CA2387188A1 - Proteine vip54 et substances liees a celle-ci - Google Patents

Proteine vip54 et substances liees a celle-ci Download PDF

Info

Publication number
CA2387188A1
CA2387188A1 CA002387188A CA2387188A CA2387188A1 CA 2387188 A1 CA2387188 A1 CA 2387188A1 CA 002387188 A CA002387188 A CA 002387188A CA 2387188 A CA2387188 A CA 2387188A CA 2387188 A1 CA2387188 A1 CA 2387188A1
Authority
CA
Canada
Prior art keywords
protein
sequence
vip54
expression
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002387188A
Other languages
English (en)
Inventor
Marina De Bernard
Cesare Montecucco
Rino Rappuoli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Chiron SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron SRL filed Critical Chiron SRL
Publication of CA2387188A1 publication Critical patent/CA2387188A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Selon l'invention, on a identifié la protéine VIP54 par le criblage de levure à deux hybrides en utilisant en tant qu'appât VacA de H. pylori. VIP54 n'est pas détectée dans les neurones mais se détecte dans les cellules de neuroblastome extraites d'une tumeur. En outre, la VIP54 est co-distribuée avec la vimentine et décore les filaments intermédiaires avec un ornement à points. L'invention concerne aussi une protéine comprenant la séquence d'acides aminés de VIP54 ainsi que des peptides, des acides nucléiques et des anticorps y relatifs, qui s'utilisent en tant que réactifs diagnostiques du neuroblastome, comme marqueurs pour filaments intermédiaires et pour inhiber l'interaction VIP54/VacA.
CA002387188A 1999-10-11 2000-10-11 Proteine vip54 et substances liees a celle-ci Abandoned CA2387188A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9924060.8 1999-10-11
GBGB9924060.8A GB9924060D0 (en) 1999-10-11 1999-10-11 VIP54 protein
PCT/IB2000/001578 WO2001027269A2 (fr) 1999-10-11 2000-10-11 Proteine vip54 et substances liees a celle-ci

Publications (1)

Publication Number Publication Date
CA2387188A1 true CA2387188A1 (fr) 2001-04-19

Family

ID=10862545

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002387188A Abandoned CA2387188A1 (fr) 1999-10-11 2000-10-11 Proteine vip54 et substances liees a celle-ci

Country Status (5)

Country Link
EP (1) EP1222268A2 (fr)
JP (1) JP2003511072A (fr)
CA (1) CA2387188A1 (fr)
GB (1) GB9924060D0 (fr)
WO (1) WO2001027269A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60239087D1 (de) 2001-05-30 2011-03-10 Chiba Prefecture Aus einem Neuroblastom isolierte Nukleinsäuren

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3630093A (en) * 1992-03-02 1993-10-05 Biocine S.P.A. Helicobacter pylori proteins useful for vaccines and diagnostics
AU3774500A (en) * 1999-03-31 2000-10-16 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; "orfx"
JP2002540790A (ja) * 1999-04-02 2002-12-03 コリクサ コーポレイション 肺癌の治療および診断のための化合物ならびにその使用のための方法

Also Published As

Publication number Publication date
WO2001027269A3 (fr) 2001-11-22
EP1222268A2 (fr) 2002-07-17
JP2003511072A (ja) 2003-03-25
WO2001027269A2 (fr) 2001-04-19
GB9924060D0 (en) 1999-12-15

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Legal Events

Date Code Title Description
FZDE Discontinued