EP1175405A4 - LACTAM INHIBITORS OF FXa AND METHOD - Google Patents

LACTAM INHIBITORS OF FXa AND METHOD

Info

Publication number
EP1175405A4
EP1175405A4 EP00904564A EP00904564A EP1175405A4 EP 1175405 A4 EP1175405 A4 EP 1175405A4 EP 00904564 A EP00904564 A EP 00904564A EP 00904564 A EP00904564 A EP 00904564A EP 1175405 A4 EP1175405 A4 EP 1175405A4
Authority
EP
European Patent Office
Prior art keywords
fxa
lactam inhibitors
lactam
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00904564A
Other languages
German (de)
French (fr)
Other versions
EP1175405A1 (en
Inventor
Gregory S Bisacchi
Steven M Seiler
R Michael Lawrence
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of EP1175405A1 publication Critical patent/EP1175405A1/en
Publication of EP1175405A4 publication Critical patent/EP1175405A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EP00904564A 1999-02-09 2000-01-27 LACTAM INHIBITORS OF FXa AND METHOD Withdrawn EP1175405A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11937499P 1999-02-09 1999-02-09
US119374P 1999-02-09
PCT/US2000/001859 WO2000047563A1 (en) 1999-02-09 2000-01-27 LACTAM INHIBITORS OF FXa AND METHOD

Publications (2)

Publication Number Publication Date
EP1175405A1 EP1175405A1 (en) 2002-01-30
EP1175405A4 true EP1175405A4 (en) 2002-05-15

Family

ID=22384077

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00904564A Withdrawn EP1175405A4 (en) 1999-02-09 2000-01-27 LACTAM INHIBITORS OF FXa AND METHOD

Country Status (5)

Country Link
EP (1) EP1175405A4 (en)
JP (1) JP2002536437A (en)
AU (1) AU756174B2 (en)
CA (1) CA2361919A1 (en)
WO (1) WO2000047563A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6344450B1 (en) * 1999-02-09 2002-02-05 Bristol-Myers Squibb Company Lactam compounds and their use as inhibitors of serine proteases and method
JP2003527429A (en) * 2000-03-21 2003-09-16 スミスクライン・ビーチャム・コーポレイション Protease inhibitor
AU2001255408A1 (en) * 2000-04-14 2001-10-30 Corvas International, Inc. Tetrahydro-azepinone derivatives as thrombin inhibitors
US6544981B2 (en) 2000-06-09 2003-04-08 Bristol-Myers Squibb Company Lactam inhibitors of factor Xa and method
US6511973B2 (en) 2000-08-02 2003-01-28 Bristol-Myers Squibb Co. Lactam inhibitors of FXa and method
US6790845B2 (en) 2001-04-09 2004-09-14 Bristol-Myers Squibb Pharma Company Fused heterocyclic inhibitors of factor Xa
GB0114004D0 (en) 2001-06-08 2001-08-01 Glaxo Group Ltd Chemical compounds
GB0114005D0 (en) 2001-06-08 2001-08-01 Glaxo Group Ltd Chemical compounds
GB0127568D0 (en) * 2001-11-16 2002-01-09 Glaxo Group Ltd Chemical compounds
JP4744149B2 (en) 2002-12-03 2011-08-10 ファーマサイクリックス インコーポレイテッド 2- (2-Hydroxybiphenyl-3-yl) -1H-benzimidazole-5-carboxamidine derivatives as factor VIIA inhibitors
US7199149B2 (en) * 2003-10-01 2007-04-03 Bristol Myers Squibb Company Monocyclic and bicyclic lactams as factor Xa inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995035311A1 (en) * 1994-06-17 1995-12-28 Corvas International, Inc. 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors
WO1998016523A2 (en) * 1996-10-11 1998-04-23 Cor Therapeutics, Inc. Selective factor xa inhibitors
WO2000015222A1 (en) * 1998-09-16 2000-03-23 Bristol-Myers Squibb Company FUSED PYRIDINE INHIBITORS OF cGMP PHOSPHODIESTERASE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1247698B (en) * 1990-06-21 1994-12-30 Sigma Tau Ind Farmaceuti 1-ALCHIL-3- (ACYLAMINE) -E-CAPROLATTAMI AS ACTIVATORS OF LEARNING PROCESSES AND MEMORY AND PHARMACEUTICAL COMPOSITIONS INCLUDING SUCH COMPOUNDS
GB9420763D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc Acetamide derivatives
US5672598A (en) * 1995-03-21 1997-09-30 The Procter & Gamble Company Lactam-containing hydroxamic acids

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995035311A1 (en) * 1994-06-17 1995-12-28 Corvas International, Inc. 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors
WO1998016523A2 (en) * 1996-10-11 1998-04-23 Cor Therapeutics, Inc. Selective factor xa inhibitors
WO2000015222A1 (en) * 1998-09-16 2000-03-23 Bristol-Myers Squibb Company FUSED PYRIDINE INHIBITORS OF cGMP PHOSPHODIESTERASE

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ADANG A E P ET AL: "Novel acylguanidine containing thrombin inhibitors with reduced basicity at the P1 moiety", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 8, no. 24, 15 December 1998 (1998-12-15), pages 3603 - 3608, XP004150375, ISSN: 0960-894X *
See also references of WO0047563A1 *

Also Published As

Publication number Publication date
EP1175405A1 (en) 2002-01-30
WO2000047563A1 (en) 2000-08-17
CA2361919A1 (en) 2000-08-17
AU2630000A (en) 2000-08-29
AU756174B2 (en) 2003-01-09
JP2002536437A (en) 2002-10-29

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