EP1195523A3 - Microfabricated elastomeric valve and pump systems - Google Patents

Microfabricated elastomeric valve and pump systems Download PDF

Info

Publication number
EP1195523A3
EP1195523A3 EP01128819A EP01128819A EP1195523A3 EP 1195523 A3 EP1195523 A3 EP 1195523A3 EP 01128819 A EP01128819 A EP 01128819A EP 01128819 A EP01128819 A EP 01128819A EP 1195523 A3 EP1195523 A3 EP 1195523A3
Authority
EP
European Patent Office
Prior art keywords
elastomeric layer
elastomeric
pump systems
elastomeric valve
micromachined mold
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP01128819A
Other languages
German (de)
French (fr)
Other versions
EP1195523B1 (en
EP1195523A2 (en
Inventor
Marc A. Unger
Axel Scherer
Stephen R. Quake
Hou-Pu Chou
Todd A. Thorsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
California Institute of Technology CalTech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology CalTech filed Critical California Institute of Technology CalTech
Priority to EP10180441.7A priority Critical patent/EP2309130B1/en
Priority to EP05075473.8A priority patent/EP1557565B1/en
Priority claimed from EP20000305389 external-priority patent/EP1065378B1/en
Publication of EP1195523A2 publication Critical patent/EP1195523A2/en
Publication of EP1195523A3 publication Critical patent/EP1195523A3/en
Application granted granted Critical
Publication of EP1195523B1 publication Critical patent/EP1195523B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/04—Pumps having electric drive
    • F04B43/043—Micropumps
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C5/00—Manufacture of fluid circuit elements; Manufacture of assemblages of such elements integrated circuits
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
    • F04B43/14—Machines, pumps, or pumping installations having flexible working members having peristaltic action having plate-like flexible members

Landscapes

  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Theoretical Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Micromachines (AREA)
  • Reciprocating Pumps (AREA)

Abstract

A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.
EP01128819A 1999-06-28 2000-06-27 Microfabricated elastomeric valve and pump systems Expired - Lifetime EP1195523B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP10180441.7A EP2309130B1 (en) 1999-06-28 2000-06-27 Microfabricated elastomeric valve and pump systems
EP05075473.8A EP1557565B1 (en) 1999-06-28 2000-06-27 Microfabricated elastomeric valve and pump systems

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US14150399P 1999-06-28 1999-06-28
US141503P 1999-06-28
US14719999P 1999-08-03 1999-08-03
US147199P 1999-08-03
US18685600P 2000-03-03 2000-03-03
US186856P 2000-03-03
EP20000305389 EP1065378B1 (en) 1999-06-28 2000-06-27 Microfabricated elastomeric valve and pump systems

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP20000305389 Division EP1065378B1 (en) 1999-06-28 2000-06-27 Microfabricated elastomeric valve and pump systems

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP10180441.7A Division EP2309130B1 (en) 1999-06-28 2000-06-27 Microfabricated elastomeric valve and pump systems
EP05075473.8A Division EP1557565B1 (en) 1999-06-28 2000-06-27 Microfabricated elastomeric valve and pump systems

Publications (3)

Publication Number Publication Date
EP1195523A2 EP1195523A2 (en) 2002-04-10
EP1195523A3 true EP1195523A3 (en) 2003-01-08
EP1195523B1 EP1195523B1 (en) 2005-03-02

Family

ID=27440044

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01128819A Expired - Lifetime EP1195523B1 (en) 1999-06-28 2000-06-27 Microfabricated elastomeric valve and pump systems

Country Status (1)

Country Link
EP (1) EP1195523B1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7411331B2 (en) 2002-05-10 2008-08-12 Massachusetts Institute Of Technology Dielectric elastomer actuated systems and methods
US7362889B2 (en) 2002-05-10 2008-04-22 Massachusetts Institute Of Technology Elastomeric actuator devices for magnetic resonance imaging
US7621317B2 (en) 2006-05-11 2009-11-24 Modine Manufacturing Company Self-breaking radiator side plates
US20090279158A1 (en) * 2008-05-08 2009-11-12 Palo Alto Research Center Incorporated Fluid Actuator For Digitally Controllable Microfluidic Display
AU2015224385B2 (en) * 2009-09-21 2016-12-01 Alcon Inc. Glaucoma drainage device with pump
US8419673B2 (en) * 2009-09-21 2013-04-16 Alcon Research, Ltd. Glaucoma drainage device with pump
US8257295B2 (en) 2009-09-21 2012-09-04 Alcon Research, Ltd. Intraocular pressure sensor with external pressure compensation
WO2013090231A1 (en) 2011-12-13 2013-06-20 Alcon Research, Ltd. Active drainage systems with dual-input pressure-driven valves
US9339187B2 (en) 2011-12-15 2016-05-17 Alcon Research, Ltd. External pressure measurement system and method for an intraocular implant
US9295389B2 (en) 2012-12-17 2016-03-29 Novartis Ag Systems and methods for priming an intraocular pressure sensor in an intraocular implant
US9528633B2 (en) 2012-12-17 2016-12-27 Novartis Ag MEMS check valve
US9572712B2 (en) 2012-12-17 2017-02-21 Novartis Ag Osmotically actuated fluidic valve
US9039993B2 (en) 2013-03-14 2015-05-26 Formulatrix, Inc. Microfluidic device
US9163277B2 (en) 2013-03-14 2015-10-20 Formulatrix, Inc. Microfluidic device
US9226851B2 (en) 2013-08-24 2016-01-05 Novartis Ag MEMS check valve chip and methods
KR101850307B1 (en) 2016-03-03 2018-04-20 한국과학기술연구원 Apparatus and method for manufacturing channel-bonding type scaffold
US11154864B2 (en) 2018-01-17 2021-10-26 Qiagen Sciences, Llc Microfluidic device with vented microchambers

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5088515A (en) * 1989-05-01 1992-02-18 Kamen Dean L Valve system with removable fluid interface
US5346372A (en) * 1991-07-18 1994-09-13 Aisin Seiki Kabushiki Kaisha Fluid flow regulating device
EP0703364A1 (en) * 1994-09-22 1996-03-27 Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V. Method and device for driving a micropump
EP0779436A2 (en) * 1995-12-13 1997-06-18 Frank T. Hartley Micromachined peristaltic pump
US5660370A (en) * 1996-03-07 1997-08-26 Integrated Fludics, Inc. Valve with flexible sheet member and two port non-flexing backer member
US5836750A (en) * 1997-10-09 1998-11-17 Honeywell Inc. Electrostatically actuated mesopump having a plurality of elementary cells
EP0999055A2 (en) * 1998-11-03 2000-05-10 Samsung Electronics Co., Ltd. Micro injecting device and method of manufacturing the same

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5088515A (en) * 1989-05-01 1992-02-18 Kamen Dean L Valve system with removable fluid interface
US5346372A (en) * 1991-07-18 1994-09-13 Aisin Seiki Kabushiki Kaisha Fluid flow regulating device
EP0703364A1 (en) * 1994-09-22 1996-03-27 Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V. Method and device for driving a micropump
EP0779436A2 (en) * 1995-12-13 1997-06-18 Frank T. Hartley Micromachined peristaltic pump
US5660370A (en) * 1996-03-07 1997-08-26 Integrated Fludics, Inc. Valve with flexible sheet member and two port non-flexing backer member
US5836750A (en) * 1997-10-09 1998-11-17 Honeywell Inc. Electrostatically actuated mesopump having a plurality of elementary cells
EP0999055A2 (en) * 1998-11-03 2000-05-10 Samsung Electronics Co., Ltd. Micro injecting device and method of manufacturing the same

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BRYZEK J ET AL: "MICROMACHINES ON THE MARCH", IEEE SPECTRUM,US,IEEE INC. NEW YORK, vol. 31, no. 5, 1 May 1994 (1994-05-01), pages 20 - 31, XP000456261, ISSN: 0018-9235 *
DUFFY D C ET AL: "PATTERNING ELECTROLUMINESCENT MATERIALS WITH FEATURE SIZES AS SMALL AS 5 MUM USING ELASTOMERIC MEMBRANES AS MASKS FOR DRY LIFT-OFF", ADVANCED MATERIALS,DE,VCH VERLAGSGESELLSCHAFT, WEINHEIM, vol. 11, no. 7, 7 May 1999 (1999-05-07), pages 546 - 552, XP000849014, ISSN: 0935-9648 *
DUFFY, D. C. ET AL.: "Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane)", ANAL. CHEM., vol. 70, 1998, pages 4974 - 4984, XP002149044 *
POL VAN DE F C M ET AL: "A THERMO-PNEUMATIC ACTUATION PRINCIPLE FOR A MICROMINIATURE PUMP AND OTHER MICROMECHANICAL DEVICES", SENSORS AND ACTUATORS, ELSEVIER SEQUOIA S.A. LAUSANNE, CH, vol. 17, no. 1/2, 3 May 1989 (1989-05-03), pages 139 - 143, XP000038020 *
QIN D ET AL: "ELASTOMERIC LIGHT VALVES", ADVANCED MATERIALS,DE,VCH VERLAGSGESELLSCHAFT, WEINHEIM, vol. 9, no. 5, 1 April 1997 (1997-04-01), pages 407 - 410, XP000683891, ISSN: 0935-9648 *
RAPP R ET AL: "LIGA MICROPUMP FOR GASES AND LIQUIDS", SENSORS AND ACTUATORS A,CH,ELSEVIER SEQUOIA S.A., LAUSANNE, vol. A40, no. 1, 1994, pages 57 - 61, XP000434539, ISSN: 0924-4247 *
XIA, Y., WHITESIDES, G. M.: "Soft Lithography", ANGEW. CHEM. INT. ED., vol. 37, 1998, pages 550 - 575, XP002149045 *

Also Published As

Publication number Publication date
EP1195523B1 (en) 2005-03-02
EP1195523A2 (en) 2002-04-10

Similar Documents

Publication Publication Date Title
WO2001001025A3 (en) Microfabricated elastomeric valve and pump systems
WO2002043615A3 (en) Microfabricated elastomeric valve and pump systems
EP1195523A3 (en) Microfabricated elastomeric valve and pump systems
EP1306311A3 (en) Composite pallet member
EP1263056A3 (en) Method of controlling stress in a polycrystalline SiGe layer deposited on a substrate
US20160258543A1 (en) Valve device
EP1760130A3 (en) A Method of Forming a Seam between Substrates
EP1405821A3 (en) Wafer level packaging technique for microdevices
EP1431633A3 (en) Lip seal having increased contact force at interface and apparatus incorporating the same
EP2275725A3 (en) Valve component with multiple surface layers
EP1229582A3 (en) Thin-film semiconductor device and method of manufacturing the same
EP0904932A3 (en) Floor material and flooring using the floor material
EP0989302A3 (en) Pump diaphragm and method for making the same
EP1107295A3 (en) Composite member separating method, thin film manufacturing method, and composite member separating apparatus
EP1318551A3 (en) Composite piezoelectric element and method of fabricating the same
EP1288933A3 (en) Bonding of plates while preventing entry of air between them
WO2003034484A3 (en) A method for forming a layered semiconductor structure and corresponding structure
EP1132543A3 (en) Multicomponent tiles and a method of manufacturing multicomponent tiles
WO2003062538A3 (en) Interlocking and securable retaining wall block and system
EP1211572A3 (en) Transfix component having fluorosilicone outer layer
WO2004053992A3 (en) Shallow trench isolation in floating gate devices
EP1203653A4 (en) Composite material
EP1557565A3 (en) Microfabricated elastomeric valve and pump systems
WO2007078799A3 (en) Low resistivity package substrate and its manufacturing method
EP1195477A3 (en) Cladding element, particularly for wood-block flooring

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20020104

AC Divisional application: reference to earlier application

Ref document number: 1065378

Country of ref document: EP

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL PAYMENT 20020104;LT PAYMENT 20020104;LV PAYMENT 20020104;MK PAYMENT 20020104;RO PAYMENT 20020104;SI PAYMENT 20020104

RIC1 Information provided on ipc code assigned before grant

Free format text: 7F 04B 43/04 A, 7F 15C 5/00 B

RIN1 Information on inventor provided before grant (corrected)

Inventor name: UNGER, MARC A.

Inventor name: CHOU, HOU-PU

Inventor name: SCHERER, AXEL

Inventor name: QUAKE, STEPHEN R.

Inventor name: THORSEN, TODD A.

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL PAYMENT 20020104;LT PAYMENT 20020104;LV PAYMENT 20020104;MK PAYMENT 20020104;RO PAYMENT 20020104;SI PAYMENT 20020104

AKX Designation fees paid

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AXX Extension fees paid

Extension state: AL

Payment date: 20020104

Extension state: SI

Payment date: 20020104

Extension state: RO

Payment date: 20020104

Extension state: MK

Payment date: 20020104

Extension state: LT

Payment date: 20020104

Extension state: LV

Payment date: 20020104

17Q First examination report despatched

Effective date: 20030820

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AC Divisional application: reference to earlier application

Ref document number: 1065378

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT;WARNING: LAPSES OF ITALIAN PATENTS WITH EFFECTIVE DATE BEFORE 2007 MAY HAVE OCCURRED AT ANY TIME BEFORE 2007. THE CORRECT EFFECTIVE DATE MAY BE DIFFERENT FROM THE ONE RECORDED.

Effective date: 20050302

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20050302

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20050302

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20050302

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REF Corresponds to:

Ref document number: 60018425

Country of ref document: DE

Date of ref document: 20050407

Kind code of ref document: P

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20050602

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20050602

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20050613

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: E. BLUM & CO. PATENTANWAELTE

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20050627

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20050817

LTIE Lt: invalidation of european patent or patent extension

Effective date: 20050302

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20051205

ET Fr: translation filed
REG Reference to a national code

Ref country code: CH

Ref legal event code: PFA

Owner name: CALIFORNIA INSTITUTE OF TECHNOLOGY

Free format text: CALIFORNIA INSTITUTE OF TECHNOLOGY#1200 EAST CALIFORNIA BOULEVARD#PASADENA, CALIFORNIA 92115 (US) -TRANSFER TO- CALIFORNIA INSTITUTE OF TECHNOLOGY#1200 EAST CALIFORNIA BOULEVARD#PASADENA, CALIFORNIA 92115 (US)

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: MC

Payment date: 20160603

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: LU

Payment date: 20160705

Year of fee payment: 17

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20170627

Year of fee payment: 18

Ref country code: CH

Payment date: 20170627

Year of fee payment: 18

Ref country code: IE

Payment date: 20170628

Year of fee payment: 18

Ref country code: GB

Payment date: 20170627

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 20170628

Year of fee payment: 18

Ref country code: NL

Payment date: 20170626

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20170628

Year of fee payment: 18

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170630

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170627

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 60018425

Country of ref document: DE

REG Reference to a national code

Ref country code: SE

Ref legal event code: EUG

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180628

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: NL

Ref legal event code: MM

Effective date: 20180701

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20180627

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180701

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180630

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180630

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180627

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180627

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180630

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190101