EP1149158A4 - Genetic and epigenetic regulation of abc transporters and ect0-phosphatases for the modulation of drug resistance - Google Patents
Genetic and epigenetic regulation of abc transporters and ect0-phosphatases for the modulation of drug resistanceInfo
- Publication number
- EP1149158A4 EP1149158A4 EP00913315A EP00913315A EP1149158A4 EP 1149158 A4 EP1149158 A4 EP 1149158A4 EP 00913315 A EP00913315 A EP 00913315A EP 00913315 A EP00913315 A EP 00913315A EP 1149158 A4 EP1149158 A4 EP 1149158A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- ect0
- phosphatases
- genetic
- modulation
- drug resistance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US244791 | 1999-02-05 | ||
US09/244,791 US6448472B1 (en) | 1999-02-05 | 1999-02-05 | Genetic and epigenetic manipulation of ABC transporters and ectophosphatases for the conference of hormone and herbicide resistance |
PCT/US2000/002493 WO2000046347A1 (en) | 1999-02-05 | 2000-02-01 | Genetic and epigenetic regulation of abc transporters and ect0-phosphatases for the modulation of drug resistance |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1149158A1 EP1149158A1 (en) | 2001-10-31 |
EP1149158A4 true EP1149158A4 (en) | 2005-01-26 |
Family
ID=22924122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00913315A Withdrawn EP1149158A4 (en) | 1999-02-05 | 2000-02-01 | Genetic and epigenetic regulation of abc transporters and ect0-phosphatases for the modulation of drug resistance |
Country Status (5)
Country | Link |
---|---|
US (1) | US6448472B1 (en) |
EP (1) | EP1149158A4 (en) |
AU (1) | AU777366B2 (en) |
CA (1) | CA2360640A1 (en) |
WO (1) | WO2000046347A1 (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020160915A1 (en) * | 1999-02-05 | 2002-10-31 | Board Of Regents | Pesticidal and herbicidal activity through modulation of animal and plant cell membrane transport |
CA2364592A1 (en) * | 1999-03-03 | 2000-09-08 | Collin E. Thomas | Genetic and epigenetic manipulation of abc transporters and ecto-phosphatases for the conference of drug resistance and for the loss of drug resistance in biological systems and methods for the detection of ecto-phosphatase inhibitors |
DE10049267B4 (en) * | 2000-09-28 | 2005-06-02 | Mpb Cologne Gmbh Molecular Plant & Protein Biotechnology | Method for producing or increasing resistance in organisms to biotic stress factors |
ATE449184T1 (en) | 2001-01-12 | 2009-12-15 | Univ Washington | MDR1 VARIANTS AND METHODS OF USE THEREOF |
AU2002254342A1 (en) * | 2001-03-23 | 2002-10-08 | The Board Of Trustees Of The University Of Illinois | Compounds capable of modulating the activity of multidrug transporters and therapeutic use of the same |
WO2004004712A1 (en) * | 2002-07-09 | 2004-01-15 | Fasgen, Llc | Methods of treating microbial infections in humans and animals |
AU2003304398A1 (en) * | 2002-10-16 | 2005-02-25 | Board Of Regents, The University Of Texas System | Methods and compositions for increasing the efficacy of biologically-active ingredients |
US7790762B2 (en) * | 2002-10-31 | 2010-09-07 | National Jewish Health | Compounds and methods for thiol-containing compound efflux and cancer treatment |
US20080221029A1 (en) * | 2002-10-31 | 2008-09-11 | Regents Of The University Of Colorado | Methods for treatment of thiol-containing compound deficient conditions |
US20040087527A1 (en) * | 2002-10-31 | 2004-05-06 | Day Brian J. | Methods for treatment of thiol-containing compound deficient conditions |
GB0307470D0 (en) * | 2003-04-01 | 2003-05-07 | Creative Gene Technology Ltd | Improvements in or relating to plant viability |
WO2010065725A2 (en) | 2008-12-05 | 2010-06-10 | Board Of Regents, The University Of Texas System | Regulation of cotton fiber growth by extracellular nucleotides and ectoapyrases |
BR112012018618A2 (en) * | 2010-01-26 | 2017-01-10 | Pioneer Hi Bred Int | method for selecting a plant or germplasm having tolerance, increased tolerance, susceptibility, or increased susceptibility to one or more herbicides, plant, kit for selecting at least one soybean plant, screening method for a soybean, method for controlling so selective weed, method for selectively screening soybean plants for tolerance to one or more herbicides |
KR102640773B1 (en) | 2015-01-27 | 2024-02-23 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | Fungicide enhancer effective in treating plants infected with fungal pathogens |
WO2017083728A2 (en) | 2015-11-12 | 2017-05-18 | Board Of Regents, The University Of Texas System | Modified plants containing combination of apyrase genes and method for making modified plants with combination of apyrase genes |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999010514A1 (en) * | 1997-08-26 | 1999-03-04 | North Carolina State University | Fumonosin resistance |
WO2000018886A1 (en) * | 1998-09-25 | 2000-04-06 | Wisconsin Alumni Research Foundation | Xenobiotic detoxification gene from plants |
WO2000052144A1 (en) * | 1999-03-03 | 2000-09-08 | Board Of Regents, The University Of Texas System | Genetic and epigenetic manipulation of abc transporters and ecto-phosphatases for the conference of drug resistance and for the loss of drug resistance in biological systems and methods for the detection of ecto-phosphatase inhibitors |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5498533A (en) * | 1993-07-30 | 1996-03-12 | Washington State University Research Foundation | Control of growth and development of potato plants |
-
1999
- 1999-02-05 US US09/244,791 patent/US6448472B1/en not_active Expired - Lifetime
-
2000
- 2000-02-01 EP EP00913315A patent/EP1149158A4/en not_active Withdrawn
- 2000-02-01 CA CA002360640A patent/CA2360640A1/en not_active Abandoned
- 2000-02-01 AU AU34783/00A patent/AU777366B2/en not_active Ceased
- 2000-02-01 WO PCT/US2000/002493 patent/WO2000046347A1/en active IP Right Grant
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999010514A1 (en) * | 1997-08-26 | 1999-03-04 | North Carolina State University | Fumonosin resistance |
WO2000018886A1 (en) * | 1998-09-25 | 2000-04-06 | Wisconsin Alumni Research Foundation | Xenobiotic detoxification gene from plants |
WO2000052144A1 (en) * | 1999-03-03 | 2000-09-08 | Board Of Regents, The University Of Texas System | Genetic and epigenetic manipulation of abc transporters and ecto-phosphatases for the conference of drug resistance and for the loss of drug resistance in biological systems and methods for the detection of ecto-phosphatase inhibitors |
Non-Patent Citations (14)
Title |
---|
LEDOUX SEVERINE ET AL: "Overexpression of ecto-5'-nucleotidase promotes p-glycoprotein expression in renal epithelial cells", KIDNEY INTERNATIONAL, vol. 52, no. 4, 1997, pages 953 - 961, XP008035923, ISSN: 0085-2538 * |
LU Y-P ET AL: "ATMRP2, AN ARABIDOPSIS ATP BINDING CASSETTE TRANSPORTER ABLE TO TRANSPORT GLUTATHIONE S-CONJUGATES AND CHLOROPHYLL CATABOLITES: FUNCTIONAL COMPARISONS WITH ATMRP1", PLANT CELL, AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS, ROCKVILLE, MD, US, vol. 10, February 1998 (1998-02-01), pages 267 - 282, XP002928654, ISSN: 1040-4651 * |
See also references of WO0046347A1 * |
SIDLER M ET AL: "INVOLVEMENT OF AN ABC TRANSPORTER IN A DEVELOPMENTAL PATHWAY REGULATING HYPOCOTYL CELL ELONGATION IN THE LIGHT", PLANT CELL, AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS, ROCKVILLE, MD, US, vol. 10, no. 10, October 1998 (1998-10-01), pages 1623 - 1636, XP002925142, ISSN: 1040-4651 * |
THOMAS COLLIN ET AL: "A role for ectophosphatase in xenobiotic resistance", PLANT CELL, vol. 12, no. 4, April 2000 (2000-04-01), pages 519 - 533, XP002297775, ISSN: 1040-4651 * |
THOMAS COLLIN ET AL: "Apyrase functions in plant phosphate nutrition and mobilizes phosphate from extracellular ATP", PLANT PHYSIOLOGY (ROCKVILLE), vol. 119, no. 2, February 1999 (1999-02-01), pages 543 - 551, XP002928134, ISSN: 0032-0889 * |
THOMAS COLLIN ET AL: "Plant metabolism of extracellular ATP: Mechanism and implications.", PLANT BIOLOGY (ROCKVILLE), vol. 1998, 1998, & ANNUAL MEETING OF THE AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS COMBINED WITH THE 9TH INTERNATIONAL CO; MADION, WI, USA; JUNE 27-JULY 01, 1998, SEESION NO 45, XP002297772 * |
THOMAS COLLINS E ET AL: "Evaluating roles for apyrase in plant growth and development", PLANT PHYSIOLOGY (ROCKVILLE), vol. 114, no. 3 SUPPL., 1997, & PLANT BIOLOGY '97: 1997 ANNUAL MEETINGS OF THE AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS AND THE CANAD; VANCOUVER, BRITISH COLUMBIA, CANADA; AUGUST 2-6, 1997, pages 48, XP002297773, ISSN: 0032-0889 * |
TOMMASINI R ET AL: "DIFFERENTIAL EXPRESSION OF GENES CODING FOR ABS TRANSPORTERS AFTER TREATMENT OF ARABIDOPSIS THALIANA WITH XENOBIOTICS", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 411, no. 2-3, 1997, pages 206 - 210, XP000919207, ISSN: 0014-5793 * |
UJHAZY PETER ET AL: "Ecto-5'-nucleotidase (CD73) in multidrug-resistant cell lines generated by doxorubicin", INTERNATIONAL JOURNAL OF CANCER, vol. 59, no. 1, 1994, pages 83 - 93, XP008035899, ISSN: 0020-7136 * |
UJHAZY PETER ET AL: "Evidence for the involvement of ecto-5'-nucleotidase (CD73) in drug resistance", INTERNATIONAL JOURNAL OF CANCER, vol. 68, no. 4, 1996, pages 493 - 500, XP002203581, ISSN: 0020-7136 * |
VAN VEEN HENDRIK W ET AL: "Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 93, no. 20, 1996, pages 10668 - 10672, XP002036835, ISSN: 0027-8424 * |
WANG T-F ET AL: "CD39 IS AN ECTO-(CA2+,MG2+)-APYRASE", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 271, no. 17, 26 April 1996 (1996-04-26), pages 9898 - 9901, XP002928135, ISSN: 0021-9258 * |
WINDSOR BRIAN ET AL: "Multiherbicide tolerance conferred by AtPgp1 and apyrase overexpression in Arabidopsis thaliana.", NATURE BIOTECHNOLOGY, vol. 21, no. 4, April 2003 (2003-04-01), pages 428 - 433, XP002297776, ISSN: 1087-0156 * |
Also Published As
Publication number | Publication date |
---|---|
CA2360640A1 (en) | 2000-08-10 |
US6448472B1 (en) | 2002-09-10 |
AU3478300A (en) | 2000-08-25 |
WO2000046347A1 (en) | 2000-08-10 |
AU777366B2 (en) | 2004-10-14 |
EP1149158A1 (en) | 2001-10-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20010905 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
AX | Request for extension of the european patent |
Free format text: AL;LT;LV;MK;RO;SI |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYST |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20041213 |
|
17Q | First examination report despatched |
Effective date: 20051006 |
|
17Q | First examination report despatched |
Effective date: 20051006 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20071113 |