EP1222268A2 - Proteine vip54 et substances liees a celle-ci - Google Patents

Proteine vip54 et substances liees a celle-ci

Info

Publication number
EP1222268A2
EP1222268A2 EP00969750A EP00969750A EP1222268A2 EP 1222268 A2 EP1222268 A2 EP 1222268A2 EP 00969750 A EP00969750 A EP 00969750A EP 00969750 A EP00969750 A EP 00969750A EP 1222268 A2 EP1222268 A2 EP 1222268A2
Authority
EP
European Patent Office
Prior art keywords
protein
sequence
vip54
expression
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00969750A
Other languages
German (de)
English (en)
Inventor
Marina De Bernard
Cesare Montecucco
Rino Rappuoli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GSK Vaccines SRL
Original Assignee
Chiron SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron SRL filed Critical Chiron SRL
Publication of EP1222268A2 publication Critical patent/EP1222268A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Selon l'invention, on a identifié la protéine VIP54 par le criblage de levure à deux hybrides en utilisant en tant qu'appât VacA de H. pylori. VIP54 n'est pas détectée dans les neurones mais se détecte dans les cellules de neuroblastome extraites d'une tumeur. En outre, la VIP54 est co-distribuée avec la vimentine et décore les filaments intermédiaires avec un ornement à points. L'invention concerne aussi une protéine comprenant la séquence d'acides aminés de VIP54 ainsi que des peptides, des acides nucléiques et des anticorps y relatifs, qui s'utilisent en tant que réactifs diagnostiques du neuroblastome, comme marqueurs pour filaments intermédiaires et pour inhiber l'interaction VIP54/VacA.
EP00969750A 1999-10-11 2000-10-11 Proteine vip54 et substances liees a celle-ci Withdrawn EP1222268A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9924060.8A GB9924060D0 (en) 1999-10-11 1999-10-11 VIP54 protein
GB9924060 1999-10-11
PCT/IB2000/001578 WO2001027269A2 (fr) 1999-10-11 2000-10-11 Proteine vip54 et substances liees a celle-ci

Publications (1)

Publication Number Publication Date
EP1222268A2 true EP1222268A2 (fr) 2002-07-17

Family

ID=10862545

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00969750A Withdrawn EP1222268A2 (fr) 1999-10-11 2000-10-11 Proteine vip54 et substances liees a celle-ci

Country Status (5)

Country Link
EP (1) EP1222268A2 (fr)
JP (1) JP2003511072A (fr)
CA (1) CA2387188A1 (fr)
GB (1) GB9924060D0 (fr)
WO (1) WO2001027269A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4129227B2 (ja) 2001-05-30 2008-08-06 千葉県 神経芽細胞腫において単離された核酸

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0967279B1 (fr) * 1992-03-02 2008-01-02 Novartis Vaccines and Diagnostics S.r.l. Cytotoxine d' Helicobacter pylori utile dans des vaccins et en diagnostique
CA2383592A1 (fr) * 1999-03-31 2000-10-05 Curagen Corporation Acides nucleiques comprenant des phases de lecture ouverte codant des polypeptides; orfx
WO2000060077A2 (fr) * 1999-04-02 2000-10-12 Corixa Corporation Composes utilises dans la therapie et le diagnostic du cancer du poumon et methodes d'utilisation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0127269A3 *

Also Published As

Publication number Publication date
WO2001027269A2 (fr) 2001-04-19
GB9924060D0 (en) 1999-12-15
JP2003511072A (ja) 2003-03-25
WO2001027269A3 (fr) 2001-11-22
CA2387188A1 (fr) 2001-04-19

Similar Documents

Publication Publication Date Title
EP2275553B1 (fr) Peptides antigéniques de Neisseria
EP1196587B1 (fr) Peptides meningococciques antigeniques
US7700119B2 (en) 85kDa neisserial antigen
US7700755B2 (en) Helicobacter pylori CAI antigen
JP4271952B2 (ja) ワクチンおよび診断に有用なＨｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉタンパク質
US20070184443A1 (en) Streptococcus pneumoniae knockout mutants
EP1222268A2 (fr) Proteine vip54 et substances liees a celle-ci
US7141244B1 (en) Helicobacter pylori proteins useful for vaccines and diagnostics
EP1237571B1 (fr) Nucleoproteine de virus toscana
US20100008942A1 (en) Histophilus Somni Polynucleotides, Polypeptides and Methods of Use

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20020501

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

17Q First examination report despatched

Effective date: 20030623

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: CHIRON S.R.L.

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20041015