EP1224208A4 - Human inwardly rectifying potassium channel subunit - Google Patents

Human inwardly rectifying potassium channel subunit

Info

Publication number
EP1224208A4
EP1224208A4 EP00968530A EP00968530A EP1224208A4 EP 1224208 A4 EP1224208 A4 EP 1224208A4 EP 00968530 A EP00968530 A EP 00968530A EP 00968530 A EP00968530 A EP 00968530A EP 1224208 A4 EP1224208 A4 EP 1224208A4
Authority
EP
European Patent Office
Prior art keywords
potassium channel
channel subunit
inwardly rectifying
rectifying potassium
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00968530A
Other languages
German (de)
French (fr)
Other versions
EP1224208A1 (en
Inventor
Richard J Swanson
Yuan Liu
Edward Mckenna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1224208A1 publication Critical patent/EP1224208A1/en
Publication of EP1224208A4 publication Critical patent/EP1224208A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP00968530A 1999-10-04 2000-09-29 Human inwardly rectifying potassium channel subunit Withdrawn EP1224208A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15749199P 1999-10-04 1999-10-04
PCT/US2000/026996 WO2001025258A1 (en) 1999-10-04 2000-09-29 Human inwardly rectifying potassium channel subunit
US157491P 2009-03-04

Publications (2)

Publication Number Publication Date
EP1224208A1 EP1224208A1 (en) 2002-07-24
EP1224208A4 true EP1224208A4 (en) 2003-03-05

Family

ID=22563970

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00968530A Withdrawn EP1224208A4 (en) 1999-10-04 2000-09-29 Human inwardly rectifying potassium channel subunit

Country Status (4)

Country Link
EP (1) EP1224208A4 (en)
JP (1) JP2003529332A (en)
CA (1) CA2386236A1 (en)
WO (1) WO2001025258A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020116728A1 (en) * 2000-12-11 2002-08-22 Allen Keith D. Transgenic mice containing Kir5.1 inwardly rectifying potassium channel gene disruptions
WO2011015572A1 (en) * 2009-08-03 2011-02-10 Galapagos Nv Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747278A (en) * 1993-05-21 1998-05-05 California Institute Of Technology DNA encoding inward rectifier, G-protein activated, mammalian, potassium KGA channel and uses thereof
EP1252314A4 (en) * 1998-03-03 2002-10-30 Icagen Inc Identification and expression of human kir5.1

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BOND C T ET AL: "CLONING AND EXPRESSION OF A FAMILY OF INWARD RECTIFIER POTASSIUM CHANNELS", RECEPTORS AND CHANNELS, HARWOOD ACADEMIC PUBLISHERS, CH, vol. 2, no. 3, 1994, pages 183 - 191, XP000615371, ISSN: 1060-6823 *
SALVATORE L ET AL: "Localization and age-dependent expression of the inward rectifier Kchannel subunit Kir 5.1 in a mammalian reproductive system", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 449, no. 2-3, 23 April 1999 (1999-04-23), pages 146 - 152, XP004259549, ISSN: 0014-5793 *
See also references of WO0125258A1 *
TUCKER STEPHEN J ET AL: "pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 22, 2 June 2000 (2000-06-02), pages 16404 - 16407, XP002226038, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
EP1224208A1 (en) 2002-07-24
JP2003529332A (en) 2003-10-07
WO2001025258A1 (en) 2001-04-12
CA2386236A1 (en) 2001-04-12

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20020506

AK Designated contracting states

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Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20030121

STAA Information on the status of an ep patent application or granted ep patent

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18W Application withdrawn

Effective date: 20040422