EP1149158A4 - Genetic and epigenetic regulation of abc transporters and ect0-phosphatases for the modulation of drug resistance - Google Patents

Genetic and epigenetic regulation of abc transporters and ect0-phosphatases for the modulation of drug resistance

Info

Publication number
EP1149158A4
EP1149158A4 EP00913315A EP00913315A EP1149158A4 EP 1149158 A4 EP1149158 A4 EP 1149158A4 EP 00913315 A EP00913315 A EP 00913315A EP 00913315 A EP00913315 A EP 00913315A EP 1149158 A4 EP1149158 A4 EP 1149158A4
Authority
EP
European Patent Office
Prior art keywords
ect0
phosphatases
genetic
modulation
drug resistance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00913315A
Other languages
German (de)
French (fr)
Other versions
EP1149158A1 (en
Inventor
Collin E Thomas
J Brian Windsor
Stan J Roux
Alan M Lloyd
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Publication of EP1149158A1 publication Critical patent/EP1149158A1/en
Publication of EP1149158A4 publication Critical patent/EP1149158A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
EP00913315A 1999-02-05 2000-02-01 Genetic and epigenetic regulation of abc transporters and ect0-phosphatases for the modulation of drug resistance Withdrawn EP1149158A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US244791 1999-02-05
US09/244,791 US6448472B1 (en) 1999-02-05 1999-02-05 Genetic and epigenetic manipulation of ABC transporters and ectophosphatases for the conference of hormone and herbicide resistance
PCT/US2000/002493 WO2000046347A1 (en) 1999-02-05 2000-02-01 Genetic and epigenetic regulation of abc transporters and ect0-phosphatases for the modulation of drug resistance

Publications (2)

Publication Number Publication Date
EP1149158A1 EP1149158A1 (en) 2001-10-31
EP1149158A4 true EP1149158A4 (en) 2005-01-26

Family

ID=22924122

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00913315A Withdrawn EP1149158A4 (en) 1999-02-05 2000-02-01 Genetic and epigenetic regulation of abc transporters and ect0-phosphatases for the modulation of drug resistance

Country Status (5)

Country Link
US (1) US6448472B1 (en)
EP (1) EP1149158A4 (en)
AU (1) AU777366B2 (en)
CA (1) CA2360640A1 (en)
WO (1) WO2000046347A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020160915A1 (en) * 1999-02-05 2002-10-31 Board Of Regents Pesticidal and herbicidal activity through modulation of animal and plant cell membrane transport
CA2364592A1 (en) * 1999-03-03 2000-09-08 Collin E. Thomas Genetic and epigenetic manipulation of abc transporters and ecto-phosphatases for the conference of drug resistance and for the loss of drug resistance in biological systems and methods for the detection of ecto-phosphatase inhibitors
DE10049267B4 (en) * 2000-09-28 2005-06-02 Mpb Cologne Gmbh Molecular Plant & Protein Biotechnology Method for producing or increasing resistance in organisms to biotic stress factors
ATE449184T1 (en) 2001-01-12 2009-12-15 Univ Washington MDR1 VARIANTS AND METHODS OF USE THEREOF
AU2002254342A1 (en) * 2001-03-23 2002-10-08 The Board Of Trustees Of The University Of Illinois Compounds capable of modulating the activity of multidrug transporters and therapeutic use of the same
WO2004004712A1 (en) * 2002-07-09 2004-01-15 Fasgen, Llc Methods of treating microbial infections in humans and animals
AU2003304398A1 (en) * 2002-10-16 2005-02-25 Board Of Regents, The University Of Texas System Methods and compositions for increasing the efficacy of biologically-active ingredients
US7790762B2 (en) * 2002-10-31 2010-09-07 National Jewish Health Compounds and methods for thiol-containing compound efflux and cancer treatment
US20080221029A1 (en) * 2002-10-31 2008-09-11 Regents Of The University Of Colorado Methods for treatment of thiol-containing compound deficient conditions
US20040087527A1 (en) * 2002-10-31 2004-05-06 Day Brian J. Methods for treatment of thiol-containing compound deficient conditions
GB0307470D0 (en) * 2003-04-01 2003-05-07 Creative Gene Technology Ltd Improvements in or relating to plant viability
WO2010065725A2 (en) 2008-12-05 2010-06-10 Board Of Regents, The University Of Texas System Regulation of cotton fiber growth by extracellular nucleotides and ectoapyrases
BR112012018618A2 (en) * 2010-01-26 2017-01-10 Pioneer Hi Bred Int method for selecting a plant or germplasm having tolerance, increased tolerance, susceptibility, or increased susceptibility to one or more herbicides, plant, kit for selecting at least one soybean plant, screening method for a soybean, method for controlling so selective weed, method for selectively screening soybean plants for tolerance to one or more herbicides
KR102640773B1 (en) 2015-01-27 2024-02-23 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 Fungicide enhancer effective in treating plants infected with fungal pathogens
WO2017083728A2 (en) 2015-11-12 2017-05-18 Board Of Regents, The University Of Texas System Modified plants containing combination of apyrase genes and method for making modified plants with combination of apyrase genes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999010514A1 (en) * 1997-08-26 1999-03-04 North Carolina State University Fumonosin resistance
WO2000018886A1 (en) * 1998-09-25 2000-04-06 Wisconsin Alumni Research Foundation Xenobiotic detoxification gene from plants
WO2000052144A1 (en) * 1999-03-03 2000-09-08 Board Of Regents, The University Of Texas System Genetic and epigenetic manipulation of abc transporters and ecto-phosphatases for the conference of drug resistance and for the loss of drug resistance in biological systems and methods for the detection of ecto-phosphatase inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498533A (en) * 1993-07-30 1996-03-12 Washington State University Research Foundation Control of growth and development of potato plants

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999010514A1 (en) * 1997-08-26 1999-03-04 North Carolina State University Fumonosin resistance
WO2000018886A1 (en) * 1998-09-25 2000-04-06 Wisconsin Alumni Research Foundation Xenobiotic detoxification gene from plants
WO2000052144A1 (en) * 1999-03-03 2000-09-08 Board Of Regents, The University Of Texas System Genetic and epigenetic manipulation of abc transporters and ecto-phosphatases for the conference of drug resistance and for the loss of drug resistance in biological systems and methods for the detection of ecto-phosphatase inhibitors

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
LEDOUX SEVERINE ET AL: "Overexpression of ecto-5'-nucleotidase promotes p-glycoprotein expression in renal epithelial cells", KIDNEY INTERNATIONAL, vol. 52, no. 4, 1997, pages 953 - 961, XP008035923, ISSN: 0085-2538 *
LU Y-P ET AL: "ATMRP2, AN ARABIDOPSIS ATP BINDING CASSETTE TRANSPORTER ABLE TO TRANSPORT GLUTATHIONE S-CONJUGATES AND CHLOROPHYLL CATABOLITES: FUNCTIONAL COMPARISONS WITH ATMRP1", PLANT CELL, AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS, ROCKVILLE, MD, US, vol. 10, February 1998 (1998-02-01), pages 267 - 282, XP002928654, ISSN: 1040-4651 *
See also references of WO0046347A1 *
SIDLER M ET AL: "INVOLVEMENT OF AN ABC TRANSPORTER IN A DEVELOPMENTAL PATHWAY REGULATING HYPOCOTYL CELL ELONGATION IN THE LIGHT", PLANT CELL, AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS, ROCKVILLE, MD, US, vol. 10, no. 10, October 1998 (1998-10-01), pages 1623 - 1636, XP002925142, ISSN: 1040-4651 *
THOMAS COLLIN ET AL: "A role for ectophosphatase in xenobiotic resistance", PLANT CELL, vol. 12, no. 4, April 2000 (2000-04-01), pages 519 - 533, XP002297775, ISSN: 1040-4651 *
THOMAS COLLIN ET AL: "Apyrase functions in plant phosphate nutrition and mobilizes phosphate from extracellular ATP", PLANT PHYSIOLOGY (ROCKVILLE), vol. 119, no. 2, February 1999 (1999-02-01), pages 543 - 551, XP002928134, ISSN: 0032-0889 *
THOMAS COLLIN ET AL: "Plant metabolism of extracellular ATP: Mechanism and implications.", PLANT BIOLOGY (ROCKVILLE), vol. 1998, 1998, & ANNUAL MEETING OF THE AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS COMBINED WITH THE 9TH INTERNATIONAL CO; MADION, WI, USA; JUNE 27-JULY 01, 1998, SEESION NO 45, XP002297772 *
THOMAS COLLINS E ET AL: "Evaluating roles for apyrase in plant growth and development", PLANT PHYSIOLOGY (ROCKVILLE), vol. 114, no. 3 SUPPL., 1997, & PLANT BIOLOGY '97: 1997 ANNUAL MEETINGS OF THE AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS AND THE CANAD; VANCOUVER, BRITISH COLUMBIA, CANADA; AUGUST 2-6, 1997, pages 48, XP002297773, ISSN: 0032-0889 *
TOMMASINI R ET AL: "DIFFERENTIAL EXPRESSION OF GENES CODING FOR ABS TRANSPORTERS AFTER TREATMENT OF ARABIDOPSIS THALIANA WITH XENOBIOTICS", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 411, no. 2-3, 1997, pages 206 - 210, XP000919207, ISSN: 0014-5793 *
UJHAZY PETER ET AL: "Ecto-5'-nucleotidase (CD73) in multidrug-resistant cell lines generated by doxorubicin", INTERNATIONAL JOURNAL OF CANCER, vol. 59, no. 1, 1994, pages 83 - 93, XP008035899, ISSN: 0020-7136 *
UJHAZY PETER ET AL: "Evidence for the involvement of ecto-5'-nucleotidase (CD73) in drug resistance", INTERNATIONAL JOURNAL OF CANCER, vol. 68, no. 4, 1996, pages 493 - 500, XP002203581, ISSN: 0020-7136 *
VAN VEEN HENDRIK W ET AL: "Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 93, no. 20, 1996, pages 10668 - 10672, XP002036835, ISSN: 0027-8424 *
WANG T-F ET AL: "CD39 IS AN ECTO-(CA2+,MG2+)-APYRASE", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 271, no. 17, 26 April 1996 (1996-04-26), pages 9898 - 9901, XP002928135, ISSN: 0021-9258 *
WINDSOR BRIAN ET AL: "Multiherbicide tolerance conferred by AtPgp1 and apyrase overexpression in Arabidopsis thaliana.", NATURE BIOTECHNOLOGY, vol. 21, no. 4, April 2003 (2003-04-01), pages 428 - 433, XP002297776, ISSN: 1087-0156 *

Also Published As

Publication number Publication date
CA2360640A1 (en) 2000-08-10
US6448472B1 (en) 2002-09-10
AU3478300A (en) 2000-08-25
WO2000046347A1 (en) 2000-08-10
AU777366B2 (en) 2004-10-14
EP1149158A1 (en) 2001-10-31

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