EP1237570A4 - Fragments et antagonistes de proteines de choc thermique 60 - Google Patents
Fragments et antagonistes de proteines de choc thermique 60Info
- Publication number
- EP1237570A4 EP1237570A4 EP00981586A EP00981586A EP1237570A4 EP 1237570 A4 EP1237570 A4 EP 1237570A4 EP 00981586 A EP00981586 A EP 00981586A EP 00981586 A EP00981586 A EP 00981586A EP 1237570 A4 EP1237570 A4 EP 1237570A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- antagonists
- fragments
- heat shock
- shock protein
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Vascular Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00981586A EP1237570A4 (fr) | 1999-12-15 | 2000-12-14 | Fragments et antagonistes de proteines de choc thermique 60 |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17229799P | 1999-12-15 | 1999-12-15 | |
EP99125035 | 1999-12-15 | ||
US172297P | 1999-12-15 | ||
EP99125035 | 1999-12-15 | ||
EP00981586A EP1237570A4 (fr) | 1999-12-15 | 2000-12-14 | Fragments et antagonistes de proteines de choc thermique 60 |
PCT/IL2000/000833 WO2001043691A2 (fr) | 1999-12-15 | 2000-12-14 | Fragments et antagonistes de proteines de choc thermique 60 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1237570A2 EP1237570A2 (fr) | 2002-09-11 |
EP1237570A4 true EP1237570A4 (fr) | 2005-01-05 |
Family
ID=32842929
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00981586A Withdrawn EP1237570A4 (fr) | 1999-12-15 | 2000-12-14 | Fragments et antagonistes de proteines de choc thermique 60 |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1237570A4 (fr) |
JP (1) | JP2004501061A (fr) |
AU (1) | AU784623B2 (fr) |
CA (1) | CA2394504A1 (fr) |
NZ (1) | NZ519348A (fr) |
WO (1) | WO2001043691A2 (fr) |
ZA (1) | ZA200204635B (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL140233A0 (en) * | 2000-12-11 | 2002-02-10 | Peptor Ltd | Backbone cyclized analogs of heat shock proteins |
US7727974B2 (en) | 2001-08-10 | 2010-06-01 | Eisai R & D Management Co., Ltd. | Methods of reducing the severity of mucositis |
US20040254128A1 (en) * | 2001-08-10 | 2004-12-16 | Seiichi Kobayashi | Treatment and prevention of heat shock protein-associated diseases and conditions |
US20030077279A1 (en) * | 2001-10-24 | 2003-04-24 | Cedars-Sinai Medical Center | Methods for treating vascular disease by inhibiting toll-like receptor-4 |
EP2157101B1 (fr) | 2002-01-31 | 2014-09-24 | Andromeda Bio Tech Ltd. | Peptides HSP et analogues pour la modulation de réponses immunes via des cellules présentant l'antigène |
WO2003070761A1 (fr) * | 2002-02-19 | 2003-08-28 | Yeda Research And Development Co. Ltd. | Ligands a double effet comprenant des epitopes de peptides hsp anti-inflammatoires pour l'immunomodulation |
WO2005040208A2 (fr) * | 2003-10-21 | 2005-05-06 | Androclus Therapeutics, Soa | Molecules pour moduler l'activite des recepteurs de type toll et procedes d'utilisation associes |
EP1758924B1 (fr) * | 2004-06-01 | 2008-12-31 | Council of Scientific and Industrial Research | Antagonistes peptidiques permettant d'inhiber la proteine de choc thermique (hsp 16.3) du bacille de koch |
CU23504A1 (es) * | 2004-09-24 | 2010-04-13 | Ct Ingenieria Genetica Biotech | Péptidos y derivados tipo apl de la hsp60 y composiciones farmacéuticas |
WO2006072946A2 (fr) | 2005-01-04 | 2006-07-13 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Hsp60, peptides hsp60 et vaccins a base de lymphocytes t pour immunomodulation |
JP4283812B2 (ja) * | 2006-01-06 | 2009-06-24 | 財団法人工業技術研究院 | 重症筋無力症の診断方法およびそのキット |
EP2170361B1 (fr) | 2007-07-06 | 2016-05-25 | Universiteit Utrecht Holding B.V. | Traitement et prévention de maladies inflammatoires et de maladies auto-immunes |
US9512196B2 (en) | 2008-09-22 | 2016-12-06 | Cedars-Sinai Medical Center | Short-form human MD-2 as a negative regulator of toll-like receptor 4 signaling |
EP2328911A4 (fr) | 2008-09-22 | 2012-03-14 | Cedars Sinai Medical Center | Md-2 humaine sous sa forme courte utilisée comme régulateur négatif de la signalisation par le récepteur de type toll-4 |
CU23701A1 (es) | 2008-12-29 | 2011-09-21 | Ct Ingenieria Genetica Biotech | Método de tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998004583A1 (fr) * | 1996-07-31 | 1998-02-05 | Peptor Ltd. | Analogues de la somatostatine cyclises par squelette a contrainte de conformation |
WO1998008536A2 (fr) * | 1996-08-30 | 1998-03-05 | Yeda Research And Development Co. Ltd. | Methode de reduction de la gravite d'une reaction de l'hote contre le greffon par regulation negative de l'autoimmunite vis-a-vis de hsp60 |
WO2000020019A2 (fr) * | 1998-10-04 | 2000-04-13 | Yehuda Shoenfeld | Composition destinee a la prevention et/ou au traitement de l'atherosclerose |
WO2002048312A2 (fr) * | 2000-12-11 | 2002-06-20 | Peptor Ltd. | Inhibiteurs a squelette cyclise de proteines de choc thermique |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5958416A (en) * | 1994-12-16 | 1999-09-28 | Regents Of The University Of Minnesota | Heat shock protein peptides and methods for modulating autoimmune central nervous system disease |
IL114407A0 (en) * | 1995-06-30 | 1995-10-31 | Yeda Res & Dev | Novel peptides and pharmaceutical compositions comprising them |
US5985270A (en) * | 1995-09-13 | 1999-11-16 | Fordham University | Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes |
-
2000
- 2000-12-14 CA CA002394504A patent/CA2394504A1/fr not_active Abandoned
- 2000-12-14 AU AU18816/01A patent/AU784623B2/en not_active Ceased
- 2000-12-14 WO PCT/IL2000/000833 patent/WO2001043691A2/fr not_active Application Discontinuation
- 2000-12-14 EP EP00981586A patent/EP1237570A4/fr not_active Withdrawn
- 2000-12-14 JP JP2001544632A patent/JP2004501061A/ja active Pending
- 2000-12-14 NZ NZ519348A patent/NZ519348A/en unknown
-
2002
- 2002-06-10 ZA ZA200204635A patent/ZA200204635B/xx unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998004583A1 (fr) * | 1996-07-31 | 1998-02-05 | Peptor Ltd. | Analogues de la somatostatine cyclises par squelette a contrainte de conformation |
WO1998008536A2 (fr) * | 1996-08-30 | 1998-03-05 | Yeda Research And Development Co. Ltd. | Methode de reduction de la gravite d'une reaction de l'hote contre le greffon par regulation negative de l'autoimmunite vis-a-vis de hsp60 |
WO2000020019A2 (fr) * | 1998-10-04 | 2000-04-13 | Yehuda Shoenfeld | Composition destinee a la prevention et/ou au traitement de l'atherosclerose |
WO2002048312A2 (fr) * | 2000-12-11 | 2002-06-20 | Peptor Ltd. | Inhibiteurs a squelette cyclise de proteines de choc thermique |
Non-Patent Citations (8)
Title |
---|
ABULAFIA-LAPID R ET AL: "T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides", JOURNAL OF AUTOIMMUNITY, LONDON, GB, vol. 12, no. 2, March 1999 (1999-03-01), pages 121 - 129, XP002246459, ISSN: 0896-8411 * |
BIRK OHAD S ET AL: "A role of Hsp60 in autoimmune diabetes: Analysis in a transgenic model", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 93, no. 3, 1996, pages 1032 - 1037, XP002291768, ISSN: 0027-8424 * |
BOCKOVA J ET AL: "TREATMENT OF NOD DIABETES WITH A NOVEL PEPTIDE OF THE HSP 60 MOLECULE INDUCES TH2-TYPE ANTIBODIES", JOURNAL OF AUTOIMMUNITY, LONDON, GB, vol. 10, no. 4, August 1997 (1997-08-01), pages 323 - 329, XP000881733, ISSN: 0896-8411 * |
CHEN W ET AL: "Human 60-kDa heat-shock protein: a danger signal to the innate immune system.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 MAR 1999, vol. 162, no. 6, 15 March 1999 (1999-03-15), pages 3212 - 3219, XP002291767, ISSN: 0022-1767 * |
KOLB H ET AL: "HEAT SHOCK PROTEINS SIGNAL THROUGH THE LPS RECEPTOR TLR4", JOURNAL OF ENDOTOXIN RESEARCH, CHURCHILL LIVINGSTONE, EDINBURGH, GB, vol. 6, no. 2, 2000, pages 89,ANS49, XP001076880, ISSN: 0968-0519 * |
MEDZHITOV R ET AL: "A HUMAN HOMOLOGUE OF THE DROSOPHILA TOLL PROTEIN SIGNALS ACTIVATIONOF ADAPTIVE IMMUNITY", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 388, 24 July 1997 (1997-07-24), pages 394 - 396, XP002056592, ISSN: 0028-0836 * |
See also references of WO0143691A3 * |
VABULAS R M ET AL: "HEAT SHOCK PROTEINS AS LIGANDS OF TOLL-LIKE RECEPTORS", CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, SPRINGER, BERLIN,, DE, vol. 270, 2002, pages 169 - 184, XP008017649, ISSN: 0070-217X * |
Also Published As
Publication number | Publication date |
---|---|
CA2394504A1 (fr) | 2001-06-21 |
EP1237570A2 (fr) | 2002-09-11 |
WO2001043691A3 (fr) | 2002-01-10 |
AU784623B2 (en) | 2006-05-18 |
AU1881601A (en) | 2001-06-25 |
NZ519348A (en) | 2006-04-28 |
ZA200204635B (en) | 2004-05-26 |
WO2001043691A2 (fr) | 2001-06-21 |
JP2004501061A (ja) | 2004-01-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20020611 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
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AX | Request for extension of the european patent |
Free format text: AL;LT;LV;MK;RO;SI |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20041122 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: DEVELOGEN ISRAEL LTD |
|
17Q | First examination report despatched |
Effective date: 20050929 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20061123 |