EP1224265A4 - Novel human potassium channel subunit - Google Patents

Novel human potassium channel subunit

Info

Publication number
EP1224265A4
EP1224265A4 EP00968933A EP00968933A EP1224265A4 EP 1224265 A4 EP1224265 A4 EP 1224265A4 EP 00968933 A EP00968933 A EP 00968933A EP 00968933 A EP00968933 A EP 00968933A EP 1224265 A4 EP1224265 A4 EP 1224265A4
Authority
EP
European Patent Office
Prior art keywords
potassium channel
novel human
channel subunit
human potassium
subunit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00968933A
Other languages
German (de)
French (fr)
Other versions
EP1224265A1 (en
Inventor
Richard J Swanson
Yuan Liu
Kimberly Folander
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1224265A1 publication Critical patent/EP1224265A1/en
Publication of EP1224265A4 publication Critical patent/EP1224265A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP00968933A 1999-10-12 2000-10-10 Novel human potassium channel subunit Withdrawn EP1224265A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15878199P 1999-10-12 1999-10-12
US158781P 1999-10-12
PCT/US2000/028014 WO2001027246A1 (en) 1999-10-12 2000-10-10 Novel human potassium channel subunit

Publications (2)

Publication Number Publication Date
EP1224265A1 EP1224265A1 (en) 2002-07-24
EP1224265A4 true EP1224265A4 (en) 2004-11-24

Family

ID=22569684

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00968933A Withdrawn EP1224265A4 (en) 1999-10-12 2000-10-10 Novel human potassium channel subunit

Country Status (4)

Country Link
EP (1) EP1224265A4 (en)
JP (1) JP2003511065A (en)
CA (1) CA2387237A1 (en)
WO (1) WO2001027246A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6864364B1 (en) 1999-04-15 2005-03-08 University Of Utah Research Foundation MinK-related genes, formation of potassium channels and association with cardiac arrhythmia
JP4643020B2 (en) * 1999-04-15 2011-03-02 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション Correlation with MinK-related genes, potassium channel formation and cardiac arrhythmia

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063434A1 (en) * 1999-04-15 2000-10-26 University Of Utah Research Foundation MinK-RELATED GENES, FORMATION OF POTASSIUM CHANNELS AND ASSOCIATION WITH CARDIAC ARRHYTHMIA
WO2002022875A2 (en) * 2000-09-11 2002-03-21 Yale University Polymorphisms associated with cardiac arrythmia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063434A1 (en) * 1999-04-15 2000-10-26 University Of Utah Research Foundation MinK-RELATED GENES, FORMATION OF POTASSIUM CHANNELS AND ASSOCIATION WITH CARDIAC ARRHYTHMIA
WO2002022875A2 (en) * 2000-09-11 2002-03-21 Yale University Polymorphisms associated with cardiac arrythmia

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
ABBOTT GEOFFREY W ET AL: "Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism", FASEB JOURNAL, vol. 16, no. 3, March 2002 (2002-03-01), pages 390 - 400, XP002297389, ISSN: 0892-6638 *
DATABASE GENEBANK 13 May 1998 (1998-05-13), "Homo sapiens genomic DNA, chromosome 21q22.1, segment 23/28, complete sequence", XP002297394, retrieved from GENEBANK Database accession no. AP000052 *
DATABASE GENEBANK 29 April 1999 (1999-04-29), ABBOTT, G.W. ET AL.: "Rattus norvegicus minK-related peptide 1 mRNA, complete cds", XP002297393, retrieved from GENEBANK Database accession no. AF071003 *
DATABASE GENEBANK 29 April 1999 (1999-04-29), ABBOTT, G.W.ET AL.: "Homo sapiens minK-related peptide 1 mRNA, complete cds", XP002297392, retrieved from GENEBANK Database accession no. AF071002 *
DATABASE UNIPROT 30 May 2000 (2000-05-30), "Potassium voltage-gated channel subfamily E member 2 (Minimum potassium ion channel-related peptide 1) (Potassium channel beta subunit MiRP1) (MinK-related peptide 1)", XP002297395, retrieved from UNIPROT Database accession no. Q9Y6J6 *
DATABASE UNIPROT 30 May 2000 (2000-05-30), "Potassium voltage-gated channel subfamily E member 2 (Minimum potassium ion channel-related peptide 1) (Potassium channel beta subunit MiRP1) (MinK-related peptide 1)", XP002297396, retrieved from UNIPROT Database accession no. Q9WTW0 *
ISBRANDT DIRK ET AL: "Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics", JOURNAL OF MOLECULAR MEDICINE (BERLIN), vol. 80, no. 8, August 2002 (2002-08-01), pages 524 - 532, XP002297390, ISSN: 0946-2716 *
See also references of WO0127246A1 *
TINEL N ET AL: "M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 480, no. 2-3, 1 September 2000 (2000-09-01), pages 137 - 141, XP004337508, ISSN: 0014-5793 *
TINEL NORBERT ET AL: "KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 19, no. 23, 1 December 2000 (2000-12-01), pages 6326 - 6330, XP002297388, ISSN: 0261-4189 *
YU H ET AL: "MinK-related peptide 1: A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation.", CIRCULATION RESEARCH. 22 JUN 2001, vol. 88, no. 12, 22 June 2001 (2001-06-22), pages E84 - E87, XP002297391, ISSN: 1524-4571 *

Also Published As

Publication number Publication date
JP2003511065A (en) 2003-03-25
CA2387237A1 (en) 2001-04-19
EP1224265A1 (en) 2002-07-24
WO2001027246A1 (en) 2001-04-19

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Legal Events

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