EP1146792A1 - Gomme a macher contenant du lactate de calcium et ameliorant la sante dentaire - Google Patents

Gomme a macher contenant du lactate de calcium et ameliorant la sante dentaire

Info

Publication number
EP1146792A1
EP1146792A1 EP00904525A EP00904525A EP1146792A1 EP 1146792 A1 EP1146792 A1 EP 1146792A1 EP 00904525 A EP00904525 A EP 00904525A EP 00904525 A EP00904525 A EP 00904525A EP 1146792 A1 EP1146792 A1 EP 1146792A1
Authority
EP
European Patent Office
Prior art keywords
chewing gum
gum
calcium lactate
calcium
ppm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00904525A
Other languages
German (de)
English (en)
Other versions
EP1146792A4 (fr
Inventor
Pamela M. Mazurek
Roman M. Barabolak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WM Wrigley Jr Co
Original Assignee
WM Wrigley Jr Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WM Wrigley Jr Co filed Critical WM Wrigley Jr Co
Publication of EP1146792A1 publication Critical patent/EP1146792A1/fr
Publication of EP1146792A4 publication Critical patent/EP1146792A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G4/126—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates generally to chewing gums. More specifically, the present invention relates to chewing gums that can provide dental benefits. Except for the common cold, dental caries (tooth decay) is the most prevalent human disorder. See, The Merck Manual, Sixteenth Edition, p. 2480. Even though, many steps have been taken to reduce dental caries and tooth decay, such as fluoridation and improved dental care, tooth decay continues to be a significant problem. This is especially true in the adult population; 80% of the tooth decay occurs in 20% of the population. See Featherstone, An Updated Understanding of the Mechanism of Dental Decay and its Prevention, Nutrition Quarterly, Vol. 14, No. 1, 1990, pp. 5-11.
  • a thin layer of dental enamel forms a protective coating over the tooth.
  • This coating consists mainly of calcium, phosphate, and other ions in a hydroxyapatite-like structure.
  • the enamel contains 2 to 5 percent carbonate; this carbonate content makes the enamel susceptible to acid dissolution. See, Featherstone, id. at 6.
  • Tooth decay begins when the Streptococcus mutans, that reside principally in the plaque that adheres to a tooth surface, metabolize the fermentable carbohydrates consumed by the host. During the metabolism of the fermentable carbohydrates by the bacteria, lactic acid and other organic acids are secreted as a by-product. These acids reduce the pH of the surrounding plaque/tooth environment. When the pH of the plaque/tooth environment drops below a critical level of 5.5 to 5.7, hydroxyapatite (calcium phosphate hydroxide, Ca 10 (PO 4 ) 6 (OH) 2 ), the key component of tooth enamel, begins to dissolve. This critical pH can change depending on the concentration of the key ions. Typically, the dissolution begins below the tooth's porous surface.
  • the natural remineralization process involves, in part, the flow of saliva over the plaque.
  • the saliva can raise the pH of the environment. Additionally, calcium and phosphate ions in the saliva precipitate out to replace the hydroxyapatite that was dissolved by the organic acids created during the metabolism of the fermentable carbohydrates.
  • this remineralization process only occurs at significant levels when the pH is above the critical level. Therefore, if the saliva does not sufficiently raise the pH, significant remineralization will not occur. But, the remineralization process may be enhanced by fluoride in the oral cavity that speeds up new crystal growth and makes a flurorapatite-like material that is precipitated on the surface of the crystals inside the caries lesion. See, Featherstone, id. at 7.
  • U.S. Patent No. 5,378,171 discloses a sugar chewing gum with dental health benefits that includes calcium glycerophosphate.
  • the present invention provides a composition and method for the remineralization of enamel.
  • sugar free chewing gum is provided that includes a therapeutically effective amount of calcium lactate. It has been found that calcium lactate counteracts the decaying process. Calcium lactate is believed to function by promoting remineralization of the tooth enamel caused by dental caries. Calcium lactate has been found to be an effective enamel remineralization agent that is acceptable from sensory and safety standpoints.
  • calcium lactate can be used in chewing gum.
  • Chewing gum is an especially good vehicle for delivering calcium lactate because it can deliver the ingredient over prolonged periods of time. Additionally, chewing gum can be conveniently used almost anywhere, at anytime, as opposed to a rinse or dentifrices.
  • a method for remineralizing enamel comprising the step of providing a chewing gum that includes a therapeutically effective amount of calcium lactate.
  • two pieces of chewing gum are chewed at a time.
  • the gum is chewed at least twice a day.
  • the chewing gum produces a calcium ion concentration in the saliva of the mouth of the chewer of at least 200 ppm.
  • the gum is chewed for at least two minutes.
  • the present invention also provides a chewing gum for reducing the generation of dental caries comprising a water insoluble base, water soluble portion and flavor, and calcium lactate.
  • the chewing gum is sugarless. In an embodiment, the chewing gum is wax-free.
  • the chewing gum is a low calorie chewing gum. In an embodiment, the chewing gum contains other therapeutic agents. In an embodiment, the chewing gum includes at least 40 mg of calcium lactate. In an embodiment, the chewing gum is in the form of a stick. In an embodiment, the chewing gum is in the form of a pellet.
  • the chewing gum includes an additional therapeutic agent.
  • An advantage of the present invention is to provide a method for preventing, or reducing the risk of, dental caries of the remineralization of enamel.
  • Another advantage of the present invention is to treat dental caries.
  • an advantage of the present invention is to provide a chewing gum that can be used to improve dental health.
  • an advantage of the present invention is to provide a chewing gum that does not have the sensory drawbacks of other sources of calcium.
  • an advantage of the present invention is to provide an easy and enjoyable way to improve dental health. Still further, an advantage of the present invention is to provide a composition and method for delivering a therapeutic agent over a prolonged period of time to the oral region.
  • the present invention provides a method and composition for remineralizing tooth enamel and thereby preventing and/or treating dental caries.
  • a chewing gum is provided that includes a therapeutically effective amount of calcium lactate.
  • the chewing gum of the present invention by including a therapeutically effective amount of calcium lactate, can improve dental health when chewed.
  • Calcium lactate is believed to function by the remineralization of tooth enamel. Calcium lactate when provided in a chewing gum can produce a calcium ion concentration in the saliva during chewing which is effective to remineralized carious lesions in teeth. For example, it has been found that 80 mg of calcium lactate in chewing gum will produce saliva calcium levels greater than 500 parts per million, this level has been shown to remineralize teeth. It is believed that the calcium ion concentration in the saliva should be above 200 ppm in order to initiate the remineralization process. Preferably the calcium ion concentration should be above 350 ppm and most preferably above 500 ppm. These levels should be provided for at least one minute, preferably more than two minutes, and most preferably more than four minutes upon chewing the gum.
  • a method for the remineralization of carious lesions in teeth comprises providing a sugarless chewing gum comprising calcium lactate.
  • the gum is chewed for at least two minutes (preferably at least 5 minutes and most preferably at least 20 minutes) whereby the calcium is released by the gum in a quantity sufficient to produce a calcium concentration which is effective to remineralized the carious lesions.
  • This treatment is repeated at least twice, preferably at least three times, and most preferably at least five times daily until the lesion has been remineralized.
  • the chewing gum composition may be any chewing gum formula and most preferably a sugarless formulation. Such formulas typically contain a major amount of a sugar alcohol bulking agent, a substantial portion of gum base, minor amounts of syrups, softeners, flavors, color and high intensity sweeteners. Low calorie gums which contain reduced levels of sugar alcohols and increased levels of base and/or low calorie or calorie- free bulking agents are also anticipated.
  • the product may be formed into tabs, sticks, chunks or coated pellets. A piece size of 1 to 4 grams is preferred. As previously mentioned, with smaller pieces sizes, it may be desirable to split the calcium lactate dosage between two or more pieces to reduce the concentration for improved sensory acceptability.
  • Chewing gum generally consists of a water insoluble gum base, a water soluble portion, and flavors.
  • the water soluble portion dissipates with a portion of the flavor over a period of time during chewing.
  • the gum base portion is retained in the mouth throughout the chew.
  • the insoluble gum base generally comprises elastomers, resins, fats and oils, softeners, and inorganic fillers.
  • the gum base may or may not include wax.
  • the insoluble gum base can constitute approximately 5 to about 95 percent, by weight, of the chewing gum, more commonly, the gum base comprises 10 to about 50 percent of the gum, and in some preferred embodiments, 20 to about 35 percent, by weight, of the chewing gum.
  • the chewing gum base of the present invention contains about
  • Synthetic elastomers may include, but are not limited to, polyisobutylene with GPC weight average molecular weight of about 10,000 to about 95,000, isobutylene- isoprene copolymer (butyl elastomer), styrene-butadiene copolymers having styrene- butadiene ratios of about 1:3 to about 3:1, polyvinyl acetate having GPC weight average molecular weight of about 2,000 to about 90,000, polyisoprene, polyethylene, vinyl acetate-vinyl laurate copolymer having vinyl laurate content of about 5 to about 50 percent by weight of the copolymer, and combinations thereof.
  • Preferred ranges are, for polyisobutylene, 50,000 to 80,000 GPC weight average molecular weight, for styrene-butadiene, 1 :1 to 1 :3 bound styrene-butadiene, for polyvinyl acetate, 10,000 to 65,000 GPC weight average molecular weight with the higher molecular weight polyvinyl acetates typically used in bubble gum base, and for vinyl acetate-vinyl laurate, vinyl laurate content of 10-45 percent.
  • Natural elastomers may include natural rubber such as smoked or liquid latex and guayule as well as natural gums such as jelutong, lechi caspi, perillo, sorva, massaranduba balata, massaranduba chocolate, nispero, rosindinha, chicle, gutta hang kang, and combinations thereof.
  • the preferred synthetic elastomer and natural elastomer concentrations vary depending on whether the chewing gum in which the base is used is abhesive or conventional, bubble gum or regular gum, as discussed below.
  • Preferred natural elastomers include jelutong, chicle, sorva and massaranduba balata.
  • Elastomer plasticizers may include, but are not limited to, natural rosin esters such as glycerol esters of partially hydrogenated rosin, glycerol esters polymerized rosin, glycerol esters of partially dimerized rosin, glycerol esters of rosin, pentaerythritol esters of partially hydrogenated rosin, methyl and partially hydrogenated methyl esters of rosin, pentaerythritol esters of rosin; synthetics such as terpene resins derived from alpha- pinene, beta-pinene, and or d-limonene; and any suitable combinations of the foregoing.
  • the preferred elastomer plasticizers will also vary depending on the specific application, and on the type of elastomer which is used.
  • Fillers/texturizers may include magnesium and calcium carbonate, ground limestone, silicate types such as magnesium and aluminum silicate, clay, alumina, talc, titanium oxide, mono-, di- and tri-calcium phosphate, cellulose polymers, such as wood, and combinations thereof.
  • Softeners/emulsifiers may include tallow, hydrogenated tallow, hydrogenated and partially hydrogenated vegetable oils, cocoa butter, glycerol monostearate, glycerol triacetate, lecithin, mono-, di- and triglycerides, acetylated monoglycerides, fatty acids (e.g. stearic, palmitic, oleic and linoleic acids), and combinations thereof.
  • Colorants and whiteners may include FD&C-type dyes and lakes, fruit and vegetable extracts, titanium dioxide, and combinations thereof.
  • the base may or may not include wax.
  • An example of a wax-free gum base is disclosed in U.S. Patent No. 5,286,500, the disclosure of which is incorporated herein by reference.
  • a typical chewing gum composition includes a water soluble bulk portion and one or more flavoring agents.
  • the water soluble portion can include bulk sweeteners, high intensity sweeteners, flavoring agents, softeners, emulsifiers, colors, acidulants, fillers, antioxidants, and other components that provide desired attributes.
  • Softeners are added to the chewing gum in order to optimize the chewability and mouth feel of the gum.
  • the softeners which are also known as plasticizers and plasticizing agents, generally constitute between approximately 0.5 to about 15% by weight of the chewing gum.
  • the softeners may include glycerin, lecithin, and combinations thereof.
  • Aqueous sweetener solutions such as those containing sorbitol, hydrogenated starch hydrolysates, corn syrup and combinations thereof, may also be used as softeners and binding agents in chewing gum.
  • Bulk sweeteners include both sugar and sugarless components. Bulk sweeteners typically constitute 5 to about 95 % by weight of the chewing gum, more typically, 20 to 80% by weight, and more commonly, 30 to 60% by weight of the gum.
  • Sugar sweeteners generally include saccharide-containing components commonly known in the chewing gum art, including, but not limited to, sucrose, dextrose, maltose, dextrin, dried invert sugar, fructose, levulose, galactose, corn syrup solids, and the like, alone or in combination.
  • Sugarless sweeteners include, but are not limited to, sugar alcohols such as sorbitol, mannitol, xylitol, hydrogenated starch hydrolysates, maltitol, and the like, alone or in combination.
  • High intensity artificial sweeteners can also be used, alone or in combination with the above.
  • Preferred sweeteners include, but are not limited to sucralose, aspartame, salts of acesulfame, alitame, saccharin and its salts, cyclamic acid and its salts, glycyrrhizin, dihydrochalcones, thaumatin, monellin, and the like, alone or in combination.
  • Such techniques as wet granulation, wax granulation, spray drying, spray chilling, fluid bed coating, coacervation, and fiber extension may be used to achieve the desired release characteristics.
  • Usage level of the artificial sweetener will vary greatly and will depend on such factors as potency of the sweetener, rate of release, desired sweetness of the product, level and type of flavor used and cost considerations. Thus, the active level of artificial sweetener may vary from 0.02 to about 8%. When carriers used for encapsulation are included, the usage level of the encapsulated sweetener will be proportionately higher. Combinations of sugar and/or sugarless sweeteners may be used in chewing gum.
  • the softener may also provide additional sweetness such as with aqueous sugar or alditol solutions.
  • a low caloric bulking agent can be used.
  • low caloric bulking agents include: polydextrose; Raftilose, Raftilin; Fructooligosaccharides (NutraFlora); Palatinose oligosaccharide; Guar Gum Hydrolysate (Sun Fiber); or indigestible dextrin (Fibersol).
  • other low calorie bulking agents can be used.
  • flavoring agents can be used.
  • the flavor can be used in amounts of approximately 0.1 to about 15 weight percent of the gum, and preferably, 0.2 to 5%.
  • Flavoring agents may include essential oils, synthetic flavors or mixtures thereof including, but not limited to, oils derived from plants and fruits such as citrus oils, fruit essences, peppermint oil, spearmint oil, other mint oils, clove oil, oil of wintergreen, anise and the like. Artificial flavoring agents and components may also be used. Natural and artificial flavoring agents may be combined in any sensorially acceptable fashion. Additional oral health ingredients may be added including but not limited to, antiplaque/anti-gingivitis agents (such as chlorhexidine, CPC, triclosan), pH control agents (including Urea and buffers,) other inorganic components for tarter or caries control (phosphates, fluoride) and biological agents (antibodies, enzymes).
  • antiplaque/anti-gingivitis agents such as chlorhexidine, CPC, triclosan
  • pH control agents including Urea and buffers,
  • other inorganic components for tarter or caries control phosphates, fluoride
  • biological agents antibodies, enzymes
  • the agents be safe and effective and that they do not react undesirably with each other such as may happen with phosphate salts.
  • the calcium lactate is mixed into the chewing gum mass but it may also be added to a coating syrup or used as a dry charge in a coating process in the case of a coated chewing gum.
  • Hydrogenated Starch 10.0 10.00 9.9 Hydrolysate Syrup (85% solids) Color 0.1 0.20 0.1 0.15
  • Examples 4 and 8 are low caloric chewing gums.
  • Example 9 may be coated with xylitol, sorbitol, palatinit or maltitol with added chlorhexidine, triclosan and/or cetylpyridinium chloride (CPC).
  • CPC cetylpyridinium chloride
  • Recommended dose is two pellets.
  • In- vitro testing was conducted to determine what level of calcium in saliva would remineralize softened tooth enamel. Enamel specimens were removed from extracted human teeth, polished and decalcified by exposure to 0.1M lactic acid solution. This treatment resulted in lesions with a surface hardness range of 25 to 45 Vicker's Hardness Number (VHN) and an average lesion depth of 40-70 microns.
  • VHN Vicker's Hardness Number
  • Solutions of calcium and fluoride in artificial saliva were prepared to treat the enamel.
  • the saliva formula includes 1.5mM (40 ppm) of calcium per liter.
  • Two calcium levels were tested, 0 and 500 ppm and each level was prepared with 0, 0.05 and 0.10 ppm fluoride to simulate the effect of tooth brushing.
  • the "Zero" calcium level had no calcium added to the 40 ppm already present.
  • the 500 ppm calcium level had 460 ppm additional calcium to bring the total concentration up to 500 ppm.
  • Table 1 The six solutions thus prepared are summarized in Table 1.
  • Enamel samples were exposed to 20 minutes of acid challenge followed by 60 minutes of one calcium fluoride solution (above) then 30 minutes of pure saliva. This cycle was repeated three times daily, four days per week for 3 weeks. The samples were tested for hardness after each week. Each treatment was performed on 12 samples. The results are reported in Table 2.
  • Example 14 used a different flavor from the other three Examples. Eight volunteers chewed the gums of Examples 11 and 12 for six minutes with saliva samples collected over two minute intervals. The saliva samples were analyzed for calcium by Direct Current Plasma. The two products delivered similar calcium levels reported in Table 6.
  • Example 11 Example 12
  • Example 13 Example 14

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Physiology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Confectionery (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne une gomme à mâcher et un procédé permettant de reminéraliser l'émail dentaire. La gomme à mâcher contient une partie base insoluble, une partie soluble dans l'eau, un arôme et une quantité thérapeutiquement efficace de lactate de calcium.
EP00904525A 1999-01-26 2000-01-21 Gomme a macher contenant du lactate de calcium et ameliorant la sante dentaire Withdrawn EP1146792A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11719599P 1999-01-26 1999-01-26
US117195P 1999-01-26
PCT/US2000/001733 WO2000042861A1 (fr) 1999-01-26 2000-01-21 Gomme a macher contenant du lactate de calcium et ameliorant la sante dentaire

Publications (2)

Publication Number Publication Date
EP1146792A1 true EP1146792A1 (fr) 2001-10-24
EP1146792A4 EP1146792A4 (fr) 2005-07-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP00904525A Withdrawn EP1146792A4 (fr) 1999-01-26 2000-01-21 Gomme a macher contenant du lactate de calcium et ameliorant la sante dentaire

Country Status (4)

Country Link
EP (1) EP1146792A4 (fr)
AU (1) AU2626700A (fr)
CA (1) CA2359641A1 (fr)
WO (1) WO2000042861A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001028503A1 (fr) * 1999-10-19 2001-04-26 The Nutrasweet Company PRODUITS D'HYGIENE PERSONNELLE A BASE DE N-[N-(3,3-DIMETHYLBUTYL)-1-α-ASPARTYL]-L-PHENYLALANINE METHYL ESTER
US20030104099A1 (en) * 2001-10-12 2003-06-05 Lee Willy W. Mineral delivery systems and methods
US8496913B2 (en) 2005-01-28 2013-07-30 Gumlink A/S Compressed chewing gum tablet
US20060182693A1 (en) 2005-01-28 2006-08-17 Gumlink A/S Chewing gum possessing tooth cleaning effect and a teeth cleaning method
EP1685875A1 (fr) * 2005-01-28 2006-08-02 Gumlink A/S Chewing gum de soins buccaux à plusieur fonctions
EP1688162A1 (fr) * 2005-01-28 2006-08-09 Gumlink A/S Chewing gum de soins buccaux à plusieurs fonctions pour nettoyage des dents
EP1693085A1 (fr) * 2005-01-28 2006-08-23 Gumlink A/S Un kit de nettoyage des dents par la mastification d'un ensemble de gomme à mâcher
EP1693086A1 (fr) * 2005-01-28 2006-08-23 Gumlink A/S Chewing gum de soins buccaux à plusieur fonctions
EP1845960B1 (fr) 2005-01-28 2008-11-26 Gumlink A/S Un kit de nettoyage des dents par la mastification d'un ensemble de gomme à mâcher
WO2012001347A1 (fr) 2010-06-29 2012-01-05 Ucl Business Plc Produits à effets bénéfiques sur la santé bucco-dentaire

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB486712A (en) * 1937-04-19 1938-06-09 Lodewijk Hamburger Improvements in or relating to the manufacture of preparations containing calcium compounds for per oral administration
US5378131A (en) * 1993-02-18 1995-01-03 The Wm. Wrigley Jr. Company Chewing gum with dental health benefits employing calcium glycerophosphate
WO1997006774A1 (fr) * 1995-08-08 1997-02-27 Enamelon, Inc. Produits et procedes de remineralisation des dents
US5645853A (en) * 1995-08-08 1997-07-08 Enamelon Inc. Chewing gum compositions and the use thereof for remineralization of lesions in teeth
US5833954A (en) * 1996-08-20 1998-11-10 American Dental Association Health Foundation Anti-carious chewing gums, candies, gels, toothpastes and dentifrices
US5958380A (en) * 1997-07-07 1999-09-28 Enamelon, Inc. Chewing gum products and the use thereof for remineralizing subsurface dental lesions and for mineralizing exposed dentinal tubules

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB486712A (en) * 1937-04-19 1938-06-09 Lodewijk Hamburger Improvements in or relating to the manufacture of preparations containing calcium compounds for per oral administration
US5378131A (en) * 1993-02-18 1995-01-03 The Wm. Wrigley Jr. Company Chewing gum with dental health benefits employing calcium glycerophosphate
WO1997006774A1 (fr) * 1995-08-08 1997-02-27 Enamelon, Inc. Produits et procedes de remineralisation des dents
US5645853A (en) * 1995-08-08 1997-07-08 Enamelon Inc. Chewing gum compositions and the use thereof for remineralization of lesions in teeth
US5833954A (en) * 1996-08-20 1998-11-10 American Dental Association Health Foundation Anti-carious chewing gums, candies, gels, toothpastes and dentifrices
US5958380A (en) * 1997-07-07 1999-09-28 Enamelon, Inc. Chewing gum products and the use thereof for remineralizing subsurface dental lesions and for mineralizing exposed dentinal tubules

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0042861A1 *

Also Published As

Publication number Publication date
EP1146792A4 (fr) 2005-07-20
CA2359641A1 (fr) 2000-07-27
AU2626700A (en) 2000-08-07
WO2000042861A1 (fr) 2000-07-27

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