EP1242080A4 - Dopamine transporter inhibitors and their use - Google Patents
Dopamine transporter inhibitors and their useInfo
- Publication number
- EP1242080A4 EP1242080A4 EP00968417A EP00968417A EP1242080A4 EP 1242080 A4 EP1242080 A4 EP 1242080A4 EP 00968417 A EP00968417 A EP 00968417A EP 00968417 A EP00968417 A EP 00968417A EP 1242080 A4 EP1242080 A4 EP 1242080A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- dopamine transporter
- transporter inhibitors
- inhibitors
- dopamine
- transporter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15579799P | 1999-09-27 | 1999-09-27 | |
US155797P | 1999-09-27 | ||
US22658100P | 2000-08-21 | 2000-08-21 | |
US226581P | 2000-08-21 | ||
PCT/US2000/026447 WO2001022964A1 (en) | 1999-09-27 | 2000-09-27 | Dopamine transporter inhibitors and their use |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1242080A1 EP1242080A1 (en) | 2002-09-25 |
EP1242080A4 true EP1242080A4 (en) | 2003-01-22 |
Family
ID=26852613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00968417A Withdrawn EP1242080A4 (en) | 1999-09-27 | 2000-09-27 | Dopamine transporter inhibitors and their use |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1242080A4 (en) |
CA (1) | CA2389049A1 (en) |
WO (1) | WO2001022964A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
EP1465869B1 (en) | 2001-12-21 | 2013-05-15 | Exelixis Patent Company LLC | Modulators of lxr |
PL2354124T3 (en) * | 2006-12-19 | 2013-07-31 | Hoffmann La Roche | Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives |
WO2009153178A2 (en) * | 2008-06-18 | 2009-12-23 | F. Hoffmann-La Roche Ag | Aryl ketone as mri |
CN107406414B (en) * | 2015-01-09 | 2022-04-19 | 基因泰克公司 | (piperidin-3-yl) (naphthalen-2-yl) methanone derivatives as inhibitors of histone demethylase KDM2B for the treatment of cancer |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998037078A1 (en) * | 1997-02-20 | 1998-08-27 | Novo Nordisk A/S | Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2489669A (en) * | 1947-01-11 | 1949-11-29 | Hoffamnn La Roche Inc | Preparation of 1-alkyl-3-benzoyl-4-hydroxy-4-phenyl-piperidines |
FR1552758A (en) * | 1963-07-01 | 1969-01-10 | ||
NL124853C (en) * | 1963-07-19 | |||
US3317548A (en) * | 1964-10-30 | 1967-05-02 | Rexall Drug Chemical | 1-allyl-3-(substituted benzoyl)-4-(substituted phenyl)-4-hydroxypiperidines |
US3408445A (en) * | 1967-04-10 | 1968-10-29 | Rexall Drug Chemical | Treatment of inflammation with 1-methyl - 3 - benzoyl - 4 - hydroxy - 4-phenylpiperidine and halo derivatives thereof |
DE1670583A1 (en) * | 1967-11-02 | 1971-02-25 | Degussa | New piperidine derivatives |
US3887568A (en) * | 1973-07-12 | 1975-06-03 | Riker Laboratories Inc | Process for piperidine derivatives |
US3965104A (en) * | 1975-06-16 | 1976-06-22 | G. D. Searle & Co. | 1-(Substituted-aminoalkyl)-3-benzoyl-4-hydroxy-4-phenylpiperidines and related compounds |
US5512584A (en) * | 1991-04-16 | 1996-04-30 | Basf Aktiengesellschaft | 1,3,4-trisubstituted piperidine derivatives, the preparation and use thereof |
US6017933A (en) * | 1998-01-30 | 2000-01-25 | University Of Saskatchewan Technologies Inc. | Mannich bases of conjugated styryl ketones |
-
2000
- 2000-09-27 CA CA002389049A patent/CA2389049A1/en not_active Abandoned
- 2000-09-27 EP EP00968417A patent/EP1242080A4/en not_active Withdrawn
- 2000-09-27 WO PCT/US2000/026447 patent/WO2001022964A1/en not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998037078A1 (en) * | 1997-02-20 | 1998-08-27 | Novo Nordisk A/S | Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes |
Non-Patent Citations (5)
Title |
---|
CASY, A.F. ET AL: "Phenindamine and its Analogues and Precursors: NMR Evidence of Structure and Configuration", MAGN. RESON. CHEM., vol. 30, no. 7, 1992, pages 621 - 625, XP009000566 * |
DIMMOCK, J.R. ET AL: "4-(beta-Arylvinyl)-3-(beta-arylvinylketo)-1-ethyl-4-piperidinols ans Related Compounds: A Novel Class of Cytotoxic and Anticancer Agents", J. MED. CHEM., vol. 41, 1998, pages 4012 - 4020, XP002221590 * |
GARCIA-MARCH, F.J. ET AL: "Pharmacological Sudies of 1-(p-Chlorophenyl)propanol and 2-(1-Hydroxy-3-butenyl)phenol: Two New Non-narcotic Analgesics Designed by Molecular Connectivity", J. PHARM. PHARMACOL., vol. 49, 1997, pages 10 - 15, XP009000642 * |
See also references of WO0122964A1 * |
STENLAKE, J.B. ET AL: "Synthesis and preliminary study of some ring-substituted arylpropanonamines and their quaternary salts", EUR. J. MED. CHEM., vol. 24, 1989, pages 591 - 597, XP009000568 * |
Also Published As
Publication number | Publication date |
---|---|
EP1242080A1 (en) | 2002-09-25 |
CA2389049A1 (en) | 2001-04-05 |
WO2001022964A1 (en) | 2001-04-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20020426 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7A 61K 31/436 A, 7A 61K 31/451 B, 7C 07D 211/52 B, 7C 07D 491/056 B, 7A 61P 25/16 B, 7A 61P 25/24 B, 7A 61P 25/30 B |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20021209 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
17Q | First examination report despatched |
Effective date: 20041119 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20050330 |