EP1135157A4 - Procede de regulation de la permeabilite de la barriere hemato-encephalique - Google Patents

Procede de regulation de la permeabilite de la barriere hemato-encephalique

Info

Publication number
EP1135157A4
EP1135157A4 EP99953234A EP99953234A EP1135157A4 EP 1135157 A4 EP1135157 A4 EP 1135157A4 EP 99953234 A EP99953234 A EP 99953234A EP 99953234 A EP99953234 A EP 99953234A EP 1135157 A4 EP1135157 A4 EP 1135157A4
Authority
EP
European Patent Office
Prior art keywords
permeability
regulating
brain barrier
blood brain
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99953234A
Other languages
German (de)
English (en)
Other versions
EP1135157A1 (fr
Inventor
Carol Shoshkes Reiss
Takashi Komatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York University NYU
Original Assignee
New York University NYU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York University NYU filed Critical New York University NYU
Publication of EP1135157A1 publication Critical patent/EP1135157A1/fr
Publication of EP1135157A4 publication Critical patent/EP1135157A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EP99953234A 1998-10-19 1999-10-19 Procede de regulation de la permeabilite de la barriere hemato-encephalique Withdrawn EP1135157A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10481798P 1998-10-19 1998-10-19
US104817P 1998-10-19
PCT/US1999/024442 WO2000023102A1 (fr) 1998-10-19 1999-10-19 Procede de regulation de la permeabilite de la barriere hemato-encephalique

Publications (2)

Publication Number Publication Date
EP1135157A1 EP1135157A1 (fr) 2001-09-26
EP1135157A4 true EP1135157A4 (fr) 2004-12-08

Family

ID=22302559

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99953234A Withdrawn EP1135157A4 (fr) 1998-10-19 1999-10-19 Procede de regulation de la permeabilite de la barriere hemato-encephalique

Country Status (2)

Country Link
EP (1) EP1135157A4 (fr)
WO (1) WO2000023102A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000056328A1 (fr) * 1999-03-19 2000-09-28 Enos Pharmaceuticals, Inc. Renforcement de la biodisponibilite des medicaments dans le cerveau
EP1251840A2 (fr) * 2000-01-26 2002-10-30 Cedars-Sinai Medical Center Procede utilisant l'activation des canaux potassiques pour l'apport d'un medicament jusqu'a une region anormale du cerveau et/ou jusqu'a une tumeur maligne
US7018979B1 (en) 2000-01-26 2006-03-28 Cedars-Sinai Medical Center Method for using potassium channel agonists for delivering a medicant to an abnormal brain region and/or a malignant tumor
US7211561B2 (en) 2001-10-12 2007-05-01 Cedars-Sinai Medical Center Method for inducing selective cell death of malignant cells by activation of calcium-activated potassium channels (KCa)
WO2009018338A2 (fr) 2007-07-31 2009-02-05 Limerick Biopharma, Inc. Analogues de pyrone phosphorylés et procédés
KR102282716B1 (ko) * 2020-02-07 2021-07-29 포항공과대학교 산학협력단 일산화질소 공여체를 포함하는 뇌-혈관 장벽 투과성을 증가시키는데 사용하기 위한 조성물 및 그의 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527527A (en) * 1989-09-07 1996-06-18 Alkermes, Inc. Transferrin receptor specific antibody-neuropharmaceutical agent conjugates
US5604198A (en) * 1994-05-12 1997-02-18 Poduslo; Joseph F. Method to enhance permeability of the blood/brain blood/nerve barriers to therapeutic agents
US5670477A (en) * 1995-04-20 1997-09-23 Joseph F. Poduslo Method to enhance permeability of the blood/brain blood/nerve bariers to therapeutic agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO0023102A1 *

Also Published As

Publication number Publication date
WO2000023102A1 (fr) 2000-04-27
EP1135157A1 (fr) 2001-09-26

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20010517

AK Designated contracting states

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Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20041026

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20060825