EP1165146A4 - Lipid soluble radioactive metal chelates for tumor therapy - Google Patents
Lipid soluble radioactive metal chelates for tumor therapyInfo
- Publication number
- EP1165146A4 EP1165146A4 EP00921373A EP00921373A EP1165146A4 EP 1165146 A4 EP1165146 A4 EP 1165146A4 EP 00921373 A EP00921373 A EP 00921373A EP 00921373 A EP00921373 A EP 00921373A EP 1165146 A4 EP1165146 A4 EP 1165146A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- tumor therapy
- radioactive metal
- metal chelates
- lipid soluble
- soluble radioactive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Radiation-Therapy Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12348399P | 1999-03-09 | 1999-03-09 | |
US123483P | 1999-03-09 | ||
PCT/US2000/006207 WO2000053234A1 (en) | 1999-03-09 | 2000-03-09 | Lipid soluble radioactive metal chelates for tumor therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1165146A1 EP1165146A1 (en) | 2002-01-02 |
EP1165146A4 true EP1165146A4 (en) | 2003-09-17 |
Family
ID=22408928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00921373A Withdrawn EP1165146A4 (en) | 1999-03-09 | 2000-03-09 | Lipid soluble radioactive metal chelates for tumor therapy |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1165146A4 (en) |
JP (1) | JP2002538225A (en) |
CA (1) | CA2366593A1 (en) |
WO (1) | WO2000053234A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4176300A (en) * | 1999-04-02 | 2000-10-23 | Ut-Battelle, Llc | Indium-114m as a source for brachytherapy and related compositions and methods |
WO2019243419A1 (en) * | 2018-06-19 | 2019-12-26 | Danmarks Tekniske Universitet | Brachygel for treatment of cancer and/or for guidance of surgery |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0225409A1 (en) * | 1985-12-02 | 1987-06-16 | The Dow Chemical Company | Organic amine phosphonic acid complexes for the treatment of calcific tumors |
US4925925A (en) * | 1988-06-15 | 1990-05-15 | University Of Cincinnati | Radioactive rhenium ligated to 2-hydroxy isobutyric acid and method of use |
US5192526A (en) * | 1989-05-02 | 1993-03-09 | Mallinckrodt Medical, Inc. | Kit for preparation of rhenium therapeutic agents for bone cancer without purification |
US5460785A (en) * | 1989-08-09 | 1995-10-24 | Rhomed Incorporated | Direct labeling of antibodies and other protein with metal ions |
DE19632052A1 (en) * | 1996-08-08 | 1998-02-12 | Michael Prof Dr Eisenhut | New benzamide compounds which complex to technetium and/or rhenium |
US5840859A (en) * | 1995-07-06 | 1998-11-24 | Research Corporation Technologies, Inc. | (Aminostyryl)pyridinium compounds for radiolabelling cell membranes |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4017596A (en) * | 1975-03-03 | 1977-04-12 | Research Corporation | Radiopharmaceutical chelates and method of external imaging |
US5130118A (en) * | 1987-11-06 | 1992-07-14 | Abbott Laboratories | Methods and materials for the preparation of metal labelled antibody solutions |
-
2000
- 2000-03-09 WO PCT/US2000/006207 patent/WO2000053234A1/en active Application Filing
- 2000-03-09 EP EP00921373A patent/EP1165146A4/en not_active Withdrawn
- 2000-03-09 JP JP2000603723A patent/JP2002538225A/en active Pending
- 2000-03-09 CA CA002366593A patent/CA2366593A1/en not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0225409A1 (en) * | 1985-12-02 | 1987-06-16 | The Dow Chemical Company | Organic amine phosphonic acid complexes for the treatment of calcific tumors |
US4925925A (en) * | 1988-06-15 | 1990-05-15 | University Of Cincinnati | Radioactive rhenium ligated to 2-hydroxy isobutyric acid and method of use |
US5192526A (en) * | 1989-05-02 | 1993-03-09 | Mallinckrodt Medical, Inc. | Kit for preparation of rhenium therapeutic agents for bone cancer without purification |
US5460785A (en) * | 1989-08-09 | 1995-10-24 | Rhomed Incorporated | Direct labeling of antibodies and other protein with metal ions |
US5840859A (en) * | 1995-07-06 | 1998-11-24 | Research Corporation Technologies, Inc. | (Aminostyryl)pyridinium compounds for radiolabelling cell membranes |
DE19632052A1 (en) * | 1996-08-08 | 1998-02-12 | Michael Prof Dr Eisenhut | New benzamide compounds which complex to technetium and/or rhenium |
Non-Patent Citations (6)
Title |
---|
BERNARD B F ET AL: "Tc-MIBI, Tc-Tetrofosmin and Tc-Q12 In Vitro and In Vivo - Human distribution, dosimetry, safety and preliminary comparison to thallium 201 for myocardial perfusion imaging", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 25, no. 3, 1 April 1998 (1998-04-01), pages 233 - 240, XP004113280, ISSN: 0969-8051 * |
DEWANJEE M K ET AL: "TECHNETIUM-99M-LABELED PLATELETS: COMPARISON OF LABELING WITH A NEWLIPID-SOLUBLE SN(II)-MERCAPTOPYRIDINE-N-OXIDE AND 99M TC-HMPAO", INTERNATIONAL JOURNAL OF RADIATION APPLICATIONS AND INSTRUMENTATION PART B: NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 18, no. 5, 1991, pages 461 - 468, XP000827908, ISSN: 0883-2897 * |
KOSTARELOS K ET AL: "LIPOSOMES AS CARRIERS OF RADIONUCLIDES: FROM IMAGING TO THERAPY", JOURNAL OF LIPOSOME RESEARCH, MARCEL DEKKER, NEW YORK, US, vol. 9, no. 4, November 1999 (1999-11-01), pages 429 - 460, XP000878065, ISSN: 0898-2104 * |
See also references of WO0053234A1 * |
VIRGOLINI I ET AL: "INDIUM-111-DOTA-LANREOTIDE: BIODISTRIBUTION, SAFETY AND RADIATION ABSORBED DOSE IN TUMOR PATIENTS", JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE. NEW YORK, US, vol. 39, no. 11, November 1998 (1998-11-01), pages 1928 - 1936, XP001073903, ISSN: 0161-5505 * |
ZWEIT J: "RADIONUCLIDES AND CARRIER MOLECULES FOR THERAPY", PHYSICS IN MEDICINE AND BIOLOGY, TAYLOR AND FRANCIS LTD. LONDON, GB, vol. 41, 1996, pages 1905 - 1914, XP001079428, ISSN: 0031-9155 * |
Also Published As
Publication number | Publication date |
---|---|
CA2366593A1 (en) | 2000-09-14 |
JP2002538225A (en) | 2002-11-12 |
WO2000053234A1 (en) | 2000-09-14 |
EP1165146A1 (en) | 2002-01-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20011009 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7A 61K 51/00 A Ipc: 7A 61K 51/04 B Ipc: 7C 07F 5/00 B Ipc: 7A 61N 5/00 B |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20030801 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20071002 |