Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/25—Silicon; Compounds thereof

Definitions

• peroxy compounds in oral care compostions has already been proposed in the prior art.
• Many peroxy compounds have been suggested for whitening/bleaching human teeth, and representative examples of such peroxy compounds are hydrogen peroxide, urea peroxide, organic peracids such as perphthalic acid, diperoxycarboxylic acids, 1,12- dodecanedioic peroxy acid, peroxy acetic acid and systems comprising a peroxy compound and a peroxy acid precursor which generate peroxy acetic acid in situ, such as sodium perborate and tetraacetylethylene diamine (TAED) .
• TAED tetraacetylethylene diamine
• the use of peroxy acetic acid is suggested in particular in e.g. EP-A- 0545,594 (Colgate), which also sets out the various prior proposals, made in the art for several peroxy compounds as bleaching/whitening agent for human teeth.
• L represents a ligand of general formula (B) :
• catalysts of the invention have a relatively low molecular weight and, consequently, are very weight-effective.
• Precursors of the active Fe-complex catalysts of the invention can be any iron co-ordination complex, which, during brushing, is transformed into the active iron complex of general formula (A) .
• the precursor of the Fe-complex of the invention can be a mixture of an iron salt, such as Fe(N0 3 ) 3 , and the ligand L. It is also possible that the catalyst is present mainly in the ligand for, i.e. without complexed Fe, as this also exhibits catalytic activity since any iron present in the oral cavity e.g. in the stain can complex with the ligand.
• a preferred class of ligands is that of compounds of general formula (B) , in which R 2 , R 3 , R 4 , R 5 are independently chosen from C 0 -C 5 alkyl substituted with nitrogen-containing heterocyclic aromatic groups, such as pyridines, pyrazines, pyrazoles, imidazoles, benzimidazoles, thiazoles, triazoles and pyrimidines, in particular pyridines, and in which the substituent group Ri represents any group other than hydrogen, e.g.
• Examples of preferred ligands in their simplest forms are: N,N-bis (pyridin-2 -yl -methyl) -1, 1-bis (pyridin-2 -yl) -1- aminoethane ; N,N-bis (pyridin-2 -yl -methyl) -1, 1-bis (pyridin-2 -yl) -2-phenyl -
• the most preferred ligands are:
• BzNPy N,N-bis (pyridin-2 -yl-methyl) -1, 1-bis (pyridin-2 -yl) -2-phenyl - 1-aminoethane, hereafter referred to as BzNPy.
• Suitable counter ions are those which give rise to the formation of storage-stable solids.
• composition of the invention has particular application in toothpaste formulations, to form a new and improved composition within the purview of the invention comprising a peroxy compound bleach as defined above, the aforesaid Fe- complex catalyst having general formula (A) , particulate abrasive cleaning agents.
• the Fe-complex catalyst will be present in the oral care composition according to the invention in amounts so as to provide the required level in the mouth.
• the Fe- complex catalyst level in the composition corresponds to an iron content of from 0.0005% to 0.5% by weight.
• the Fe content in the formulation is suitably 0.0025 to 0.5%, preferably 0.005 to 0.25% by weight.
• the Fe content in the formulation is suitably 0.0005 to 0.1%, preferably 0.001 to 0.05% by weight.
• compositions of the invention are effective over a wide pH- range of between 7 and 13, with optimal pH-range lying between 8 and 10.
• the peroxy compound is preferably hydrogen peroxide but it may also be a compound which is capable of yielding hydrogen peroxide in aqueous solution.
• Hydrogen peroxide sources are well known in the art. They include the alkali metal peroxides, organic peroxides such as urea peroxide, and inorganic persalts, such as the alkali metal perborates, percarbonates, perphosphates persilicates and persulphates . Mixtures of two or more such compounds may also be suitable.
• Another suitable hydrogen peroxide generating system is a combination of a C ⁇ -C 4 alkanol oxidase and a C ⁇ -C 4 alkanol, especially a combination of methanol oxidase (MOX) and ethanol or even a similar system such as glucose oxidase and glucose.
• MOX methanol oxidase
• ethanol or even a similar system such as glucose oxidase and glucose.
• Organic peroxyacids may also be suitable as the peroxy bleaching compound.
• Such materials normally have the general formula :
• R is an alkyl- or alkylidene- or substituted alkylene group containing from 1 to about 20 carbon atoms, optionally having an internal amide linkage; or a phenylene or substituted phenylene group; and Y is hydrogen, halogen, alkyl, aryl, an imido-aromatic or non-aromatic group, a COOH or COOOH group or a quaternary ammonium group .
• Typical diperoxyacids useful herein include, for example
• inorganic peroxyacid compounds are suitable, such as for example potassium monopersulphate (MPS) . If organic or inorganic peroxyacids are used as the peroxygen compound, the amount thereof will normally be within the range of about 2-10 % by weight, preferably from 4-8 % by weight.
• MPS potassium monopersulphate
• Peroxyacid bleach precursors are known and amply described in literature, such as in GB-A-836988 ; GB-A-86 , 798 ; GB-A- 907,356; GB-A-1 , 003 , 310 and GB-A-1 , 519 , 351 ; DE-A-3 , 337 , 921 ; EP-A-0,185,522; EP-A-0 , 174 , 132 ; EP-A- 0 , 120 , 591 ; and US-A- 1,246,339; US-A-3 , 332 , 882 ; US-A-4 , 128 , 494 ; US-A-4 , 412 , 934 and US-A-4, 675, 393.
• peroxyacid bleach precursors are those of the cationic i.e. quaternary ammonium substituted peroxyacid precursors as disclosed in US-A-4 , 751 , 015 and US- A-4, 397, 757, in EP-A-0,284,292 and EP-A-331 , 229.
• peroxyacid bleach precursors of this class are:
• the oral care compositions of the present invention may furthermore comprise optional, conventional ingredients such as pharmaceutically acceptable carriers like starch, sucrose, water or water/alcohol systems etc.. Small amounts of surfactants may also be included, such as anionic, nonionic and amphoteric surfactants. When formulated into a dentifrice, such formulation may contain all the usual dentifrice ingredients.
• effervescing systems such as sodium bicarbonate/citric acid systems, colour change systems, and so on.
• the oral care composition When formulated as a mouthwash, the oral care composition usually comprises a water/alcohol solution, flavour, humectant, sweetener and colorant.

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Oral & Maxillofacial Surgery (AREA)
• Chemical & Material Sciences (AREA)
• Inorganic Chemistry (AREA)
• Birds (AREA)
• Epidemiology (AREA)
• Cosmetics (AREA)

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• 2000
  • 2000-03-31 EP EP00914175A patent/EP1165029A1/en not_active Withdrawn
  • 2000-03-31 AU AU35585/00A patent/AU3558500A/en not_active Abandoned
  • 2000-03-31 ID IDW00200102098A patent/ID30331A/id unknown
  • 2000-03-31 BR BR0009452-8A patent/BR0009452A/pt not_active Application Discontinuation
  • 2000-03-31 WO PCT/EP2000/002858 patent/WO2000059461A1/en not_active Application Discontinuation
  • 2000-03-31 CN CN 00805516 patent/CN1345223A/zh active Pending

Non-Patent Citations (1)

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