EP1165598A4 - Hookworm platelet inhibitor - Google Patents

Hookworm platelet inhibitor

Info

Publication number
EP1165598A4
EP1165598A4 EP00918509A EP00918509A EP1165598A4 EP 1165598 A4 EP1165598 A4 EP 1165598A4 EP 00918509 A EP00918509 A EP 00918509A EP 00918509 A EP00918509 A EP 00918509A EP 1165598 A4 EP1165598 A4 EP 1165598A4
Authority
EP
European Patent Office
Prior art keywords
hookworm
platelet inhibitor
platelet
inhibitor
hookworm platelet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00918509A
Other languages
German (de)
French (fr)
Other versions
EP1165598A1 (en
Inventor
Michael Cappello
Robert C Chadderdon
Valle Antonio Del
Lisa M Harrison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Original Assignee
Yale University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yale University filed Critical Yale University
Publication of EP1165598A1 publication Critical patent/EP1165598A1/en
Publication of EP1165598A4 publication Critical patent/EP1165598A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • C07K14/4354—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP00918509A 1999-03-31 2000-03-30 Hookworm platelet inhibitor Withdrawn EP1165598A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12723999P 1999-03-31 1999-03-31
US127239P 1999-03-31
PCT/US2000/008519 WO2000058341A1 (en) 1999-03-31 2000-03-30 Hookworm platelet inhibitor

Publications (2)

Publication Number Publication Date
EP1165598A1 EP1165598A1 (en) 2002-01-02
EP1165598A4 true EP1165598A4 (en) 2002-10-30

Family

ID=22429047

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00918509A Withdrawn EP1165598A4 (en) 1999-03-31 2000-03-30 Hookworm platelet inhibitor

Country Status (5)

Country Link
EP (1) EP1165598A4 (en)
JP (1) JP2002539817A (en)
AU (1) AU3930800A (en)
CA (1) CA2367424A1 (en)
WO (1) WO2000058341A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7691839B2 (en) 2005-09-28 2010-04-06 Biovascular, Inc. Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789178A (en) * 1992-05-11 1998-08-04 Corvas International, Inc. Neutrophil inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9322576D0 (en) * 1993-11-02 1993-12-22 Univ Nottingham Antihaemostatic agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789178A (en) * 1992-05-11 1998-08-04 Corvas International, Inc. Neutrophil inhibitors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHADDERDON ROBERT C ET AL: "The hookworm platelet inhibitor: Functional blockade of integrins GPIIb/IIIa (alphaIIbbeta3) and GPIa/IIa (alpha2beta1) inhibits platelet aggregation and adhesion in vitro.", JOURNAL OF INFECTIOUS DISEASES, vol. 179, no. 5, May 1999 (1999-05-01), pages 1235 - 1241, XP002210470, ISSN: 0022-1899 *
HAWDON J M ET AL: "ANCYLOSTOMA SECRETED PROTEIN 2: CLONING AND CHARACTERIZATION OF A SECOND MEMBER OF A FAMILY OF NEMATODE SECRETED PROTEINS FROM ANCYLOSTOMA CANINUM", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 99, no. 2, 30 April 1999 (1999-04-30), pages 149 - 165, XP001005293, ISSN: 0166-6851 *
MOYLE MATTHEW ET AL: "A hookworm glycoprotein that inhibits neutrophil function is a ligand of the integrin CD11b/CD18.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 13, 1994, pages 10008 - 10015, XP002210469, ISSN: 0021-9258 *
See also references of WO0058341A1 *

Also Published As

Publication number Publication date
JP2002539817A (en) 2002-11-26
CA2367424A1 (en) 2000-10-05
AU3930800A (en) 2000-10-16
WO2000058341A1 (en) 2000-10-05
EP1165598A1 (en) 2002-01-02

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