EP1213977B1 - Filtering method and filter consisting of nitrogen-containing cycles or heterocyles such as dna or rna designed in particular for filtering tobacco smoke and cigarette containing such a filter - Google Patents

Abstract

The methods concerns a method for general use and more particularly used for tobacco products. The method uses in particular nitrogen-containing heterocycles such as DNA and RNA bases and complementarily polymer fibers. Said molecules and said fibers can partly halogenated, or in halogenated salt media. The halogen is preferably fluorine. Fluorine may be added to may bei n the form of a medium of fluorinated salts such as NaF, KF, Na2PO3F. The filtering acts against the formation of human intracellular DNA or RNA adducts, while preserving the nicotine and the tobacco aromas.

Description

The present invention relates to a filtration method and a filter of general use, applicable in particular to tobacco products, and especially for the filter tip of a cigarette. The invention has more particularly to protect molecules in the human genome against the toxic carcinogens of inhaled smoke.

Cigarette filters known to date generally contain derivatives polysaccharides, of natural or thermoplastic origin, polyesters, such as polyethylene and polypropylene terephthalate. EP patents 434332 and EP 434339 by RJ Reynolds Tobacco Cie describe such filters, they can also contain dried tobacco grains. In these different patents, mention is made of the use of salts, acids, bases, of surfactants, in a medium with basic PH.

More particularly against carcinogenic substances, the WO patent 96/00019 describes a cigarette filter enriched with Fe ++, Cu ++ or Mg ++ ions. The objective is the retention of free radicals and particularly the protection of metalloproteins.

WO 96/10929 describes a free radical inhibitor, such as a O-alkylated derivative of 2,4-monofurfurylidene sorbitol, associated with a antioxidant, whose action is to filter Polycyclic Hydrocarbons Aromatics (HPA), mainly 3,4-Benzo-a-pyrene (BaP), known carcinogenicity.

Furthermore, it is known that fluoride has anti-tumor effects. He took part especially in the composition of dexamethasone and 5-fluorouracil. In addition, the use of laboratory filter paper in polytetrafluoroethylene (PTFE) is known.

The filtration process according to the invention has a selective, chemical action direct, anti-carcinogenic. It is intended to filter toxic products, in particularly polycyclic aromatic hydrocarbons (HPA) such as benzo (a) pyrènc (BaP) and nitrosamines, contained in tobacco smoke of a cigarette.

The filtration process includes the step of controlling the rate of the products toxic compared to nicotine so that the reduction the rate at the filter outlet is greater than a predetermined threshold. So the nicotine and aromas of taste for the satisfaction and pleasure of smokers are kept.

The selective mode of action of the method according to the invention, with respect to toxic carcinogenic compared to nicotine, is one of its main properties.

Its second main characteristic is its direct chemical action. That is to say its action with regard to toxic carcinogenic products in level of the very reactive site of DNA.

• l'étape de capter tout ou partie des produits toxiques au moyen d'un principe actif agissant sur lesdits produits toxiques selon des processus moléculaires comparables à ceux selon lesquels réagit l'ADN et/ou l'ARN de la cellule humaine vis à vis desdits produits toxiques,
• l'étape de contrôler les conditions opératoires du filtre en opérant en milieu sensiblement non aqueux et de pH basique, de préférence supérieur ou égal à 8,
• l'étape d'ajuster la masse du principe actif de telle sorte qu'elle soit supérieure ou égale à 0,1 % de la masse du filtre de la cigarette et de préférence supérieure ou égale à 1 % de la masse du filtre.

Preferably, to control the level of toxic products, in particular the level of polycyclic aromatic hydrocarbons (HPA) and nitrosamines, relative to that of nicotine, the method according to the invention comprises the following steps:

• the step of capturing all or part of the toxic products by means of an active principle acting on said toxic products according to molecular processes comparable to those according to which the DNA and / or RNA of the human cell reacts with respect to said toxic products,
• the step of controlling the operating conditions of the filter by operating in a substantially non-aqueous medium and of basic pH, preferably greater than or equal to 8,
• the step of adjusting the mass of the active principle so that it is greater than or equal to 0.1% of the mass of the filter of the cigarette and preferably greater than or equal to 1% of the mass of the filter.

These are the attacks against the DNA and / or RNA molecules of the cell which are mainly responsible for cancerous tumors. Through therefore, by filtering tobacco smoke by molecular mechanisms of the same nature as those which degrade DNA and / or RNA, selectively and directly toxic carcinogenic products, contained in tobacco smoke.

The inventors have found that these are with the minimum quantities of active ingredient and under the operating conditions mentioned above that is possible to control the rate of toxic products, especially the rate polycyclic aromatic hydrocarbons (HPA) and nitrosamines, compared to that of nicotine.

• d'une chaíne desdites molécules et/ou
• desdites molécules liées, dans un arrangement chimique commun, à une fibre tel qu'une fibre composée d'acétate de cellulose.

Preferably, said active principle is composed of molecules consisting of one or more nitrogen rings or nitrogen heterocycles, preferably nitrogen heteroaromatics, in particular pentacycles or hexacycles or a combination of the two. Advantageously, according to the invention, said active principle must be in the form:

• of a chain of said molecules and / or
• said molecules linked, in a common chemical arrangement, to a fiber such as a fiber composed of cellulose acetate.

Preferably, the molecule of the active principle is DNA and / or RNA and / or a derivative of DNA or RNA, such as for example adenosine triphosphate (ATP), cyclic adenosine monophosphate (AMP), adenyl cyclase.

The invention also relates to a cigarette filter implementing the process described above. The cigarette filter according to the invention has a selective action, direct chemical, anti-carcinogenic. It is intended to filter particularly polycyclic aromatic hydrocarbons (HPA) and in particular benzo (a) pyrene (BaP) as well as nitrosamines, in retaining the nicotine level and flavor aromas for satisfaction and the pleasure of the smoker. The filter contains an active ingredient composed of molecules made up of one or more nitrogen rings or heterocycles nitrogen, and particularly nitrogen heteroaromatics, especially pentacycles or hexacycles or a combination of the two. Advantageously, said active principle must be in the form of a chain of said molecules and / or of said molecules linked to a fiber, in particular a cellulose acetate fiber, in a chemical arrangement common. The mass of said nitrogenous cycles or heterocycles and particularly nitrogen heteroaromatics is at least equal or greater than 0.1% of the total mass of the filter. The environment in which said nitrogen rings or heterocycles and particularly heteroaromatics nitrogenous operate is a substantially non-aqueous medium having a pH basic. Under these operating conditions, it has been found that it is possible to reduce substantially, at the outlet of the filter, the rate of polycyclic aromatic hydrocarbons compared to nicotine. The rate can be reduced by more than 90% by keeping the nicotine level and aromas of taste for the satisfaction and pleasure of the smoker. According to one alternative embodiment of the filter, other fibers are also used of natural or artificial origin, mainly aromatics of ethylene (for example, polyethylene terephthalate), propylene (for example, polypropylene terephthalate), in the middle of fluorinated salts.

Advantageously, in an alternative embodiment of the invention, the molecules are made up of polymer in the broad sense.

Advantageously also, in another alternative embodiment of the invention, the active principle consists exclusively of molecules and / or of said polymers.

Preferably, the mass of said nitrogenous cycles or heterocycles and particularly nitrogen heteroaromatics is at least equal or greater than 1% of the total mass of the filter.

Advantageously, the humidity level of the filter is between 5 and 10%.

Advantageously, the pH of the filter is greater than 8.

Preferably, the molecule of the active principle is DNA and / or RNA and / or a derivative of DNA or RNA, such as for example adenosine triphosphate (ATP), cyclic adenosine monophosphate or adenyl cyclase.

Thus, toxic carcinogenic products, contained in tobacco smoke, directly affecting the DNA and / or RNA molecules of the cell human, are selectively captured by the filter according to processes molecular compounds comparable to those according to which said toxic products act on the DNA and / or RNA of the human cell.

• amine NH2,
• cétone, aldéhyde,
• méthyle
• alcène, alcyle ou aryle,

Advantageously, the molecule of the active principle is added, on at least one of the nitrogen cycles or nitrogen heterocycles and particularly of the nitrogen heteroaromatics, to at least one function chosen from a group comprising the functions:

• amine NH2,
• ketone, aldehyde,
• methyl
• alkene, alkyl or aryl,

Advantageously, at least one molecule of the active principle is added one or more sugars such as ribose or deoxyribose.

Advantageously, at least one molecule of the active principle is added one or more acid functions, in particular phosphoric acid (H3PO4) pentavalent and / or another molecule comprising a trivalent phosphorus.

Advantageously, in the case of a chain of molecules made up of polymer, polymerization is carried out in the broad sense at the level of the cycles nitrogen, i.e. nitrogen heterocycles and particularly nitrogen heteroaromatics and / or added functions and / or acids and / or sugars.

Advantageously, the molecule of the active principle comprises one or more atoms and / or one or more molecules and / or one or more radicals and / or one or more ions of a halogen, such as in particular fluorine.

Advantageously, the molecule of the active principle is located in a medium containing halogenated salts, especially sodium fluoride salts NaF.

Advantageously, in the case where said active principle is present under the form of a chain of said molecules and / or of said molecules linked to a fiber, said fiber is partially halogenated, such as in particular by fluorine. Advantageously also in this case, said fiber, partially halogenated or not, is in a medium containing atoms, molecules, radicals or ions of a halogen, such as in particular the fluorine.

The invention also relates to a method of manufacturing a filter. comprising an active principle composed of chains of molecules having the characteristics defined above. The method includes the step to extrude and / or roll together said chains of molecules. In the case where said molecules are linked in a common chemical arrangement fibers, in particular cellulose acetate fibers, said method of manufacturing includes the step of extruding and / or rolling together the said fibers.

The invention also relates to an application filtration device general comprising an active ingredient composed of molecules and / or fibers having the characteristics and operating under the above conditions defined.

Advantageously, the filtration device according to the invention is such that said molecules and / or said fibers are incorporated into separate compartments, or in the form of grains and / or filaments.

Advantageously, the filtration device according to the invention is such that said molecules and / or said fibers present in a physical state gelatinous, liquid or gaseous.

The filtration device can be applied to the selective filtration of toxic products. The filtration device according to the invention can be applied to the selective purification of tobacco smoke, in order to conserve the usual nicotine levels, for smoker satisfaction, and tar containing tobacco aromas, for the preservation of taste.

The invention also relates to a cigarette comprising a device for filtration such as that described above. As shown in the Figure 2, the cigarette according to the invention comprises a tobacco rod 2. A one end of the rod 2 is mounted a filtration device 1 such as the one described above.

The invention protects molecules of the human genome against toxic substances tobacco smoke carcinogens. In addition, in the case of a smoking article, this filter has the particularity of preserving in their totality the usual rates of nicotine and tar aromas. This low cost filter and whose maximum efficiency allows a practical and industrial realization for the best of the smoker's satisfaction and pleasure thanks to the conservation of taste, while considerably reducing the risks incurred, particularly in the field of pathology bronchopulmonary and cardiovascular.

The invention in question here is intended to protect the genome human against attacks of carcinogens, main process invested in the mechanism of initiation and promotion of the phenomenon cancerous. The invention is less concerned with indirect attack processes cells produced at the level of molecules such as metalloproteins or globulins involved in the immune response system.

In the case of a smoking article filter, the carcinogenic etiogeny is molecules that are not always originally found in tobacco itself, but which are intermediate pyrolysis derivatives constituted on along the stem of the cigarette through a cooling corridor to the filter during inhalation-aspiration.

These derivatives, free radicals or carbocations, are electrophilic.

Free radicals and carbocations are now better known as genotoxicity agents modifying the rules for duplication of DNA and / or constituting adducts with it. They can also be responsible for disorders in the DNA coding of proteins essential to cell life.

The invention uses molecules including several nuclei nucleophiles prevent the electrophilic attack of these agents. The molecules according to the invention filter, thanks to their quantity present in the filter, toxins whose destiny would have a carcinogenic action in the smoker's body either in situ or after a process of metabolism in the smoker's faith.

In the human body, the compounds and radicals to be filtered constitute powerful adducts with DNA by penetration into cell nuclei or after passage, for precancerogens, by bioactivating systems of the body, and cause mutagenic and carcinogenic processes.

It is known that the carcinogenic process most often involves electrophilic atoms in molecules whose transmembrane passage towards the cell nucleus is favored by an electric density medium positive.

According to the invention, to filter these precursor molecules of genotoxicity, we uses molecules made up of nucleophilic dipoles, forces of voltage, of π electronic clouds which make nucleophilic poles of attraction for electrophilic compounds and radicals.

During the tests, it was found that the components of the molecules of the filter according to the invention, and in particular the nucleotides of DNA and RNA, obstruct the compounds and radicals to be filtered before they even do not reach the human genetic heritage.

We will now describe Figure 1 which represents the diagram of an example of molecule according to the invention. The radicals R1, R2, R3 and R4 are amine, ketone, aldehyde, methyl, alkenes, alkyl, aryl, etc. functions

These functions, added to the molecule, can be used to filter out alkyl or aryl epoxides, sulfate esters, nitrosamines at direct carcinogenic power.

These radicals R1, R2, R3 and R4 can also be one or more atoms or a radical of a halogen such as fluorine.

By way of example, the molecules of the purine or pyrimidine type can be produced in the form of filaments, single-stranded strands obtained by denaturation of DNA, or mostly RNA strands.

It is known that DNA or RNA can be obtained by culturing microorganisms, by bursting nuclei and a process gel electrophoresis.

The filter can use one or more halogens, but preferably fluorine, in the form of an atom, a molecule, a radical or an ion.

When used, fluorine can be added beforehand on a phenyl nucleus possible precursor of synthesis of the molecule according to the invention via a mineral acid, a Brönsted acid, or a Lewis acid.

In the case of halogenation, the "polymer fever" syndrome or "Influenza Like" will be avoided by performing a partial halogenation fibers.

The halogenated salts used are preferably soluble metal salts alkaline and alkaline earth, for example sodium fluoride.

The molecules according to the invention and / or the other fibers of the filter can be extruded or rolled together with halogenated salts, such as example in the manufacturing process described in patent WO / 24078 of Caredent Ltd.

Certain toxic substances are to be excluded, such as the carboxylic acids of fluorine or their precursors, particularly fluoroacetic acid as well as some dangerous organophosphates.

The level of halogen used will not exceed the threshold imposed by restriction measures on biodegradation and fluoride level consumable.

In the case of halogenation, the filter may also present for the fibers of the molecules according to the invention and / or for the other fibers of the filter a distribution with high fluorine content then with lower fluorine content, center towards the periphery of the filter or vice versa, or in compartments separate ones arranged according to the length of the filter.

The filter, as described here, has the function of filtering the electrophilic compounds and radicals such as Hydrocarbons Polycyclic Aromatics (HPA) - and especially BaP - and Nitrosamines.

The filter also includes, in certain variant embodiments, solvents surfactants or other materials (mineral type acids or carboxylic, bases or salts especially for preservation of a certain basic PH.

The molecules of the filter according to the invention operate at basic pH of preferably greater than or equal to 8, which facilitates the conservation of the rate of nicotine as indicated above.

The acid, base and salt functions can either be added to molecules according to the invention and / or to the other fibers of the filter substrate, either located at their contact. They can also be used for the halogenation of the molecule of the active principle and / or of the other fibers of the filter substrate.

The greater cleanliness of the inhaled flow, combined with an action of decluttering of tissue, allows a very favorable prognosis as to the limitation of bronchopulmonary, cardiovascular and mutagenic or carcinogenic processes.

The filter is used for general filtration of pollutants and products toxic. In the case of filtration of a smoking article, the filter thus described is not necessarily in contact with tobacco; it can for example be accommodated in a cigarette holder.

During testing for a smoking article, it was found that a few milligrams of the active ingredient added to the mass of the filter in the middle humidity corresponding to that of a conventional cigarette filter, or around 7 ± 2%, are sufficient to filter almost all of the products carcinogens implicated in tobacco.

In general, the mass of nitrogen cycles and nitrogen heterocycles and particularly nitrogen heteroaromatics present in the filter represents at least 0.1% and, preferably, more than 1% of the mass filter total.

Tests performed.

The tests were carried out under the following conditions.

1) Comparatif Peter Stuyvesant normales et Peter Stuyvesant normales modifiées.

2) Comparatif Peter Stuyvesant Extra Light et Peter Stuyvesant normales modifiées

Teneurs moyennes exprimées par cigarette.
Mesures de nicotine et goudrons selon les normes ISO 3402/4387/3308/10315/10362
Mesures de benzo(a)pyrene selon l'article "Mariner D.C; Tuck D.J.; Frost B.E.; benzo(a)pyrene analysis in main stream cigarette smoke, CORESTA meeting Hamburg 1999, abstr. ST3". Les teneurs en benzo(a)pyrene ont été arrondies à 0.5 ng/cigarette.Standard size cigarette filter injected with single-stranded salmon DNA filaments composed of about a thousand nucleotides, the mass of DNA being 10 mg per cigarette filter, the filter being dried before smoking and dosage.
Humidity level: 7 ± 2%,
PH: about 8
Control cigarettes used: Peter Stuyvesant ™ normal and "extra light".
Cigarettes used whose filter is modified: Peter Stuyvesant ™ normal.

1) Comparison of normal Peter Stuyvesant and modified normal Peter Stuyvesant.

2) Comparison of Peter Stuyvesant Extra Light and Peter Stuyvesant normal modified

Average contents expressed by cigarette.
Nicotine and tar measurements according to ISO 3402/4387/3308/10315/10362
Measures of benzo (a) pyrene according to the article "Mariner DC; Tuck DJ; Frost BE; benzo (a) pyrene analysis in main stream cigarette smoke, CORESTA meeting Hamburg 1999, abstr. ST3". The benzo (a) pyrene contents have been rounded to 0.5 ng / cigarette.

Example of filters according to the invention Example 1

Conventional cigarette filter in cellulose acetate of around 200mg.

The filter is injected with single-stranded strands of salmon DNA, of a length of approximately 2000 base pairs and for an amount equal to 10 mg for a conventional cigarette filter.
In a salt medium containing 0.1% NaF.
Humidity level: 7 ± 2%
PH: about 8

Example 2

Conventional cigarette filter in cellulose acetate of around 200mg.

The filter consists on its axis of a mixed compartment of filaments of salmon DNA and polypropylene terephthalate fibers, and of a compartment consisting only of these latter fibers. The mass of DNA filaments representing 10 mg for a conventional cigarette filter.
In a salt medium containing 0.1% NaF.
Humidity level: 7 ± 2%
PH: about 8

Example 3

Conventional cigarette filter in cellulose acetate of around 200mg.

The cigarette filter is made up of a mixture of linear filaments of salmon DNA tangled with polypropylene terephthalate fibers. The mass of DNA filaments representing 10 mg for a conventional cigarette filter.
In the midst of fluorinated salts containing 0.1% KF, NaF, Na2PO3F in a ratio of 1: 1: 1.
Humidity level: 7 ± 2%
PH: about 8.

Claims (20)

1. Filtering method with a selective, direct chemical, anti-carcinogenic action, intended to filter toxic products, particularly polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BaP) and nitrosamines, contained in the tobacco smoke of a cigarette; said method comprising the step of controlling the level of toxic products in relation to that of nicotine in such a way that the reduction in level on leaving the filter is greater than a predetermined threshold,
   in such a way that the nicotine and the flavour aromas are preserved for the satisfaction and pleasure of the smokers; to control the level of toxic products in relation to that of nicotine, particularly the level of polycyclic aromatic hydrocarbons (PAHs) and nitrosamines, said method comprises the following steps:

   the step of capturing all or part of the toxic products by means of an active principle acting on said toxic products by molecular processes comparable with those by which the DNA and/or RNA in the human cell reacts towards said toxic products,

   the step of controlling the filter's operating conditions by operating in a substantially non-aqueous medium with a basic pH, preferably greater than or equal to 8,

   the step of adjusting the mass of the active principle in such a way that it is greater than or equal to 0.1% of the mass of the cigarette filter and preferably greater than or equal to 1% of the mass of the filter;

   said active principle being made up of molecules consisting of one or more nitrogen-containing cyclic compounds or nitrogen-containing heterocyclic compounds, and particularly nitrogen-containing heteroaromatics, particularly pentacycles or hexacycles or a combination of the two; said active principle taking the form of:

   a chain of said molecules and/or

   said molecules linked in a common chemical arrangement to a fibre, particularly a fibre made of cellulose acetate.
2. Method according to claim 1, wherein the molecule of the active principle is DNA and/or RNA and/or a derivative of DNA or of RNA, such as e.g. adenosine triphosphate (ATP), cyclic adenosine monophosphate (AMP), adenyl cyclase.
3. Cigarette filter with a selective, direct chemical, anti-carcinogenic action, intended to filter particularly polycyclic aromatic hydrocarbons (PAHs), especially benzo(a)pyrene (BaP), as well as nitrosamines, while preserving the level of nicotine and the flavour aromas for the satisfaction and pleasure of the smoker;
   said filter containing an active principle made up of molecules consisting of one or more nitrogen-containing cyclic compounds or nitrogen-containing heterocyclic compounds, and particularly nitrogen-containing heteroaromatics, particularly pentacycles or hexacycles or a combination of the two; said active principle taking the form of :

   a chain of said molecules and/or

   said molecules linked to a fibre in a common chemical arrangement, particularly a fibre made of cellulose acetate;

   the mass of said nitrogen-containing cyclic compounds or heterocyclic compounds, and particularly of the nitrogen-containing heteroaromatics, being at least equal to or greater than 0.1% of the total mass of the filter; said nitrogen-containing cyclic compounds or heterocyclic compounds and particularly nitrogen-containing heteroaromatics operating in a substantially non-aqueous medium with a basic pH;
   in such a way that it is thus possible to reduce substantially, on leaving the filter, the level of polycyclic aromatic hydrocarbons in relation to nicotine, particularly by more than 90%, while preserving the level of nicotine and the flavour aromas for the satisfaction and pleasure of the smoker.
4. Filter according to claim 3, wherein the molecules are brought together into a polymer in the general sense.
5. Filter according to any one of claims 3 or 4, wherein the active principle is exclusively made up of said molecules and/or said polymers.
6. Filter according to any one of claims 3 or 5, wherein the mass of said nitrogen-containing cyclic compounds or heterocyclic compounds, and particularly of the nitrogen-containing heteroaromatics, is at least equal to or greater than 1% of the total mass of the filter.
7. Filter according to any one of claims 3 to 6 wherein the level of humidity of the filter is between 5 and 10% inclusive.
8. Filter according to any one of claims 3 to 7, wherein the pH of the filter is greater than 8.
9. Filter according to any one of claims 3 to 8, wherein the molecule of the active principle is DNA and/or RNA and/or a derivative of DNA or of RNA, such as e.g. adenosine triphosphate (ATP), cyclic adenosine monophosphate or adenyl cyclase;
   such that the carcinogenic toxic products contained in the tobacco smoke, affecting the DNA and/or RNA molecules of the human cell, are captured by the filter by molecular processes comparable with those by which said toxic products act on the DNA and/or RNA of the human cell.
10. Filter according to any one of claims 3 to 9, wherein the molecule of the active principle has added to it at least one function selected from a group comprising the following functions:

    amine NH2,

    ketone, aldehyde,

    methyl,

    alkene, alkyl or aryl,

    on at least one of the nitrogen-containing cyclic compounds or nitrogen-containing heterocyclic compounds, and particularly the nitrogen-containing heteroaromatics.
11. Filter according to any one of claims 3 to 10, wherein at least one molecule of the active principle has added to it one or more sugars such as ribose or deoxyribose.
12. Filter according to any one of claims 3 to 11, wherein at least one molecule of the active principle has added to it one or more acid functions, particularly pentavalent phosphoric acid (H3PO4) and/or another molecule containing a trivalent phosphorus.
13. Filter according to any one of claims 3 to 12, wherein the polymerisation is carried out in the general sense at the level of the nitrogen-containing cyclic compounds or nitrogen-containing heterocyclic compounds, and particularly of the nitrogen-containing heteroaromatics and/or the added functions and/or acids and/or sugars.
14. Filter according to any one of claims 3 to 13, wherein the molecule of the active principle contains one or more atoms and/or one or more molecules and/or one or more radicals and/or one or more ions of a halogen, such as in particular fluorine.
15. Filter according to any one of claims 3 to 14, wherein the molecule of the active principle is in a medium of halogenated salts, particularly in a medium of sodium fluoride salts NaF.
16. Filter according to any one of claims 3 to 15, wherein said fibres are partly halogenated, such as in particular by fluorine, and/or are in a medium containing atoms, molecules, radicals or ions of a halogen, such as in particular fluorine.
17. Filter according to any one of claims 3 to 16, wherein said molecules and/or said fibres are incorporated in separate compartments.
18. Filter according to any one of claims 3 to 17, wherein said molecules and/or said fibres are present in a gelatinous, liquid or gaseous physical state.
19. Method for producing a filter containing molecules and/or fibres according to any one of claims 3 to 18, said method comprising the step of extruding and/or rolling said molecules and said fibres together.
20. Cigarette containing a filter according to any one of claims 3 to 19.

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