EP1276713A4 - Inhibition of angiogenesis and tumor growth - Google Patents

Inhibition of angiogenesis and tumor growth

Info

Publication number
EP1276713A4
EP1276713A4 EP01924359A EP01924359A EP1276713A4 EP 1276713 A4 EP1276713 A4 EP 1276713A4 EP 01924359 A EP01924359 A EP 01924359A EP 01924359 A EP01924359 A EP 01924359A EP 1276713 A4 EP1276713 A4 EP 1276713A4
Authority
EP
European Patent Office
Prior art keywords
angiogenesis
inhibition
tumor growth
tumor
growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP01924359A
Other languages
German (de)
French (fr)
Other versions
EP1276713A1 (en
Inventor
Dale L Boger
David A Cheresh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of EP1276713A1 publication Critical patent/EP1276713A1/en
Publication of EP1276713A4 publication Critical patent/EP1276713A4/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP01924359A 2000-03-27 2001-03-27 Inhibition of angiogenesis and tumor growth Ceased EP1276713A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19226000P 2000-03-27 2000-03-27
US192260P 2000-03-27
PCT/US2001/009756 WO2001072699A1 (en) 2000-03-27 2001-03-27 Inhibition of angiogenesis and tumor growth

Publications (2)

Publication Number Publication Date
EP1276713A1 EP1276713A1 (en) 2003-01-22
EP1276713A4 true EP1276713A4 (en) 2006-05-03

Family

ID=22708924

Family Applications (2)

Application Number Title Priority Date Filing Date
EP01924359A Ceased EP1276713A4 (en) 2000-03-27 2001-03-27 Inhibition of angiogenesis and tumor growth
EP01922734A Withdrawn EP1272173A4 (en) 2000-03-27 2001-03-27 Methods for inhibiting angiogenesis and tumor growth

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP01922734A Withdrawn EP1272173A4 (en) 2000-03-27 2001-03-27 Methods for inhibiting angiogenesis and tumor growth

Country Status (15)

Country Link
EP (2) EP1276713A4 (en)
JP (2) JP2003528140A (en)
KR (2) KR100776185B1 (en)
CN (2) CN1245967C (en)
AU (4) AU5101801A (en)
CA (3) CA2403630C (en)
CZ (2) CZ20023509A3 (en)
HU (2) HUP0301797A3 (en)
MX (2) MXPA02009510A (en)
NO (2) NO328969B1 (en)
PL (2) PL358272A1 (en)
RU (2) RU2276133C2 (en)
SK (2) SK14842002A3 (en)
WO (2) WO2001072297A1 (en)
ZA (2) ZA200208628B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1870980B (en) 2003-10-23 2010-06-23 大冢制药株式会社 Controlled release sterile injectable aripiprazole formulation and method
BRPI0815382A2 (en) 2007-07-31 2015-02-10 Otsuka Pharma Co Ltd METHODS FOR PRODUCING ARIPIPRAZOL SUSPENSION AND FREEZING DRY FORMULATION

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511504A (en) * 1983-04-26 1985-04-16 G.D. Searle & Co. Carboxyalkyl peptide derivatives
WO1994025435A1 (en) * 1993-04-27 1994-11-10 Celltech Limited Peptidyl derivatives and their use as metalloproteinase inhibitors
WO1998035231A1 (en) * 1997-02-07 1998-08-13 The Scripps Research Institute Convergent synthesis of combinatorial library

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05125029A (en) 1991-11-06 1993-05-21 Yamanouchi Pharmaceut Co Ltd New amide compound or its salt
GB9405076D0 (en) * 1994-03-16 1994-04-27 Inst Of Ophtalmology A medical use of matrix metalloproteinase inhibitors
AUPO104496A0 (en) * 1996-07-17 1996-08-08 Biomolecular Research Institute Limited Angiogenic inhibitory compounds
JP2002514180A (en) * 1996-09-04 2002-05-14 ワーナー―ランバート・コンパニー Compounds for inhibiting matrix metalloproteinases and methods thereof
IL138297A0 (en) * 1998-03-27 2001-10-31 Genentech Inc Antagonists for treatment of cd11/cd18 adhesion receptor mediated disorders

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511504A (en) * 1983-04-26 1985-04-16 G.D. Searle & Co. Carboxyalkyl peptide derivatives
WO1994025435A1 (en) * 1993-04-27 1994-11-10 Celltech Limited Peptidyl derivatives and their use as metalloproteinase inhibitors
WO1998035231A1 (en) * 1997-02-07 1998-08-13 The Scripps Research Institute Convergent synthesis of combinatorial library

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BOGER D L ET AL: "Higher order iminodiacetic acid libraries for probing protein-protein interactions.", BIOORGANIC & MEDICINAL CHEMISTRY. AUG 1998, vol. 6, no. 8, August 1998 (1998-08-01), pages 1347 - 1378, XP002369171, ISSN: 0968-0896 *
BOGER D L ET AL: "Identification of a novel class of small-molecule antiangiogenic agents through the screening of combinatorial libraries which function by inhibiting the binding and localization of proteinase MMP2 to integrin.alpha.V.beta.3", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 123, no. 7, 2001, pages 1280 - 1288, XP002215423, ISSN: 0002-7863 *
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002369179, retrieved from STN accession no. 1998:550559 Database accession no. 129:189127 *
See also references of WO0172699A1 *
SILLETTI S ET AL: "DISRUPTION OF MATRIX METALLOPROTEINASE 2 BINDING TO INTEGRIN ALPHAVBETA3 BY AN ORGANIC MOLECULE INHIBITS ANGIOGENESIS AND TUMOR GROWTH IN VIVO", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 98, no. 1, 2 January 2001 (2001-01-02), pages 119 - 124, XP001115022, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
EP1272173A1 (en) 2003-01-08
CA2403630C (en) 2009-05-26
RU2269339C2 (en) 2006-02-10
AU2001249499B2 (en) 2005-04-21
AU2001251018B2 (en) 2005-12-01
HUP0301621A3 (en) 2009-06-29
NO20024576D0 (en) 2002-09-24
EP1272173A4 (en) 2006-05-03
CZ20023510A3 (en) 2003-03-12
CN1429106A (en) 2003-07-09
PL205134B1 (en) 2010-03-31
PL358272A1 (en) 2004-08-09
SK14842002A3 (en) 2003-04-01
NO20024576L (en) 2002-11-20
CA2403630A1 (en) 2001-10-04
JP2003528850A (en) 2003-09-30
RU2276133C2 (en) 2006-05-10
SK14852002A3 (en) 2003-06-03
WO2001072699A1 (en) 2001-10-04
MXPA02009504A (en) 2003-05-21
CN1441777A (en) 2003-09-10
KR20020084258A (en) 2002-11-04
NO328969B1 (en) 2010-06-28
CA2403871A1 (en) 2001-10-04
JP2003528140A (en) 2003-09-24
MXPA02009510A (en) 2003-05-21
ZA200208626B (en) 2004-02-16
CA2403871C (en) 2010-05-11
PL366316A1 (en) 2005-01-24
HUP0301797A2 (en) 2003-09-29
ZA200208628B (en) 2004-02-12
CZ20023509A3 (en) 2003-06-18
RU2002128751A (en) 2004-03-10
CN1229339C (en) 2005-11-30
HUP0301621A2 (en) 2003-09-29
CN1245967C (en) 2006-03-22
HUP0301797A3 (en) 2010-09-28
KR20020091156A (en) 2002-12-05
NO20024578L (en) 2002-11-20
KR100776185B1 (en) 2007-11-16
WO2001072297A1 (en) 2001-10-04
NO20024578D0 (en) 2002-09-24
CA2659030A1 (en) 2001-10-04
AU4949901A (en) 2001-10-08
EP1276713A1 (en) 2003-01-22
AU5101801A (en) 2001-10-08
KR100767616B1 (en) 2007-10-18

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