EP1268439A1 - 5-hydroxy indazole derivatives for treating glaucoma - Google Patents

5-hydroxy indazole derivatives for treating glaucoma

Info

Publication number
EP1268439A1
EP1268439A1 EP00982109A EP00982109A EP1268439A1 EP 1268439 A1 EP1268439 A1 EP 1268439A1 EP 00982109 A EP00982109 A EP 00982109A EP 00982109 A EP00982109 A EP 00982109A EP 1268439 A1 EP1268439 A1 EP 1268439A1
Authority
EP
European Patent Office
Prior art keywords
alkyl
hydrogen
indazol
halogen
aminopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00982109A
Other languages
German (de)
English (en)
French (fr)
Inventor
Jesse A. May
Zixia Feng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon Inc
Alcon Universal Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc, Alcon Universal Ltd filed Critical Alcon Inc
Publication of EP1268439A1 publication Critical patent/EP1268439A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
EP00982109A 2000-03-17 2000-11-14 5-hydroxy indazole derivatives for treating glaucoma Withdrawn EP1268439A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19028300P 2000-03-17 2000-03-17
US190283P 2000-03-17
PCT/US2000/031143 WO2001070701A1 (en) 2000-03-17 2000-11-14 5-hydroxy indazole derivatives for treating glaucoma

Publications (1)

Publication Number Publication Date
EP1268439A1 true EP1268439A1 (en) 2003-01-02

Family

ID=22700701

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00982109A Withdrawn EP1268439A1 (en) 2000-03-17 2000-11-14 5-hydroxy indazole derivatives for treating glaucoma

Country Status (12)

Country Link
EP (1) EP1268439A1 (pt)
JP (1) JP2003535821A (pt)
KR (1) KR20030095183A (pt)
CN (1) CN1450995A (pt)
AR (1) AR026708A1 (pt)
AU (2) AU1918001A (pt)
BR (1) BR0017163A (pt)
CA (1) CA2401959A1 (pt)
MX (1) MXPA02008825A (pt)
PL (1) PL365422A1 (pt)
WO (1) WO2001070701A1 (pt)
ZA (1) ZA200206853B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
EP1392292B1 (en) 2001-06-01 2006-03-01 Alcon, Inc. Pyranoindazoles and their use for the treatment of glaucoma
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
US7528163B2 (en) 2002-11-08 2009-05-05 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
CN100384827C (zh) * 2002-11-08 2008-04-30 默克公司 用于治疗高眼压症的眼用组合物
US7196082B2 (en) 2002-11-08 2007-03-27 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
WO2004054572A2 (en) 2002-12-13 2004-07-01 Alcon, Inc. Novel benzopyran analogs and their use for the treatment of glaucoma
JP2004262812A (ja) * 2003-02-28 2004-09-24 Rohto Pharmaceut Co Ltd 眼圧低下剤
JP2007504236A (ja) * 2003-09-04 2007-03-01 メルク　エンド　カムパニー　インコーポレーテッド 高眼圧症を治療するための眼用組成物
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
TW200520760A (en) 2003-12-15 2005-07-01 Alcon Inc Substituted [1,4] oxazino [2,3-g] indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
JP4130219B2 (ja) 2004-11-29 2008-08-06 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 治療用のピラゾロ［３，４−ｂ］ピリジンおよびインダゾール
US7425572B2 (en) 2004-12-08 2008-09-16 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
KR100972921B1 (ko) * 2009-12-02 2010-07-28 제이케이이앤씨 주식회사 회전 격판식 선회류 세정 및 탈취장치

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
BR9910590A (pt) * 1998-05-19 2001-01-23 Alcon Lab Inc Composto, processo para diminuir iop, para melhorar o fluxo sanguìneo para a extremidade do nervo óptico e a retina, e para tratar doenças retinais, composições para diminuir iop, para melhorar o fluxo sanguìneo para a extremidade do nervo óptico e a retina, e para tratar doenças retinais, processo e composição para prover neuroproteção para a extremidade do nervo óptico ou a retina, e, processo para tratar pessoas sofrendo de distúrbios do sono, depressão, esquizofrenia, ansiedade, distúrbios rìtmicos circadianos e hipertensão centralmente e perifericamente mediada
GB9819020D0 (en) * 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds III
WO2000016761A2 (en) * 1998-09-18 2000-03-30 Alcon Laboratories, Inc. Serotonergic 5ht2 agonists for treating glaucoma

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0170701A1 *

Also Published As

Publication number Publication date
MXPA02008825A (es) 2004-10-15
CA2401959A1 (en) 2001-09-27
ZA200206853B (en) 2004-11-02
WO2001070701A1 (en) 2001-09-27
PL365422A1 (en) 2005-01-10
BR0017163A (pt) 2003-01-14
AR026708A1 (es) 2003-02-26
AU1918001A (en) 2001-10-03
KR20030095183A (ko) 2003-12-18
JP2003535821A (ja) 2003-12-02
AU2001219180B2 (en) 2005-04-07
CN1450995A (zh) 2003-10-22

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