very complex and difficult to regulate with regard to maintaining the specified temperature.
  • the Superimposition of cooling and heating is often very much due to the inertia of the individual systems large, so that either compromises on the constant temperature or must be made complex control systems have to be installed. It is particularly difficult to heat and To coordinate the cooling system so that a constant temperature with low Deviations in temperature around a setpoint is reached.
  • the disadvantage of this prior art is the complex control technology call to separate systems of heating and cooling the interior of the Adjust the incubation device to each other.
  • the carriers in which the heating elements or the coolant are located in the interior which is the Cleaning options for hygienically demanding applications in biology and Medicine severely impaired.
  • Water jacket circulates.
  • the water jacket is a second container around the inner container arranged around. This makes the temperature stability very good, but the system is extraordinarily sluggish. Temperature regimes with short phases of different temperatures are included practically impossible to implement in this system. Another disadvantage is that this system cannot be cooled easily since an evaporator ices up within a short time. Out For this reason, these systems are only suitable for temperatures above room temperature and available without cooling system.
  • the object is achieved in that the incubation and storage device is heated and cooled indirectly via a liquid heat transfer medium.
  • Means for cooling and heating the heat transfer medium are also provided according to the invention.
  • the required temperature stability is advantageous Easy to reach inside the device.
  • the combined is particularly effective at indoor temperatures close to the ambient temperature indirect cooling and heating are noticeable. Dynamic temperature control of the interior is via the system, which is coupled to a heat transfer circuit Heating and cooling, possible, causing a change in temperature due to changes contributions can be avoided.
  • FIG. 1 shows an embodiment of an incubation and storage device according to the invention shown in perspective.
  • the interior 2 is formed by inner boundary surfaces which heat exchanger elements 3 are arranged from the outside.
  • the heat exchanger elements 3 are thermally aligned with the boundary surfaces of the interior 2 in connection or form part of the boundary surfaces themselves.
  • a liquid heat transfer medium flows through the 10 heat exchanger elements 3 and takes, depending on the temperature, heat from the interior 2 of the incubation and Storage device 1 or gives off heat to the interior 2.
  • the liquid heat transfer medium will preferably pumped in a circuit by means of a pump 11.
  • the heat exchanger elements 3 are according to the preferred embodiment shown in FIG Invention box-shaped. This box-shaped heat exchanger elements 3 to the Boundary surfaces of the interior 2 are connected to one another by pipe connections 12
  • the heat transfer fluid is through a heat exchanger 9, not shown Heating heated or cooled by the heat exchanger / evaporator 7 of a refrigeration system.
  • the refrigeration system has a compressor 4, in which the vaporous refrigerant is compressed.
  • This is shown in the condenser 5, in the exemplary embodiment as an air condenser Liquefied refrigerant, relaxed in the expansion element 6 and finally gets into the Evaporator 7, where it evaporates while absorbing heat from the heat transfer medium.
  • the refrigerant vapor is sucked in by the compressor 4, which closes the refrigerant circuit.
  • the heat transfer system is alternatively advantageously completed by an expansion tank 10, the volume fluctuations of the heat carrier caused by temperature changes balances.
  • the two heat exchangers 7, 9 for cooling and heating the heat transfer medium are arranged in a heat carrier reservoir 8 according to the preferred embodiment. This results in advantageous dynamics for the regulation of the heat transfer circuit.
  • the heat exchanger elements 3 are in accordance with a further embodiment of the invention Coiled coils. These run around the 10 boundary surfaces of the interior 2 around and are thermally connected to them.
  • an external one to temper the incubation and storage device Thermostats with cooling and heating function or an internal heater and optionally an external one To use cooling device.
  • the external components with the required Connections and a container for receiving the heat transfer medium and a pump equip.
  • the external components have their own Provide temperature control.
  • the transparent surfaces such as Glass panes, heatable.
  • the heating medium of the incubation and storage device is advantageously heated by resistance heating.
  • R134a, propane, butane or carbon dioxide is preferably used as the refrigerant for the refrigeration system.
  • a mixture of water and glycol is preferred as a heat transfer medium for the invention Incubation and storage device used.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
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Abstract

The incubation and storage device (1) has its inner space (2) thermally connected to heat transfer elements (3) for subsequent circulation of liquid heat carriers. The heat carriers are heated via a heat transfer unit (9), and cooled by an evaporator (7).

Description

Die Erfindung betrifft eine Inkubations- und Lagervorrichtung, insbesondere für Proben aus organischem Material.The invention relates to an incubation and storage device, in particular for samples organic material.

Vorrichtungen der genannten Art werden in Biologie und Medizin beispielsweise dazu verwendet, um organische Materialien unter definierten äußeren Bedingungen zu lagern.Devices of the type mentioned are used in biology and medicine for example to to store organic materials under defined external conditions.

Große Verbreitungen haben derartige Vorrichtungen für die Aufzucht und Lagerung von Mikroorganismen, welche unter speziellen Lebensbedingungen ihr Wachstum stark beschleunigen können. Im Allgemeinen wird in diesen Vorrichtungen die Temperatur als wichtiger Wachstumsparameter auf einem bestimmten Niveau für eine längere Zeit konstant gehalten. Es sind aber auch Anwendungsfälle bekannt, bei denen nach einem vorgegebenen Temperaturregime in bestimmten Zeiten bestimmte Temperaturen erreicht und für eine gewisse Zeit konstant gehalten werden. Dabei sind diese Geräte häufig sowohl für einen Heiz- als auch für einen Kühlbetrieb mit Heizvorrichtungen und Kälteanlagen ausgestattet.Such devices for the rearing and storage of Microorganisms that greatly accelerate their growth under special living conditions can. In general, temperature is considered to be more important in these devices Growth parameters kept constant at a certain level for a long time. It however, there are also known use cases in which according to a given Temperature regimes reached certain temperatures at certain times and for a certain Time kept constant. These devices are often used for both heating and a cooling operation equipped with heaters and refrigeration systems.

In der Medizin finden temperierbare Inkubationsvorrichtungen oder Lagereinrichtungen zur Lagerung von Geweben Einsatz.Temperature-adjustable incubation devices or storage facilities are used in medicine Storage of fabrics use.

Dabei ist es sehr wichtig, dass diese Vorrichtungen aus hygienischen Gründen sehr leicht zu reinigen sind. Insbesondere ist dies erforderlich, um eine Keimverschleppung und unerwünschte Infektionen zu verhindern. It is very important that these devices very easily for hygienic reasons are clean. In particular, this is necessary to prevent germs from spreading and undesirable To prevent infections.

Im Stand der Technik sind verschiedene Grundformen von Inkubations- und Lagervorrichtungen bekannt.Various basic forms of incubation and storage devices are in the prior art known.

Man unterscheidet zwischen folgenden Systemen:A distinction is made between the following systems:

1. Direkt-Verdampfer für Kältemittel und elektrischen Heizelementen1. Direct evaporator for refrigerants and electrical heating elements

Dabei sind die elektrischen Heizelemente von außen auf dem Innenbehälter der Inkubationsvorrichtung aufgebracht oder auch in seltenen Fällen im Innenraum angeordnet. Die Kühlung erfolgt über die Kältemittelverdampfer, die beispielsweise direkt im Innenraum angeordnet sind. Alternativ wird ein Teil der Innenraumluft über einen Bypass zum Verdampfer geführt und gekühlt, bevor die abgekühlte Luft wieder dem Innenraum der Inkubationsvorrichtung zugeführt wird.The electrical heating elements are on the outside of the inner container Incubation device applied or in rare cases arranged in the interior. The Cooling takes place via the refrigerant evaporator, for example directly in the interior are arranged. Alternatively, part of the indoor air is bypassed to the evaporator led and cooled before the cooled air returned to the interior of the Incubation device is supplied.

Als Nachteil dieser bekannten Lösung ist hervorzuheben, dass die beiden voneinander getrennten Systeme der Beheizung und Kühlung der Inkubationsvorrichtung nur sehr aufwendig und schwierig in Bezug auf die Einhaltung der vorgegebenen Temperatur zu regeln sind. Die Überlagerung von Kühlung und Heizung ist infolge der Trägheit der Einzelsysteme häufig sehr groß, so dass entweder Abstriche an die Temperaturkonstanz gemacht werden müssen oder aber aufwändige Regelsysteme zu installieren sind. Insbesondere schwierig ist es, das Heiz- und Kühlsystem so aufeinander abzustimmen, dass eine Temperaturkonstanz mit geringen Abweichungen der Temperatur um einen Sollwert erreicht wird.A disadvantage of this known solution is that the two are separate Systems of heating and cooling of the incubation device are only very complex and difficult to regulate with regard to maintaining the specified temperature. The Superimposition of cooling and heating is often very much due to the inertia of the individual systems large, so that either compromises on the constant temperature or must be made complex control systems have to be installed. It is particularly difficult to heat and To coordinate the cooling system so that a constant temperature with low Deviations in temperature around a setpoint is reached.

2. Indirekte Kühlung und elektrische Heizelemente2. Indirect cooling and electrical heating elements

Ein solches System wird in der DE 873892 offenbart. Dabei sind im Innenraum rohrförmige Heizelemente in Trägern angeordnet, welche nach einer Ausgestaltung des Gegenstandes der genannten Erfindung auch teilweise durch Kühlrohre ersetzt werden können. Dadurch wird die kombinierte Kühlung und Beheizung des Innenraumes ermöglicht.Such a system is disclosed in DE 873892. The interior is tubular Heating elements arranged in supports, which according to an embodiment of the object mentioned invention can also be partially replaced by cooling tubes. This will make the Combined cooling and heating of the interior enables.

Wiederum ist als Nachteil dieses Standes der Technik die aufwändige Regelungstechnik zu nennen, um die voneinander getrennten Systeme der Heizung und Kühlung des Innenraumes der Inkubationsvorrichtung aufeinander abzustimmen. Darüber hinaus sind die Träger, in denen sich die Heizelemente oder die Kühlflüssigkeit befinden, im Innenraum angeordnet, was die Reinigungsmöglichkeiten bei hygienisch anspruchsvollen Anwendungen in der Biologie und der Medizin stark beeinträchtigt.Again, the disadvantage of this prior art is the complex control technology call to separate systems of heating and cooling the interior of the Adjust the incubation device to each other. In addition, the carriers in which the heating elements or the coolant are located in the interior, which is the Cleaning options for hygienically demanding applications in biology and Medicine severely impaired.

3. Wassermantel3. Water jacket

Bei diesem System wird als Wärmeträger Wasser verwendet, welches im sogenannten "Wassermantel" zirkuliert. Der Wassermantel ist dabei als zweiter Behälter um den Innenbehälter herum angeordnet. Dadurch ist die Temperaturkonstanz zwar sehr gut, aber das System ist außerordentlich träge. Temperaturregime mit kurzen Phasen verschiedener Temperatur sind mit diesem System praktisch nicht realisierbar. Zudem ist weiterhin von Nachteil, dass dieses System nicht ohne weiteres gekühlt werden kann, da ein Verdampfer binnen kurzer Zeit vereist. Aus diesem Grund sind diese Systeme nur für Temperaturen oberhalb der Raumtemperatur geeignet und ohne Kühlsystem erhältlich.In this system, water is used as the heat transfer medium "Water jacket" circulates. The water jacket is a second container around the inner container arranged around. This makes the temperature stability very good, but the system is extraordinarily sluggish. Temperature regimes with short phases of different temperatures are included practically impossible to implement in this system. Another disadvantage is that this system cannot be cooled easily since an evaporator ices up within a short time. Out For this reason, these systems are only suitable for temperatures above room temperature and available without cooling system.

Als weiterer Nachteil der direkten Beheizung ist zu nennen, dass die verwendeten Elektroheizelemente bei einer relativ geringen Oberfläche eine sehr hohe Temperatur erzeugen, wobei die Wärme durch Strahlung und Konvektion an die Luft im Innenraum der Inkubationsvorrichtung abgegeben wird. Da dort aber nur beispielsweise 37°C gefordert sind, entstehen Strömungen unterschiedlicher Temperatur, ehe sich der gewünschte Mittelwert einstellt. Es ist somit nicht nur regelungstechnisch, sondern auch strömungstechnisch schwierig, die Temperatur im Innenraum gleichmäßig zu verteilen.Another disadvantage of direct heating is that the used Electric heating elements generate a very high temperature with a relatively small surface, the heat from radiation and convection to the air inside the Incubator is dispensed. However, since only 37 ° C is required there, for example, flows of different temperatures arise before the desired mean value is reached established. It is therefore not only difficult in terms of control technology, but also in terms of flow technology, to distribute the temperature evenly inside.

Es ist Aufgabe der Erfindung, eine Inkubations- und Lagervorrichtung derart auszubilden, dass diese zur Temperierung von Proben aus organischem Material geeignet ist und darüber hinaus im Innenraum leicht zu reinigen ist. Zudem soll die konstante Einhaltung der Temperatur im Innenraum sichergestellt werden.It is an object of the invention to design an incubation and storage device in such a way that this is suitable for tempering samples made of organic material and also in Interior is easy to clean. In addition, the constant maintenance of the temperature in the Interior can be ensured.

Erfindungsgemäß wird die Aufgabe dadurch gelöst, dass die Inkubations- und Lagervorrichtung indirekt über einen flüssigen Wärmeträger beheizt und gekühlt wird. Dazu stehen die Begrenzungsflächen des Innenraumes der Inkubations- und Lagervorrichtung mit von außen angebrachten Wärmeübertragerelementen thermisch in Verbindung, wobei die Wärmeüber tragerelemente wiederum von einem flüssigen Wärmeträger im Kreislauf durchströmt werden. Ebenso sind Mittel zur Kühlung und Erwärmung des Wärmeträgers erfindungsgemäß vorgesehen.According to the invention, the object is achieved in that the incubation and storage device is heated and cooled indirectly via a liquid heat transfer medium. The are Boundary surfaces of the interior of the incubation and storage device with from the outside attached heat transfer elements thermally in connection, the heat transfer Carrier elements are in turn flowed through by a liquid heat transfer medium in the circuit. Means for cooling and heating the heat transfer medium are also provided according to the invention.

Durch den Einsatz eines Wärmeträgers ist die erforderliche Temperaturkonstanz vorteilhaft im Inneren der Vorrichtung gut zu erreichen.By using a heat transfer medium, the required temperature stability is advantageous Easy to reach inside the device.

Besonders bei Innenraumtemperaturen nahe der Umgebungstemperatur macht sich die kombinierte indirekte Kühlung und Beheizung vorteilhaft bemerkbar.Eine dynamische Temperaturführung des Innenraums wird über das System, der an einen Wärmeträgerkreislauf gekoppelten Erwärmung und Kühlung, möglich, wodurch eine Temperaturänderung aufgrund veränderter eingebrachter Leistungen vermieden werden kann.The combined is particularly effective at indoor temperatures close to the ambient temperature indirect cooling and heating are noticeable. Dynamic temperature control of the interior is via the system, which is coupled to a heat transfer circuit Heating and cooling, possible, causing a change in temperature due to changes contributions can be avoided.

Weitere Einzelheiten, Merkmale und Vorteile der Erfindung ergeben sich aus der nachfolgenden Beschreibung von Ausführungsbeispielen mit Bezugnahme auf die zugehörige Zeichnung. Es zeigt:

  • Fig. 1: perspektivische Prinzipdarstellung einer Inkubations- und Lagervorrichtung
    • Further details, features and advantages of the invention result from the following description of exemplary embodiments with reference to the associated drawing. It shows:
  • 1: Principle perspective view of an incubation and storage device

    • In Fig.1 ist eine erfindungsgemäße Ausgestaltung einer Inkubations- und Lagervorrichtung perspektivisch dargestellt. Der Innenraum 2 wird durch innere Begrenzungsflächen gebildet, auf denen Wärmeübertragerelemente 3 von außen angeordnet sind.1 shows an embodiment of an incubation and storage device according to the invention shown in perspective. The interior 2 is formed by inner boundary surfaces which heat exchanger elements 3 are arranged from the outside.

    Die Wärmeübertragerelemente 3 stehen thermisch mit den Begrenzungsflächen des Innenraumes 2 in Verbindung oder bilden selbst einen Teil der Begrenzungsflächen.The heat exchanger elements 3 are thermally aligned with the boundary surfaces of the interior 2 in connection or form part of the boundary surfaces themselves.

    Ein flüssiger Wärmeträger durchströmt im Kreislauf die 10 Wärmeübertragerelemente 3 und nimmt dabei, je nach Temperatur, Wärme aus dem Innenraum 2 der Inkubations- und Lagervorrichtung 1 auf oder gibt Wärme an den Innenraum 2 ab. Der flüssige Wärmeträger wird mittels einer Pumpe 11 bevorzugt im Kreislauf gepumpt.A liquid heat transfer medium flows through the 10 heat exchanger elements 3 and takes, depending on the temperature, heat from the interior 2 of the incubation and Storage device 1 or gives off heat to the interior 2. The liquid heat transfer medium will preferably pumped in a circuit by means of a pump 11.

    Die Wärmeübertragerelemente 3 sind gemäß der dargestellt bevorzugten Ausführungsform der Erfindung kastenförmig ausgebildet. Diese kastenförmigen Wärmeübertragerelemente 3 an den Begrenzungsflächen des Innenraumes 2 sind durch Rohrverbindungen 12 miteinander verbun- The heat exchanger elements 3 are according to the preferred embodiment shown in FIG Invention box-shaped. This box-shaped heat exchanger elements 3 to the Boundary surfaces of the interior 2 are connected to one another by pipe connections 12

    Die Wärmeträgerflüssigkeit wird durch einen Wärmeübertrager 9 einer nicht dargestellten Heizung erwärmt oder aber durch den Wärmeübertrager/Verdampfer 7 einer Kälteanlage gekühlt.The heat transfer fluid is through a heat exchanger 9, not shown Heating heated or cooled by the heat exchanger / evaporator 7 of a refrigeration system.

    Die Kälteanlage weist dazu einen Verdichter 4 auf, in welchem das dampfförmige Kältemittel verdichtet wird. Im Kondensator 5, im Ausführungsbeispiel als Luftverflüssiger dargestellt, wird das Kältemittel verflüssigt, im Entspannungsorgan 6 entspannt und gelangt schließlich in den Verdampfer 7, wo es unter Wärmeaufnahme vom Wärmeträger verdampft. Der Kältemitteldampf wird vom Verdichter 4 angesaugt, womit sich der Kältemittelkreislauf schließt.For this purpose, the refrigeration system has a compressor 4, in which the vaporous refrigerant is compressed. This is shown in the condenser 5, in the exemplary embodiment as an air condenser Liquefied refrigerant, relaxed in the expansion element 6 and finally gets into the Evaporator 7, where it evaporates while absorbing heat from the heat transfer medium. The refrigerant vapor is sucked in by the compressor 4, which closes the refrigerant circuit.

    Das Wärmeträgersystem wird alternativ vorteilhaft vervollständigt durch einen Ausgleichsbehälter 10, der die durch Temperaturwechsel verursachten Volumenschwankungen des Wärmeträgers ausgleicht. Die beiden Wärmeübertrager 7, 9 zur Kühlung und Heizung des Wärmeträgers werden gemäß der bevorzugten Ausführungsform in einem Wärmeträgerreservoir 8 angeordnet. Hierdurch ergibt sich für die Regelung des Wärmeträgerkreislaufes eine vorteilhafte Dynamik.The heat transfer system is alternatively advantageously completed by an expansion tank 10, the volume fluctuations of the heat carrier caused by temperature changes balances. The two heat exchangers 7, 9 for cooling and heating the heat transfer medium are arranged in a heat carrier reservoir 8 according to the preferred embodiment. This results in advantageous dynamics for the regulation of the heat transfer circuit.

    Die Wärmeübertragerelemente 3 sind nach einer weiteren Ausführungsform der Erfindung als Rohrschlangen ausgebildet. Diese verlaufen um die 10 Begrenzungsflächen des Innenraumes 2 herum und sind mit diesen thermisch verbunden.The heat exchanger elements 3 are in accordance with a further embodiment of the invention Coiled coils. These run around the 10 boundary surfaces of the interior 2 around and are thermally connected to them.

    Ebenso vorteilhaft ist es, zur Temperierung der Inkubations- und Lagervorrichtung einen externen Thermostaten mit Kühl- und Heizfunktion oder ein internes Heizgerät und optional ein externes Kühlgerät zu verwenden. Dazu sind die externen Komponenten mit den erforderlichen Anschlüssen und einem Behälter für die Aufnahme des Wärmeträgers und einer Pumpe auszustatten. Des Weiteren sind die externen Komponenten mit einer eigenen Temperaturregelung versehen.It is also advantageous to use an external one to temper the incubation and storage device Thermostats with cooling and heating function or an internal heater and optionally an external one To use cooling device. For this, the external components with the required Connections and a container for receiving the heat transfer medium and a pump equip. Furthermore, the external components have their own Provide temperature control.

    Bei einer Inkubations- und Lagervorrichtung mit einer externen Kälteanlage wird das Wärmeträgersystem vorteilhaft als offenes bzw. erweiterbares System ausgeführt. Somit können Kältekapazitätsreserven der Kälteanlage über vorzusehende Anschlüsse beim Wärmeträgersystem für andere Anwendungen genutzt werden. In the case of an incubation and storage device with an external refrigeration system, this becomes Heat transfer system advantageously designed as an open or expandable system. So you can Cooling capacity reserves of the refrigeration system via connections to be provided in the heat transfer system can be used for other applications.

    Um die Kondensatbildung von Luftfeuchtigkeit an Sichtfenstern der Inkubations- und Lagervorrichtung zu verhindern, werden die transparenten Flächen, wie beispielsweise Glasscheiben, beheizbar ausgeführt.In order to prevent the formation of condensate from air humidity on viewing windows of the incubation and To prevent storage device, the transparent surfaces, such as Glass panes, heatable.

    Die Erwärmung des Wärmeträgers der Inkubations- und Lagervorrichtung wird vorteilhaft durch eine Widerstandsheizung vorgenommen.
    Als Kältemittel der Kälteanlage kommt bevorzugt R134a, Propan, Butan oder Kohlendioxid zum Einsatz.    The heating medium of the incubation and storage device is advantageously heated by resistance heating.
    R134a, propane, butane or carbon dioxide is preferably used as the refrigerant for the refrigeration system.

    Ein Gemisch aus Wasser und Glykol wird bevorzugt als Wärmeträger für die erfindungsgemäße Inkubations- und Lagervorrichtung eingesetzt. A mixture of water and glycol is preferred as a heat transfer medium for the invention Incubation and storage device used.

    LISTE DER BEZUGSZEICHENLIST OF REFERENCES

    11
    Inkubations- und LagervorrichtungIncubation and storage device
    22
    Innenrauminner space
    33
    Wärmeübertragerelementheat transfer element
    44
    Verdichtercompressor
    55
    Kondensatorcapacitor
    66
    Entspannungsorganexpansion element
    77
    Wärmeübertrager/VerdampferThe heat exchanger / evaporator
    88th
    WärmeträgerreservoireHeat transfer reservoirs
    99
    Wärmeübertrager HeizungHeat exchanger heating
    1010
    Ausgleichsbehälter WärmeträgersystemExpansion tank heat transfer system
    1111
    Pumpepump
    1212
    Rohrverbindungpipe connection

    Claims (8)

    Inkubations- und Lagervorrichtung, insbesondere für Proben aus organischem Material, dadurch gekennzeichnet, dass die Begrenzungsflächen des Innenraumes (2) der Inkubations- und Lagervorrichtung (1) mit von außen angebrachten Wärmeübertragerelementen (3) thermisch in Verbindung stehen und dass die Wärmeübertragerelemente (3) von einem flüssigen Wärmeträger im Kreislauf durchströmt werden, wobei Mittel zur Kühlung und Erwärmung des Wärmeträgers vorgesehen sind und dass die Temperierung des Innenraumes (2) indirekt über den flüssigen Wärmeträger erfolgt.Incubation and storage device, in particular for samples made of organic material, characterized in that the boundary surfaces of the interior (2) of the incubation and storage device (1) are thermally connected to heat transfer elements (3) attached from the outside and that the heat transfer elements (3) are flowed through by a liquid heat transfer medium in the circuit, wherein means for cooling and heating the heat transfer medium are provided and that the temperature of the interior (2) is carried out indirectly via the liquid heat transfer medium. Inkubations- und Lagervorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass die Wärmeübertragerelemente (3) kastenförmig ausgebildet sind.Incubation and storage device according to claim 1, characterized in that the heat exchanger elements (3) are box-shaped. Inkubations- und Lagervorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass die Wärmeübertragerelemente (3) als Rohrschlangen ausgebildet sind.Incubation and storage device according to claim 1, characterized in that the heat exchanger elements (3) are designed as coils. Inkubations- und Lagervorrichtung nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, dass für den Kreislauf des Wärmeträgers die Wärmeübertragerelemente (3) und eine Pumpe (11 ) durch Rohrverbindungen (12) miteinander verbunden sind und dass weiterhin ein Wärmeübertrager (9) für die Erwärmung und ein Wärmeübertrager/Verdampfer (7) für die Kühlung des Wärmeträgers vorgesehen sind.Incubation and storage device according to one of claims 1 to 3, characterized in that for the circuit of the heat transfer medium, the heat transfer elements (3) and a pump (11) are connected to one another by pipe connections (12), and in that a heat transfer unit (9) for the Heating and a heat exchanger / evaporator (7) are provided for cooling the heat transfer medium. Inkubations- und Lagervorrichtung nach einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, dass im Kreislauf für den Wärmeträger ein Wärmeträgerreservoire (8) vorgesehen ist und dass der Wärmeübertrager (9) und der Verdampfer (7) im Wärmeträgerreservoire (8) angeordnet sind. Incubation and storage device according to one of claims 1 to 4, characterized in that a heat transfer reservoir (8) is provided in the circuit for the heat transfer medium and that the heat exchanger (9) and the evaporator (7) are arranged in the heat transfer medium reservoir (8). Inkubations- und Lagervorrichtung nach einem der Ansprüche 1 bis 5, dadurch gekennzeichnet,dass im Kreislauf für den Wärmeträger ein Ausgleichsbehälter (10) vorgesehen ist.Incubation and storage device according to one of claims 1 to 5, characterized in that an expansion tank (10) is provided in the circuit for the heat transfer medium. Inkubations- und Lagervorrichtung nach einem der Ansprüche 1 bis 6, dadurch gekennzeichnet, dass zur Erwärmung des Wärmeträgers eine Widerstandsheizung vorgesehen ist.Incubation and storage device according to one of claims 1 to 6, characterized in that a resistance heater is provided for heating the heat carrier. Inkubations- und Lagervorrichtung nach einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, dass zur Kühlung des Wärmeträgers ein Kältemittelkreislauf vorgesehen ist.Incubation and storage device according to one of claims 1 to 7, characterized in that a refrigerant circuit is provided for cooling the heat carrier.
    EP02021917A 2001-11-01 2002-09-27 Apparatus for the incubation and storage especially for samples of organic material Expired - Lifetime EP1308504B1 (en)

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    DE10154663 2001-11-01
    DE10154663A DE10154663B4 (en) 2001-11-01 2001-11-01 Incubation and storage device, in particular for samples made of organic material

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    EP1308504B1 EP1308504B1 (en) 2007-01-17

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    EP (1) EP1308504B1 (en)
    JP (1) JP2003144135A (en)
    AT (1) ATE351899T1 (en)
    CA (1) CA2410068A1 (en)
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    CN109089951A (en) * 2018-08-10 2018-12-28 四川大仁新创科技有限公司 A kind of air convection incubator
    US20210222111A1 (en) * 2020-01-20 2021-07-22 Exxonmobil Research And Engineering Company Bioreactor waste heat utilization

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    Also Published As

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    CA2410068A1 (en) 2003-05-01
    US7152664B2 (en) 2006-12-26
    EP1308504B1 (en) 2007-01-17
    DE50209276D1 (en) 2007-03-08
    DE10154663B4 (en) 2004-02-05
    US20030085218A1 (en) 2003-05-08
    DE10154663A1 (en) 2003-05-15
    JP2003144135A (en) 2003-05-20
    ATE351899T1 (en) 2007-02-15

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